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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNJ8
Full Name:
ATP-sensitive inward rectifier potassium channel 8
Alias:
Inwardly rectifier K(+) channel Kir6.1; IRK8; KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; Potassium inwardly-rectifying channel, subfamily J, member 8; UKATP-1
Type:
Channel, potassium
Mass (Da):
47968
Number AA:
424
UniProt ID:
Q15842
International Prot ID:
IPI00020003
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0015272
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
ATP-sensitive inward rectifier potassium channel 8 pan-specific antibody AB-NN280-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN280-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
L
A
R
K
S
I
I
P
E
E
Y
V
Site 2
S40
K
A
R
F
I
A
K
S
G
A
C
N
L
A
H
Site 3
T62
R
F
L
Q
D
I
F
T
T
L
V
D
L
K
W
Site 4
Y102
A
F
A
H
G
D
I
Y
A
Y
M
E
K
S
G
Site 5
Y104
A
H
G
D
I
Y
A
Y
M
E
K
S
G
M
E
Site 6
S108
I
Y
A
Y
M
E
K
S
G
M
E
K
S
G
L
Site 7
S113
E
K
S
G
M
E
K
S
G
L
E
S
T
V
C
Site 8
T118
E
K
S
G
L
E
S
T
V
C
V
T
N
V
R
Site 9
T190
Q
A
H
R
R
A
E
T
L
I
F
S
R
H
A
Site 10
S194
R
A
E
T
L
I
F
S
R
H
A
V
I
A
V
Site 11
T233
R
I
Q
V
V
K
K
T
T
T
P
E
G
E
V
Site 12
T234
I
Q
V
V
K
K
T
T
T
P
E
G
E
V
V
Site 13
T235
Q
V
V
K
K
T
T
T
P
E
G
E
V
V
P
Site 14
S275
C
H
V
I
D
K
R
S
P
L
Y
D
I
S
A
Site 15
Y278
I
D
K
R
S
P
L
Y
D
I
S
A
T
D
L
Site 16
S281
R
S
P
L
Y
D
I
S
A
T
D
L
A
N
Q
Site 17
S312
I
T
T
Q
A
R
T
S
Y
I
A
E
E
I
Q
Site 18
Y313
T
T
Q
A
R
T
S
Y
I
A
E
E
I
Q
W
Site 19
S326
Q
W
G
H
R
F
V
S
I
V
T
E
E
E
G
Site 20
Y335
V
T
E
E
E
G
V
Y
S
V
D
Y
S
K
F
Site 21
S336
T
E
E
E
G
V
Y
S
V
D
Y
S
K
F
G
Site 22
Y339
E
G
V
Y
S
V
D
Y
S
K
F
G
N
T
V
Site 23
S340
G
V
Y
S
V
D
Y
S
K
F
G
N
T
V
K
Site 24
T345
D
Y
S
K
F
G
N
T
V
K
V
A
A
P
R
Site 25
S354
K
V
A
A
P
R
C
S
A
R
E
L
D
E
K
Site 26
T368
K
P
S
I
L
I
Q
T
L
Q
K
S
E
L
S
Site 27
S372
L
I
Q
T
L
Q
K
S
E
L
S
H
Q
N
S
Site 28
S375
T
L
Q
K
S
E
L
S
H
Q
N
S
L
R
K
Site 29
S379
S
E
L
S
H
Q
N
S
L
R
K
R
N
S
M
Site 30
S385
N
S
L
R
K
R
N
S
M
R
R
N
N
S
M
Site 31
S391
N
S
M
R
R
N
N
S
M
R
R
N
N
S
I
Site 32
S397
N
S
M
R
R
N
N
S
I
R
R
N
N
S
S
Site 33
S403
N
S
I
R
R
N
N
S
S
L
M
V
P
K
V
Site 34
S404
S
I
R
R
N
N
S
S
L
M
V
P
K
V
Q
Site 35
T414
V
P
K
V
Q
F
M
T
P
E
G
N
Q
N
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation