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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IFI16
Full Name:
Gamma-interferon-inducible protein 16
Alias:
IF16; IFI-16; IFI4; IFNGIP1; Interferon, gamma-inducible protein 16; Interferon-inducible myeloid differentiation transcription activator; Interferon-inducible myeloid differentiation transcriptional activator; PYHIN2
Type:
Transcription regulation protein
Mass (Da):
88256
Number AA:
785
UniProt ID:
Q16666
International Prot ID:
IPI00003443
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003690
GO:0005515
GO:0016564
PhosphoSite+
KinaseNET
Biological Process:
GO:0042771
GO:0008283
GO:0030224
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
G
L
E
V
I
N
D
Y
H
F
R
M
V
K
S
Site 2
S27
Y
H
F
R
M
V
K
S
L
L
S
N
D
L
K
Site 3
S30
R
M
V
K
S
L
L
S
N
D
L
K
L
N
L
Site 4
Y43
N
L
K
M
R
E
E
Y
D
K
I
Q
I
A
D
Site 5
T74
K
I
F
E
D
I
P
T
L
E
D
L
A
E
T
Site 6
S95
K
V
K
G
P
A
L
S
R
K
R
K
K
E
V
Site 7
T105
R
K
K
E
V
D
A
T
S
P
A
P
S
T
S
Site 8
S106
K
K
E
V
D
A
T
S
P
A
P
S
T
S
S
Site 9
S110
D
A
T
S
P
A
P
S
T
S
S
T
V
K
T
Site 10
T111
A
T
S
P
A
P
S
T
S
S
T
V
K
T
E
Site 11
S112
T
S
P
A
P
S
T
S
S
T
V
K
T
E
G
Site 12
S113
S
P
A
P
S
T
S
S
T
V
K
T
E
G
A
Site 13
T114
P
A
P
S
T
S
S
T
V
K
T
E
G
A
E
Site 14
T117
S
T
S
S
T
V
K
T
E
G
A
E
A
T
P
Site 15
T123
K
T
E
G
A
E
A
T
P
G
A
Q
K
R
K
Site 16
S132
G
A
Q
K
R
K
K
S
T
K
E
K
A
G
P
Site 17
S142
E
K
A
G
P
K
G
S
K
V
S
E
E
Q
T
Site 18
T149
S
K
V
S
E
E
Q
T
Q
P
P
S
P
A
G
Site 19
S153
E
E
Q
T
Q
P
P
S
P
A
G
A
G
M
S
Site 20
S160
S
P
A
G
A
G
M
S
T
A
M
G
R
S
P
Site 21
T161
P
A
G
A
G
M
S
T
A
M
G
R
S
P
S
Site 22
S166
M
S
T
A
M
G
R
S
P
S
P
K
T
S
L
Site 23
S168
T
A
M
G
R
S
P
S
P
K
T
S
L
S
A
Site 24
T171
G
R
S
P
S
P
K
T
S
L
S
A
P
P
N
Site 25
S172
R
S
P
S
P
K
T
S
L
S
A
P
P
N
S
Site 26
S174
P
S
P
K
T
S
L
S
A
P
P
N
S
S
S
Site 27
S179
S
L
S
A
P
P
N
S
S
S
T
E
N
P
K
Site 28
S180
L
S
A
P
P
N
S
S
S
T
E
N
P
K
T
Site 29
S181
S
A
P
P
N
S
S
S
T
E
N
P
K
T
V
Site 30
T182
A
P
P
N
S
S
S
T
E
N
P
K
T
V
A
Site 31
T187
S
S
T
E
N
P
K
T
V
A
K
C
Q
V
T
Site 32
T194
T
V
A
K
C
Q
V
T
P
R
R
N
V
L
Q
Site 33
Y218
S
T
T
K
P
F
E
Y
E
T
P
E
M
E
K
Site 34
T220
T
K
P
F
E
Y
E
T
P
E
M
E
K
K
I
Site 35
T232
K
K
I
M
F
H
A
T
V
A
T
Q
T
Q
F
Site 36
T237
H
A
T
V
A
T
Q
T
Q
F
F
H
V
K
V
Site 37
S262
G
K
K
I
I
I
I
S
D
Y
L
E
Y
D
S
Site 38
S269
S
D
Y
L
E
Y
D
S
L
L
E
V
N
E
E
Site 39
T278
L
E
V
N
E
E
S
T
V
S
E
A
G
P
N
Site 40
T287
S
E
A
G
P
N
Q
T
F
E
V
P
N
K
I
Site 41
T326
V
F
M
L
H
K
K
T
V
N
Q
K
T
T
I
Site 42
S376
L
R
K
K
N
Q
M
S
K
L
I
S
E
M
H
Site 43
S384
K
L
I
S
E
M
H
S
F
I
Q
I
K
K
K
Site 44
S401
P
R
N
N
D
P
K
S
M
K
L
P
Q
E
Q
Site 45
Y413
Q
E
Q
R
Q
L
P
Y
P
S
E
A
S
T
T
Site 46
S415
Q
R
Q
L
P
Y
P
S
E
A
S
T
T
F
P
Site 47
T419
P
Y
P
S
E
A
S
T
T
F
P
E
S
H
L
Site 48
T420
Y
P
S
E
A
S
T
T
F
P
E
S
H
L
R
Site 49
S424
A
S
T
T
F
P
E
S
H
L
R
T
P
Q
M
Site 50
T428
F
P
E
S
H
L
R
T
P
Q
M
P
P
T
T
Site 51
T434
R
T
P
Q
M
P
P
T
T
P
S
S
S
F
F
Site 52
T435
T
P
Q
M
P
P
T
T
P
S
S
S
F
F
T
Site 53
S437
Q
M
P
P
T
T
P
S
S
S
F
F
T
K
K
Site 54
S438
M
P
P
T
T
P
S
S
S
F
F
T
K
K
S
Site 55
S439
P
P
T
T
P
S
S
S
F
F
T
K
K
S
E
Site 56
T442
T
P
S
S
S
F
F
T
K
K
S
E
D
T
I
Site 57
S445
S
S
F
F
T
K
K
S
E
D
T
I
S
K
M
Site 58
S450
K
K
S
E
D
T
I
S
K
M
N
D
F
M
R
Site 59
S474
F
P
G
P
F
M
T
S
I
G
P
A
E
S
H
Site 60
S480
T
S
I
G
P
A
E
S
H
P
H
T
P
Q
M
Site 61
T484
P
A
E
S
H
P
H
T
P
Q
M
P
P
S
T
Site 62
S490
H
T
P
Q
M
P
P
S
T
P
S
S
S
F
L
Site 63
T491
T
P
Q
M
P
P
S
T
P
S
S
S
F
L
T
Site 64
S493
Q
M
P
P
S
T
P
S
S
S
F
L
T
T
K
Site 65
S494
M
P
P
S
T
P
S
S
S
F
L
T
T
K
S
Site 66
S495
P
P
S
T
P
S
S
S
F
L
T
T
K
S
E
Site 67
T498
T
P
S
S
S
F
L
T
T
K
S
E
D
T
I
Site 68
T499
P
S
S
S
F
L
T
T
K
S
E
D
T
I
S
Site 69
S501
S
S
F
L
T
T
K
S
E
D
T
I
S
K
M
Site 70
S506
T
K
S
E
D
T
I
S
K
M
N
D
F
M
R
Site 71
S549
Q
M
P
P
S
T
P
S
S
S
F
L
T
T
L
Site 72
S550
M
P
P
S
T
P
S
S
S
F
L
T
T
L
K
Site 73
S551
P
P
S
T
P
S
S
S
F
L
T
T
L
K
P
Site 74
T554
T
P
S
S
S
F
L
T
T
L
K
P
R
L
K
Site 75
T555
P
S
S
S
F
L
T
T
L
K
P
R
L
K
T
Site 76
T562
T
L
K
P
R
L
K
T
E
P
E
E
V
S
I
Site 77
S568
K
T
E
P
E
E
V
S
I
E
D
S
A
Q
S
Site 78
S572
E
E
V
S
I
E
D
S
A
Q
S
D
L
K
E
Site 79
S575
S
I
E
D
S
A
Q
S
D
L
K
E
V
M
V
Site 80
S588
M
V
L
N
A
T
E
S
F
V
Y
E
P
K
E
Site 81
Y591
N
A
T
E
S
F
V
Y
E
P
K
E
Q
K
K
Site 82
T603
Q
K
K
M
F
H
A
T
V
A
T
E
N
E
V
Site 83
S670
K
G
L
I
R
S
A
S
V
T
P
K
I
N
Q
Site 84
S680
P
K
I
N
Q
L
C
S
Q
T
K
G
S
F
V
Site 85
Y704
N
V
R
G
E
F
T
Y
Y
E
I
Q
D
N
T
Site 86
Y705
V
R
G
E
F
T
Y
Y
E
I
Q
D
N
T
G
Site 87
T724
V
V
H
G
R
L
T
T
I
N
C
E
E
G
D
Site 88
T736
E
G
D
K
L
K
L
T
C
F
E
L
A
P
K
Site 89
S744
C
F
E
L
A
P
K
S
G
N
T
G
E
L
R
Site 90
S752
G
N
T
G
E
L
R
S
V
I
H
S
H
I
K
Site 91
S756
E
L
R
S
V
I
H
S
H
I
K
V
I
K
T
Site 92
S775
K
D
I
L
N
P
D
S
S
M
E
T
S
P
D
Site 93
S776
D
I
L
N
P
D
S
S
M
E
T
S
P
D
F
Site 94
T779
N
P
D
S
S
M
E
T
S
P
D
F
F
F
_
Site 95
S780
P
D
S
S
M
E
T
S
P
D
F
F
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation