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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKN2
Full Name:
Serine/threonine-protein kinase N2
Alias:
Cardiolipin-activated protein kinase Pak2; EC 2.7.11.13; PAK-2; PRK2; PRKCL2; Protease-activated kinase 2; Protein kinase C-like 2; Protein kinase N2; Protein-kinase C-related kinase 2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13;
AGC
group; PKN family
Mass (Da):
112035
Number AA:
984
UniProt ID:
Q16513
International Prot ID:
IPI00002804
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase N2 (G637-Q655, human) peptide - Powder PE-01BEY99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEY99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
N
P
E
R
G
E
I
Site 2
T13
E
R
G
E
I
L
L
T
E
L
Q
G
D
S
R
Site 3
S19
L
T
E
L
Q
G
D
S
R
S
L
P
F
S
E
Site 4
S21
E
L
Q
G
D
S
R
S
L
P
F
S
E
N
V
Site 5
S25
D
S
R
S
L
P
F
S
E
N
V
S
A
V
Q
Site 6
S37
A
V
Q
K
L
D
F
S
D
T
M
V
Q
Q
K
Site 7
T39
Q
K
L
D
F
S
D
T
M
V
Q
Q
K
L
D
Site 8
T73
A
E
N
L
R
K
V
T
T
D
K
K
S
L
A
Site 9
T74
E
N
L
R
K
V
T
T
D
K
K
S
L
A
Y
Site 10
S78
K
V
T
T
D
K
K
S
L
A
Y
V
D
N
I
Site 11
Y81
T
D
K
K
S
L
A
Y
V
D
N
I
L
K
K
Site 12
S110
L
N
A
H
I
V
V
S
D
P
E
D
I
T
D
Site 13
T116
V
S
D
P
E
D
I
T
D
C
P
R
T
P
D
Site 14
T121
D
I
T
D
C
P
R
T
P
D
T
P
N
N
D
Site 15
T124
D
C
P
R
T
P
D
T
P
N
N
D
P
R
C
Site 16
S132
P
N
N
D
P
R
C
S
T
S
N
N
R
L
K
Site 17
T133
N
N
D
P
R
C
S
T
S
N
N
R
L
K
A
Site 18
S134
N
D
P
R
C
S
T
S
N
N
R
L
K
A
L
Site 19
Y162
A
E
N
M
I
Q
M
Y
S
N
G
S
S
K
D
Site 20
S163
E
N
M
I
Q
M
Y
S
N
G
S
S
K
D
R
Site 21
S167
Q
M
Y
S
N
G
S
S
K
D
R
K
L
H
G
Site 22
T175
K
D
R
K
L
H
G
T
A
Q
Q
L
L
Q
D
Site 23
S183
A
Q
Q
L
L
Q
D
S
K
T
K
I
E
V
I
Site 24
T185
Q
L
L
Q
D
S
K
T
K
I
E
V
I
R
M
Site 25
S213
D
N
A
K
P
V
I
S
P
L
E
L
R
M
E
Site 26
T249
L
L
G
S
G
K
V
T
D
R
K
A
L
S
E
Site 27
S255
V
T
D
R
K
A
L
S
E
A
Q
A
R
F
N
Site 28
S264
A
Q
A
R
F
N
E
S
S
Q
K
L
D
L
L
Site 29
S265
Q
A
R
F
N
E
S
S
Q
K
L
D
L
L
K
Site 30
Y273
Q
K
L
D
L
L
K
Y
S
L
E
Q
R
L
N
Site 31
S274
K
L
D
L
L
K
Y
S
L
E
Q
R
L
N
E
Site 32
S289
V
P
K
N
H
P
K
S
R
I
I
I
E
E
L
Site 33
S302
E
L
S
L
V
A
A
S
P
T
L
S
P
R
Q
Site 34
T304
S
L
V
A
A
S
P
T
L
S
P
R
Q
S
M
Site 35
S306
V
A
A
S
P
T
L
S
P
R
Q
S
M
I
S
Site 36
S310
P
T
L
S
P
R
Q
S
M
I
S
T
Q
N
Q
Site 37
S313
S
P
R
Q
S
M
I
S
T
Q
N
Q
Y
S
T
Site 38
T314
P
R
Q
S
M
I
S
T
Q
N
Q
Y
S
T
L
Site 39
S319
I
S
T
Q
N
Q
Y
S
T
L
S
K
P
A
A
Site 40
T320
S
T
Q
N
Q
Y
S
T
L
S
K
P
A
A
L
Site 41
S322
Q
N
Q
Y
S
T
L
S
K
P
A
A
L
T
G
Site 42
S349
L
E
N
V
P
G
R
S
K
A
T
S
V
A
L
Site 43
S353
P
G
R
S
K
A
T
S
V
A
L
P
G
W
S
Site 44
S360
S
V
A
L
P
G
W
S
P
S
E
T
R
S
S
Site 45
S362
A
L
P
G
W
S
P
S
E
T
R
S
S
F
M
Site 46
T364
P
G
W
S
P
S
E
T
R
S
S
F
M
S
R
Site 47
S366
W
S
P
S
E
T
R
S
S
F
M
S
R
T
S
Site 48
S367
S
P
S
E
T
R
S
S
F
M
S
R
T
S
K
Site 49
S370
E
T
R
S
S
F
M
S
R
T
S
K
S
K
S
Site 50
T372
R
S
S
F
M
S
R
T
S
K
S
K
S
G
S
Site 51
S373
S
S
F
M
S
R
T
S
K
S
K
S
G
S
S
Site 52
S375
F
M
S
R
T
S
K
S
K
S
G
S
S
R
N
Site 53
S377
S
R
T
S
K
S
K
S
G
S
S
R
N
L
L
Site 54
S379
T
S
K
S
K
S
G
S
S
R
N
L
L
K
T
Site 55
T386
S
S
R
N
L
L
K
T
D
D
L
S
N
D
V
Site 56
S408
N
T
V
V
G
Q
T
S
W
K
P
I
S
N
Q
Site 57
S413
Q
T
S
W
K
P
I
S
N
Q
S
W
D
Q
K
Site 58
S416
W
K
P
I
S
N
Q
S
W
D
Q
K
F
T
L
Site 59
S428
F
T
L
E
L
D
R
S
R
E
L
E
I
S
V
Site 60
S434
R
S
R
E
L
E
I
S
V
Y
W
R
D
W
R
Site 61
Y436
R
E
L
E
I
S
V
Y
W
R
D
W
R
S
L
Site 62
Y465
Q
R
H
G
M
C
L
Y
L
E
P
Q
G
T
L
Site 63
S497
Q
R
Q
K
K
I
F
S
K
Q
Q
G
K
T
F
Site 64
T503
F
S
K
Q
Q
G
K
T
F
L
R
A
P
Q
M
Site 65
T527
L
V
R
R
A
I
P
T
V
N
H
S
G
T
F
Site 66
S531
A
I
P
T
V
N
H
S
G
T
F
S
P
Q
A
Site 67
T533
P
T
V
N
H
S
G
T
F
S
P
Q
A
P
V
Site 68
S535
V
N
H
S
G
T
F
S
P
Q
A
P
V
P
T
Site 69
S559
P
Q
L
A
P
P
A
S
D
S
T
V
T
K
L
Site 70
S561
L
A
P
P
A
S
D
S
T
V
T
K
L
D
F
Site 71
T562
A
P
P
A
S
D
S
T
V
T
K
L
D
F
D
Site 72
S582
P
P
A
P
P
R
A
S
S
L
G
E
I
D
E
Site 73
S583
P
A
P
P
R
A
S
S
L
G
E
I
D
E
S
Site 74
S590
S
L
G
E
I
D
E
S
S
E
L
R
V
L
D
Site 75
S591
L
G
E
I
D
E
S
S
E
L
R
V
L
D
I
Site 76
S603
L
D
I
P
G
Q
D
S
E
T
V
F
D
I
Q
Site 77
T605
I
P
G
Q
D
S
E
T
V
F
D
I
Q
N
D
Site 78
S615
D
I
Q
N
D
R
N
S
I
L
P
K
S
Q
S
Site 79
S620
R
N
S
I
L
P
K
S
Q
S
E
Y
K
P
D
Site 80
S622
S
I
L
P
K
S
Q
S
E
Y
K
P
D
T
P
Site 81
Y624
L
P
K
S
Q
S
E
Y
K
P
D
T
P
Q
S
Site 82
T628
Q
S
E
Y
K
P
D
T
P
Q
S
G
L
E
Y
Site 83
S631
Y
K
P
D
T
P
Q
S
G
L
E
Y
S
G
I
Site 84
Y635
T
P
Q
S
G
L
E
Y
S
G
I
Q
E
L
E
Site 85
S636
P
Q
S
G
L
E
Y
S
G
I
Q
E
L
E
D
Site 86
S646
Q
E
L
E
D
R
R
S
Q
Q
R
F
Q
F
N
Site 87
Y676
G
K
V
L
L
A
E
Y
K
N
T
N
E
M
F
Site 88
T679
L
L
A
E
Y
K
N
T
N
E
M
F
A
I
K
Site 89
S701
V
A
R
D
E
V
D
S
L
M
C
E
K
R
I
Site 90
T711
C
E
K
R
I
F
E
T
V
N
S
V
R
H
P
Site 91
T751
D
L
M
M
H
I
H
T
D
V
F
S
E
P
R
Site 92
Y810
L
C
K
E
G
M
G
Y
G
D
R
T
S
T
F
Site 93
T814
G
M
G
Y
G
D
R
T
S
T
F
C
G
T
P
Site 94
S815
M
G
Y
G
D
R
T
S
T
F
C
G
T
P
E
Site 95
T816
G
Y
G
D
R
T
S
T
F
C
G
T
P
E
F
Site 96
T820
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
Site 97
Y834
E
V
L
T
E
T
S
Y
T
R
A
V
D
W
W
Site 98
S855
Y
E
M
L
V
G
E
S
P
F
P
G
D
D
E
Site 99
S868
D
E
E
E
V
F
D
S
I
V
N
D
E
V
R
Site 100
Y876
I
V
N
D
E
V
R
Y
P
R
F
L
S
T
E
Site 101
T882
R
Y
P
R
F
L
S
T
E
A
I
S
I
M
R
Site 102
S903
P
E
R
R
L
G
A
S
E
K
D
A
E
D
V
Site 103
T936
V
K
P
P
F
I
P
T
I
R
G
R
E
D
V
Site 104
T958
T
S
E
A
P
I
L
T
P
P
R
E
P
R
I
Site 105
S967
P
R
E
P
R
I
L
S
E
E
E
Q
E
M
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation