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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NMDAR2C
Full Name:
Glutamate [NMDA] receptor subunit epsilon-3
Alias:
Glutamate NMDA receptor subunit epsilon 3 precursor; Glutamate receptor, ionotropic, N-methyl D-aspartate 2C; GRIN2C; NMDE3; N-methyl D- aspartate receptor subtype 2C; N-methyl D-aspartate receptor subtype 2C; NR2C
Type:
Channel, ligand-gated; Channel, calcium
Mass (Da):
134532
Number AA:
1236
UniProt ID:
Q14957
International Prot ID:
IPI00215887
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004972
GO:0005509
GO:0005234
PhosphoSite+
KinaseNET
Biological Process:
GO:0007215
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T51
A
Q
F
R
A
R
L
T
P
Q
S
F
L
D
L
Site 2
S54
R
A
R
L
T
P
Q
S
F
L
D
L
P
L
E
Site 3
T131
G
G
S
A
V
V
L
T
P
K
E
P
G
S
A
Site 4
T212
P
G
G
P
R
A
R
T
Q
R
L
L
R
Q
L
Site 5
Y227
D
A
P
V
F
V
A
Y
C
S
R
E
E
A
E
Site 6
S229
P
V
F
V
A
Y
C
S
R
E
E
A
E
V
L
Site 7
S284
V
T
E
S
W
R
L
S
L
R
Q
K
V
R
D
Site 8
Y303
L
A
L
G
A
H
S
Y
W
R
Q
H
G
T
L
Site 9
T309
S
Y
W
R
Q
H
G
T
L
P
A
P
A
G
D
Site 10
S325
R
V
H
P
G
P
V
S
P
A
R
E
A
F
Y
Site 11
S346
T
W
E
G
R
D
F
S
F
S
P
G
G
Y
L
Site 12
S348
E
G
R
D
F
S
F
S
P
G
G
Y
L
V
Q
Site 13
Y384
H
G
V
L
Y
M
K
Y
P
V
W
P
R
Y
S
Site 14
Y390
K
Y
P
V
W
P
R
Y
S
A
S
L
Q
P
V
Site 15
S391
Y
P
V
W
P
R
Y
S
A
S
L
Q
P
V
V
Site 16
S393
V
W
P
R
Y
S
A
S
L
Q
P
V
V
D
S
Site 17
S400
S
L
Q
P
V
V
D
S
R
H
L
T
V
A
T
Site 18
T404
V
V
D
S
R
H
L
T
V
A
T
L
E
E
R
Site 19
T407
S
R
H
L
T
V
A
T
L
E
E
R
P
F
V
Site 20
S418
R
P
F
V
I
V
E
S
P
D
P
G
T
G
G
Site 21
T423
V
E
S
P
D
P
G
T
G
G
C
V
P
N
T
Site 22
T430
T
G
G
C
V
P
N
T
V
P
C
R
R
Q
S
Site 23
S437
T
V
P
C
R
R
Q
S
N
H
T
F
S
S
G
Site 24
T440
C
R
R
Q
S
N
H
T
F
S
S
G
D
V
A
Site 25
S442
R
Q
S
N
H
T
F
S
S
G
D
V
A
P
Y
Site 26
T450
S
G
D
V
A
P
Y
T
K
L
C
C
K
G
F
Site 27
Y476
V
K
F
S
Y
D
L
Y
L
V
T
N
G
K
H
Site 28
Y499
N
G
M
I
G
E
V
Y
Y
K
R
A
D
M
A
Site 29
S509
R
A
D
M
A
I
G
S
L
T
I
N
E
E
R
Site 30
S543
A
R
S
N
G
T
V
S
P
S
A
F
L
E
P
Site 31
S545
S
N
G
T
V
S
P
S
A
F
L
E
P
Y
S
Site 32
S581
F
E
Y
F
S
P
V
S
Y
N
Q
N
L
T
R
Site 33
Y582
E
Y
F
S
P
V
S
Y
N
Q
N
L
T
R
G
Site 34
T587
V
S
Y
N
Q
N
L
T
R
G
K
K
S
G
G
Site 35
S614
W
A
L
V
F
N
N
S
V
P
I
E
N
P
R
Site 36
T623
P
I
E
N
P
R
G
T
T
S
K
I
M
V
L
Site 37
T659
I
Q
E
Q
Y
I
D
T
V
S
G
L
S
D
K
Site 38
Y675
F
Q
R
P
Q
D
Q
Y
P
P
F
R
F
G
T
Site 39
T682
Y
P
P
F
R
F
G
T
V
P
N
G
S
T
E
Site 40
S687
F
G
T
V
P
N
G
S
T
E
R
N
I
R
S
Site 41
S694
S
T
E
R
N
I
R
S
N
Y
R
D
M
H
T
Site 42
Y696
E
R
N
I
R
S
N
Y
R
D
M
H
T
H
M
Site 43
S710
M
V
K
F
N
Q
R
S
V
E
D
A
L
T
S
Site 44
T716
R
S
V
E
D
A
L
T
S
L
K
M
G
K
L
Site 45
Y728
G
K
L
D
A
F
I
Y
D
A
A
V
L
N
Y
Site 46
Y735
Y
D
A
A
V
L
N
Y
M
A
G
K
D
E
G
Site 47
T786
Q
F
L
G
D
G
E
T
Q
K
L
E
T
V
W
Site 48
T791
G
E
T
Q
K
L
E
T
V
W
L
S
G
I
C
Site 49
S808
E
K
N
E
V
M
S
S
K
L
D
I
D
N
M
Site 50
Y840
F
A
W
E
H
L
V
Y
W
K
L
R
H
S
V
Site 51
S846
V
Y
W
K
L
R
H
S
V
P
N
S
S
Q
L
Site 52
S850
L
R
H
S
V
P
N
S
S
Q
L
D
F
L
L
Site 53
S851
R
H
S
V
P
N
S
S
Q
L
D
F
L
L
A
Site 54
S872
S
C
F
S
G
V
Q
S
L
A
S
P
P
R
Q
Site 55
S875
S
G
V
Q
S
L
A
S
P
P
R
Q
A
S
P
Site 56
S881
A
S
P
P
R
Q
A
S
P
D
L
T
A
S
S
Site 57
T885
R
Q
A
S
P
D
L
T
A
S
S
A
Q
A
S
Site 58
S888
S
P
D
L
T
A
S
S
A
Q
A
S
V
L
K
Site 59
T905
Q
A
A
R
D
M
V
T
T
A
G
V
S
S
S
Site 60
S910
M
V
T
T
A
G
V
S
S
S
L
D
R
A
T
Site 61
S912
T
T
A
G
V
S
S
S
L
D
R
A
T
R
T
Site 62
T917
S
S
S
L
D
R
A
T
R
T
I
E
N
W
G
Site 63
T919
S
L
D
R
A
T
R
T
I
E
N
W
G
G
G
Site 64
S933
G
R
R
A
P
P
P
S
P
C
P
T
P
R
S
Site 65
T937
P
P
P
S
P
C
P
T
P
R
S
G
P
S
P
Site 66
S940
S
P
C
P
T
P
R
S
G
P
S
P
C
L
P
Site 67
S943
P
T
P
R
S
G
P
S
P
C
L
P
T
P
D
Site 68
T948
G
P
S
P
C
L
P
T
P
D
P
P
P
E
P
Site 69
S956
P
D
P
P
P
E
P
S
P
T
G
W
G
P
P
Site 70
T958
P
P
P
E
P
S
P
T
G
W
G
P
P
D
G
Site 71
T983
Q
P
P
G
R
P
P
T
P
G
P
P
L
S
D
Site 72
S989
P
T
P
G
P
P
L
S
D
V
S
R
V
S
R
Site 73
S992
G
P
P
L
S
D
V
S
R
V
S
R
R
P
A
Site 74
S995
L
S
D
V
S
R
V
S
R
R
P
A
W
E
A
Site 75
T1008
E
A
R
W
P
V
R
T
G
H
C
G
R
H
L
Site 76
S1016
G
H
C
G
R
H
L
S
A
S
E
R
P
L
S
Site 77
S1018
C
G
R
H
L
S
A
S
E
R
P
L
S
P
A
Site 78
S1023
S
A
S
E
R
P
L
S
P
A
R
C
H
Y
S
Site 79
Y1029
L
S
P
A
R
C
H
Y
S
S
F
P
R
A
D
Site 80
S1031
P
A
R
C
H
Y
S
S
F
P
R
A
D
R
S
Site 81
S1038
S
F
P
R
A
D
R
S
G
R
P
F
L
P
L
Site 82
S1078
H
A
A
W
A
R
G
S
R
P
R
H
A
S
L
Site 83
S1084
G
S
R
P
R
H
A
S
L
P
S
S
V
A
E
Site 84
S1088
R
H
A
S
L
P
S
S
V
A
E
A
F
A
R
Site 85
S1098
E
A
F
A
R
P
S
S
L
P
A
G
C
T
G
Site 86
S1115
C
A
R
P
D
G
H
S
A
C
R
R
L
A
Q
Site 87
S1125
R
R
L
A
Q
A
Q
S
M
C
L
P
I
Y
R
Site 88
Y1131
Q
S
M
C
L
P
I
Y
R
E
A
C
Q
E
G
Site 89
S1176
P
H
L
P
P
C
A
S
H
G
S
W
L
S
G
Site 90
S1179
P
P
C
A
S
H
G
S
W
L
S
G
A
W
G
Site 91
S1182
A
S
H
G
S
W
L
S
G
A
W
G
P
L
G
Site 92
T1194
P
L
G
H
R
G
R
T
L
G
L
G
T
G
Y
Site 93
Y1201
T
L
G
L
G
T
G
Y
R
D
S
G
G
L
D
Site 94
S1204
L
G
T
G
Y
R
D
S
G
G
L
D
E
I
S
Site 95
S1211
S
G
G
L
D
E
I
S
R
V
A
R
G
T
Q
Site 96
T1217
I
S
R
V
A
R
G
T
Q
G
F
P
G
P
C
Site 97
T1225
Q
G
F
P
G
P
C
T
W
R
R
I
S
S
L
Site 98
S1230
P
C
T
W
R
R
I
S
S
L
E
S
E
V
_
Site 99
S1231
C
T
W
R
R
I
S
S
L
E
S
E
V
_
_
Site 100
S1234
R
R
I
S
S
L
E
S
E
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation