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Updated November 2019
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Protein Info
Short Name:
MED1
Full Name:
Mediator of RNA polymerase II transcription subunit 1
Alias:
Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1: Mediator complex subunit 1: Peroxisome proliferator-activated receptor-binding protein: Thyroid hormone receptor-associated protein complex 220 kDa component: Thyroid receptor-interacting protein 2: p53 regulatory protein RB18A: Vitamin D receptor-interacting protein complex component DRIP205: Activator-recruited cofactor 205 kDa component
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
168478
Number AA:
1581
UniProt ID:
Q15648
International Prot ID:
IPI00829826
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000119
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003702
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006352
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
Q
G
E
T
E
E
S
E
K
L
S
K
M
S
Site 2
S14
T
E
E
S
E
K
L
S
K
M
S
S
L
L
E
Site 3
S18
E
K
L
S
K
M
S
S
L
L
E
R
L
H
A
Site 4
S34
F
N
Q
N
R
P
W
S
E
T
I
K
L
V
R
Site 5
T36
Q
N
R
P
W
S
E
T
I
K
L
V
R
Q
V
Site 6
S52
E
K
R
V
V
M
S
S
G
G
H
Q
H
L
V
Site 7
S60
G
G
H
Q
H
L
V
S
C
L
E
T
L
Q
K
Site 8
S73
Q
K
A
L
K
V
T
S
L
P
A
M
T
D
R
Site 9
S83
A
M
T
D
R
L
E
S
I
A
R
Q
N
G
L
Site 10
S95
N
G
L
G
S
H
L
S
A
S
G
T
E
C
Y
Site 11
T99
S
H
L
S
A
S
G
T
E
C
Y
I
T
S
D
Site 12
Y102
S
A
S
G
T
E
C
Y
I
T
S
D
M
F
Y
Site 13
T104
S
G
T
E
C
Y
I
T
S
D
M
F
Y
V
E
Site 14
S134
H
H
G
E
N
P
V
S
C
P
E
L
V
Q
Q
Site 15
S151
E
K
N
F
D
E
F
S
K
H
L
K
G
L
V
Site 16
Y161
L
K
G
L
V
N
L
Y
N
L
P
G
D
N
K
Site 17
T171
P
G
D
N
K
L
K
T
K
M
Y
L
A
L
Q
Site 18
Y174
N
K
L
K
T
K
M
Y
L
A
L
Q
S
L
E
Site 19
S179
K
M
Y
L
A
L
Q
S
L
E
Q
D
L
S
K
Site 20
S185
Q
S
L
E
Q
D
L
S
K
M
A
I
M
Y
W
Site 21
S207
L
D
K
I
L
H
G
S
V
G
Y
L
T
P
R
Site 22
Y210
I
L
H
G
S
V
G
Y
L
T
P
R
S
G
G
Site 23
T212
H
G
S
V
G
Y
L
T
P
R
S
G
G
H
L
Site 24
S215
V
G
Y
L
T
P
R
S
G
G
H
L
M
N
L
Site 25
Y224
G
H
L
M
N
L
K
Y
Y
V
S
P
S
D
L
Site 26
Y225
H
L
M
N
L
K
Y
Y
V
S
P
S
D
L
L
Site 27
S227
M
N
L
K
Y
Y
V
S
P
S
D
L
L
D
D
Site 28
T236
S
D
L
L
D
D
K
T
A
S
P
I
I
L
H
Site 29
S238
L
L
D
D
K
T
A
S
P
I
I
L
H
E
N
Site 30
S250
H
E
N
N
V
S
R
S
L
G
M
N
A
S
V
Site 31
S256
R
S
L
G
M
N
A
S
V
T
I
E
G
T
S
Site 32
T285
H
P
V
D
N
K
W
T
P
S
F
S
S
I
T
Site 33
S287
V
D
N
K
W
T
P
S
F
S
S
I
T
S
A
Site 34
S289
N
K
W
T
P
S
F
S
S
I
T
S
A
N
S
Site 35
S290
K
W
T
P
S
F
S
S
I
T
S
A
N
S
V
Site 36
S293
P
S
F
S
S
I
T
S
A
N
S
V
D
L
P
Site 37
T335
P
L
F
E
T
Q
P
T
Y
A
P
L
Y
E
L
Site 38
Y340
Q
P
T
Y
A
P
L
Y
E
L
I
T
Q
F
E
Site 39
T344
A
P
L
Y
E
L
I
T
Q
F
E
L
S
K
D
Site 40
S349
L
I
T
Q
F
E
L
S
K
D
P
D
P
I
P
Site 41
Y364
L
N
H
N
M
R
F
Y
A
A
L
P
G
Q
Q
Site 42
Y374
L
P
G
Q
Q
H
C
Y
F
L
N
K
D
A
P
Site 43
S387
A
P
L
P
D
G
R
S
L
Q
G
T
L
V
S
Site 44
T391
D
G
R
S
L
Q
G
T
L
V
S
K
I
T
F
Site 45
S394
S
L
Q
G
T
L
V
S
K
I
T
F
Q
H
P
Site 46
T397
G
T
L
V
S
K
I
T
F
Q
H
P
G
R
V
Site 47
T419
R
H
Q
V
A
Y
N
T
L
I
G
S
C
V
K
Site 48
S434
R
T
I
L
K
E
D
S
P
G
L
L
Q
F
E
Site 49
S446
Q
F
E
V
C
P
L
S
E
S
R
F
S
V
S
Site 50
S448
E
V
C
P
L
S
E
S
R
F
S
V
S
F
Q
Site 51
S451
P
L
S
E
S
R
F
S
V
S
F
Q
H
P
V
Site 52
S453
S
E
S
R
F
S
V
S
F
Q
H
P
V
N
D
Site 53
T473
V
M
D
V
Q
D
S
T
H
V
S
C
K
L
Y
Site 54
S476
V
Q
D
S
T
H
V
S
C
K
L
Y
K
G
L
Site 55
Y480
T
H
V
S
C
K
L
Y
K
G
L
S
D
A
L
Site 56
S503
K
V
V
Q
R
C
M
S
I
P
V
T
M
R
A
Site 57
T507
R
C
M
S
I
P
V
T
M
R
A
I
R
R
K
Site 58
T517
A
I
R
R
K
A
E
T
I
Q
A
D
T
P
A
Site 59
S544
K
K
N
L
P
P
A
S
S
P
G
Y
G
M
T
Site 60
S545
K
N
L
P
P
A
S
S
P
G
Y
G
M
T
T
Site 61
Y548
P
P
A
S
S
P
G
Y
G
M
T
T
G
N
N
Site 62
T551
S
S
P
G
Y
G
M
T
T
G
N
N
P
M
S
Site 63
S558
T
T
G
N
N
P
M
S
G
T
T
T
P
T
N
Site 64
T562
N
P
M
S
G
T
T
T
P
T
N
T
F
P
G
Site 65
T566
G
T
T
T
P
T
N
T
F
P
G
G
P
I
T
Site 66
S581
T
L
F
N
M
S
M
S
I
K
D
R
H
E
S
Site 67
S588
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Site 68
S596
V
G
H
G
E
D
F
S
K
V
S
Q
N
P
I
Site 69
S599
G
E
D
F
S
K
V
S
Q
N
P
I
L
T
S
Site 70
S616
Q
I
T
G
N
G
G
S
T
I
G
S
S
P
T
Site 71
T617
I
T
G
N
G
G
S
T
I
G
S
S
P
T
P
Site 72
S620
N
G
G
S
T
I
G
S
S
P
T
P
P
H
H
Site 73
S621
G
G
S
T
I
G
S
S
P
T
P
P
H
H
T
Site 74
T623
S
T
I
G
S
S
P
T
P
P
H
H
T
P
P
Site 75
T628
S
P
T
P
P
H
H
T
P
P
P
V
S
S
M
Site 76
S633
H
H
T
P
P
P
V
S
S
M
A
G
N
T
K
Site 77
S634
H
T
P
P
P
V
S
S
M
A
G
N
T
K
N
Site 78
S658
D
N
P
A
Q
D
F
S
T
L
Y
G
S
S
P
Site 79
T659
N
P
A
Q
D
F
S
T
L
Y
G
S
S
P
L
Site 80
Y661
A
Q
D
F
S
T
L
Y
G
S
S
P
L
E
R
Site 81
S663
D
F
S
T
L
Y
G
S
S
P
L
E
R
Q
N
Site 82
S664
F
S
T
L
Y
G
S
S
P
L
E
R
Q
N
S
Site 83
S671
S
P
L
E
R
Q
N
S
S
S
G
S
P
R
M
Site 84
S672
P
L
E
R
Q
N
S
S
S
G
S
P
R
M
E
Site 85
S673
L
E
R
Q
N
S
S
S
G
S
P
R
M
E
I
Site 86
S675
R
Q
N
S
S
S
G
S
P
R
M
E
I
C
S
Site 87
S682
S
P
R
M
E
I
C
S
G
S
N
K
T
K
K
Site 88
T687
I
C
S
G
S
N
K
T
K
K
K
K
S
S
R
Site 89
S692
N
K
T
K
K
K
K
S
S
R
L
P
P
E
K
Site 90
S714
D
F
Q
R
E
L
F
S
M
D
V
D
S
Q
N
Site 91
T735
M
T
A
D
T
L
D
T
P
H
I
T
P
A
P
Site 92
T739
T
L
D
T
P
H
I
T
P
A
P
S
Q
C
S
Site 93
S743
P
H
I
T
P
A
P
S
Q
C
S
T
P
P
T
Site 94
S746
T
P
A
P
S
Q
C
S
T
P
P
T
T
Y
P
Site 95
T747
P
A
P
S
Q
C
S
T
P
P
T
T
Y
P
Q
Site 96
T750
S
Q
C
S
T
P
P
T
T
Y
P
Q
P
V
P
Site 97
Y752
C
S
T
P
P
T
T
Y
P
Q
P
V
P
H
P
Site 98
S762
P
V
P
H
P
Q
P
S
I
Q
R
M
V
R
L
Site 99
S770
I
Q
R
M
V
R
L
S
S
S
D
S
I
G
P
Site 100
S771
Q
R
M
V
R
L
S
S
S
D
S
I
G
P
D
Site 101
S772
R
M
V
R
L
S
S
S
D
S
I
G
P
D
V
Site 102
S774
V
R
L
S
S
S
D
S
I
G
P
D
V
T
D
Site 103
T780
D
S
I
G
P
D
V
T
D
I
L
S
D
I
A
Site 104
S784
P
D
V
T
D
I
L
S
D
I
A
E
E
A
S
Site 105
S791
S
D
I
A
E
E
A
S
K
L
P
S
T
S
D
Site 106
S795
E
E
A
S
K
L
P
S
T
S
D
D
C
P
A
Site 107
T796
E
A
S
K
L
P
S
T
S
D
D
C
P
A
I
Site 108
S797
A
S
K
L
P
S
T
S
D
D
C
P
A
I
G
Site 109
T805
D
D
C
P
A
I
G
T
P
L
R
D
S
S
S
Site 110
S810
I
G
T
P
L
R
D
S
S
S
S
G
H
S
Q
Site 111
S811
G
T
P
L
R
D
S
S
S
S
G
H
S
Q
S
Site 112
S812
T
P
L
R
D
S
S
S
S
G
H
S
Q
S
T
Site 113
S813
P
L
R
D
S
S
S
S
G
H
S
Q
S
T
L
Site 114
S816
D
S
S
S
S
G
H
S
Q
S
T
L
F
D
S
Site 115
S818
S
S
S
G
H
S
Q
S
T
L
F
D
S
D
V
Site 116
T819
S
S
G
H
S
Q
S
T
L
F
D
S
D
V
F
Site 117
S823
S
Q
S
T
L
F
D
S
D
V
F
Q
T
N
N
Site 118
Y835
T
N
N
N
E
N
P
Y
T
D
P
A
D
L
I
Site 119
T836
N
N
N
E
N
P
Y
T
D
P
A
D
L
I
A
Site 120
S848
L
I
A
D
A
A
G
S
P
S
S
D
S
P
T
Site 121
S851
D
A
A
G
S
P
S
S
D
S
P
T
N
H
F
Site 122
S853
A
G
S
P
S
S
D
S
P
T
N
H
F
F
H
Site 123
T855
S
P
S
S
D
S
P
T
N
H
F
F
H
D
G
Site 124
S872
F
N
P
D
L
L
N
S
Q
S
Q
S
G
F
G
Site 125
S874
P
D
L
L
N
S
Q
S
Q
S
G
F
G
E
E
Site 126
S876
L
L
N
S
Q
S
Q
S
G
F
G
E
E
Y
F
Site 127
Y882
Q
S
G
F
G
E
E
Y
F
D
E
S
S
Q
S
Site 128
S886
G
E
E
Y
F
D
E
S
S
Q
S
G
D
N
D
Site 129
S887
E
E
Y
F
D
E
S
S
Q
S
G
D
N
D
D
Site 130
S889
Y
F
D
E
S
S
Q
S
G
D
N
D
D
F
K
Site 131
S900
D
D
F
K
G
F
A
S
Q
A
L
N
T
L
G
Site 132
T928
K
G
N
N
Q
A
D
T
V
D
F
S
I
I
S
Site 133
S951
A
D
L
M
E
H
H
S
G
S
Q
G
P
L
L
Site 134
S953
L
M
E
H
H
S
G
S
Q
G
P
L
L
T
T
Site 135
T968
G
D
L
G
K
E
K
T
Q
K
R
V
K
E
G
Site 136
T978
R
V
K
E
G
N
G
T
S
N
S
T
L
S
G
Site 137
S979
V
K
E
G
N
G
T
S
N
S
T
L
S
G
P
Site 138
S981
E
G
N
G
T
S
N
S
T
L
S
G
P
G
L
Site 139
T982
G
N
G
T
S
N
S
T
L
S
G
P
G
L
D
Site 140
S984
G
T
S
N
S
T
L
S
G
P
G
L
D
S
K
Site 141
S990
L
S
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S
P
Site 293
Y1431
Q
M
A
S
S
K
N
Y
G
S
P
L
I
S
G
Site 294
S1433
A
S
S
K
N
Y
G
S
P
L
I
S
G
S
T
Site 295
S1437
N
Y
G
S
P
L
I
S
G
S
T
P
K
H
E
Site 296
S1439
G
S
P
L
I
S
G
S
T
P
K
H
E
R
G
Site 297
T1440
S
P
L
I
S
G
S
T
P
K
H
E
R
G
S
Site 298
S1447
T
P
K
H
E
R
G
S
P
S
H
S
K
S
P
Site 299
S1449
K
H
E
R
G
S
P
S
H
S
K
S
P
A
Y
Site 300
S1451
E
R
G
S
P
S
H
S
K
S
P
A
Y
T
P
Site 301
S1453
G
S
P
S
H
S
K
S
P
A
Y
T
P
Q
N
Site 302
Y1456
S
H
S
K
S
P
A
Y
T
P
Q
N
L
D
S
Site 303
T1457
H
S
K
S
P
A
Y
T
P
Q
N
L
D
S
E
Site 304
S1463
Y
T
P
Q
N
L
D
S
E
S
E
S
G
S
S
Site 305
S1465
P
Q
N
L
D
S
E
S
E
S
G
S
S
I
A
Site 306
S1467
N
L
D
S
E
S
E
S
G
S
S
I
A
E
K
Site 307
S1469
D
S
E
S
E
S
G
S
S
I
A
E
K
S
Y
Site 308
S1470
S
E
S
E
S
G
S
S
I
A
E
K
S
Y
Q
Site 309
S1475
G
S
S
I
A
E
K
S
Y
Q
N
S
P
S
S
Site 310
Y1476
S
S
I
A
E
K
S
Y
Q
N
S
P
S
S
D
Site 311
S1479
A
E
K
S
Y
Q
N
S
P
S
S
D
D
G
I
Site 312
S1481
K
S
Y
Q
N
S
P
S
S
D
D
G
I
R
P
Site 313
S1482
S
Y
Q
N
S
P
S
S
D
D
G
I
R
P
L
Site 314
Y1492
G
I
R
P
L
P
E
Y
S
T
E
K
H
K
K
Site 315
T1494
R
P
L
P
E
Y
S
T
E
K
H
K
K
H
K
Site 316
S1525
K
D
R
D
K
K
K
S
H
S
I
K
P
E
S
Site 317
S1527
R
D
K
K
K
S
H
S
I
K
P
E
S
W
S
Site 318
S1532
S
H
S
I
K
P
E
S
W
S
K
S
P
I
S
Site 319
S1534
S
I
K
P
E
S
W
S
K
S
P
I
S
S
D
Site 320
S1536
K
P
E
S
W
S
K
S
P
I
S
S
D
Q
S
Site 321
S1539
S
W
S
K
S
P
I
S
S
D
Q
S
L
S
M
Site 322
S1540
W
S
K
S
P
I
S
S
D
Q
S
L
S
M
T
Site 323
S1543
S
P
I
S
S
D
Q
S
L
S
M
T
S
N
T
Site 324
S1545
I
S
S
D
Q
S
L
S
M
T
S
N
T
I
L
Site 325
T1547
S
D
Q
S
L
S
M
T
S
N
T
I
L
S
A
Site 326
S1548
D
Q
S
L
S
M
T
S
N
T
I
L
S
A
D
Site 327
S1553
M
T
S
N
T
I
L
S
A
D
R
P
S
R
L
Site 328
S1558
I
L
S
A
D
R
P
S
R
L
S
P
D
F
M
Site 329
S1561
A
D
R
P
S
R
L
S
P
D
F
M
I
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation