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Updated November 2019
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Protein Info
Short Name:
NOLC1
Full Name:
Nucleolar and coiled-body phosphoprotein 1
Alias:
140 kDa nucleolar phosphoprotein; HCV NS5A trans-regulated protein 13; KIAA0035; NOPP130; Nopp140; Nucleolar 130 kDa protein; Nucleolar and coiled-body phosphoprotein 1; Nucleolar phosphoprotein p130; P130
Type:
Transcription, coactivator/corepressor
Mass (Da):
73603
Number AA:
699
UniProt ID:
Q14978
International Prot ID:
IPI00216654
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
F
L
R
D
N
Q
L
S
E
V
A
N
K
F
A
Site 2
T38
A
N
K
F
A
K
A
T
G
A
T
Q
Q
D
A
Site 3
T41
F
A
K
A
T
G
A
T
Q
Q
D
A
N
A
S
Site 4
S49
Q
Q
D
A
N
A
S
S
L
L
D
I
Y
S
F
Site 5
S55
S
S
L
L
D
I
Y
S
F
W
L
K
S
A
K
Site 6
S83
K
K
A
K
K
K
A
S
S
S
D
S
E
D
S
Site 7
S84
K
A
K
K
K
A
S
S
S
D
S
E
D
S
S
Site 8
S85
A
K
K
K
A
S
S
S
D
S
E
D
S
S
E
Site 9
S87
K
K
A
S
S
S
D
S
E
D
S
S
E
E
E
Site 10
S90
S
S
S
D
S
E
D
S
S
E
E
E
E
E
V
Site 11
S91
S
S
D
S
E
D
S
S
E
E
E
E
E
V
Q
Site 12
S124
G
K
A
A
A
K
A
S
E
S
S
S
S
E
E
Site 13
S126
A
A
A
K
A
S
E
S
S
S
S
E
E
S
S
Site 14
S127
A
A
K
A
S
E
S
S
S
S
E
E
S
S
D
Site 15
S128
A
K
A
S
E
S
S
S
S
E
E
S
S
D
D
Site 16
S129
K
A
S
E
S
S
S
S
E
E
S
S
D
D
D
Site 17
S132
E
S
S
S
S
E
E
S
S
D
D
D
D
E
E
Site 18
S133
S
S
S
S
E
E
S
S
D
D
D
D
E
E
D
Site 19
S166
A
P
P
K
K
A
K
S
S
D
S
D
S
D
S
Site 20
S167
P
P
K
K
A
K
S
S
D
S
D
S
D
S
S
Site 21
S169
K
K
A
K
S
S
D
S
D
S
D
S
S
S
E
Site 22
S171
A
K
S
S
D
S
D
S
D
S
S
S
E
D
E
Site 23
S173
S
S
D
S
D
S
D
S
S
S
E
D
E
P
P
Site 24
S174
S
D
S
D
S
D
S
S
S
E
D
E
P
P
K
Site 25
S175
D
S
D
S
D
S
S
S
E
D
E
P
P
K
N
Site 26
T188
K
N
Q
K
P
K
I
T
P
V
T
V
K
A
Q
Site 27
T191
K
P
K
I
T
P
V
T
V
K
A
Q
T
K
A
Site 28
S216
I
A
N
G
K
A
A
S
S
S
S
S
S
S
S
Site 29
S217
A
N
G
K
A
A
S
S
S
S
S
S
S
S
S
Site 30
S218
N
G
K
A
A
S
S
S
S
S
S
S
S
S
S
Site 31
S219
G
K
A
A
S
S
S
S
S
S
S
S
S
S
S
Site 32
S220
K
A
A
S
S
S
S
S
S
S
S
S
S
S
S
Site 33
S221
A
A
S
S
S
S
S
S
S
S
S
S
S
S
D
Site 34
S222
A
S
S
S
S
S
S
S
S
S
S
S
S
D
D
Site 35
S223
S
S
S
S
S
S
S
S
S
S
S
S
D
D
S
Site 36
S224
S
S
S
S
S
S
S
S
S
S
S
D
D
S
E
Site 37
S225
S
S
S
S
S
S
S
S
S
S
D
D
S
E
E
Site 38
S226
S
S
S
S
S
S
S
S
S
D
D
S
E
E
E
Site 39
S227
S
S
S
S
S
S
S
S
D
D
S
E
E
E
K
Site 40
S230
S
S
S
S
S
D
D
S
E
E
E
K
A
A
A
Site 41
T238
E
E
E
K
A
A
A
T
P
K
K
T
V
P
K
Site 42
T259
A
P
V
K
A
A
T
T
P
T
R
K
S
S
S
Site 43
T261
V
K
A
A
T
T
P
T
R
K
S
S
S
S
E
Site 44
S264
A
T
T
P
T
R
K
S
S
S
S
E
D
S
S
Site 45
S265
T
T
P
T
R
K
S
S
S
S
E
D
S
S
S
Site 46
S266
T
P
T
R
K
S
S
S
S
E
D
S
S
S
D
Site 47
S267
P
T
R
K
S
S
S
S
E
D
S
S
S
D
E
Site 48
S270
K
S
S
S
S
E
D
S
S
S
D
E
E
E
E
Site 49
S271
S
S
S
S
E
D
S
S
S
D
E
E
E
E
Q
Site 50
S272
S
S
S
E
D
S
S
S
D
E
E
E
E
Q
K
Site 51
Y289
M
K
N
K
P
G
P
Y
S
S
V
P
P
P
S
Site 52
S290
K
N
K
P
G
P
Y
S
S
V
P
P
P
S
A
Site 53
S291
N
K
P
G
P
Y
S
S
V
P
P
P
S
A
P
Site 54
S296
Y
S
S
V
P
P
P
S
A
P
P
P
K
K
S
Site 55
S303
S
A
P
P
P
K
K
S
L
G
T
Q
P
P
K
Site 56
T306
P
P
K
K
S
L
G
T
Q
P
P
K
K
A
V
Site 57
S321
E
K
Q
Q
P
V
E
S
S
E
D
S
S
D
E
Site 58
S322
K
Q
Q
P
V
E
S
S
E
D
S
S
D
E
S
Site 59
S325
P
V
E
S
S
E
D
S
S
D
E
S
D
S
S
Site 60
S326
V
E
S
S
E
D
S
S
D
E
S
D
S
S
S
Site 61
S329
S
E
D
S
S
D
E
S
D
S
S
S
E
E
E
Site 62
S331
D
S
S
D
E
S
D
S
S
S
E
E
E
K
K
Site 63
S332
S
S
D
E
S
D
S
S
S
E
E
E
K
K
P
Site 64
S333
S
D
E
S
D
S
S
S
E
E
E
K
K
P
P
Site 65
T341
E
E
E
K
K
P
P
T
K
A
V
V
S
K
A
Site 66
T350
A
V
V
S
K
A
T
T
K
P
P
P
A
K
K
Site 67
S361
P
A
K
K
A
A
E
S
S
S
D
S
S
D
S
Site 68
S362
A
K
K
A
A
E
S
S
S
D
S
S
D
S
D
Site 69
S363
K
K
A
A
E
S
S
S
D
S
S
D
S
D
S
Site 70
S365
A
A
E
S
S
S
D
S
S
D
S
D
S
S
E
Site 71
S366
A
E
S
S
S
D
S
S
D
S
D
S
S
E
D
Site 72
S368
S
S
S
D
S
S
D
S
D
S
S
E
D
D
E
Site 73
S370
S
D
S
S
D
S
D
S
S
E
D
D
E
A
P
Site 74
S371
D
S
S
D
S
D
S
S
E
D
D
E
A
P
S
Site 75
S378
S
E
D
D
E
A
P
S
K
P
A
G
T
T
K
Site 76
T383
A
P
S
K
P
A
G
T
T
K
N
S
S
N
K
Site 77
T384
P
S
K
P
A
G
T
T
K
N
S
S
N
K
P
Site 78
S388
A
G
T
T
K
N
S
S
N
K
P
A
V
T
T
Site 79
T395
S
N
K
P
A
V
T
T
K
S
P
A
V
K
P
Site 80
S397
K
P
A
V
T
T
K
S
P
A
V
K
P
A
A
Site 81
T418
G
G
G
Q
K
L
L
T
R
K
A
D
S
S
S
Site 82
S423
L
L
T
R
K
A
D
S
S
S
S
E
E
E
S
Site 83
S424
L
T
R
K
A
D
S
S
S
S
E
E
E
S
S
Site 84
S425
T
R
K
A
D
S
S
S
S
E
E
E
S
S
S
Site 85
S426
R
K
A
D
S
S
S
S
E
E
E
S
S
S
S
Site 86
S430
S
S
S
S
E
E
E
S
S
S
S
E
E
E
K
Site 87
S431
S
S
S
E
E
E
S
S
S
S
E
E
E
K
T
Site 88
S432
S
S
E
E
E
S
S
S
S
E
E
E
K
T
K
Site 89
S433
S
E
E
E
S
S
S
S
E
E
E
K
T
K
K
Site 90
T438
S
S
S
E
E
E
K
T
K
K
M
V
A
T
T
Site 91
S466
A
K
Q
A
P
Q
G
S
R
D
S
S
S
D
S
Site 92
S469
A
P
Q
G
S
R
D
S
S
S
D
S
D
S
S
Site 93
S470
P
Q
G
S
R
D
S
S
S
D
S
D
S
S
S
Site 94
S471
Q
G
S
R
D
S
S
S
D
S
D
S
S
S
S
Site 95
S473
S
R
D
S
S
S
D
S
D
S
S
S
S
E
E
Site 96
S475
D
S
S
S
D
S
D
S
S
S
S
E
E
E
E
Site 97
S476
S
S
S
D
S
D
S
S
S
S
E
E
E
E
E
Site 98
S477
S
S
D
S
D
S
S
S
S
E
E
E
E
E
K
Site 99
T485
S
E
E
E
E
E
K
T
S
K
S
A
V
K
K
Site 100
S488
E
E
E
K
T
S
K
S
A
V
K
K
K
P
Q
Site 101
S504
V
A
G
G
A
A
P
S
K
P
A
S
A
K
K
Site 102
S508
A
A
P
S
K
P
A
S
A
K
K
G
K
A
E
Site 103
S516
A
K
K
G
K
A
E
S
S
N
S
S
S
S
D
Site 104
S517
K
K
G
K
A
E
S
S
N
S
S
S
S
D
D
Site 105
S519
G
K
A
E
S
S
N
S
S
S
S
D
D
S
S
Site 106
S520
K
A
E
S
S
N
S
S
S
S
D
D
S
S
E
Site 107
S521
A
E
S
S
N
S
S
S
S
D
D
S
S
E
E
Site 108
S522
E
S
S
N
S
S
S
S
D
D
S
S
E
E
E
Site 109
S525
N
S
S
S
S
D
D
S
S
E
E
E
E
E
K
Site 110
S526
S
S
S
S
D
D
S
S
E
E
E
E
E
K
L
Site 111
S538
E
K
L
K
G
K
G
S
P
R
P
Q
A
P
K
Site 112
S563
N
G
K
A
A
K
N
S
E
E
E
E
E
E
K
Site 113
S578
K
K
A
A
V
V
V
S
K
S
G
S
L
K
K
Site 114
S580
A
A
V
V
V
S
K
S
G
S
L
K
K
R
K
Site 115
S582
V
V
V
S
K
S
G
S
L
K
K
R
K
Q
N
Site 116
T597
E
A
A
K
E
A
E
T
P
Q
A
K
K
I
K
Site 117
T607
A
K
K
I
K
L
Q
T
P
N
T
F
P
K
R
Site 118
T610
I
K
L
Q
T
P
N
T
F
P
K
R
K
K
G
Site 119
S622
K
K
G
E
K
R
A
S
S
P
F
R
R
V
R
Site 120
S623
K
G
E
K
R
A
S
S
P
F
R
R
V
R
E
Site 121
S643
D
S
R
V
A
D
N
S
F
D
A
K
R
G
A
Site 122
S669
L
K
F
T
K
G
K
S
F
R
H
E
K
T
K
Site 123
T675
K
S
F
R
H
E
K
T
K
K
K
R
G
S
Y
Site 124
S681
K
T
K
K
K
R
G
S
Y
R
G
G
S
I
S
Site 125
Y682
T
K
K
K
R
G
S
Y
R
G
G
S
I
S
V
Site 126
S686
R
G
S
Y
R
G
G
S
I
S
V
Q
V
N
S
Site 127
S688
S
Y
R
G
G
S
I
S
V
Q
V
N
S
I
K
Site 128
S693
S
I
S
V
Q
V
N
S
I
K
F
D
S
E
_
Site 129
S698
V
N
S
I
K
F
D
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation