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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASP8
Full Name:
Caspase-8
Alias:
Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; Casp-8; Caspase 8, apoptosis-related cysteine peptidase; FADD-homologous ICE/CED-3- like protease; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; ICE8; ICE-like apoptotic protease 5; MACH; MCH5; MORT1-associated CED-3 homolog
Type:
EC 3.4.22.-; Protease; Apoptosis; EC 3.4.22.61
Mass (Da):
55391
Number AA:
479
UniProt ID:
Q14790
International Prot ID:
IPI00000149
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0008633
GO:0008624
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
D
F
S
R
N
L
Y
D
I
G
E
Q
L
D
Site 2
S16
D
I
G
E
Q
L
D
S
E
D
L
A
S
L
K
Site 3
Y29
L
K
F
L
S
L
D
Y
I
P
Q
R
K
Q
E
Site 4
S57
E
K
R
M
L
E
E
S
N
L
S
F
L
K
E
Site 5
Y78
R
L
D
L
L
I
T
Y
L
N
T
R
K
E
E
Site 6
T92
E
M
E
R
E
L
Q
T
P
G
R
A
Q
I
S
Site 7
S99
T
P
G
R
A
Q
I
S
A
Y
R
V
M
L
Y
Site 8
Y106
S
A
Y
R
V
M
L
Y
Q
I
S
E
E
V
S
Site 9
S109
R
V
M
L
Y
Q
I
S
E
E
V
S
R
S
E
Site 10
S113
Y
Q
I
S
E
E
V
S
R
S
E
L
R
S
F
Site 11
S115
I
S
E
E
V
S
R
S
E
L
R
S
F
K
F
Site 12
S119
V
S
R
S
E
L
R
S
F
K
F
L
L
Q
E
Site 13
S129
F
L
L
Q
E
E
I
S
K
C
K
L
D
D
D
Site 14
Y178
L
L
K
I
I
N
D
Y
E
E
F
S
K
E
R
Site 15
S182
I
N
D
Y
E
E
F
S
K
E
R
S
S
S
L
Site 16
S186
E
E
F
S
K
E
R
S
S
S
L
E
G
S
P
Site 17
S187
E
F
S
K
E
R
S
S
S
L
E
G
S
P
D
Site 18
S188
F
S
K
E
R
S
S
S
L
E
G
S
P
D
E
Site 19
S192
R
S
S
S
L
E
G
S
P
D
E
F
S
N
G
Site 20
S197
E
G
S
P
D
E
F
S
N
G
E
E
L
C
G
Site 21
T207
E
E
L
C
G
V
M
T
I
S
D
S
P
R
E
Site 22
S209
L
C
G
V
M
T
I
S
D
S
P
R
E
Q
D
Site 23
S211
G
V
M
T
I
S
D
S
P
R
E
Q
D
S
E
Site 24
S217
D
S
P
R
E
Q
D
S
E
S
Q
T
L
D
K
Site 25
S219
P
R
E
Q
D
S
E
S
Q
T
L
D
K
V
Y
Site 26
T221
E
Q
D
S
E
S
Q
T
L
D
K
V
Y
Q
M
Site 27
Y226
S
Q
T
L
D
K
V
Y
Q
M
K
S
K
P
R
Site 28
Y235
M
K
S
K
P
R
G
Y
C
L
I
I
N
N
H
Site 29
S256
E
K
V
P
K
L
H
S
I
R
D
R
N
G
T
Site 30
T263
S
I
R
D
R
N
G
T
H
L
D
A
G
A
L
Site 31
T273
D
A
G
A
L
T
T
T
F
E
E
L
H
F
E
Site 32
T288
I
K
P
H
D
D
C
T
V
E
Q
I
Y
E
I
Site 33
Y293
D
C
T
V
E
Q
I
Y
E
I
L
K
I
Y
Q
Site 34
Y299
I
Y
E
I
L
K
I
Y
Q
L
M
D
H
S
N
Site 35
Y324
H
G
D
K
G
I
I
Y
G
T
D
G
Q
E
A
Site 36
Y334
D
G
Q
E
A
P
I
Y
E
L
T
S
Q
F
T
Site 37
S347
F
T
G
L
K
C
P
S
L
A
G
K
P
K
V
Site 38
Y365
Q
A
C
Q
G
D
N
Y
Q
K
G
I
P
V
E
Site 39
Y380
T
D
S
E
E
Q
P
Y
L
E
M
D
L
S
S
Site 40
S386
P
Y
L
E
M
D
L
S
S
P
Q
T
R
Y
I
Site 41
S387
Y
L
E
M
D
L
S
S
P
Q
T
R
Y
I
P
Site 42
T390
M
D
L
S
S
P
Q
T
R
Y
I
P
D
E
A
Site 43
S411
A
T
V
N
N
C
V
S
Y
R
N
P
A
E
G
Site 44
Y412
T
V
N
N
C
V
S
Y
R
N
P
A
E
G
T
Site 45
Y421
N
P
A
E
G
T
W
Y
I
Q
S
L
C
Q
S
Site 46
S424
E
G
T
W
Y
I
Q
S
L
C
Q
S
L
R
E
Site 47
S428
Y
I
Q
S
L
C
Q
S
L
R
E
R
C
P
R
Site 48
T441
P
R
G
D
D
I
L
T
I
L
T
E
V
N
Y
Site 49
Y448
T
I
L
T
E
V
N
Y
E
V
S
N
K
D
D
Site 50
T467
G
K
Q
M
P
Q
P
T
F
T
L
R
K
K
L
Site 51
T469
Q
M
P
Q
P
T
F
T
L
R
K
K
L
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation