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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGK-D
Full Name:
Diacylglycerol kinase delta
Alias:
130 kDa diacylglycerol kinase;Diglyceride kinase delta
Type:
Kinase, lipid
Mass (Da):
134526
Number AA:
1195
UniProt ID:
Q16760
International Prot ID:
IPI00303136
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0019992
GO:0004143
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0016049
GO:0046339
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
P
P
P
P
P
E
E
S
S
D
S
E
P
E
A
Site 2
S25
P
P
P
P
E
E
S
S
D
S
E
P
E
A
E
Site 3
S27
P
P
E
E
S
S
D
S
E
P
E
A
E
P
G
Site 4
S35
E
P
E
A
E
P
G
S
P
Q
K
L
I
R
K
Site 5
S44
Q
K
L
I
R
K
V
S
T
S
G
Q
I
R
Q
Site 6
T45
K
L
I
R
K
V
S
T
S
G
Q
I
R
Q
K
Site 7
S46
L
I
R
K
V
S
T
S
G
Q
I
R
Q
K
T
Site 8
T53
S
G
Q
I
R
Q
K
T
I
I
K
E
G
M
L
Site 9
T61
I
I
K
E
G
M
L
T
K
Q
N
N
S
F
Q
Site 10
S66
M
L
T
K
Q
N
N
S
F
Q
R
S
K
R
R
Site 11
S70
Q
N
N
S
F
Q
R
S
K
R
R
Y
F
K
L
Site 12
Y74
F
Q
R
S
K
R
R
Y
F
K
L
R
G
R
T
Site 13
T81
Y
F
K
L
R
G
R
T
L
Y
Y
A
K
T
A
Site 14
Y83
K
L
R
G
R
T
L
Y
Y
A
K
T
A
K
S
Site 15
T87
R
T
L
Y
Y
A
K
T
A
K
S
I
I
F
D
Site 16
S90
Y
Y
A
K
T
A
K
S
I
I
F
D
E
V
D
Site 17
S102
E
V
D
L
T
D
A
S
V
A
E
S
S
T
K
Site 18
S106
T
D
A
S
V
A
E
S
S
T
K
N
V
N
N
Site 19
S114
S
T
K
N
V
N
N
S
F
T
V
I
T
P
C
Site 20
Y155
E
H
F
E
P
T
Q
Y
S
M
D
H
F
S
G
Site 21
Y176
C
S
H
A
R
P
T
Y
C
N
V
C
R
E
A
Site 22
S281
V
H
T
S
C
K
E
S
L
L
T
K
C
P
L
Site 23
S303
I
P
P
T
A
L
N
S
I
D
S
D
G
F
W
Site 24
S306
T
A
L
N
S
I
D
S
D
G
F
W
K
A
S
Site 25
S313
S
D
G
F
W
K
A
S
C
P
P
S
C
T
S
Site 26
S328
P
L
L
V
F
V
N
S
K
S
G
D
N
Q
G
Site 27
S330
L
V
F
V
N
S
K
S
G
D
N
Q
G
V
K
Site 28
T426
G
S
A
C
D
D
D
T
Q
L
P
Q
I
L
E
Site 29
S439
L
E
K
L
E
R
A
S
T
K
M
L
D
R
W
Site 30
T440
E
K
L
E
R
A
S
T
K
M
L
D
R
W
S
Site 31
Y451
D
R
W
S
V
M
A
Y
E
A
K
L
P
R
Q
Site 32
S460
A
K
L
P
R
Q
A
S
S
S
T
V
T
E
D
Site 33
S462
L
P
R
Q
A
S
S
S
T
V
T
E
D
F
S
Site 34
T465
Q
A
S
S
S
T
V
T
E
D
F
S
E
D
S
Site 35
S469
S
T
V
T
E
D
F
S
E
D
S
E
V
Q
Q
Site 36
S472
T
E
D
F
S
E
D
S
E
V
Q
Q
I
L
F
Site 37
S489
D
S
V
A
A
H
L
S
K
I
L
T
S
D
Q
Site 38
T493
A
H
L
S
K
I
L
T
S
D
Q
H
S
V
V
Site 39
Y522
V
A
R
V
G
K
A
Y
E
K
T
T
E
S
S
Site 40
T525
V
G
K
A
Y
E
K
T
T
E
S
S
E
E
S
Site 41
S528
A
Y
E
K
T
T
E
S
S
E
E
S
E
V
M
Site 42
S532
T
T
E
S
S
E
E
S
E
V
M
A
K
K
C
Site 43
S548
V
L
K
E
K
L
D
S
L
L
K
T
L
D
D
Site 44
T552
K
L
D
S
L
L
K
T
L
D
D
E
S
Q
A
Site 45
S557
L
K
T
L
D
D
E
S
Q
A
S
S
S
L
P
Site 46
S560
L
D
D
E
S
Q
A
S
S
S
L
P
N
P
P
Site 47
S561
D
D
E
S
Q
A
S
S
S
L
P
N
P
P
P
Site 48
S562
D
E
S
Q
A
S
S
S
L
P
N
P
P
P
T
Site 49
T569
S
L
P
N
P
P
P
T
I
A
E
E
A
E
D
Site 50
S580
E
A
E
D
G
D
G
S
G
S
I
C
G
S
T
Site 51
S582
E
D
G
D
G
S
G
S
I
C
G
S
T
G
D
Site 52
S594
T
G
D
R
L
V
A
S
A
C
P
A
R
P
Q
Site 53
S615
Q
L
M
L
R
A
N
S
L
K
K
A
I
R
Q
Site 54
S649
E
G
F
V
L
G
L
S
E
S
E
E
K
M
D
Site 55
S651
F
V
L
G
L
S
E
S
E
E
K
M
D
H
R
Site 56
S664
H
R
V
C
P
P
L
S
H
S
E
S
F
G
V
Site 57
S666
V
C
P
P
L
S
H
S
E
S
F
G
V
P
K
Site 58
S668
P
P
L
S
H
S
E
S
F
G
V
P
K
G
R
Site 59
S676
F
G
V
P
K
G
R
S
Q
R
K
V
S
K
S
Site 60
S681
G
R
S
Q
R
K
V
S
K
S
P
C
E
K
L
Site 61
S683
S
Q
R
K
V
S
K
S
P
C
E
K
L
I
S
Site 62
S690
S
P
C
E
K
L
I
S
K
G
S
L
S
L
G
Site 63
S693
E
K
L
I
S
K
G
S
L
S
L
G
S
S
A
Site 64
S698
K
G
S
L
S
L
G
S
S
A
S
L
P
P
Q
Site 65
S699
G
S
L
S
L
G
S
S
A
S
L
P
P
Q
P
Site 66
S701
L
S
L
G
S
S
A
S
L
P
P
Q
P
G
S
Site 67
S708
S
L
P
P
Q
P
G
S
R
D
G
L
P
A
L
Site 68
S729
P
N
V
R
A
G
M
S
G
S
L
P
G
G
S
Site 69
S750
I
N
A
D
P
F
N
S
E
P
E
T
L
E
Y
Site 70
T754
P
F
N
S
E
P
E
T
L
E
Y
Y
T
E
K
Site 71
Y757
S
E
P
E
T
L
E
Y
Y
T
E
K
C
V
M
Site 72
Y758
E
P
E
T
L
E
Y
Y
T
E
K
C
V
M
N
Site 73
S777
I
G
L
D
A
K
I
S
L
D
F
N
N
K
R
Site 74
Y801
R
T
K
N
M
M
W
Y
G
V
L
G
T
K
E
Site 75
Y814
K
E
L
L
H
R
T
Y
K
N
L
E
Q
K
V
Site 76
T861
G
G
T
K
E
D
D
T
F
A
A
P
S
F
D
Site 77
S866
D
D
T
F
A
A
P
S
F
D
D
K
I
L
E
Site 78
S886
G
S
M
Q
M
A
V
S
R
V
I
R
L
Q
H
Site 79
Y927
A
W
V
Q
P
P
G
Y
I
R
I
V
H
K
N
Site 80
T938
V
H
K
N
R
A
Q
T
L
T
R
D
R
A
F
Site 81
T940
K
N
R
A
Q
T
L
T
R
D
R
A
F
E
S
Site 82
S947
T
R
D
R
A
F
E
S
T
L
K
S
W
E
D
Site 83
T948
R
D
R
A
F
E
S
T
L
K
S
W
E
D
K
Site 84
S951
A
F
E
S
T
L
K
S
W
E
D
K
Q
K
C
Site 85
S965
C
E
L
P
R
P
P
S
C
S
L
H
P
E
M
Site 86
S967
L
P
R
P
P
S
C
S
L
H
P
E
M
L
S
Site 87
S974
S
L
H
P
E
M
L
S
E
E
E
A
T
Q
M
Site 88
T979
M
L
S
E
E
E
A
T
Q
M
D
Q
F
G
Q
Site 89
S1001
S
I
R
E
I
A
Q
S
H
R
D
M
E
Q
E
Site 90
S1019
A
V
N
A
S
S
K
S
M
D
R
V
Y
G
K
Site 91
Y1024
S
K
S
M
D
R
V
Y
G
K
P
R
T
T
E
Site 92
T1029
R
V
Y
G
K
P
R
T
T
E
G
L
N
C
S
Site 93
T1030
V
Y
G
K
P
R
T
T
E
G
L
N
C
S
F
Site 94
S1050
N
N
F
R
A
L
R
S
E
T
E
L
L
L
S
Site 95
T1052
F
R
A
L
R
S
E
T
E
L
L
L
S
G
K
Site 96
S1074
P
Q
K
E
Q
L
G
S
A
L
A
E
M
D
R
Site 97
T1089
Q
L
R
R
L
A
D
T
P
W
L
C
Q
S
A
Site 98
S1095
D
T
P
W
L
C
Q
S
A
E
P
G
D
E
E
Site 99
S1103
A
E
P
G
D
E
E
S
V
M
L
D
L
A
K
Site 100
S1114
D
L
A
K
R
S
R
S
G
K
F
R
L
V
T
Site 101
T1121
S
G
K
F
R
L
V
T
K
F
K
K
E
K
N
Site 102
S1137
K
N
K
E
A
H
S
S
L
G
A
P
V
H
L
Site 103
Y1162
E
H
L
S
L
C
E
Y
K
D
I
F
T
R
H
Site 104
S1174
T
R
H
D
I
R
G
S
E
L
L
H
L
E
R
Site 105
S1208
G
I
K
E
L
S
R
S
A
P
A
V
E
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation