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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE3A
Full Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Alias:
CGI-PDE A; CGMP-inhibited 3',5'-cyclic phosphodiesterase A: Cyclic GMP-inhibited phosphodiesterase A; EC 3.1.4.17
Type:
Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine
Mass (Da):
124979
Number AA:
1141
UniProt ID:
Q14432
International Prot ID:
IPI00291205
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0004119
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
V
R
D
K
P
V
H
S
G
V
S
Q
A
P
T
Site 2
S20
K
P
V
H
S
G
V
S
Q
A
P
T
A
G
R
Site 3
T24
S
G
V
S
Q
A
P
T
A
G
R
D
C
H
H
Site 4
S37
H
H
R
A
D
P
A
S
P
R
D
S
G
C
R
Site 5
S41
D
P
A
S
P
R
D
S
G
C
R
G
C
W
G
Site 6
S57
L
V
L
Q
P
L
R
S
S
R
K
L
S
S
A
Site 7
S58
V
L
Q
P
L
R
S
S
R
K
L
S
S
A
L
Site 8
S62
L
R
S
S
R
K
L
S
S
A
L
C
A
G
S
Site 9
S63
R
S
S
R
K
L
S
S
A
L
C
A
G
S
L
Site 10
S127
P
G
G
G
A
R
L
S
P
W
L
Q
P
S
A
Site 11
S262
V
E
Q
I
L
P
Q
S
A
E
A
A
P
R
E
Site 12
S273
A
P
R
E
H
L
G
S
Q
L
I
A
G
T
K
Site 13
S292
V
F
K
R
R
R
R
S
S
S
V
V
S
A
E
Site 14
S293
F
K
R
R
R
R
S
S
S
V
V
S
A
E
M
Site 15
S294
K
R
R
R
R
S
S
S
V
V
S
A
E
M
S
Site 16
S297
R
R
S
S
S
V
V
S
A
E
M
S
G
C
S
Site 17
S301
S
V
V
S
A
E
M
S
G
C
S
S
K
S
H
Site 18
S304
S
A
E
M
S
G
C
S
S
K
S
H
R
R
T
Site 19
S305
A
E
M
S
G
C
S
S
K
S
H
R
R
T
S
Site 20
S307
M
S
G
C
S
S
K
S
H
R
R
T
S
L
P
Site 21
T311
S
S
K
S
H
R
R
T
S
L
P
C
I
P
R
Site 22
S312
S
K
S
H
R
R
T
S
L
P
C
I
P
R
E
Site 23
S336
H
K
R
G
P
R
G
S
Q
S
S
G
T
S
I
Site 24
S338
R
G
P
R
G
S
Q
S
S
G
T
S
I
T
V
Site 25
S339
G
P
R
G
S
Q
S
S
G
T
S
I
T
V
D
Site 26
T386
N
L
L
S
T
Q
L
T
F
Q
A
I
H
K
P
Site 27
T399
K
P
R
V
N
P
V
T
S
L
S
E
N
Y
T
Site 28
S400
P
R
V
N
P
V
T
S
L
S
E
N
Y
T
C
Site 29
S402
V
N
P
V
T
S
L
S
E
N
Y
T
C
S
D
Site 30
T406
T
S
L
S
E
N
Y
T
C
S
D
S
E
E
S
Site 31
S408
L
S
E
N
Y
T
C
S
D
S
E
E
S
S
E
Site 32
S410
E
N
Y
T
C
S
D
S
E
E
S
S
E
K
D
Site 33
S414
C
S
D
S
E
E
S
S
E
K
D
K
L
A
I
Site 34
S428
I
P
K
R
L
R
R
S
L
P
P
G
L
L
R
Site 35
S438
P
G
L
L
R
R
V
S
S
T
W
T
T
T
T
Site 36
S439
G
L
L
R
R
V
S
S
T
W
T
T
T
T
S
Site 37
T440
L
L
R
R
V
S
S
T
W
T
T
T
T
S
A
Site 38
T442
R
R
V
S
S
T
W
T
T
T
T
S
A
T
G
Site 39
T443
R
V
S
S
T
W
T
T
T
T
S
A
T
G
L
Site 40
T444
V
S
S
T
W
T
T
T
T
S
A
T
G
L
P
Site 41
S446
S
T
W
T
T
T
T
S
A
T
G
L
P
T
L
Site 42
T452
T
S
A
T
G
L
P
T
L
E
P
A
P
V
R
Site 43
S463
A
P
V
R
R
D
R
S
T
S
I
K
L
Q
E
Site 44
T464
P
V
R
R
D
R
S
T
S
I
K
L
Q
E
A
Site 45
S465
V
R
R
D
R
S
T
S
I
K
L
Q
E
A
P
Site 46
S473
I
K
L
Q
E
A
P
S
S
S
P
D
S
W
N
Site 47
S474
K
L
Q
E
A
P
S
S
S
P
D
S
W
N
N
Site 48
S475
L
Q
E
A
P
S
S
S
P
D
S
W
N
N
P
Site 49
S478
A
P
S
S
S
P
D
S
W
N
N
P
V
M
M
Site 50
T486
W
N
N
P
V
M
M
T
L
T
K
S
R
S
F
Site 51
T488
N
P
V
M
M
T
L
T
K
S
R
S
F
T
S
Site 52
S490
V
M
M
T
L
T
K
S
R
S
F
T
S
S
Y
Site 53
S492
M
T
L
T
K
S
R
S
F
T
S
S
Y
A
I
Site 54
T494
L
T
K
S
R
S
F
T
S
S
Y
A
I
S
A
Site 55
S495
T
K
S
R
S
F
T
S
S
Y
A
I
S
A
A
Site 56
S496
K
S
R
S
F
T
S
S
Y
A
I
S
A
A
N
Site 57
Y497
S
R
S
F
T
S
S
Y
A
I
S
A
A
N
H
Site 58
S520
P
G
A
L
A
K
I
S
P
L
S
S
P
C
S
Site 59
S523
L
A
K
I
S
P
L
S
S
P
C
S
S
P
L
Site 60
S524
A
K
I
S
P
L
S
S
P
C
S
S
P
L
Q
Site 61
S527
S
P
L
S
S
P
C
S
S
P
L
Q
G
T
P
Site 62
S528
P
L
S
S
P
C
S
S
P
L
Q
G
T
P
A
Site 63
T533
C
S
S
P
L
Q
G
T
P
A
S
S
L
V
S
Site 64
S536
P
L
Q
G
T
P
A
S
S
L
V
S
K
I
S
Site 65
S550
S
A
V
Q
F
P
E
S
A
D
T
T
A
K
Q
Site 66
T553
Q
F
P
E
S
A
D
T
T
A
K
Q
S
L
G
Site 67
T554
F
P
E
S
A
D
T
T
A
K
Q
S
L
G
S
Site 68
S561
T
A
K
Q
S
L
G
S
H
R
A
L
T
Y
T
Site 69
T566
L
G
S
H
R
A
L
T
Y
T
Q
S
A
P
D
Site 70
T568
S
H
R
A
L
T
Y
T
Q
S
A
P
D
L
S
Site 71
S570
R
A
L
T
Y
T
Q
S
A
P
D
L
S
P
Q
Site 72
S575
T
Q
S
A
P
D
L
S
P
Q
I
L
T
P
P
Site 73
T580
D
L
S
P
Q
I
L
T
P
P
V
I
C
S
S
Site 74
S587
T
P
P
V
I
C
S
S
C
G
R
P
Y
S
Q
Site 75
Y592
C
S
S
C
G
R
P
Y
S
Q
G
N
P
A
D
Site 76
S593
S
S
C
G
R
P
Y
S
Q
G
N
P
A
D
E
Site 77
T609
L
E
R
S
G
V
A
T
R
T
P
S
R
T
D
Site 78
T611
R
S
G
V
A
T
R
T
P
S
R
T
D
D
T
Site 79
S613
G
V
A
T
R
T
P
S
R
T
D
D
T
A
Q
Site 80
T615
A
T
R
T
P
S
R
T
D
D
T
A
Q
V
T
Site 81
T618
T
P
S
R
T
D
D
T
A
Q
V
T
S
D
Y
Site 82
T622
T
D
D
T
A
Q
V
T
S
D
Y
E
T
N
N
Site 83
S623
D
D
T
A
Q
V
T
S
D
Y
E
T
N
N
N
Site 84
Y625
T
A
Q
V
T
S
D
Y
E
T
N
N
N
S
D
Site 85
T627
Q
V
T
S
D
Y
E
T
N
N
N
S
D
S
S
Site 86
S631
D
Y
E
T
N
N
N
S
D
S
S
D
I
V
Q
Site 87
S633
E
T
N
N
N
S
D
S
S
D
I
V
Q
N
E
Site 88
S634
T
N
N
N
S
D
S
S
D
I
V
Q
N
E
D
Site 89
T643
I
V
Q
N
E
D
E
T
E
C
L
R
E
P
L
Site 90
S654
R
E
P
L
R
K
A
S
A
C
S
T
Y
A
P
Site 91
T658
R
K
A
S
A
C
S
T
Y
A
P
E
T
M
M
Site 92
S712
R
K
C
G
R
I
L
S
Q
V
S
Y
R
L
F
Site 93
S715
G
R
I
L
S
Q
V
S
Y
R
L
F
E
D
M
Site 94
Y716
R
I
L
S
Q
V
S
Y
R
L
F
E
D
M
G
Site 95
Y751
I
G
Y
R
D
I
P
Y
H
N
R
I
H
A
T
Site 96
S776
T
Q
P
I
P
G
L
S
T
V
I
N
D
H
G
Site 97
S784
T
V
I
N
D
H
G
S
T
S
D
S
D
S
D
Site 98
S786
I
N
D
H
G
S
T
S
D
S
D
S
D
S
G
Site 99
S788
D
H
G
S
T
S
D
S
D
S
D
S
G
F
T
Site 100
S790
G
S
T
S
D
S
D
S
D
S
G
F
T
H
G
Site 101
S792
T
S
D
S
D
S
D
S
G
F
T
H
G
H
M
Site 102
Y801
F
T
H
G
H
M
G
Y
V
F
S
K
T
Y
N
Site 103
T806
M
G
Y
V
F
S
K
T
Y
N
V
T
D
D
K
Site 104
Y814
Y
N
V
T
D
D
K
Y
G
C
L
S
G
N
I
Site 105
S818
D
D
K
Y
G
C
L
S
G
N
I
P
A
L
E
Site 106
Y838
V
A
A
A
M
H
D
Y
D
H
P
G
R
T
N
Site 107
Y859
S
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Site 108
S863
A
V
L
Y
N
D
R
S
V
L
E
N
H
H
A
Site 109
Y883
L
F
M
S
R
P
E
Y
N
F
L
I
N
L
D
Site 110
T933
D
D
V
G
I
D
W
T
N
E
N
D
R
L
L
Site 111
Y973
D
G
I
V
N
E
F
Y
E
Q
G
D
E
E
A
Site 112
S981
E
Q
G
D
E
E
A
S
L
G
L
P
I
S
P
Site 113
S993
I
S
P
F
M
D
R
S
A
P
Q
L
A
N
L
Site 114
S1030
P
G
K
W
V
E
D
S
D
E
S
G
D
T
D
Site 115
S1033
W
V
E
D
S
D
E
S
G
D
T
D
D
P
E
Site 116
T1036
D
S
D
E
S
G
D
T
D
D
P
E
E
E
E
Site 117
S1060
E
T
C
E
N
N
E
S
P
K
K
K
T
F
K
Site 118
T1065
N
E
S
P
K
K
K
T
F
K
R
R
K
I
Y
Site 119
Y1072
T
F
K
R
R
K
I
Y
C
Q
I
T
Q
H
L
Site 120
S1103
L
A
G
I
E
N
Q
S
L
D
Q
T
P
Q
S
Site 121
T1107
E
N
Q
S
L
D
Q
T
P
Q
S
H
S
S
E
Site 122
S1110
S
L
D
Q
T
P
Q
S
H
S
S
E
Q
I
Q
Site 123
T1136
P
R
G
E
E
I
P
T
Q
K
P
D
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation