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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERK3
Full Name:
Mitogen-activated protein kinase 6
Alias:
EC 2.7.11.24; MAPK6; Mitogen-activated protein kinase 6; MK06; P55-MAPK; P97-MAPK; PRKM4; PRKM6
Type:
Protein-serine kinase, CMGC group, MAPK family, ERK subfamily
Mass (Da):
82681
Number AA:
721
UniProt ID:
Q16659
International Prot ID:
IPI00003431
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004707
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Extracellular regulated protein-serine kinase 3 S189 phosphosite-specific antibody AB-PK623#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK623#Extracellular regulated protein-serine kinase 3 (G186-L192, human) pS189 phosphopeptide - Powder PE-04AKF90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKF90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
G
F
D
L
G
S
R
Y
M
D
L
K
P
L
G
Site 2
S36
G
G
N
G
L
V
F
S
A
V
D
N
D
C
D
Site 3
T54
A
I
K
K
I
V
L
T
D
P
Q
S
V
K
H
Site 4
S58
I
V
L
T
D
P
Q
S
V
K
H
A
L
R
E
Site 5
S87
V
F
E
I
L
G
P
S
G
S
Q
L
T
D
D
Site 6
S89
E
I
L
G
P
S
G
S
Q
L
T
D
D
V
G
Site 7
T92
G
P
S
G
S
Q
L
T
D
D
V
G
S
L
T
Site 8
S97
Q
L
T
D
D
V
G
S
L
T
E
L
N
S
V
Site 9
T99
T
D
D
V
G
S
L
T
E
L
N
S
V
Y
I
Site 10
S103
G
S
L
T
E
L
N
S
V
Y
I
V
Q
E
Y
Site 11
Y105
L
T
E
L
N
S
V
Y
I
V
Q
E
Y
M
E
Site 12
Y110
S
V
Y
I
V
Q
E
Y
M
E
T
D
L
A
N
Site 13
Y134
E
H
A
R
L
F
M
Y
Q
L
L
R
G
L
K
Site 14
S145
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
Site 15
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Site 16
S183
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
E
Site 17
S189
Y
S
H
K
G
H
L
S
E
G
L
V
T
K
W
Extracellular regulated protein-serine kinase 3 S189 phosphosite-specific antibody AB-PK623#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK623#Extracellular regulated protein-serine kinase 3 (G186-L192, human) pS189 phosphopeptide - Powder PE-04AKF90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKF90
Site 18
T194
H
L
S
E
G
L
V
T
K
W
Y
R
S
P
R
Site 19
Y197
E
G
L
V
T
K
W
Y
R
S
P
R
L
L
L
Site 20
S199
L
V
T
K
W
Y
R
S
P
R
L
L
L
S
P
Site 21
S205
R
S
P
R
L
L
L
S
P
N
N
Y
T
K
A
Site 22
Y209
L
L
L
S
P
N
N
Y
T
K
A
I
D
M
W
Site 23
S261
E
D
R
Q
E
L
L
S
V
I
P
V
Y
I
R
Site 24
T272
V
Y
I
R
N
D
M
T
E
P
H
K
P
L
T
Site 25
T279
T
E
P
H
K
P
L
T
Q
L
L
P
G
I
S
Site 26
T306
F
S
P
M
D
R
L
T
A
E
E
A
L
S
H
Site 27
S312
L
T
A
E
E
A
L
S
H
P
Y
M
S
I
Y
Site 28
Y315
E
E
A
L
S
H
P
Y
M
S
I
Y
S
F
P
Site 29
Y319
S
H
P
Y
M
S
I
Y
S
F
P
M
D
E
P
Site 30
S328
F
P
M
D
E
P
I
S
S
H
P
F
H
I
E
Site 31
S329
P
M
D
E
P
I
S
S
H
P
F
H
I
E
D
Site 32
S363
R
Y
H
D
C
Q
F
S
E
H
D
W
P
V
H
Site 33
S386
Q
L
D
P
R
A
L
S
D
V
T
D
E
E
E
Site 34
T389
P
R
A
L
S
D
V
T
D
E
E
E
V
Q
V
Site 35
Y401
V
Q
V
D
P
R
K
Y
L
D
G
D
R
E
K
Site 36
Y409
L
D
G
D
R
E
K
Y
L
E
D
P
A
F
D
Site 37
T417
L
E
D
P
A
F
D
T
N
Y
S
T
E
P
C
Site 38
Y419
D
P
A
F
D
T
N
Y
S
T
E
P
C
W
Q
Site 39
Y435
S
D
H
H
E
N
K
Y
C
D
L
E
C
S
H
Site 40
Y446
E
C
S
H
T
C
N
Y
K
T
R
S
S
S
Y
Site 41
T448
S
H
T
C
N
Y
K
T
R
S
S
S
Y
L
D
Site 42
S450
T
C
N
Y
K
T
R
S
S
S
Y
L
D
N
L
Site 43
S451
C
N
Y
K
T
R
S
S
S
Y
L
D
N
L
V
Site 44
S452
N
Y
K
T
R
S
S
S
Y
L
D
N
L
V
W
Site 45
Y453
Y
K
T
R
S
S
S
Y
L
D
N
L
V
W
R
Site 46
Y467
R
E
S
E
V
N
H
Y
Y
E
P
K
L
I
I
Site 47
Y468
E
S
E
V
N
H
Y
Y
E
P
K
L
I
I
D
Site 48
S477
P
K
L
I
I
D
L
S
N
W
K
E
Q
S
K
Site 49
S483
L
S
N
W
K
E
Q
S
K
E
K
S
D
K
K
Site 50
S487
K
E
Q
S
K
E
K
S
D
K
K
G
K
S
K
Site 51
S493
K
S
D
K
K
G
K
S
K
C
E
R
N
G
L
Site 52
S538
I
A
G
T
I
Q
L
S
S
Q
H
E
P
T
D
Site 53
S539
A
G
T
I
Q
L
S
S
Q
H
E
P
T
D
V
Site 54
S555
D
K
L
N
D
L
N
S
S
V
S
Q
L
E
L
Site 55
S558
N
D
L
N
S
S
V
S
Q
L
E
L
K
S
L
Site 56
S567
L
E
L
K
S
L
I
S
K
S
V
S
Q
E
K
Site 57
S569
L
K
S
L
I
S
K
S
V
S
Q
E
K
Q
E
Site 58
S571
S
L
I
S
K
S
V
S
Q
E
K
Q
E
K
G
Site 59
Y589
L
A
Q
L
E
A
L
Y
Q
S
S
W
D
S
Q
Site 60
S591
Q
L
E
A
L
Y
Q
S
S
W
D
S
Q
F
V
Site 61
S595
L
Y
Q
S
S
W
D
S
Q
F
V
S
G
G
E
Site 62
T624
E
Q
V
E
K
E
N
T
Y
T
S
Y
L
D
K
Site 63
T626
V
E
K
E
N
T
Y
T
S
Y
L
D
K
F
F
Site 64
S627
E
K
E
N
T
Y
T
S
Y
L
D
K
F
F
S
Site 65
Y628
K
E
N
T
Y
T
S
Y
L
D
K
F
F
S
R
Site 66
S634
S
Y
L
D
K
F
F
S
R
K
E
D
T
E
M
Site 67
T644
E
D
T
E
M
L
E
T
E
P
V
E
D
G
K
Site 68
S665
E
E
G
F
L
N
N
S
G
E
F
L
F
N
K
Site 69
S684
I
G
I
P
Q
F
H
S
P
V
G
S
P
L
K
Site 70
S688
Q
F
H
S
P
V
G
S
P
L
K
S
I
Q
A
Site 71
T696
P
L
K
S
I
Q
A
T
L
T
P
S
A
M
K
Site 72
T698
K
S
I
Q
A
T
L
T
P
S
A
M
K
S
S
Site 73
S700
I
Q
A
T
L
T
P
S
A
M
K
S
S
P
Q
Site 74
S704
L
T
P
S
A
M
K
S
S
P
Q
I
P
H
Q
Site 75
S705
T
P
S
A
M
K
S
S
P
Q
I
P
H
Q
T
Site 76
T712
S
P
Q
I
P
H
Q
T
Y
S
S
I
L
K
H
Site 77
Y713
P
Q
I
P
H
Q
T
Y
S
S
I
L
K
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation