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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R5D
Full Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Alias:
2A5D; B56D; PP2A B subunit B' delta isoform; PP2A B subunit B56 delta isoform; PP2A B subunit PR61 delta isoform; PP2A B subunit R5 delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit delta isoform
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
69992
Number AA:
602
UniProt ID:
Q14738
International Prot ID:
IPI00000030
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0000159
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008601
GO:0008601
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0007165
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
P
P
K
V
A
K
C
T
A
K
P
S
S
S
G
Site 2
S22
A
K
C
T
A
K
P
S
S
S
G
K
D
G
G
Site 3
S23
K
C
T
A
K
P
S
S
S
G
K
D
G
G
G
Site 4
S24
C
T
A
K
P
S
S
S
G
K
D
G
G
G
E
Site 5
S50
Q
P
Q
P
Q
A
Q
S
Q
P
P
S
S
N
K
Site 6
S54
Q
A
Q
S
Q
P
P
S
S
N
K
R
P
S
N
Site 7
S55
A
Q
S
Q
P
P
S
S
N
K
R
P
S
N
S
Site 8
S60
P
S
S
N
K
R
P
S
N
S
T
P
P
P
T
Site 9
S62
S
N
K
R
P
S
N
S
T
P
P
P
T
Q
L
Site 10
T63
N
K
R
P
S
N
S
T
P
P
P
T
Q
L
S
Site 11
T67
S
N
S
T
P
P
P
T
Q
L
S
K
I
K
Y
Site 12
S70
T
P
P
P
T
Q
L
S
K
I
K
Y
S
G
G
Site 13
Y74
T
Q
L
S
K
I
K
Y
S
G
G
P
Q
I
V
Site 14
S75
Q
L
S
K
I
K
Y
S
G
G
P
Q
I
V
K
Site 15
S88
V
K
K
E
R
R
Q
S
S
S
R
F
N
L
S
Site 16
S89
K
K
E
R
R
Q
S
S
S
R
F
N
L
S
K
Site 17
S90
K
E
R
R
Q
S
S
S
R
F
N
L
S
K
N
Site 18
S95
S
S
S
R
F
N
L
S
K
N
R
E
L
Q
K
Site 19
S109
K
L
P
A
L
K
D
S
P
T
Q
E
R
E
E
Site 20
T111
P
A
L
K
D
S
P
T
Q
E
R
E
E
L
F
Site 21
S137
D
F
V
S
D
P
L
S
D
L
K
F
K
E
V
Site 22
Y155
G
L
N
E
M
V
E
Y
I
T
H
S
R
D
V
Site 23
T164
T
H
S
R
D
V
V
T
E
A
I
Y
P
E
A
Site 24
T182
F
S
V
N
L
F
R
T
L
P
P
S
S
N
P
Site 25
S186
L
F
R
T
L
P
P
S
S
N
P
T
G
A
E
Site 26
S187
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
Site 27
T190
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
Site 28
T202
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
Site 29
S223
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
Site 30
S249
A
L
L
D
L
F
D
S
E
D
P
R
E
R
D
Site 31
T260
R
E
R
D
F
L
K
T
I
L
H
R
I
Y
G
Site 32
Y266
K
T
I
L
H
R
I
Y
G
K
F
L
G
L
R
Site 33
Y275
K
F
L
G
L
R
A
Y
I
R
R
Q
I
N
H
Site 34
S335
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
Site 35
S337
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Site 36
Y339
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
Site 37
S356
Q
F
L
E
K
E
S
S
L
T
E
P
V
I
V
Site 38
T372
L
L
K
F
W
P
K
T
H
S
P
K
E
V
M
Site 39
S374
K
F
W
P
K
T
H
S
P
K
E
V
M
F
L
Site 40
S412
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
Site 41
S413
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
Site 42
Y424
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
Site 43
Y425
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
Site 44
Y430
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
Site 45
Y451
P
I
M
F
P
A
L
Y
R
N
S
K
S
H
W
Site 46
T485
Q
K
L
F
D
D
C
T
Q
Q
Y
K
A
E
K
Site 47
Y488
F
D
D
C
T
Q
Q
Y
K
A
E
K
Q
K
G
Site 48
Y519
L
A
R
L
N
P
Q
Y
P
M
F
R
A
P
P
Site 49
Y532
P
P
P
L
P
P
V
Y
S
M
E
T
E
T
P
Site 50
S533
P
P
L
P
P
V
Y
S
M
E
T
E
T
P
T
Site 51
T538
V
Y
S
M
E
T
E
T
P
T
A
E
D
I
Q
Site 52
T553
L
L
K
R
T
V
E
T
E
A
V
Q
M
L
K
Site 53
S573
K
V
L
L
R
R
K
S
E
L
P
Q
D
V
Y
Site 54
Y580
S
E
L
P
Q
D
V
Y
T
I
K
A
L
E
A
Site 55
T581
E
L
P
Q
D
V
Y
T
I
K
A
L
E
A
H
Site 56
T596
K
R
A
E
E
F
L
T
A
S
Q
E
A
L
_
Site 57
S598
A
E
E
F
L
T
A
S
Q
E
A
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation