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Updated November 2019
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Protein Info
Short Name:
ITPR1
Full Name:
Inositol 1,4,5-trisphosphate receptor type 1
Alias:
Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 inositol 1;4;5-trisphosphate receptor;Type 1 InsP3 receptor;IP3 receptor isoform 1;InsP3R1;IP3R
Type:
Channel protein
Mass (Da):
313945
Number AA:
2758
UniProt ID:
Q14643
International Prot ID:
IPI00333753
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0031088
GO:0031095
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0015085
GO:0005220
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0008219
GO:0001666
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
I
G
D
I
C
S
L
Y
A
E
G
S
T
N
G
Site 2
S22
C
S
L
Y
A
E
G
S
T
N
G
F
I
S
T
Site 3
T84
K
P
G
A
N
S
T
T
D
A
V
L
L
N
K
Site 4
T113
E
N
R
K
L
L
G
T
V
I
Q
Y
G
N
V
Site 5
S128
I
Q
L
L
H
L
K
S
N
K
Y
L
T
V
N
Site 6
Y131
L
H
L
K
S
N
K
Y
L
T
V
N
K
R
L
Site 7
T133
L
K
S
N
K
Y
L
T
V
N
K
R
L
P
A
Site 8
T150
E
K
N
A
M
R
V
T
L
D
E
A
G
N
E
Site 9
Y162
G
N
E
G
S
W
F
Y
I
Q
P
F
Y
K
L
Site 10
Y167
W
F
Y
I
Q
P
F
Y
K
L
R
S
I
G
D
Site 11
S196
A
G
Q
P
L
H
A
S
S
H
Q
L
V
D
N
Site 12
T252
A
E
Q
E
K
F
L
T
C
D
E
H
R
K
K
Site 13
T267
Q
H
V
F
L
R
T
T
G
R
Q
S
A
T
S
Site 14
S271
L
R
T
T
G
R
Q
S
A
T
S
A
T
S
S
Site 15
T273
T
T
G
R
Q
S
A
T
S
A
T
S
S
K
A
Site 16
S274
T
G
R
Q
S
A
T
S
A
T
S
S
K
A
L
Site 17
S278
S
A
T
S
A
T
S
S
K
A
L
W
E
V
E
Site 18
Y298
P
C
R
G
G
A
G
Y
W
N
S
L
F
R
F
Site 19
S332
E
C
L
E
F
Q
P
S
V
D
P
D
Q
D
A
Site 20
Y353
N
A
Q
E
K
M
V
Y
S
L
V
S
V
P
E
Site 21
S354
A
Q
E
K
M
V
Y
S
L
V
S
V
P
E
G
Site 22
S365
V
P
E
G
N
D
I
S
S
I
F
E
L
D
P
Site 23
S366
P
E
G
N
D
I
S
S
I
F
E
L
D
P
T
Site 24
T373
S
I
F
E
L
D
P
T
T
L
R
G
G
D
S
Site 25
T374
I
F
E
L
D
P
T
T
L
R
G
G
D
S
L
Site 26
S380
T
T
L
R
G
G
D
S
L
V
P
R
N
S
Y
Site 27
S386
D
S
L
V
P
R
N
S
Y
V
R
L
R
H
L
Site 28
Y387
S
L
V
P
R
N
S
Y
V
R
L
R
H
L
C
Site 29
T420
P
V
M
L
K
I
G
T
S
P
V
K
E
D
K
Site 30
S421
V
M
L
K
I
G
T
S
P
V
K
E
D
K
E
Site 31
S436
A
F
A
I
V
P
V
S
P
A
E
V
R
D
L
Site 32
S472
I
T
Q
N
E
R
R
S
V
T
K
L
L
E
D
Site 33
T474
Q
N
E
R
R
S
V
T
K
L
L
E
D
L
V
Site 34
S500
D
V
L
E
V
V
F
S
K
P
N
R
E
R
Q
Site 35
T528
K
L
L
Q
A
P
F
T
D
C
G
D
G
P
M
Site 36
Y557
R
H
I
C
R
L
C
Y
R
V
L
R
H
S
Q
Site 37
Y567
L
R
H
S
Q
Q
D
Y
R
K
N
Q
E
Y
I
Site 38
Y573
D
Y
R
K
N
Q
E
Y
I
A
K
Q
F
G
F
Site 39
Y587
F
M
Q
K
Q
I
G
Y
D
V
L
A
E
D
T
Site 40
T611
K
L
L
E
K
H
I
T
A
A
E
I
D
T
F
Site 41
S620
A
E
I
D
T
F
V
S
L
V
R
K
N
R
E
Site 42
Y633
R
E
P
R
F
L
D
Y
L
S
D
L
C
V
S
Site 43
S682
F
E
F
E
G
V
S
S
T
G
E
N
A
L
E
Site 44
S704
V
W
L
F
W
R
D
S
N
K
E
I
R
S
K
Site 45
S712
N
K
E
I
R
S
K
S
V
R
E
L
A
Q
D
Site 46
S732
K
E
D
R
D
V
L
S
Y
Y
R
Y
Q
L
N
Site 47
Y733
E
D
R
D
V
L
S
Y
Y
R
Y
Q
L
N
L
Site 48
Y734
D
R
D
V
L
S
Y
Y
R
Y
Q
L
N
L
F
Site 49
Y736
D
V
L
S
Y
Y
R
Y
Q
L
N
L
F
A
R
Site 50
Y750
R
M
C
L
D
R
Q
Y
L
A
I
N
E
I
S
Site 51
S770
D
L
I
L
R
C
M
S
D
E
N
L
P
Y
D
Site 52
Y776
M
S
D
E
N
L
P
Y
D
L
R
A
S
F
C
Site 53
T800
R
D
P
Q
E
Q
V
T
P
V
K
Y
A
R
L
Site 54
Y804
E
Q
V
T
P
V
K
Y
A
R
L
W
S
E
I
Site 55
S809
V
K
Y
A
R
L
W
S
E
I
P
S
E
I
A
Site 56
S813
R
L
W
S
E
I
P
S
E
I
A
I
D
D
Y
Site 57
Y820
S
E
I
A
I
D
D
Y
D
S
S
G
A
S
K
Site 58
S822
I
A
I
D
D
Y
D
S
S
G
A
S
K
D
E
Site 59
S823
A
I
D
D
Y
D
S
S
G
A
S
K
D
E
I
Site 60
S826
D
Y
D
S
S
G
A
S
K
D
E
I
K
E
R
Site 61
Y844
T
M
E
F
V
E
E
Y
L
R
D
V
V
C
Q
Site 62
S856
V
C
Q
R
F
P
F
S
D
K
E
K
N
K
L
Site 63
T864
D
K
E
K
N
K
L
T
F
E
V
V
N
L
A
Site 64
S883
Y
F
G
F
Y
N
F
S
D
L
L
R
L
T
K
Site 65
S908
V
T
T
I
F
P
I
S
K
M
A
K
G
E
E
Site 66
S927
N
D
V
E
K
L
K
S
S
N
V
M
R
S
I
Site 67
T955
G
G
G
F
L
P
M
T
P
M
A
A
A
P
E
Site 68
S1014
F
K
R
E
F
D
E
S
N
S
Q
T
S
E
T
Site 69
S1016
R
E
F
D
E
S
N
S
Q
T
S
E
T
S
S
Site 70
T1018
F
D
E
S
N
S
Q
T
S
E
T
S
S
G
N
Site 71
S1019
D
E
S
N
S
Q
T
S
E
T
S
S
G
N
S
Site 72
T1021
S
N
S
Q
T
S
E
T
S
S
G
N
S
S
Q
Site 73
S1022
N
S
Q
T
S
E
T
S
S
G
N
S
S
Q
E
Site 74
S1023
S
Q
T
S
E
T
S
S
G
N
S
S
Q
E
G
Site 75
S1026
S
E
T
S
S
G
N
S
S
Q
E
G
P
S
N
Site 76
S1027
E
T
S
S
G
N
S
S
Q
E
G
P
S
N
V
Site 77
S1032
N
S
S
Q
E
G
P
S
N
V
P
G
A
L
D
Site 78
S1054
A
E
G
I
F
G
G
S
E
E
N
T
P
L
D
Site 79
T1058
F
G
G
S
E
E
N
T
P
L
D
L
D
D
H
Site 80
T1069
L
D
D
H
G
G
R
T
F
L
R
V
L
L
H
Site 81
S1098
Q
L
L
F
R
H
F
S
Q
R
Q
E
V
L
Q
Site 82
S1116
Q
V
Q
L
L
V
T
S
Q
D
V
D
N
Y
K
Site 83
Y1122
T
S
Q
D
V
D
N
Y
K
Q
I
K
Q
D
L
Site 84
S1134
Q
D
L
D
Q
L
R
S
I
V
E
K
S
E
L
Site 85
Y1144
E
K
S
E
L
W
V
Y
K
G
Q
G
P
D
E
Site 86
T1152
K
G
Q
G
P
D
E
T
M
D
G
A
S
G
E
Site 87
T1165
G
E
N
E
H
K
K
T
E
E
G
N
N
K
P
Site 88
S1177
N
K
P
Q
K
H
E
S
T
S
S
Y
N
Y
R
Site 89
S1180
Q
K
H
E
S
T
S
S
Y
N
Y
R
V
V
K
Site 90
Y1181
K
H
E
S
T
S
S
Y
N
Y
R
V
V
K
E
Site 91
Y1183
E
S
T
S
S
Y
N
Y
R
V
V
K
E
I
L
Site 92
S1201
S
K
L
C
V
Q
E
S
A
S
V
R
K
S
R
Site 93
S1203
L
C
V
Q
E
S
A
S
V
R
K
S
R
K
Q
Site 94
S1207
E
S
A
S
V
R
K
S
R
K
Q
Q
Q
R
L
Site 95
T1238
P
Y
E
K
A
E
D
T
K
M
Q
E
I
M
R
Site 96
Y1355
G
E
D
V
L
V
F
Y
N
D
R
A
S
F
Q
Site 97
T1363
N
D
R
A
S
F
Q
T
L
I
Q
M
M
R
S
Site 98
S1370
T
L
I
Q
M
M
R
S
E
R
D
R
M
D
E
Site 99
Y1383
D
E
N
S
P
L
M
Y
H
I
H
L
V
E
L
Site 100
S1408
Y
T
E
I
K
C
N
S
L
L
P
L
D
D
I
Site 101
T1420
D
D
I
V
R
V
V
T
H
E
D
C
I
P
E
Site 102
Y1451
E
V
E
M
K
E
I
Y
T
S
N
H
M
W
K
Site 103
S1482
S
D
R
K
H
A
D
S
I
L
E
K
Y
V
T
Site 104
S1501
S
I
V
T
T
F
F
S
S
P
F
S
D
Q
S
Site 105
S1502
I
V
T
T
F
F
S
S
P
F
S
D
Q
S
T
Site 106
S1505
T
F
F
S
S
P
F
S
D
Q
S
T
T
L
Q
Site 107
S1508
S
S
P
F
S
D
Q
S
T
T
L
Q
T
R
Q
Site 108
T1509
S
P
F
S
D
Q
S
T
T
L
Q
T
R
Q
P
Site 109
S1544
S
Q
K
A
S
V
E
S
C
I
R
V
L
S
D
Site 110
S1550
E
S
C
I
R
V
L
S
D
V
A
K
S
R
A
Site 111
S1575
V
N
N
L
F
L
K
S
H
S
I
V
Q
K
T
Site 112
S1577
N
L
F
L
K
S
H
S
I
V
Q
K
T
A
M
Site 113
S1589
T
A
M
N
W
R
L
S
A
R
N
A
A
R
R
Site 114
S1598
R
N
A
A
R
R
D
S
V
L
A
A
S
R
D
Site 115
Y1606
V
L
A
A
S
R
D
Y
R
N
I
I
E
R
L
Site 116
S1618
E
R
L
Q
D
I
V
S
A
L
E
D
R
L
R
Site 117
T1650
E
L
L
F
P
E
N
T
D
A
R
R
K
C
E
Site 118
S1658
D
A
R
R
K
C
E
S
G
G
F
I
C
K
L
Site 119
T1687
L
C
I
K
V
L
Q
T
L
R
E
M
M
T
K
Site 120
Y1698
M
M
T
K
D
R
G
Y
G
E
K
L
I
S
I
Site 121
S1704
G
Y
G
E
K
L
I
S
I
D
E
L
D
N
A
Site 122
S1719
E
L
P
P
A
P
D
S
E
N
S
T
E
E
L
Site 123
T1723
A
P
D
S
E
N
S
T
E
E
L
E
P
S
P
Site 124
S1729
S
T
E
E
L
E
P
S
P
P
L
R
Q
L
E
Site 125
Y1753
Q
V
L
V
N
R
Y
Y
G
N
V
R
P
S
G
Site 126
S1759
Y
Y
G
N
V
R
P
S
G
R
R
E
S
L
T
Site 127
S1764
R
P
S
G
R
R
E
S
L
T
S
F
G
N
G
Site 128
T1766
S
G
R
R
E
S
L
T
S
F
G
N
G
P
L
Site 129
S1767
G
R
R
E
S
L
T
S
F
G
N
G
P
L
S
Site 130
S1774
S
F
G
N
G
P
L
S
A
G
G
P
G
K
P
Site 131
S1788
P
G
G
G
G
G
G
S
G
S
S
S
M
S
R
Site 132
S1790
G
G
G
G
G
S
G
S
S
S
M
S
R
G
E
Site 133
S1791
G
G
G
G
S
G
S
S
S
M
S
R
G
E
M
Site 134
S1792
G
G
G
S
G
S
S
S
M
S
R
G
E
M
S
Site 135
S1794
G
S
G
S
S
S
M
S
R
G
E
M
S
L
A
Site 136
S1799
S
M
S
R
G
E
M
S
L
A
E
V
Q
C
H
Site 137
S1824
I
D
L
I
M
N
A
S
S
D
R
V
F
H
E
Site 138
S1825
D
L
I
M
N
A
S
S
D
R
V
F
H
E
S
Site 139
T1856
H
S
F
F
C
R
L
T
E
D
K
K
S
E
K
Site 140
S1861
R
L
T
E
D
K
K
S
E
K
F
F
K
V
F
Site 141
Y1869
E
K
F
F
K
V
F
Y
D
R
M
K
V
A
Q
Site 142
T1882
A
Q
Q
E
I
K
A
T
V
T
V
N
T
S
D
Site 143
T1884
Q
E
I
K
A
T
V
T
V
N
T
S
D
L
G
Site 144
S1928
R
D
Q
L
L
E
A
S
A
A
T
R
K
A
F
Site 145
T1937
A
T
R
K
A
F
T
T
F
R
R
E
A
D
P
Site 146
Y1948
E
A
D
P
D
D
H
Y
Q
P
G
E
G
T
Q
Site 147
S2047
L
I
N
Q
T
L
E
S
L
T
E
Y
C
Q
G
Site 148
Y2051
T
L
E
S
L
T
E
Y
C
Q
G
P
C
H
E
Site 149
S2110
L
L
L
A
I
M
E
S
R
H
D
S
E
N
A
Site 150
S2114
I
M
E
S
R
H
D
S
E
N
A
E
R
I
L
Site 151
Y2122
E
N
A
E
R
I
L
Y
N
M
R
P
K
E
L
Site 152
S2156
N
G
E
D
G
A
A
S
P
R
N
V
G
H
N
Site 153
Y2165
R
N
V
G
H
N
I
Y
I
L
A
H
Q
L
A
Site 154
S2180
R
H
N
K
E
L
Q
S
M
L
K
P
G
G
Q
Site 155
T2228
P
S
I
C
E
F
L
T
K
E
S
K
L
R
I
Site 156
Y2236
K
E
S
K
L
R
I
Y
Y
T
T
E
R
D
E
Site 157
Y2237
E
S
K
L
R
I
Y
Y
T
T
E
R
D
E
Q
Site 158
T2238
S
K
L
R
I
Y
Y
T
T
E
R
D
E
Q
G
Site 159
T2239
K
L
R
I
Y
Y
T
T
E
R
D
E
Q
G
S
Site 160
S2246
T
E
R
D
E
Q
G
S
K
I
N
D
F
F
L
Site 161
Y2275
L
R
A
Q
P
V
L
Y
W
C
A
R
N
M
S
Site 162
T2312
F
K
G
V
R
G
G
T
L
E
P
H
W
S
G
Site 163
T2386
S
F
V
G
N
C
G
T
F
T
R
G
Y
R
A
Site 164
T2434
D
L
V
Y
R
E
E
T
L
L
N
V
I
K
S
Site 165
S2441
T
L
L
N
V
I
K
S
V
T
R
N
G
R
S
Site 166
T2486
V
D
R
L
P
N
E
T
A
V
P
E
T
G
E
Site 167
S2497
E
T
G
E
S
L
A
S
E
F
L
F
S
D
V
Site 168
S2509
S
D
V
C
R
V
E
S
G
E
N
C
S
S
P
Site 169
S2515
E
S
G
E
N
C
S
S
P
A
P
R
E
E
L
Site 170
S2565
G
D
V
L
R
K
P
S
K
E
E
P
L
F
A
Site 171
T2633
R
D
K
F
D
N
K
T
V
T
F
E
E
H
I
Site 172
T2635
K
F
D
N
K
T
V
T
F
E
E
H
I
K
E
Site 173
Y2649
E
E
H
N
M
W
H
Y
L
C
F
I
V
L
V
Site 174
S2661
V
L
V
K
V
K
D
S
T
E
Y
T
G
P
E
Site 175
T2662
L
V
K
V
K
D
S
T
E
Y
T
G
P
E
S
Site 176
Y2664
K
V
K
D
S
T
E
Y
T
G
P
E
S
Y
V
Site 177
T2665
V
K
D
S
T
E
Y
T
G
P
E
S
Y
V
A
Site 178
S2669
T
E
Y
T
G
P
E
S
Y
V
A
E
M
I
K
Site 179
Y2670
E
Y
T
G
P
E
S
Y
V
A
E
M
I
K
E
Site 180
S2690
F
P
R
M
R
A
M
S
L
V
S
S
D
S
E
Site 181
S2694
R
A
M
S
L
V
S
S
D
S
E
G
E
Q
N
Site 182
S2696
M
S
L
V
S
S
D
S
E
G
E
Q
N
E
L
Site 183
T2718
E
S
T
M
K
L
V
T
N
L
S
G
Q
L
S
Site 184
S2721
M
K
L
V
T
N
L
S
G
Q
L
S
E
L
K
Site 185
S2725
T
N
L
S
G
Q
L
S
E
L
K
D
Q
M
T
Site 186
T2732
S
E
L
K
D
Q
M
T
E
Q
R
K
Q
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation