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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF7
Full Name:
Rho guanine nucleotide exchange factor 7
Alias:
ARH7; ARHG7; Beta-Pix; COOL1; COOL-1; DKFZp686C12170; DKFZp761K1021; Guanine nucleotide exchange factor 7; KIAA0142; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; Pak3bp; PAK-interacting exchange factor beta; Pixb; Rho; Rho guanine nucleotide exchange factor (GEF) 7; SH3 domain-containing proline-rich protein
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
90012
Number AA:
803
UniProt ID:
Q14155
International Prot ID:
IPI00449906
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
I
T
L
G
V
L
E
S
P
K
K
T
I
S
D
Site 2
T23
V
L
E
S
P
K
K
T
I
S
D
P
E
G
F
Site 3
S25
E
S
P
K
K
T
I
S
D
P
E
G
F
L
Q
Site 4
S34
P
E
G
F
L
Q
A
S
L
K
D
G
V
V
L
Site 5
T52
L
E
R
L
L
P
G
T
I
E
K
V
Y
P
E
Site 6
Y57
P
G
T
I
E
K
V
Y
P
E
P
R
S
E
S
Site 7
S62
K
V
Y
P
E
P
R
S
E
S
E
C
L
S
N
Site 8
S64
Y
P
E
P
R
S
E
S
E
C
L
S
N
I
R
Site 9
S68
R
S
E
S
E
C
L
S
N
I
R
E
F
L
R
Site 10
S90
L
E
L
L
F
P
P
S
Q
P
P
Q
H
L
V
Site 11
Y113
T
F
D
A
N
D
L
Y
Q
G
Q
N
F
N
K
Site 12
S141
D
I
G
L
G
S
D
S
V
C
A
R
P
S
S
Site 13
S147
D
S
V
C
A
R
P
S
S
H
R
I
K
S
F
Site 14
S148
S
V
C
A
R
P
S
S
H
R
I
K
S
F
D
Site 15
S153
P
S
S
H
R
I
K
S
F
D
S
L
G
S
Q
Site 16
S156
H
R
I
K
S
F
D
S
L
G
S
Q
S
L
H
Site 17
S159
K
S
F
D
S
L
G
S
Q
S
L
H
T
R
T
Site 18
S161
F
D
S
L
G
S
Q
S
L
H
T
R
T
S
K
Site 19
S167
Q
S
L
H
T
R
T
S
K
L
F
Q
G
Q
Y
Site 20
Y174
S
K
L
F
Q
G
Q
Y
R
S
L
D
M
T
D
Site 21
S176
L
F
Q
G
Q
Y
R
S
L
D
M
T
D
N
S
Site 22
T180
Q
Y
R
S
L
D
M
T
D
N
S
N
N
Q
L
Site 23
S183
S
L
D
M
T
D
N
S
N
N
Q
L
V
V
R
Site 24
T198
A
K
F
N
F
Q
Q
T
N
E
D
E
L
S
F
Site 25
S204
Q
T
N
E
D
E
L
S
F
S
K
G
D
V
I
Site 26
S206
N
E
D
E
L
S
F
S
K
G
D
V
I
H
V
Site 27
T214
K
G
D
V
I
H
V
T
R
V
E
E
G
G
W
Site 28
S235
G
R
T
G
W
F
P
S
N
Y
V
R
E
V
K
Site 29
Y237
T
G
W
F
P
S
N
Y
V
R
E
V
K
A
S
Site 30
S244
Y
V
R
E
V
K
A
S
E
K
P
V
S
P
K
Site 31
S249
K
A
S
E
K
P
V
S
P
K
S
G
T
L
K
Site 32
S252
E
K
P
V
S
P
K
S
G
T
L
K
S
P
P
Site 33
T254
P
V
S
P
K
S
G
T
L
K
S
P
P
K
G
Site 34
S257
P
K
S
G
T
L
K
S
P
P
K
G
F
D
T
Site 35
T264
S
P
P
K
G
F
D
T
T
A
I
N
K
S
Y
Site 36
T265
P
P
K
G
F
D
T
T
A
I
N
K
S
Y
Y
Site 37
Y271
T
T
A
I
N
K
S
Y
Y
N
V
V
L
Q
N
Site 38
Y272
T
A
I
N
K
S
Y
Y
N
V
V
L
Q
N
I
Site 39
S287
L
E
T
E
N
E
Y
S
K
E
L
Q
T
V
L
Site 40
S295
K
E
L
Q
T
V
L
S
T
Y
L
R
P
L
Q
Site 41
Y297
L
Q
T
V
L
S
T
Y
L
R
P
L
Q
T
S
Site 42
T303
T
Y
L
R
P
L
Q
T
S
E
K
L
S
S
A
Site 43
S304
Y
L
R
P
L
Q
T
S
E
K
L
S
S
A
N
Site 44
S308
L
Q
T
S
E
K
L
S
S
A
N
I
S
Y
L
Site 45
S309
Q
T
S
E
K
L
S
S
A
N
I
S
Y
L
M
Site 46
S313
K
L
S
S
A
N
I
S
Y
L
M
G
N
L
E
Site 47
Y361
M
P
Q
M
K
T
L
Y
L
T
Y
C
A
N
H
Site 48
T376
P
S
A
V
N
V
L
T
E
H
S
E
E
L
G
Site 49
T388
E
L
G
E
F
M
E
T
K
G
A
S
S
P
G
Site 50
Y413
P
F
M
R
L
D
K
Y
P
T
L
L
K
E
L
Site 51
Y427
L
E
R
H
M
E
D
Y
H
T
D
R
Q
D
I
Site 52
T429
R
H
M
E
D
Y
H
T
D
R
Q
D
I
Q
K
Site 53
S437
D
R
Q
D
I
Q
K
S
M
A
A
F
K
N
L
Site 54
S493
V
L
I
Q
C
A
G
S
E
E
K
N
E
R
Y
Site 55
Y500
S
E
E
K
N
E
R
Y
L
L
L
F
P
N
V
Site 56
S518
L
S
A
S
P
R
M
S
G
F
I
Y
Q
G
K
Site 57
Y522
P
R
M
S
G
F
I
Y
Q
G
K
L
P
T
T
Site 58
S539
T
I
T
K
L
E
D
S
E
N
H
R
N
A
F
Site 59
T580
L
Q
K
Q
T
K
V
T
S
V
G
N
P
T
I
Site 60
S581
Q
K
Q
T
K
V
T
S
V
G
N
P
T
I
K
Site 61
T586
V
T
S
V
G
N
P
T
I
K
P
H
S
V
P
Site 62
S591
N
P
T
I
K
P
H
S
V
P
S
H
T
L
P
Site 63
S594
I
K
P
H
S
V
P
S
H
T
L
P
S
H
P
Site 64
T596
P
H
S
V
P
S
H
T
L
P
S
H
P
V
T
Site 65
S599
V
P
S
H
T
L
P
S
H
P
V
T
P
S
S
Site 66
T603
T
L
P
S
H
P
V
T
P
S
S
K
H
A
D
Site 67
S605
P
S
H
P
V
T
P
S
S
K
H
A
D
S
K
Site 68
S606
S
H
P
V
T
P
S
S
K
H
A
D
S
K
P
Site 69
S611
P
S
S
K
H
A
D
S
K
P
A
P
L
T
P
Site 70
T617
D
S
K
P
A
P
L
T
P
A
Y
H
T
L
P
Site 71
Y620
P
A
P
L
T
P
A
Y
H
T
L
P
H
P
S
Site 72
T634
S
H
H
G
T
P
H
T
T
I
N
W
G
P
L
Site 73
T646
G
P
L
E
P
P
K
T
P
K
P
W
S
L
S
Site 74
S651
P
K
T
P
K
P
W
S
L
S
C
L
R
P
A
Site 75
S653
T
P
K
P
W
S
L
S
C
L
R
P
A
P
P
Site 76
S664
P
A
P
P
L
R
P
S
A
A
L
C
Y
K
E
Site 77
S674
L
C
Y
K
E
D
L
S
K
S
P
K
T
M
K
Site 78
S676
Y
K
E
D
L
S
K
S
P
K
T
M
K
K
L
Site 79
T679
D
L
S
K
S
P
K
T
M
K
K
L
L
P
K
Site 80
S694
R
K
P
E
R
K
P
S
D
E
E
F
A
S
R
Site 81
S700
P
S
D
E
E
F
A
S
R
K
S
T
A
A
L
Site 82
S703
E
E
F
A
S
R
K
S
T
A
A
L
E
E
D
Site 83
T704
E
F
A
S
R
K
S
T
A
A
L
E
E
D
A
Site 84
Y720
I
L
K
V
I
E
A
Y
C
T
S
A
K
T
R
Site 85
T722
K
V
I
E
A
Y
C
T
S
A
K
T
R
Q
T
Site 86
T729
T
S
A
K
T
R
Q
T
L
N
S
T
W
Q
G
Site 87
S732
K
T
R
Q
T
L
N
S
T
W
Q
G
T
D
L
Site 88
T733
T
R
Q
T
L
N
S
T
W
Q
G
T
D
L
M
Site 89
S752
L
A
D
D
D
Q
P
S
L
D
S
L
G
R
R
Site 90
S755
D
D
Q
P
S
L
D
S
L
G
R
R
S
S
L
Site 91
S760
L
D
S
L
G
R
R
S
S
L
S
R
L
E
P
Site 92
S761
D
S
L
G
R
R
S
S
L
S
R
L
E
P
S
Site 93
S763
L
G
R
R
S
S
L
S
R
L
E
P
S
D
L
Site 94
S768
S
L
S
R
L
E
P
S
D
L
S
E
D
S
D
Site 95
S771
R
L
E
P
S
D
L
S
E
D
S
D
Y
D
S
Site 96
S774
P
S
D
L
S
E
D
S
D
Y
D
S
I
W
T
Site 97
Y776
D
L
S
E
D
S
D
Y
D
S
I
W
T
A
H
Site 98
S778
S
E
D
S
D
Y
D
S
I
W
T
A
H
S
Y
Site 99
S784
D
S
I
W
T
A
H
S
Y
R
M
G
S
T
S
Site 100
Y785
S
I
W
T
A
H
S
Y
R
M
G
S
T
S
R
Site 101
S789
A
H
S
Y
R
M
G
S
T
S
R
K
S
C
C
Site 102
T790
H
S
Y
R
M
G
S
T
S
R
K
S
C
C
S
Site 103
S791
S
Y
R
M
G
S
T
S
R
K
S
C
C
S
Y
Site 104
S794
M
G
S
T
S
R
K
S
C
C
S
Y
I
S
H
Site 105
S800
K
S
C
C
S
Y
I
S
H
Q
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation