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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv2.1
Full Name:
Potassium voltage-gated channel subfamily B member 1
Alias:
Delayed rectifier potassium channel 1; DRK1; KCB1; KCNB1; Potassium channel Kv2.1; Potassium voltage-gated channel, Shab-related subfamily, member 1; Voltage-gated potassium channel subunit Kv2.1
Type:
Channel, cation; Channel, potassium; Channel, ligand-gated
Mass (Da):
95878
Number AA:
858
UniProt ID:
Q14721
International Prot ID:
IPI00033019
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005515
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
G
M
T
K
H
G
S
R
S
T
S
S
L
P
Site 2
S12
M
T
K
H
G
S
R
S
T
S
S
L
P
P
E
Site 3
T13
T
K
H
G
S
R
S
T
S
S
L
P
P
E
P
Site 4
S14
K
H
G
S
R
S
T
S
S
L
P
P
E
P
M
Site 5
S15
H
G
S
R
S
T
S
S
L
P
P
E
P
M
E
Site 6
S26
E
P
M
E
I
V
R
S
K
A
C
S
R
R
V
Site 7
S30
I
V
R
S
K
A
C
S
R
R
V
R
L
N
V
Site 8
T48
A
H
E
V
L
W
R
T
L
D
R
L
P
R
T
Site 9
T55
T
L
D
R
L
P
R
T
R
L
G
K
L
R
D
Site 10
T65
G
K
L
R
D
C
N
T
H
D
S
L
L
E
V
Site 11
S68
R
D
C
N
T
H
D
S
L
L
E
V
C
D
D
Site 12
Y76
L
L
E
V
C
D
D
Y
S
L
D
D
N
E
Y
Site 13
Y83
Y
S
L
D
D
N
E
Y
F
F
D
R
H
P
G
Site 14
T93
D
R
H
P
G
A
F
T
S
I
L
N
F
Y
R
Site 15
S94
R
H
P
G
A
F
T
S
I
L
N
F
Y
R
T
Site 16
Y99
F
T
S
I
L
N
F
Y
R
T
G
R
L
H
M
Site 17
T101
S
I
L
N
F
Y
R
T
G
R
L
H
M
M
E
Site 18
S114
M
E
E
M
C
A
L
S
F
S
Q
E
L
D
Y
Site 19
Y121
S
F
S
Q
E
L
D
Y
W
G
I
D
E
I
Y
Site 20
Y128
Y
W
G
I
D
E
I
Y
L
E
S
C
C
Q
A
Site 21
Y137
E
S
C
C
Q
A
R
Y
H
Q
K
K
E
Q
M
Site 22
T166
E
G
E
E
F
D
N
T
C
C
A
E
K
R
K
Site 23
S216
N
T
L
P
E
L
Q
S
L
D
E
F
G
Q
S
Site 24
S223
S
L
D
E
F
G
Q
S
T
D
N
P
Q
L
A
Site 25
T224
L
D
E
F
G
Q
S
T
D
N
P
Q
L
A
H
Site 26
S250
E
Y
L
L
R
F
L
S
S
P
K
K
W
K
F
Site 27
S251
Y
L
L
R
F
L
S
S
P
K
K
W
K
F
F
Site 28
S285
F
L
T
E
S
N
K
S
V
L
Q
F
Q
N
V
Site 29
T315
L
K
L
A
R
H
S
T
G
L
Q
S
L
G
F
Site 30
S319
R
H
S
T
G
L
Q
S
L
G
F
T
L
R
R
Site 31
T323
G
L
Q
S
L
G
F
T
L
R
R
S
Y
N
E
Site 32
T359
A
E
K
D
E
D
D
T
K
F
K
S
I
P
A
Site 33
T374
S
F
W
W
A
T
I
T
M
T
T
V
G
Y
G
Site 34
Y384
T
V
G
Y
G
D
I
Y
P
K
T
L
L
G
K
Site 35
S444
E
R
A
K
R
N
G
S
I
V
S
M
N
M
K
Site 36
S447
K
R
N
G
S
I
V
S
M
N
M
K
D
A
F
Site 37
S457
M
K
D
A
F
A
R
S
I
E
M
M
D
I
V
Site 38
S484
K
V
Q
D
N
H
L
S
P
N
K
W
K
W
T
Site 39
T491
S
P
N
K
W
K
W
T
K
R
T
L
S
E
T
Site 40
T494
K
W
K
W
T
K
R
T
L
S
E
T
S
S
S
Site 41
S496
K
W
T
K
R
T
L
S
E
T
S
S
S
K
S
Site 42
T498
T
K
R
T
L
S
E
T
S
S
S
K
S
F
E
Site 43
S499
K
R
T
L
S
E
T
S
S
S
K
S
F
E
T
Site 44
S500
R
T
L
S
E
T
S
S
S
K
S
F
E
T
K
Site 45
S501
T
L
S
E
T
S
S
S
K
S
F
E
T
K
E
Site 46
S503
S
E
T
S
S
S
K
S
F
E
T
K
E
Q
G
Site 47
S511
F
E
T
K
E
Q
G
S
P
E
K
A
R
S
S
Site 48
S517
G
S
P
E
K
A
R
S
S
S
S
P
Q
H
L
Site 49
S518
S
P
E
K
A
R
S
S
S
S
P
Q
H
L
N
Site 50
S519
P
E
K
A
R
S
S
S
S
P
Q
H
L
N
V
Site 51
S520
E
K
A
R
S
S
S
S
P
Q
H
L
N
V
Q
Site 52
Y533
V
Q
Q
L
E
D
M
Y
N
K
M
A
K
T
Q
Site 53
T539
M
Y
N
K
M
A
K
T
Q
S
Q
P
I
L
N
Site 54
S541
N
K
M
A
K
T
Q
S
Q
P
I
L
N
T
K
Site 55
S550
P
I
L
N
T
K
E
S
A
A
Q
S
K
P
K
Site 56
S554
T
K
E
S
A
A
Q
S
K
P
K
E
E
L
E
Site 57
S567
L
E
M
E
S
I
P
S
P
V
A
P
L
P
T
Site 58
S584
E
G
V
I
D
M
R
S
M
S
S
I
D
S
F
Site 59
S590
R
S
M
S
S
I
D
S
F
I
S
C
A
T
D
Site 60
S593
S
S
I
D
S
F
I
S
C
A
T
D
F
P
E
Site 61
S605
F
P
E
A
T
R
F
S
H
S
P
L
T
S
L
Site 62
S607
E
A
T
R
F
S
H
S
P
L
T
S
L
P
S
Site 63
T610
R
F
S
H
S
P
L
T
S
L
P
S
K
T
G
Site 64
S611
F
S
H
S
P
L
T
S
L
P
S
K
T
G
G
Site 65
S614
S
P
L
T
S
L
P
S
K
T
G
G
S
T
A
Site 66
S619
L
P
S
K
T
G
G
S
T
A
P
E
V
G
W
Site 67
S633
W
R
G
A
L
G
A
S
G
G
R
F
V
E
A
Site 68
S643
R
F
V
E
A
N
P
S
P
D
A
S
Q
H
S
Site 69
S647
A
N
P
S
P
D
A
S
Q
H
S
S
F
F
I
Site 70
S650
S
P
D
A
S
Q
H
S
S
F
F
I
E
S
P
Site 71
S651
P
D
A
S
Q
H
S
S
F
F
I
E
S
P
K
Site 72
S656
H
S
S
F
F
I
E
S
P
K
S
S
M
K
T
Site 73
S659
F
F
I
E
S
P
K
S
S
M
K
T
N
N
P
Site 74
S660
F
I
E
S
P
K
S
S
M
K
T
N
N
P
L
Site 75
T663
S
P
K
S
S
M
K
T
N
N
P
L
K
L
R
Site 76
Y691
L
L
P
V
L
G
M
Y
H
D
P
L
R
N
R
Site 77
S700
D
P
L
R
N
R
G
S
A
A
A
A
V
A
G
Site 78
S720
L
L
D
K
A
V
L
S
P
E
S
S
I
Y
T
Site 79
S723
K
A
V
L
S
P
E
S
S
I
Y
T
T
A
S
Site 80
Y726
L
S
P
E
S
S
I
Y
T
T
A
S
A
K
T
Site 81
T727
S
P
E
S
S
I
Y
T
T
A
S
A
K
T
P
Site 82
T728
P
E
S
S
I
Y
T
T
A
S
A
K
T
P
P
Site 83
S730
S
S
I
Y
T
T
A
S
A
K
T
P
P
R
S
Site 84
T733
Y
T
T
A
S
A
K
T
P
P
R
S
P
E
K
Site 85
S737
S
A
K
T
P
P
R
S
P
E
K
H
T
A
I
Site 86
T760
H
Q
Y
I
D
A
D
T
D
D
E
G
Q
L
L
Site 87
Y768
D
D
E
G
Q
L
L
Y
S
V
D
S
S
P
P
Site 88
S769
D
E
G
Q
L
L
Y
S
V
D
S
S
P
P
K
Site 89
S772
Q
L
L
Y
S
V
D
S
S
P
P
K
S
L
P
Site 90
S773
L
L
Y
S
V
D
S
S
P
P
K
S
L
P
G
Site 91
S777
V
D
S
S
P
P
K
S
L
P
G
S
T
S
P
Site 92
S781
P
P
K
S
L
P
G
S
T
S
P
K
F
S
T
Site 93
S783
K
S
L
P
G
S
T
S
P
K
F
S
T
G
T
Site 94
S787
G
S
T
S
P
K
F
S
T
G
T
R
S
E
K
Site 95
T788
S
T
S
P
K
F
S
T
G
T
R
S
E
K
N
Site 96
S792
K
F
S
T
G
T
R
S
E
K
N
H
F
E
S
Site 97
S799
S
E
K
N
H
F
E
S
S
P
L
P
T
S
P
Site 98
S800
E
K
N
H
F
E
S
S
P
L
P
T
S
P
K
Site 99
T804
F
E
S
S
P
L
P
T
S
P
K
F
L
R
Q
Site 100
S805
E
S
S
P
L
P
T
S
P
K
F
L
R
Q
N
Site 101
Y815
F
L
R
Q
N
C
I
Y
S
T
E
A
L
T
G
Site 102
S838
C
K
L
E
N
H
I
S
P
D
V
R
V
L
P
Site 103
S852
P
G
G
G
A
H
G
S
T
R
D
Q
S
I
_
Site 104
T853
G
G
G
A
H
G
S
T
R
D
Q
S
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation