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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFE2L1
Full Name:
Nuclear factor erythroid 2-related factor 1
Alias:
Locus control region-factor 1;Nuclear factor, erythroid derived 2, like 1;Transcription factor 11;Transcription factor HBZ17;Transcription factor LCR-F1
Type:
Transcription protein
Mass (Da):
84704
Number AA:
772
UniProt ID:
Q14494
International Prot ID:
IPI00031017
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0046983
GO:0043565
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0006783
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
L
S
L
K
K
Y
L
T
E
Site 2
T30
G
V
R
V
D
V
D
T
Y
L
T
S
Q
L
P
Site 3
Y31
V
R
V
D
V
D
T
Y
L
T
S
Q
L
P
P
Site 4
S34
D
V
D
T
Y
L
T
S
Q
L
P
P
L
R
E
Site 5
S48
E
I
I
L
G
P
S
S
A
Y
T
Q
T
Q
F
Site 6
T51
L
G
P
S
S
A
Y
T
Q
T
Q
F
H
N
L
Site 7
T61
Q
F
H
N
L
R
N
T
L
D
G
Y
G
I
H
Site 8
Y65
L
R
N
T
L
D
G
Y
G
I
H
P
K
S
I
Site 9
Y77
K
S
I
D
L
D
N
Y
F
T
A
R
R
L
L
Site 10
T79
I
D
L
D
N
Y
F
T
A
R
R
L
L
S
Q
Site 11
S85
F
T
A
R
R
L
L
S
Q
V
R
A
L
D
R
Site 12
T97
L
D
R
F
Q
V
P
T
T
E
V
N
A
W
L
Site 13
S112
V
H
R
D
P
E
G
S
V
S
G
S
Q
P
N
Site 14
S114
R
D
P
E
G
S
V
S
G
S
Q
P
N
S
G
Site 15
S116
P
E
G
S
V
S
G
S
Q
P
N
S
G
L
A
Site 16
S120
V
S
G
S
Q
P
N
S
G
L
A
L
E
S
S
Site 17
S126
N
S
G
L
A
L
E
S
S
S
G
L
Q
D
V
Site 18
S127
S
G
L
A
L
E
S
S
S
G
L
Q
D
V
T
Site 19
T134
S
S
G
L
Q
D
V
T
G
P
D
N
G
V
R
Site 20
S143
P
D
N
G
V
R
E
S
E
T
E
Q
G
F
G
Site 21
T145
N
G
V
R
E
S
E
T
E
Q
G
F
G
E
D
Site 22
S164
G
A
V
A
P
P
V
S
G
D
L
T
K
E
D
Site 23
T168
P
P
V
S
G
D
L
T
K
E
D
I
D
L
I
Site 24
Y194
A
G
R
E
V
F
D
Y
S
H
R
Q
K
E
Q
Site 25
S195
G
R
E
V
F
D
Y
S
H
R
Q
K
E
Q
D
Site 26
T215
R
D
G
G
E
Q
D
T
W
A
G
E
G
A
E
Site 27
T234
N
L
L
V
D
G
E
T
G
E
S
F
P
A
Q
Site 28
S237
V
D
G
E
T
G
E
S
F
P
A
Q
V
P
S
Site 29
S244
S
F
P
A
Q
V
P
S
G
E
D
Q
T
A
L
Site 30
S252
G
E
D
Q
T
A
L
S
L
E
E
C
L
R
L
Site 31
S278
E
F
P
A
D
I
S
S
I
T
E
A
V
P
S
Site 32
S285
S
I
T
E
A
V
P
S
E
S
E
P
P
A
L
Site 33
S287
T
E
A
V
P
S
E
S
E
P
P
A
L
Q
N
Site 34
T302
N
L
L
S
P
L
L
T
G
T
E
S
P
F
D
Site 35
T304
L
S
P
L
L
T
G
T
E
S
P
F
D
L
E
Site 36
S306
P
L
L
T
G
T
E
S
P
F
D
L
E
Q
Q
Site 37
S331
Q
A
M
E
V
N
T
S
A
S
E
I
L
Y
S
Site 38
Y337
T
S
A
S
E
I
L
Y
S
A
P
P
G
D
P
Site 39
S338
S
A
S
E
I
L
Y
S
A
P
P
G
D
P
L
Site 40
S346
A
P
P
G
D
P
L
S
T
N
Y
S
L
A
P
Site 41
S350
D
P
L
S
T
N
Y
S
L
A
P
N
T
P
I
Site 42
T355
N
Y
S
L
A
P
N
T
P
I
N
Q
N
V
S
Site 43
S362
T
P
I
N
Q
N
V
S
L
H
Q
A
S
L
G
Site 44
S367
N
V
S
L
H
Q
A
S
L
G
G
C
S
Q
D
Site 45
S379
S
Q
D
F
L
L
F
S
P
E
V
E
S
L
P
Site 46
S399
T
L
L
P
L
A
P
S
N
S
T
S
L
N
S
Site 47
S401
L
P
L
A
P
S
N
S
T
S
L
N
S
T
F
Site 48
S403
L
A
P
S
N
S
T
S
L
N
S
T
F
G
S
Site 49
S406
S
N
S
T
S
L
N
S
T
F
G
S
T
N
L
Site 50
T407
N
S
T
S
L
N
S
T
F
G
S
T
N
L
T
Site 51
T429
L
N
G
T
A
N
D
T
A
G
P
E
L
P
D
Site 52
S467
G
F
N
P
V
Q
A
S
Q
L
E
E
E
F
D
Site 53
S475
Q
L
E
E
E
F
D
S
D
S
G
L
S
L
D
Site 54
S477
E
E
E
F
D
S
D
S
G
L
S
L
D
S
S
Site 55
S480
F
D
S
D
S
G
L
S
L
D
S
S
H
S
P
Site 56
S483
D
S
G
L
S
L
D
S
S
H
S
P
S
S
L
Site 57
S484
S
G
L
S
L
D
S
S
H
S
P
S
S
L
S
Site 58
S486
L
S
L
D
S
S
H
S
P
S
S
L
S
S
S
Site 59
S488
L
D
S
S
H
S
P
S
S
L
S
S
S
E
G
Site 60
S489
D
S
S
H
S
P
S
S
L
S
S
S
E
G
S
Site 61
S491
S
H
S
P
S
S
L
S
S
S
E
G
S
S
S
Site 62
S492
H
S
P
S
S
L
S
S
S
E
G
S
S
S
S
Site 63
S493
S
P
S
S
L
S
S
S
E
G
S
S
S
S
S
Site 64
S496
S
L
S
S
S
E
G
S
S
S
S
S
S
S
S
Site 65
S497
L
S
S
S
E
G
S
S
S
S
S
S
S
S
S
Site 66
S498
S
S
S
E
G
S
S
S
S
S
S
S
S
S
S
Site 67
S499
S
S
E
G
S
S
S
S
S
S
S
S
S
S
S
Site 68
S500
S
E
G
S
S
S
S
S
S
S
S
S
S
S
S
Site 69
S501
E
G
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 70
S502
G
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 71
S503
S
S
S
S
S
S
S
S
S
S
S
S
S
S
A
Site 72
S504
S
S
S
S
S
S
S
S
S
S
S
S
S
A
S
Site 73
S505
S
S
S
S
S
S
S
S
S
S
S
S
A
S
S
Site 74
S506
S
S
S
S
S
S
S
S
S
S
S
A
S
S
S
Site 75
S507
S
S
S
S
S
S
S
S
S
S
A
S
S
S
A
Site 76
S508
S
S
S
S
S
S
S
S
S
A
S
S
S
A
S
Site 77
S509
S
S
S
S
S
S
S
S
A
S
S
S
A
S
S
Site 78
S511
S
S
S
S
S
S
A
S
S
S
A
S
S
S
F
Site 79
S512
S
S
S
S
S
A
S
S
S
A
S
S
S
F
S
Site 80
S513
S
S
S
S
A
S
S
S
A
S
S
S
F
S
E
Site 81
S515
S
S
A
S
S
S
A
S
S
S
F
S
E
E
G
Site 82
S516
S
A
S
S
S
A
S
S
S
F
S
E
E
G
A
Site 83
S517
A
S
S
S
A
S
S
S
F
S
E
E
G
A
V
Site 84
S519
S
S
A
S
S
S
F
S
E
E
G
A
V
G
Y
Site 85
Y526
S
E
E
G
A
V
G
Y
S
S
D
S
E
T
L
Site 86
S528
E
G
A
V
G
Y
S
S
D
S
E
T
L
D
L
Site 87
S530
A
V
G
Y
S
S
D
S
E
T
L
D
L
E
E
Site 88
T532
G
Y
S
S
D
S
E
T
L
D
L
E
E
A
E
Site 89
Y548
A
V
G
Y
Q
P
E
Y
S
K
F
C
R
M
S
Site 90
Y556
S
K
F
C
R
M
S
Y
Q
D
P
A
Q
L
S
Site 91
S563
Y
Q
D
P
A
Q
L
S
C
L
P
Y
L
E
H
Site 92
Y567
A
Q
L
S
C
L
P
Y
L
E
H
V
G
H
N
Site 93
S582
H
T
Y
N
M
A
P
S
A
L
D
S
A
D
L
Site 94
S586
M
A
P
S
A
L
D
S
A
D
L
P
P
P
S
Site 95
S593
S
A
D
L
P
P
P
S
A
L
K
K
G
S
K
Site 96
S599
P
S
A
L
K
K
G
S
K
E
K
Q
A
D
F
Site 97
S612
D
F
L
D
K
Q
M
S
R
D
E
H
R
A
R
Site 98
T626
R
A
M
K
I
P
F
T
N
D
K
I
I
N
L
Site 99
Y645
F
N
E
L
L
S
K
Y
Q
L
S
E
A
Q
L
Site 100
S653
Q
L
S
E
A
Q
L
S
L
I
R
D
I
R
R
Site 101
S706
E
K
V
E
F
L
R
S
L
R
Q
M
K
Q
K
Site 102
Y718
K
Q
K
V
Q
S
L
Y
Q
E
V
F
G
R
L
Site 103
Y733
R
D
E
N
G
R
P
Y
S
P
S
Q
Y
A
L
Site 104
S734
D
E
N
G
R
P
Y
S
P
S
Q
Y
A
L
Q
Site 105
S736
N
G
R
P
Y
S
P
S
Q
Y
A
L
Q
Y
A
Site 106
Y738
R
P
Y
S
P
S
Q
Y
A
L
Q
Y
A
G
D
Site 107
Y742
P
S
Q
Y
A
L
Q
Y
A
G
D
G
S
V
L
Site 108
T754
S
V
L
L
I
P
R
T
M
A
D
Q
Q
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation