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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
dynactin 1
Full Name:
Dynactin subunit 1
Alias:
150 kDa dynein-associated polypeptide; 150 kDa dynein-associated polypeptide;DP-150;DAP-150;p150-glued;p135; DAP-150; DCTN1; DP-150; DYNA; Dynactin 1 (p150, glued); DYNAN; P135; P150-glued
Type:
Motor protein
Mass (Da):
141695
Number AA:
1278
UniProt ID:
Q14203
International Prot ID:
IPI00029485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030286
GO:0000776
Uniprot
OncoNet
Molecular Function:
GO:0003774
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0007067
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
Q
S
K
R
H
V
Y
S
R
Site 2
Y9
A
Q
S
K
R
H
V
Y
S
R
T
P
S
G
S
Site 3
S10
Q
S
K
R
H
V
Y
S
R
T
P
S
G
S
R
Site 4
T12
K
R
H
V
Y
S
R
T
P
S
G
S
R
M
S
Site 5
S14
H
V
Y
S
R
T
P
S
G
S
R
M
S
A
E
Site 6
S16
Y
S
R
T
P
S
G
S
R
M
S
A
E
A
S
Site 7
S19
T
P
S
G
S
R
M
S
A
E
A
S
A
R
P
Site 8
S23
S
R
M
S
A
E
A
S
A
R
P
L
R
V
G
Site 9
S31
A
R
P
L
R
V
G
S
R
V
E
V
I
G
K
Site 10
T72
A
K
G
K
N
D
G
T
V
Q
G
R
K
Y
F
Site 11
Y78
G
T
V
Q
G
R
K
Y
F
T
C
D
E
G
H
Site 12
T103
V
F
E
D
G
A
D
T
T
S
P
E
T
P
D
Site 13
T104
F
E
D
G
A
D
T
T
S
P
E
T
P
D
S
Site 14
S105
E
D
G
A
D
T
T
S
P
E
T
P
D
S
S
Site 15
T108
A
D
T
T
S
P
E
T
P
D
S
S
A
S
K
Site 16
S111
T
S
P
E
T
P
D
S
S
A
S
K
V
L
K
Site 17
S112
S
P
E
T
P
D
S
S
A
S
K
V
L
K
R
Site 18
S114
E
T
P
D
S
S
A
S
K
V
L
K
R
E
G
Site 19
T122
K
V
L
K
R
E
G
T
D
T
T
A
K
T
S
Site 20
T124
L
K
R
E
G
T
D
T
T
A
K
T
S
K
L
Site 21
T125
K
R
E
G
T
D
T
T
A
K
T
S
K
L
R
Site 22
T141
L
K
P
K
K
A
P
T
A
R
K
T
T
T
R
Site 23
T145
K
A
P
T
A
R
K
T
T
T
R
R
P
K
P
Site 24
T146
A
P
T
A
R
K
T
T
T
R
R
P
K
P
T
Site 25
T147
P
T
A
R
K
T
T
T
R
R
P
K
P
T
R
Site 26
T153
T
T
R
R
P
K
P
T
R
P
A
S
T
G
V
Site 27
S157
P
K
P
T
R
P
A
S
T
G
V
A
G
A
S
Site 28
T158
K
P
T
R
P
A
S
T
G
V
A
G
A
S
S
Site 29
S164
S
T
G
V
A
G
A
S
S
S
L
G
P
S
G
Site 30
S165
T
G
V
A
G
A
S
S
S
L
G
P
S
G
S
Site 31
S170
A
S
S
S
L
G
P
S
G
S
A
S
A
G
E
Site 32
S172
S
S
L
G
P
S
G
S
A
S
A
G
E
L
S
Site 33
S174
L
G
P
S
G
S
A
S
A
G
E
L
S
S
S
Site 34
S179
S
A
S
A
G
E
L
S
S
S
E
P
S
T
P
Site 35
S180
A
S
A
G
E
L
S
S
S
E
P
S
T
P
A
Site 36
S181
S
A
G
E
L
S
S
S
E
P
S
T
P
A
Q
Site 37
S184
E
L
S
S
S
E
P
S
T
P
A
Q
T
P
L
Site 38
T185
L
S
S
S
E
P
S
T
P
A
Q
T
P
L
A
Site 39
S203
I
P
T
P
V
L
T
S
P
G
A
V
P
P
L
Site 40
S212
G
A
V
P
P
L
P
S
P
S
K
E
E
E
G
Site 41
S214
V
P
P
L
P
S
P
S
K
E
E
E
G
L
R
Site 42
T233
D
L
E
E
K
L
E
T
L
R
L
K
R
A
E
Site 43
S320
M
A
E
E
R
A
E
S
L
Q
Q
E
V
E
A
Site 44
T336
K
E
R
V
D
E
L
T
T
D
L
E
I
L
K
Site 45
S351
A
E
I
E
E
K
G
S
D
G
A
A
S
S
Y
Site 46
S357
G
S
D
G
A
A
S
S
Y
Q
L
K
Q
L
E
Site 47
S381
L
V
R
M
R
D
L
S
S
S
E
K
Q
E
H
Site 48
S382
V
R
M
R
D
L
S
S
S
E
K
Q
E
H
V
Site 49
S383
R
M
R
D
L
S
S
S
E
K
Q
E
H
V
K
Site 50
S417
E
R
L
Q
E
E
L
S
Q
A
E
S
T
I
D
Site 51
S421
E
E
L
S
Q
A
E
S
T
I
D
E
L
K
E
Site 52
T444
E
E
M
V
E
M
L
T
D
R
N
L
N
L
E
Site 53
T460
K
V
R
E
L
R
E
T
V
G
D
L
E
A
M
Site 54
T481
L
Q
E
N
A
R
E
T
E
L
E
L
R
E
Q
Site 55
Y513
A
Q
E
T
V
A
D
Y
Q
Q
T
I
K
K
Y
Site 56
T524
I
K
K
Y
R
Q
L
T
A
H
L
Q
D
V
N
Site 57
T535
Q
D
V
N
R
E
L
T
N
Q
Q
E
A
S
V
Site 58
S541
L
T
N
Q
Q
E
A
S
V
E
R
Q
Q
Q
P
Site 59
T552
Q
Q
Q
P
P
P
E
T
F
D
F
K
I
K
F
Site 60
S595
L
T
A
F
M
P
D
S
F
L
R
P
G
G
D
Site 61
S633
A
Q
E
K
F
E
L
S
E
N
C
S
E
R
P
Site 62
S637
F
E
L
S
E
N
C
S
E
R
P
G
L
R
G
Site 63
Y670
L
Q
A
T
L
H
R
Y
E
H
A
L
S
Q
C
Site 64
S675
H
R
Y
E
H
A
L
S
Q
C
S
V
D
V
Y
Site 65
Y682
S
Q
C
S
V
D
V
Y
K
K
V
G
S
L
Y
Site 66
S687
D
V
Y
K
K
V
G
S
L
Y
P
E
M
S
A
Site 67
Y689
Y
K
K
V
G
S
L
Y
P
E
M
S
A
H
E
Site 68
S693
G
S
L
Y
P
E
M
S
A
H
E
R
S
L
D
Site 69
S698
E
M
S
A
H
E
R
S
L
D
F
L
I
E
L
Site 70
T714
H
K
D
Q
L
D
E
T
V
N
V
E
P
L
T
Site 71
T721
T
V
N
V
E
P
L
T
K
A
I
K
Y
Y
Q
Site 72
Y726
P
L
T
K
A
I
K
Y
Y
Q
H
L
Y
S
I
Site 73
Y727
L
T
K
A
I
K
Y
Y
Q
H
L
Y
S
I
H
Site 74
S761
Q
S
A
L
D
C
M
S
V
E
V
G
R
L
R
Site 75
T789
L
L
L
R
D
L
E
T
S
C
S
D
I
R
Q
Site 76
S790
L
L
R
D
L
E
T
S
C
S
D
I
R
Q
F
Site 77
S792
R
D
L
E
T
S
C
S
D
I
R
Q
F
C
K
Site 78
T808
I
R
R
R
M
P
G
T
D
A
P
G
I
P
A
Site 79
T826
F
G
P
Q
V
S
D
T
L
L
D
C
R
K
H
Site 80
Y878
F
K
A
S
E
Q
I
Y
G
T
P
S
S
S
P
Site 81
T880
A
S
E
Q
I
Y
G
T
P
S
S
S
P
Y
E
Site 82
S882
E
Q
I
Y
G
T
P
S
S
S
P
Y
E
C
L
Site 83
S883
Q
I
Y
G
T
P
S
S
S
P
Y
E
C
L
R
Site 84
S884
I
Y
G
T
P
S
S
S
P
Y
E
C
L
R
Q
Site 85
Y886
G
T
P
S
S
S
P
Y
E
C
L
R
Q
S
C
Site 86
Y912
T
A
M
Q
E
G
E
Y
D
A
E
R
P
P
S
Site 87
S919
Y
D
A
E
R
P
P
S
K
P
P
P
V
E
L
Site 88
T950
L
K
L
E
D
R
E
T
V
I
K
E
L
K
K
Site 89
S958
V
I
K
E
L
K
K
S
L
K
I
K
G
E
E
Site 90
S967
K
I
K
G
E
E
L
S
E
A
N
V
R
L
S
Site 91
S974
S
E
A
N
V
R
L
S
L
L
E
K
K
L
D
Site 92
T996
E
R
I
E
K
V
Q
T
R
L
E
E
T
Q
A
Site 93
T1001
V
Q
T
R
L
E
E
T
Q
A
L
L
R
K
K
Site 94
T1015
K
E
K
E
F
E
E
T
M
D
A
L
Q
A
D
Site 95
S1039
E
L
K
Q
R
L
N
S
Q
S
K
R
T
I
E
Site 96
S1041
K
Q
R
L
N
S
Q
S
K
R
T
I
E
G
L
Site 97
S1105
S
A
M
R
L
H
I
S
Q
L
Q
H
E
N
S
Site 98
S1112
S
Q
L
Q
H
E
N
S
I
L
K
G
A
Q
M
Site 99
S1135
P
L
H
V
A
K
L
S
H
E
G
P
G
S
E
Site 100
S1141
L
S
H
E
G
P
G
S
E
L
P
A
G
A
L
Site 101
Y1149
E
L
P
A
G
A
L
Y
R
K
T
S
Q
L
L
Site 102
T1152
A
G
A
L
Y
R
K
T
S
Q
L
L
E
T
L
Site 103
S1153
G
A
L
Y
R
K
T
S
Q
L
L
E
T
L
N
Site 104
T1158
K
T
S
Q
L
L
E
T
L
N
Q
L
S
T
H
Site 105
S1175
V
V
D
I
T
R
T
S
P
A
A
K
S
P
S
Site 106
S1180
R
T
S
P
A
A
K
S
P
S
A
Q
L
M
E
Site 107
S1194
E
Q
V
A
Q
L
K
S
L
S
D
T
V
E
K
Site 108
S1196
V
A
Q
L
K
S
L
S
D
T
V
E
K
L
K
Site 109
T1198
Q
L
K
S
L
S
D
T
V
E
K
L
K
D
E
Site 110
T1210
K
D
E
V
L
K
E
T
V
S
Q
R
P
G
A
Site 111
S1212
E
V
L
K
E
T
V
S
Q
R
P
G
A
T
V
Site 112
S1229
D
F
A
T
F
P
S
S
A
F
L
R
A
K
E
Site 113
T1242
K
E
E
Q
Q
D
D
T
V
Y
M
G
K
V
T
Site 114
Y1244
E
Q
Q
D
D
T
V
Y
M
G
K
V
T
F
S
Site 115
T1265
Q
R
H
R
L
V
L
T
Q
E
Q
L
H
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation