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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RapGEF1
Full Name:
Rap guanine nucleotide exchange factor 1
Alias:
C3G; C3G protein; CRK SH3-binding GNRP; GRF2; Guanine nucleotide-releasing factor 2; Rap guanine nucleotide exchange factor (GEF) 1; RPGF1
Type:
Guanine nucleotide exchange factor for Rap G protein
Mass (Da):
120548
Number AA:
1077
UniProt ID:
Q13905
International Prot ID:
IPI00332841
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007264
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
T
D
S
Q
R
S
H
L
S
S
F
T
M
Site 2
S11
D
S
Q
R
S
H
L
S
S
F
T
M
K
L
M
Site 3
S12
S
Q
R
S
H
L
S
S
F
T
M
K
L
M
D
Site 4
S23
K
L
M
D
K
F
H
S
P
K
I
K
R
T
P
Site 5
T29
H
S
P
K
I
K
R
T
P
S
K
K
G
K
P
Site 6
S31
P
K
I
K
R
T
P
S
K
K
G
K
P
A
E
Site 7
T53
K
P
V
N
K
E
A
T
D
R
F
L
P
E
G
Site 8
Y61
D
R
F
L
P
E
G
Y
P
L
P
L
D
L
E
Site 9
T77
Q
A
V
E
F
M
S
T
S
A
V
A
S
R
S
Site 10
S78
A
V
E
F
M
S
T
S
A
V
A
S
R
S
Q
Site 11
S82
M
S
T
S
A
V
A
S
R
S
Q
R
Q
K
N
Site 12
S84
T
S
A
V
A
S
R
S
Q
R
Q
K
N
L
S
Site 13
S91
S
Q
R
Q
K
N
L
S
W
L
E
E
K
E
K
Site 14
S102
E
K
E
K
E
V
V
S
A
L
R
Y
F
K
T
Site 15
T109
S
A
L
R
Y
F
K
T
I
V
D
K
M
A
I
Site 16
S148
N
D
P
R
I
Q
H
S
S
A
L
S
S
C
Y
Site 17
S149
D
P
R
I
Q
H
S
S
A
L
S
S
C
Y
S
Site 18
S152
I
Q
H
S
S
A
L
S
S
C
Y
S
R
V
Y
Site 19
S153
Q
H
S
S
A
L
S
S
C
Y
S
R
V
Y
Q
Site 20
Y155
S
S
A
L
S
S
C
Y
S
R
V
Y
Q
S
L
Site 21
S156
S
A
L
S
S
C
Y
S
R
V
Y
Q
S
L
A
Site 22
Y159
S
S
C
Y
S
R
V
Y
Q
S
L
A
N
L
I
Site 23
S179
V
M
L
E
G
V
N
S
E
D
K
E
M
V
T
Site 24
T187
E
D
K
E
M
V
T
T
V
K
G
V
I
K
A
Site 25
T206
V
K
E
L
V
R
L
T
I
E
K
Q
G
R
P
Site 26
S214
I
E
K
Q
G
R
P
S
P
T
S
P
V
K
P
Site 27
T216
K
Q
G
R
P
S
P
T
S
P
V
K
P
S
S
Site 28
S217
Q
G
R
P
S
P
T
S
P
V
K
P
S
S
P
Site 29
S222
P
T
S
P
V
K
P
S
S
P
A
S
K
P
D
Site 30
S223
T
S
P
V
K
P
S
S
P
A
S
K
P
D
G
Site 31
S226
V
K
P
S
S
P
A
S
K
P
D
G
P
A
E
Site 32
T237
G
P
A
E
L
P
L
T
D
R
E
V
E
I
L
Site 33
S251
L
N
K
T
T
G
M
S
Q
S
T
E
L
L
P
Site 34
T261
T
E
L
L
P
D
A
T
D
E
E
V
A
P
P
Site 35
S281
G
I
R
V
V
D
N
S
P
P
P
A
L
P
P
Site 36
S293
L
P
P
K
K
R
Q
S
A
P
S
P
T
R
V
Site 37
S296
K
K
R
Q
S
A
P
S
P
T
R
V
A
V
V
Site 38
S307
V
A
V
V
A
P
M
S
R
A
T
S
G
S
S
Site 39
T310
V
A
P
M
S
R
A
T
S
G
S
S
L
P
V
Site 40
S311
A
P
M
S
R
A
T
S
G
S
S
L
P
V
G
Site 41
S313
M
S
R
A
T
S
G
S
S
L
P
V
G
I
N
Site 42
S314
S
R
A
T
S
G
S
S
L
P
V
G
I
N
R
Site 43
Y329
Q
D
F
D
V
D
C
Y
A
Q
R
R
L
S
G
Site 44
S335
C
Y
A
Q
R
R
L
S
G
G
S
H
S
Y
G
Site 45
S338
Q
R
R
L
S
G
G
S
H
S
Y
G
G
E
S
Site 46
S340
R
L
S
G
G
S
H
S
Y
G
G
E
S
P
R
Site 47
Y341
L
S
G
G
S
H
S
Y
G
G
E
S
P
R
L
Site 48
S345
S
H
S
Y
G
G
E
S
P
R
L
S
P
C
S
Site 49
S349
G
G
E
S
P
R
L
S
P
C
S
S
I
G
K
Site 50
S352
S
P
R
L
S
P
C
S
S
I
G
K
L
S
K
Site 51
S353
P
R
L
S
P
C
S
S
I
G
K
L
S
K
S
Site 52
S358
C
S
S
I
G
K
L
S
K
S
D
E
Q
L
S
Site 53
S360
S
I
G
K
L
S
K
S
D
E
Q
L
S
S
L
Site 54
S365
S
K
S
D
E
Q
L
S
S
L
D
R
D
S
G
Site 55
S366
K
S
D
E
Q
L
S
S
L
D
R
D
S
G
Q
Site 56
S371
L
S
S
L
D
R
D
S
G
Q
C
S
R
N
T
Site 57
S375
D
R
D
S
G
Q
C
S
R
N
T
S
C
E
T
Site 58
T378
S
G
Q
C
S
R
N
T
S
C
E
T
L
D
H
Site 59
S379
G
Q
C
S
R
N
T
S
C
E
T
L
D
H
Y
Site 60
Y386
S
C
E
T
L
D
H
Y
D
P
D
Y
E
F
L
Site 61
Y390
L
D
H
Y
D
P
D
Y
E
F
L
Q
Q
D
L
Site 62
S398
E
F
L
Q
Q
D
L
S
N
A
D
Q
I
P
Q
Site 63
S412
Q
Q
T
A
W
N
L
S
P
L
P
E
S
L
G
Site 64
S417
N
L
S
P
L
P
E
S
L
G
E
S
G
S
P
Site 65
S421
L
P
E
S
L
G
E
S
G
S
P
F
L
G
P
Site 66
S423
E
S
L
G
E
S
G
S
P
F
L
G
P
P
F
Site 67
T452
A
P
G
Q
Q
T
D
T
P
P
A
L
P
E
K
Site 68
S463
L
P
E
K
K
R
R
S
A
A
S
Q
T
A
D
Site 69
S466
K
K
R
R
S
A
A
S
Q
T
A
D
G
S
G
Site 70
T468
R
R
S
A
A
S
Q
T
A
D
G
S
G
C
R
Site 71
S472
A
S
Q
T
A
D
G
S
G
C
R
V
S
Y
E
Site 72
S477
D
G
S
G
C
R
V
S
Y
E
R
H
P
S
Q
Site 73
Y478
G
S
G
C
R
V
S
Y
E
R
H
P
S
Q
Y
Site 74
S483
V
S
Y
E
R
H
P
S
Q
Y
D
N
I
S
G
Site 75
Y485
Y
E
R
H
P
S
Q
Y
D
N
I
S
G
E
D
Site 76
S489
P
S
Q
Y
D
N
I
S
G
E
D
L
Q
S
T
Site 77
S495
I
S
G
E
D
L
Q
S
T
A
P
I
P
S
V
Site 78
Y504
A
P
I
P
S
V
P
Y
A
P
F
A
A
I
L
Site 79
S519
P
F
Q
H
G
G
S
S
A
P
V
E
F
V
G
Site 80
T529
V
E
F
V
G
D
F
T
A
P
E
S
T
G
D
Site 81
S533
G
D
F
T
A
P
E
S
T
G
D
P
E
K
P
Site 82
Y561
Y
M
Q
L
L
E
D
Y
S
E
P
Q
P
S
M
Site 83
S562
M
Q
L
L
E
D
Y
S
E
P
Q
P
S
M
F
Site 84
S567
D
Y
S
E
P
Q
P
S
M
F
Y
Q
T
P
Q
Site 85
Y570
E
P
Q
P
S
M
F
Y
Q
T
P
Q
N
E
H
Site 86
T572
Q
P
S
M
F
Y
Q
T
P
Q
N
E
H
I
Y
Site 87
Y579
T
P
Q
N
E
H
I
Y
Q
Q
K
N
K
L
L
Site 88
Y590
N
K
L
L
M
E
V
Y
G
F
S
D
S
F
S
Site 89
S595
E
V
Y
G
F
S
D
S
F
S
G
V
D
S
V
Site 90
S597
Y
G
F
S
D
S
F
S
G
V
D
S
V
Q
E
Site 91
S601
D
S
F
S
G
V
D
S
V
Q
E
L
A
P
P
Site 92
S632
D
G
H
P
R
D
P
S
A
V
S
G
V
P
G
Site 93
S642
S
G
V
P
G
K
D
S
R
D
G
S
E
R
A
Site 94
S646
G
K
D
S
R
D
G
S
E
R
A
P
K
S
P
Site 95
S652
G
S
E
R
A
P
K
S
P
D
A
L
E
S
A
Site 96
S658
K
S
P
D
A
L
E
S
A
Q
S
E
E
E
V
Site 97
S661
D
A
L
E
S
A
Q
S
E
E
E
V
D
E
L
Site 98
S669
E
E
E
V
D
E
L
S
L
I
D
H
N
E
I
Site 99
T681
N
E
I
M
S
R
L
T
L
K
Q
E
G
D
D
Site 100
S696
G
P
D
V
R
G
G
S
G
D
I
L
L
V
H
Site 101
Y715
D
R
K
D
L
V
L
Y
C
E
A
F
L
T
T
Site 102
Y723
C
E
A
F
L
T
T
Y
R
T
F
I
S
P
E
Site 103
T725
A
F
L
T
T
Y
R
T
F
I
S
P
E
E
L
Site 104
S728
T
T
Y
R
T
F
I
S
P
E
E
L
I
K
K
Site 105
Y740
I
K
K
L
Q
Y
R
Y
E
K
F
S
P
F
A
Site 106
S744
Q
Y
R
Y
E
K
F
S
P
F
A
D
T
F
K
Site 107
T749
K
F
S
P
F
A
D
T
F
K
K
R
V
S
K
Site 108
S755
D
T
F
K
K
R
V
S
K
N
T
F
F
V
L
Site 109
T758
K
K
R
V
S
K
N
T
F
F
V
L
V
R
V
Site 110
T819
K
K
L
L
R
C
A
T
S
S
Q
P
L
A
A
Site 111
S820
K
L
L
R
C
A
T
S
S
Q
P
L
A
A
R
Site 112
T835
G
V
A
A
R
P
G
T
L
H
D
F
H
S
H
Site 113
S841
G
T
L
H
D
F
H
S
H
E
I
A
E
Q
L
Site 114
S876
K
E
Q
N
E
E
K
S
P
N
L
T
Q
F
T
Site 115
T880
E
E
K
S
P
N
L
T
Q
F
T
E
H
F
N
Site 116
S928
R
K
L
N
N
F
N
S
Y
L
A
I
L
S
A
Site 117
T950
R
L
E
W
Q
K
Q
T
S
E
G
L
A
E
Y
Site 118
S951
L
E
W
Q
K
Q
T
S
E
G
L
A
E
Y
C
Site 119
T959
E
G
L
A
E
Y
C
T
L
I
D
S
S
S
S
Site 120
S963
E
Y
C
T
L
I
D
S
S
S
S
F
R
A
Y
Site 121
S965
C
T
L
I
D
S
S
S
S
F
R
A
Y
R
A
Site 122
S966
T
L
I
D
S
S
S
S
F
R
A
Y
R
A
A
Site 123
Y970
S
S
S
S
F
R
A
Y
R
A
A
L
S
E
V
Site 124
S975
R
A
Y
R
A
A
L
S
E
V
E
P
P
C
I
Site 125
Y1002
V
H
L
G
N
P
D
Y
I
D
G
K
V
N
F
Site 126
Y1030
R
C
F
Q
Q
A
H
Y
D
M
R
R
N
D
D
Site 127
S1058
E
E
A
L
W
E
L
S
L
K
I
K
P
R
N
Site 128
T1067
K
I
K
P
R
N
I
T
R
R
K
T
D
R
E
Site 129
T1071
R
N
I
T
R
R
K
T
D
R
E
E
K
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation