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Updated November 2019
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Protein Info
Short Name:
SCN5A
Full Name:
Sodium channel protein type 5 subunit alpha
Alias:
CDCD2; CIN5; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; Long QT syndrome 3; LQT3; Nav1.5; PFHB1; Sodium channel protein, cardiac muscle alpha-subunit; Sodium channel, voltage-gated, type V, alpha subunit; SSS1
Type:
Channel, sodium
Mass (Da):
226940
Number AA:
2016
UniProt ID:
Q14524
International Prot ID:
IPI00377006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006936
GO:0008016
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
N
F
L
L
P
R
G
T
S
S
F
R
R
F
T
Site 2
S11
F
L
L
P
R
G
T
S
S
F
R
R
F
T
R
Site 3
S12
L
L
P
R
G
T
S
S
F
R
R
F
T
R
E
Site 4
T17
T
S
S
F
R
R
F
T
R
E
S
L
A
A
I
Site 5
S20
F
R
R
F
T
R
E
S
L
A
A
I
E
K
R
Site 6
S36
A
E
K
Q
A
R
G
S
T
T
L
Q
E
S
R
Site 7
T37
E
K
Q
A
R
G
S
T
T
L
Q
E
S
R
E
Site 8
T38
K
Q
A
R
G
S
T
T
L
Q
E
S
R
E
G
Site 9
Y68
S
K
K
L
P
D
L
Y
G
N
P
P
Q
E
L
Site 10
Y87
L
E
D
L
D
P
F
Y
S
T
Q
K
T
F
I
Site 11
S88
E
D
L
D
P
F
Y
S
T
Q
K
T
F
I
V
Site 12
T92
P
F
Y
S
T
Q
K
T
F
I
V
L
N
K
G
Site 13
S115
T
N
A
L
Y
V
L
S
P
F
H
P
I
R
R
Site 14
Y159
D
P
P
P
W
T
K
Y
V
E
Y
T
F
T
A
Site 15
T165
K
Y
V
E
Y
T
F
T
A
I
Y
T
F
E
S
Site 16
S231
L
R
A
L
K
T
I
S
V
I
S
G
L
K
T
Site 17
T285
H
K
C
V
R
N
F
T
A
L
N
G
T
N
G
Site 18
Y307
V
W
E
S
L
D
L
Y
L
S
D
P
E
N
Y
Site 19
S309
E
S
L
D
L
Y
L
S
D
P
E
N
Y
L
L
Site 20
T334
G
N
S
S
D
A
G
T
C
P
E
G
Y
R
C
Site 21
Y339
A
G
T
C
P
E
G
Y
R
C
L
K
A
G
E
Site 22
Y352
G
E
N
P
D
H
G
Y
T
S
F
D
S
F
A
Site 23
Y378
Q
D
C
W
E
R
L
Y
Q
Q
T
L
R
S
A
Site 24
T381
W
E
R
L
Y
Q
Q
T
L
R
S
A
G
K
I
Site 25
T455
L
T
I
R
G
V
D
T
V
S
R
S
S
L
E
Site 26
S457
I
R
G
V
D
T
V
S
R
S
S
L
E
M
S
Site 27
S459
G
V
D
T
V
S
R
S
S
L
E
M
S
P
L
Site 28
S460
V
D
T
V
S
R
S
S
L
E
M
S
P
L
A
Site 29
S464
S
R
S
S
L
E
M
S
P
L
A
P
V
N
S
Site 30
S471
S
P
L
A
P
V
N
S
H
E
R
R
S
K
R
Site 31
S476
V
N
S
H
E
R
R
S
K
R
R
K
R
M
S
Site 32
S483
S
K
R
R
K
R
M
S
S
G
T
E
E
C
G
Site 33
S484
K
R
R
K
R
M
S
S
G
T
E
E
C
G
E
Site 34
T486
R
K
R
M
S
S
G
T
E
E
C
G
E
D
R
Site 35
S497
G
E
D
R
L
P
K
S
D
S
E
D
G
P
R
Site 36
S499
D
R
L
P
K
S
D
S
E
D
G
P
R
A
M
Site 37
S510
P
R
A
M
N
H
L
S
L
T
R
G
L
S
R
Site 38
T512
A
M
N
H
L
S
L
T
R
G
L
S
R
T
S
Site 39
S516
L
S
L
T
R
G
L
S
R
T
S
M
K
P
R
Site 40
T518
L
T
R
G
L
S
R
T
S
M
K
P
R
S
S
Site 41
S519
T
R
G
L
S
R
T
S
M
K
P
R
S
S
R
Site 42
S524
R
T
S
M
K
P
R
S
S
R
G
S
I
F
T
Site 43
S525
T
S
M
K
P
R
S
S
R
G
S
I
F
T
F
Site 44
S528
K
P
R
S
S
R
G
S
I
F
T
F
R
R
R
Site 45
T531
S
S
R
G
S
I
F
T
F
R
R
R
D
L
G
Site 46
S539
F
R
R
R
D
L
G
S
E
A
D
F
A
D
D
Site 47
S549
D
F
A
D
D
E
N
S
T
A
G
E
S
E
S
Site 48
S556
S
T
A
G
E
S
E
S
H
H
T
S
L
L
V
Site 49
T559
G
E
S
E
S
H
H
T
S
L
L
V
P
W
P
Site 50
S560
E
S
E
S
H
H
T
S
L
L
V
P
W
P
L
Site 51
T570
V
P
W
P
L
R
R
T
S
A
Q
G
Q
P
S
Site 52
S571
P
W
P
L
R
R
T
S
A
Q
G
Q
P
S
P
Site 53
S577
T
S
A
Q
G
Q
P
S
P
G
T
S
A
P
G
Site 54
T580
Q
G
Q
P
S
P
G
T
S
A
P
G
H
A
L
Site 55
S581
G
Q
P
S
P
G
T
S
A
P
G
H
A
L
H
Site 56
S593
A
L
H
G
K
K
N
S
T
V
D
C
N
G
V
Site 57
T594
L
H
G
K
K
N
S
T
V
D
C
N
G
V
V
Site 58
S613
A
G
D
P
E
A
T
S
P
G
S
H
L
L
R
Site 59
S616
P
E
A
T
S
P
G
S
H
L
L
R
P
V
M
Site 60
T630
M
L
E
H
P
P
D
T
T
T
P
S
E
E
P
Site 61
T631
L
E
H
P
P
D
T
T
T
P
S
E
E
P
G
Site 62
T632
E
H
P
P
D
T
T
T
P
S
E
E
P
G
G
Site 63
S634
P
P
D
T
T
T
P
S
E
E
P
G
G
P
Q
Site 64
T644
P
G
G
P
Q
M
L
T
S
Q
A
P
C
V
D
Site 65
S645
G
G
P
Q
M
L
T
S
Q
A
P
C
V
D
G
Site 66
S679
A
L
E
E
L
E
E
S
R
H
K
C
P
P
C
Site 67
Y739
L
F
M
A
L
E
H
Y
N
M
T
S
E
F
E
Site 68
Y774
K
I
I
A
L
D
P
Y
Y
Y
F
Q
Q
G
W
Site 69
Y775
I
I
A
L
D
P
Y
Y
Y
F
Q
Q
G
W
N
Site 70
S802
E
L
G
L
S
R
M
S
N
L
S
V
L
R
S
Site 71
S821
R
V
F
K
L
A
K
S
W
P
T
L
N
T
L
Site 72
T827
K
S
W
P
T
L
N
T
L
I
K
I
I
G
N
Site 73
S866
Q
L
F
G
K
N
Y
S
E
L
R
D
S
D
S
Site 74
S871
N
Y
S
E
L
R
D
S
D
S
G
L
L
P
R
Site 75
S873
S
E
L
R
D
S
D
S
G
L
L
P
R
W
H
Site 76
T948
S
F
S
A
D
N
L
T
A
P
D
E
D
R
E
Site 77
S1003
A
A
Q
G
Q
L
P
S
C
I
A
T
P
Y
S
Site 78
T1007
Q
L
P
S
C
I
A
T
P
Y
S
P
P
P
P
Site 79
Y1009
P
S
C
I
A
T
P
Y
S
P
P
P
P
E
T
Site 80
S1010
S
C
I
A
T
P
Y
S
P
P
P
P
E
T
E
Site 81
T1016
Y
S
P
P
P
P
E
T
E
K
V
P
P
T
R
Site 82
T1026
V
P
P
T
R
K
E
T
R
F
E
E
G
E
Q
Site 83
T1038
G
E
Q
P
G
Q
G
T
P
G
D
P
E
P
V
Site 84
S1074
L
G
T
E
E
E
S
S
K
Q
Q
E
S
Q
P
Site 85
S1079
E
S
S
K
Q
Q
E
S
Q
P
V
S
G
G
P
Site 86
S1083
Q
Q
E
S
Q
P
V
S
G
G
P
E
A
P
P
Site 87
S1092
G
P
E
A
P
P
D
S
R
T
W
S
Q
V
S
Site 88
T1094
E
A
P
P
D
S
R
T
W
S
Q
V
S
A
T
Site 89
S1096
P
P
D
S
R
T
W
S
Q
V
S
A
T
A
S
Site 90
S1099
S
R
T
W
S
Q
V
S
A
T
A
S
S
E
A
Site 91
S1103
S
Q
V
S
A
T
A
S
S
E
A
E
A
S
A
Site 92
S1104
Q
V
S
A
T
A
S
S
E
A
E
A
S
A
S
Site 93
S1109
A
S
S
E
A
E
A
S
A
S
Q
A
D
W
R
Site 94
S1111
S
E
A
E
A
S
A
S
Q
A
D
W
R
Q
Q
Site 95
T1131
Q
A
P
G
C
G
E
T
P
E
D
S
C
S
E
Site 96
S1135
C
G
E
T
P
E
D
S
C
S
E
G
S
T
A
Site 97
S1137
E
T
P
E
D
S
C
S
E
G
S
T
A
D
M
Site 98
T1145
E
G
S
T
A
D
M
T
N
T
A
E
L
L
E
Site 99
T1169
K
D
P
E
D
C
F
T
E
G
C
V
R
R
C
Site 100
Y1228
A
L
A
F
E
D
I
Y
L
E
E
R
K
T
I
Site 101
T1234
I
Y
L
E
E
R
K
T
I
K
V
L
L
E
Y
Site 102
T1304
G
P
I
K
S
L
R
T
L
R
A
L
R
P
L
Site 103
S1315
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 104
T1367
F
G
R
C
I
N
Q
T
E
G
D
L
P
L
N
Site 105
Y1375
E
G
D
L
P
L
N
Y
T
I
V
N
N
K
S
Site 106
T1376
G
D
L
P
L
N
Y
T
I
V
N
N
K
S
Q
Site 107
S1382
Y
T
I
V
N
N
K
S
Q
C
E
S
L
N
L
Site 108
S1386
N
N
K
S
Q
C
E
S
L
N
L
T
G
E
L
Site 109
T1390
Q
C
E
S
L
N
L
T
G
E
L
Y
W
T
K
Site 110
Y1394
L
N
L
T
G
E
L
Y
W
T
K
V
K
V
N
Site 111
T1396
L
T
G
E
L
Y
W
T
K
V
K
V
N
F
D
Site 112
Y1426
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
G
Site 113
Y1434
A
A
V
D
S
R
G
Y
E
E
Q
P
Q
W
E
Site 114
T1488
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 115
Y1494
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 116
Y1495
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
G
Site 117
S1503
N
A
M
K
K
L
G
S
K
K
P
Q
K
P
I
Site 118
Y1517
I
P
R
P
L
N
K
Y
Q
G
F
I
F
D
I
Site 119
S1553
M
V
E
T
D
D
Q
S
P
E
K
I
N
I
L
Site 120
Y1585
K
L
A
A
L
R
H
Y
Y
F
T
N
S
W
N
Site 121
Y1586
L
A
A
L
R
H
Y
Y
F
T
N
S
W
N
I
Site 122
Y1727
I
L
N
T
G
P
P
Y
C
D
P
T
L
P
N
Site 123
T1731
G
P
P
Y
C
D
P
T
L
P
N
S
N
G
S
Site 124
S1735
C
D
P
T
L
P
N
S
N
G
S
R
G
D
C
Site 125
S1782
F
S
V
A
T
E
E
S
T
E
P
L
S
E
D
Site 126
S1787
E
E
S
T
E
P
L
S
E
D
D
F
D
M
F
Site 127
Y1795
E
D
D
F
D
M
F
Y
E
I
W
E
K
F
D
Site 128
S1822
S
D
F
A
D
A
L
S
E
P
L
R
I
A
K
Site 129
S1865
T
K
R
V
L
G
E
S
G
E
M
D
A
L
K
Site 130
S1885
K
F
M
A
A
N
P
S
K
I
S
Y
E
P
I
Site 131
Y1889
A
N
P
S
K
I
S
Y
E
P
I
T
T
T
L
Site 132
T1894
I
S
Y
E
P
I
T
T
T
L
R
R
K
H
E
Site 133
T1895
S
Y
E
P
I
T
T
T
L
R
R
K
H
E
E
Site 134
S1920
R
R
H
L
L
Q
R
S
L
K
H
A
S
F
L
Site 135
S1925
Q
R
S
L
K
H
A
S
F
L
F
R
Q
Q
A
Site 136
S1934
L
F
R
Q
Q
A
G
S
G
L
S
E
E
D
A
Site 137
Y1950
E
R
E
G
L
I
A
Y
V
M
S
E
N
F
S
Site 138
S1957
Y
V
M
S
E
N
F
S
R
P
L
G
P
P
S
Site 139
S1964
S
R
P
L
G
P
P
S
S
S
S
I
S
S
T
Site 140
S1965
R
P
L
G
P
P
S
S
S
S
I
S
S
T
S
Site 141
S1966
P
L
G
P
P
S
S
S
S
I
S
S
T
S
F
Site 142
S1967
L
G
P
P
S
S
S
S
I
S
S
T
S
F
P
Site 143
S1969
P
P
S
S
S
S
I
S
S
T
S
F
P
P
S
Site 144
S1970
P
S
S
S
S
I
S
S
T
S
F
P
P
S
Y
Site 145
T1971
S
S
S
S
I
S
S
T
S
F
P
P
S
Y
D
Site 146
S1972
S
S
S
I
S
S
T
S
F
P
P
S
Y
D
S
Site 147
S1976
S
S
T
S
F
P
P
S
Y
D
S
V
T
R
A
Site 148
Y1977
S
T
S
F
P
P
S
Y
D
S
V
T
R
A
T
Site 149
S1979
S
F
P
P
S
Y
D
S
V
T
R
A
T
S
D
Site 150
T1981
P
P
S
Y
D
S
V
T
R
A
T
S
D
N
L
Site 151
T1984
Y
D
S
V
T
R
A
T
S
D
N
L
Q
V
R
Site 152
S1985
D
S
V
T
R
A
T
S
D
N
L
Q
V
R
G
Site 153
S1993
D
N
L
Q
V
R
G
S
D
Y
S
H
S
E
D
Site 154
Y1995
L
Q
V
R
G
S
D
Y
S
H
S
E
D
L
A
Site 155
S1996
Q
V
R
G
S
D
Y
S
H
S
E
D
L
A
D
Site 156
S1998
R
G
S
D
Y
S
H
S
E
D
L
A
D
F
P
Site 157
S2007
D
L
A
D
F
P
P
S
P
D
R
D
R
E
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation