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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTTN
Full Name:
Src substrate cortactin
Alias:
Amplaxin; Cortactin; EMS1; Oncogene EMS1; SRC8
Type:
Cytoskeletal protein, Actin binding protein
Mass (Da):
61586
Number AA:
550
UniProt ID:
Q14247
International Prot ID:
IPI00029601
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005938
GO:0005856
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
W
K
A
S
A
G
H
A
V
S
I
Site 2
S11
A
S
A
G
H
A
V
S
I
A
Q
D
D
A
G
Site 3
T24
A
G
A
D
D
W
E
T
D
P
D
F
V
N
D
Site 4
S33
P
D
F
V
N
D
V
S
E
K
E
Q
R
W
G
Site 5
T43
E
Q
R
W
G
A
K
T
V
Q
G
S
G
H
Q
Site 6
Y84
G
P
K
A
S
H
G
Y
G
G
K
F
G
V
E
Site 7
S98
E
Q
D
R
M
D
K
S
A
V
G
H
E
Y
Q
Site 8
Y104
K
S
A
V
G
H
E
Y
Q
S
K
L
S
K
H
Site 9
S106
A
V
G
H
E
Y
Q
S
K
L
S
K
H
C
S
Site 10
S109
H
E
Y
Q
S
K
L
S
K
H
C
S
Q
V
D
Site 11
S113
S
K
L
S
K
H
C
S
Q
V
D
S
V
R
G
Site 12
S117
K
H
C
S
Q
V
D
S
V
R
G
F
G
G
K
Site 13
S135
Q
M
D
R
V
D
Q
S
A
V
G
F
E
Y
Q
Site 14
Y141
Q
S
A
V
G
F
E
Y
Q
G
K
T
E
K
H
Site 15
T145
G
F
E
Y
Q
G
K
T
E
K
H
A
S
Q
K
Site 16
S150
G
K
T
E
K
H
A
S
Q
K
D
Y
S
S
G
Site 17
Y154
K
H
A
S
Q
K
D
Y
S
S
G
F
G
G
K
Site 18
S155
H
A
S
Q
K
D
Y
S
S
G
F
G
G
K
Y
Site 19
S156
A
S
Q
K
D
Y
S
S
G
F
G
G
K
Y
G
Site 20
Y162
S
S
G
F
G
G
K
Y
G
V
Q
A
D
R
V
Site 21
S172
Q
A
D
R
V
D
K
S
A
V
G
F
D
Y
Q
Site 22
Y178
K
S
A
V
G
F
D
Y
Q
G
K
T
E
K
H
Site 23
T182
G
F
D
Y
Q
G
K
T
E
K
H
E
S
Q
R
Site 24
S187
G
K
T
E
K
H
E
S
Q
R
D
Y
S
K
G
Site 25
Y191
K
H
E
S
Q
R
D
Y
S
K
G
F
G
G
K
Site 26
S192
H
E
S
Q
R
D
Y
S
K
G
F
G
G
K
Y
Site 27
Y199
S
K
G
F
G
G
K
Y
G
I
D
K
D
K
V
Site 28
S209
D
K
D
K
V
D
K
S
A
V
G
F
E
Y
Q
Site 29
Y215
K
S
A
V
G
F
E
Y
Q
G
K
T
E
K
H
Site 30
T219
G
F
E
Y
Q
G
K
T
E
K
H
E
S
Q
K
Site 31
S224
G
K
T
E
K
H
E
S
Q
K
D
Y
V
K
G
Site 32
Y228
K
H
E
S
Q
K
D
Y
V
K
G
F
G
G
K
Site 33
T240
G
G
K
F
G
V
Q
T
D
R
Q
D
K
C
A
Site 34
S261
E
K
L
Q
L
H
E
S
Q
K
D
Y
K
T
G
Site 35
Y265
L
H
E
S
Q
K
D
Y
K
T
G
F
G
G
K
Site 36
T267
E
S
Q
K
D
Y
K
T
G
F
G
G
K
F
G
Site 37
S277
G
G
K
F
G
V
Q
S
E
R
Q
D
S
A
A
Site 38
S282
V
Q
S
E
R
Q
D
S
A
A
V
G
F
D
Y
Site 39
Y289
S
A
A
V
G
F
D
Y
K
E
K
L
A
K
H
Site 40
S298
E
K
L
A
K
H
E
S
Q
Q
D
Y
S
K
G
Site 41
Y302
K
H
E
S
Q
Q
D
Y
S
K
G
F
G
G
K
Site 42
S303
H
E
S
Q
Q
D
Y
S
K
G
F
G
G
K
Y
Site 43
Y310
S
K
G
F
G
G
K
Y
G
V
Q
K
D
R
M
Site 44
S322
D
R
M
D
K
N
A
S
T
F
E
D
V
T
Q
Site 45
T323
R
M
D
K
N
A
S
T
F
E
D
V
T
Q
V
Site 46
T328
A
S
T
F
E
D
V
T
Q
V
S
S
A
Y
Q
Site 47
Y334
V
T
Q
V
S
S
A
Y
Q
K
T
V
P
V
E
Site 48
T337
V
S
S
A
Y
Q
K
T
V
P
V
E
A
V
T
Site 49
S345
V
P
V
E
A
V
T
S
K
T
S
N
I
R
A
Site 50
S348
E
A
V
T
S
K
T
S
N
I
R
A
N
F
E
Site 51
T399
E
E
Q
A
R
A
K
T
Q
T
P
P
V
S
P
Site 52
T401
Q
A
R
A
K
T
Q
T
P
P
V
S
P
A
P
Site 53
S405
K
T
Q
T
P
P
V
S
P
A
P
Q
P
T
E
Site 54
T411
V
S
P
A
P
Q
P
T
E
E
R
L
P
S
S
Site 55
S417
P
T
E
E
R
L
P
S
S
P
V
Y
E
D
A
Site 56
S418
T
E
E
R
L
P
S
S
P
V
Y
E
D
A
A
Site 57
Y421
R
L
P
S
S
P
V
Y
E
D
A
A
S
F
K
Site 58
S426
P
V
Y
E
D
A
A
S
F
K
A
E
L
S
Y
Site 59
S432
A
S
F
K
A
E
L
S
Y
R
G
P
V
S
G
Site 60
Y433
S
F
K
A
E
L
S
Y
R
G
P
V
S
G
T
Site 61
S438
L
S
Y
R
G
P
V
S
G
T
E
P
E
P
V
Site 62
T440
Y
R
G
P
V
S
G
T
E
P
E
P
V
Y
S
Site 63
Y446
G
T
E
P
E
P
V
Y
S
M
E
A
A
D
Y
Site 64
S447
T
E
P
E
P
V
Y
S
M
E
A
A
D
Y
R
Site 65
Y453
Y
S
M
E
A
A
D
Y
R
E
A
S
S
Q
Q
Site 66
S457
A
A
D
Y
R
E
A
S
S
Q
Q
G
L
A
Y
Site 67
S458
A
D
Y
R
E
A
S
S
Q
Q
G
L
A
Y
A
Site 68
Y464
S
S
Q
Q
G
L
A
Y
A
T
E
A
V
Y
E
Site 69
Y470
A
Y
A
T
E
A
V
Y
E
S
A
E
A
P
G
Site 70
S472
A
T
E
A
V
Y
E
S
A
E
A
P
G
H
Y
Site 71
Y479
S
A
E
A
P
G
H
Y
P
A
E
D
S
T
Y
Site 72
S484
G
H
Y
P
A
E
D
S
T
Y
D
E
Y
E
N
Site 73
T485
H
Y
P
A
E
D
S
T
Y
D
E
Y
E
N
D
Site 74
Y486
Y
P
A
E
D
S
T
Y
D
E
Y
E
N
D
L
Site 75
Y489
E
D
S
T
Y
D
E
Y
E
N
D
L
G
I
T
Site 76
Y503
T
A
V
A
L
Y
D
Y
Q
A
A
G
D
D
E
Site 77
S512
A
A
G
D
D
E
I
S
F
D
P
D
D
I
I
Site 78
Y538
R
G
V
C
K
G
R
Y
G
L
F
P
A
N
Y
Site 79
Y545
Y
G
L
F
P
A
N
Y
V
E
L
R
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation