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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R5A
Full Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Alias:
2A5A; B56A; PP2A B subunit B' alpha isoform; PP2A B subunit B56 alpha isoform; PP2A B subunit PR61 alpha isoform; PP2A B subunit R5 alpha isoform; PR61A
Type:
Protein-serine phosphatase, regulatory subunit
Mass (Da):
56194
Number AA:
486
UniProt ID:
Q15172
International Prot ID:
IPI00014978
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000775
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008601
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
S
S
S
P
P
A
G
A
A
S
Site 2
S28
V
D
G
F
T
R
K
S
V
R
K
A
Q
R
Q
Site 3
S38
K
A
Q
R
Q
K
R
S
Q
G
S
S
Q
F
R
Site 4
S41
R
Q
K
R
S
Q
G
S
S
Q
F
R
S
Q
G
Site 5
S42
Q
K
R
S
Q
G
S
S
Q
F
R
S
Q
G
S
Site 6
S46
Q
G
S
S
Q
F
R
S
Q
G
S
Q
A
E
L
Site 7
S49
S
Q
F
R
S
Q
G
S
Q
A
E
L
H
P
L
Site 8
S64
P
Q
L
K
D
A
T
S
N
E
Q
Q
E
L
F
Site 9
S89
F
D
F
M
D
S
V
S
D
L
K
S
K
E
I
Site 10
S93
D
S
V
S
D
L
K
S
K
E
I
K
R
A
T
Site 11
T100
S
K
E
I
K
R
A
T
L
N
E
L
V
E
Y
Site 12
Y107
T
L
N
E
L
V
E
Y
V
S
T
N
R
G
V
Site 13
T134
I
S
A
N
I
F
R
T
L
P
P
S
D
N
P
Site 14
S138
I
F
R
T
L
P
P
S
D
N
P
D
F
D
P
Site 15
T151
D
P
E
E
D
E
P
T
L
E
A
S
W
P
H
Site 16
S178
E
S
P
D
F
Q
P
S
I
A
K
R
Y
I
D
Site 17
S198
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
Site 18
T209
R
E
R
D
F
L
K
T
V
L
H
R
I
Y
G
Site 19
Y215
K
T
V
L
H
R
I
Y
G
K
F
L
G
L
R
Site 20
Y238
N
I
F
L
R
F
I
Y
E
T
E
H
F
N
G
Site 21
T305
Q
F
L
E
K
D
T
T
L
T
E
P
V
I
R
Site 22
T321
L
L
K
F
W
P
K
T
C
S
Q
K
E
V
M
Site 23
S357
E
P
L
F
K
Q
I
S
K
C
V
S
S
S
H
Site 24
S361
K
Q
I
S
K
C
V
S
S
S
H
F
Q
V
A
Site 25
S362
Q
I
S
K
C
V
S
S
S
H
F
Q
V
A
E
Site 26
S363
I
S
K
C
V
S
S
S
H
F
Q
V
A
E
R
Site 27
Y373
Q
V
A
E
R
A
L
Y
F
W
N
N
E
Y
I
Site 28
Y400
P
I
M
F
A
S
L
Y
K
I
S
K
E
H
W
Site 29
T434
G
K
L
F
D
D
L
T
S
S
Y
K
A
E
R
Site 30
S472
K
A
L
E
K
Q
N
S
A
Y
N
M
H
S
I
Site 31
Y474
L
E
K
Q
N
S
A
Y
N
M
H
S
I
L
S
Site 32
S478
N
S
A
Y
N
M
H
S
I
L
S
N
T
S
A
Site 33
S484
H
S
I
L
S
N
T
S
A
E
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation