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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R3A
Full Name:
Protein phosphatase 1 regulatory subunit 3A
Alias:
PP1G; PPR3A; protein phosphatase 1 regulatory subunit 3A
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
125837
Number AA:
1122
UniProt ID:
Q16821
International Prot ID:
IPI00003091
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0005977
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
P
S
E
V
P
S
Q
I
S
K
D
N
F
Site 2
S11
S
E
V
P
S
Q
I
S
K
D
N
F
L
E
V
Site 3
S22
F
L
E
V
P
N
L
S
D
S
L
C
E
D
E
Site 4
S24
E
V
P
N
L
S
D
S
L
C
E
D
E
E
V
Site 5
T32
L
C
E
D
E
E
V
T
F
Q
P
G
F
S
P
Site 6
S38
V
T
F
Q
P
G
F
S
P
Q
P
S
R
R
G
Site 7
S42
P
G
F
S
P
Q
P
S
R
R
G
S
D
S
S
Site 8
S46
P
Q
P
S
R
R
G
S
D
S
S
E
D
I
Y
Site 9
S48
P
S
R
R
G
S
D
S
S
E
D
I
Y
L
D
Site 10
S49
S
R
R
G
S
D
S
S
E
D
I
Y
L
D
T
Site 11
Y53
S
D
S
S
E
D
I
Y
L
D
T
P
S
S
G
Site 12
T56
S
E
D
I
Y
L
D
T
P
S
S
G
T
R
R
Site 13
S59
I
Y
L
D
T
P
S
S
G
T
R
R
V
S
F
Site 14
T61
L
D
T
P
S
S
G
T
R
R
V
S
F
A
D
Site 15
S65
S
S
G
T
R
R
V
S
F
A
D
S
F
G
F
Site 16
S69
R
R
V
S
F
A
D
S
F
G
F
N
L
V
S
Site 17
T91
E
L
P
S
A
S
T
T
F
D
L
G
T
D
I
Site 18
T96
S
T
T
F
D
L
G
T
D
I
F
H
T
E
E
Site 19
S114
A
P
L
F
D
L
P
S
S
K
E
D
L
M
Q
Site 20
S115
P
L
F
D
L
P
S
S
K
E
D
L
M
Q
Q
Site 21
Y170
L
D
D
W
Q
T
H
Y
D
I
L
A
E
Y
V
Site 22
Y176
H
Y
D
I
L
A
E
Y
V
P
N
S
C
D
G
Site 23
S180
L
A
E
Y
V
P
N
S
C
D
G
E
T
D
Q
Site 24
T185
P
N
S
C
D
G
E
T
D
Q
F
S
F
K
I
Site 25
S189
D
G
E
T
D
Q
F
S
F
K
I
V
L
V
P
Site 26
Y198
K
I
V
L
V
P
P
Y
Q
K
D
G
S
K
V
Site 27
S203
P
P
Y
Q
K
D
G
S
K
V
E
F
C
I
R
Site 28
Y227
S
N
N
N
G
T
N
Y
T
F
I
C
Q
K
K
Site 29
S260
K
G
C
L
K
V
K
S
S
K
E
E
S
S
V
Site 30
S261
G
C
L
K
V
K
S
S
K
E
E
S
S
V
T
Site 31
S265
V
K
S
S
K
E
E
S
S
V
T
S
E
E
N
Site 32
S266
K
S
S
K
E
E
S
S
V
T
S
E
E
N
N
Site 33
T268
S
K
E
E
S
S
V
T
S
E
E
N
N
F
E
Site 34
S269
K
E
E
S
S
V
T
S
E
E
N
N
F
E
N
Site 35
T282
E
N
P
K
N
T
D
T
Y
I
P
T
I
I
C
Site 36
Y283
N
P
K
N
T
D
T
Y
I
P
T
I
I
C
S
Site 37
S300
D
K
E
D
L
E
A
S
N
R
N
V
K
D
V
Site 38
S332
Q
H
L
I
R
T
R
S
T
A
S
R
D
E
R
Site 39
T333
H
L
I
R
T
R
S
T
A
S
R
D
E
R
N
Site 40
T341
A
S
R
D
E
R
N
T
F
S
T
D
P
V
N
Site 41
S343
R
D
E
R
N
T
F
S
T
D
P
V
N
F
P
Site 42
T344
D
E
R
N
T
F
S
T
D
P
V
N
F
P
N
Site 43
S373
C
T
D
L
F
Q
R
S
L
S
P
S
S
S
A
Site 44
S375
D
L
F
Q
R
S
L
S
P
S
S
S
A
E
S
Site 45
S377
F
Q
R
S
L
S
P
S
S
S
A
E
S
S
V
Site 46
S378
Q
R
S
L
S
P
S
S
S
A
E
S
S
V
K
Site 47
S379
R
S
L
S
P
S
S
S
A
E
S
S
V
K
G
Site 48
S382
S
P
S
S
S
A
E
S
S
V
K
G
D
F
Y
Site 49
S383
P
S
S
S
A
E
S
S
V
K
G
D
F
Y
C
Site 50
Y389
S
S
V
K
G
D
F
Y
C
N
E
K
Y
S
S
Site 51
Y394
D
F
Y
C
N
E
K
Y
S
S
G
D
D
C
T
Site 52
T401
Y
S
S
G
D
D
C
T
H
Q
P
S
E
E
T
Site 53
S405
D
D
C
T
H
Q
P
S
E
E
T
T
S
N
M
Site 54
S410
Q
P
S
E
E
T
T
S
N
M
G
E
I
K
P
Site 55
S418
N
M
G
E
I
K
P
S
L
G
D
T
S
S
D
Site 56
T422
I
K
P
S
L
G
D
T
S
S
D
E
L
V
Q
Site 57
S423
K
P
S
L
G
D
T
S
S
D
E
L
V
Q
L
Site 58
S424
P
S
L
G
D
T
S
S
D
E
L
V
Q
L
H
Site 59
S458
M
Q
I
P
C
P
S
S
D
Q
L
M
A
G
N
Site 60
S491
C
L
R
R
D
F
H
S
D
T
S
A
C
L
K
Site 61
T493
R
R
D
F
H
S
D
T
S
A
C
L
K
E
S
Site 62
S494
R
D
F
H
S
D
T
S
A
C
L
K
E
S
T
Site 63
S500
T
S
A
C
L
K
E
S
T
E
E
G
S
S
K
Site 64
T501
S
A
C
L
K
E
S
T
E
E
G
S
S
K
E
Site 65
S506
E
S
T
E
E
G
S
S
K
E
D
Y
Y
G
N
Site 66
Y510
E
G
S
S
K
E
D
Y
Y
G
N
G
K
D
D
Site 67
Y511
G
S
S
K
E
D
Y
Y
G
N
G
K
D
D
E
Site 68
Y523
D
D
E
E
Q
R
I
Y
L
G
V
N
E
K
Q
Site 69
T536
K
Q
R
K
N
F
Q
T
I
L
H
D
Q
E
R
Site 70
T564
A
S
N
R
D
L
A
T
L
L
S
E
H
T
A
Site 71
S567
R
D
L
A
T
L
L
S
E
H
T
A
I
P
T
Site 72
T578
A
I
P
T
R
A
I
T
A
D
V
S
H
S
P
Site 73
S582
R
A
I
T
A
D
V
S
H
S
P
R
T
N
L
Site 74
S584
I
T
A
D
V
S
H
S
P
R
T
N
L
S
W
Site 75
S590
H
S
P
R
T
N
L
S
W
E
E
A
V
L
T
Site 76
T597
S
W
E
E
A
V
L
T
P
E
H
H
H
L
T
Site 77
T604
T
P
E
H
H
H
L
T
S
E
G
S
A
L
G
Site 78
S605
P
E
H
H
H
L
T
S
E
G
S
A
L
G
G
Site 79
Y630
G
N
V
L
R
N
D
Y
L
F
Q
V
E
E
K
Site 80
S638
L
F
Q
V
E
E
K
S
G
G
I
N
S
E
D
Site 81
S643
E
K
S
G
G
I
N
S
E
D
Q
D
N
S
P
Site 82
S649
N
S
E
D
Q
D
N
S
P
Q
H
K
Q
S
W
Site 83
S655
N
S
P
Q
H
K
Q
S
W
N
V
L
E
S
Q
Site 84
S661
Q
S
W
N
V
L
E
S
Q
G
K
S
R
E
N
Site 85
S665
V
L
E
S
Q
G
K
S
R
E
N
K
T
N
I
Site 86
T692
V
W
G
K
R
D
N
T
R
S
L
K
A
T
T
Site 87
S694
G
K
R
D
N
T
R
S
L
K
A
T
T
E
E
Site 88
T698
N
T
R
S
L
K
A
T
T
E
E
L
F
T
C
Site 89
T735
G
T
A
Y
I
I
K
T
T
S
E
S
T
P
E
Site 90
S737
A
Y
I
I
K
T
T
S
E
S
T
P
E
S
M
Site 91
S739
I
I
K
T
T
S
E
S
T
P
E
S
M
S
A
Site 92
T740
I
K
T
T
S
E
S
T
P
E
S
M
S
A
R
Site 93
S743
T
S
E
S
T
P
E
S
M
S
A
R
E
K
A
Site 94
S745
E
S
T
P
E
S
M
S
A
R
E
K
A
I
I
Site 95
T759
I
A
K
L
P
Q
E
T
A
R
S
D
R
P
I
Site 96
S762
L
P
Q
E
T
A
R
S
D
R
P
I
E
V
K
Site 97
T771
R
P
I
E
V
K
E
T
A
F
D
P
H
E
G
Site 98
Y785
G
R
N
D
D
S
H
Y
T
L
C
Q
R
D
T
Site 99
T786
R
N
D
D
S
H
Y
T
L
C
Q
R
D
T
V
Site 100
T792
Y
T
L
C
Q
R
D
T
V
G
V
I
Y
D
N
Site 101
Y797
R
D
T
V
G
V
I
Y
D
N
D
F
E
K
E
Site 102
T822
D
E
M
E
K
E
E
T
M
S
M
Y
N
P
R
Site 103
S824
M
E
K
E
E
T
M
S
M
Y
N
P
R
K
T
Site 104
Y826
K
E
E
T
M
S
M
Y
N
P
R
K
T
H
D
Site 105
T831
S
M
Y
N
P
R
K
T
H
D
R
E
K
C
G
Site 106
T839
H
D
R
E
K
C
G
T
G
N
I
T
S
V
E
Site 107
T843
K
C
G
T
G
N
I
T
S
V
E
E
S
S
W
Site 108
S844
C
G
T
G
N
I
T
S
V
E
E
S
S
W
V
Site 109
S848
N
I
T
S
V
E
E
S
S
W
V
I
T
E
Y
Site 110
S849
I
T
S
V
E
E
S
S
W
V
I
T
E
Y
Q
Site 111
T853
E
E
S
S
W
V
I
T
E
Y
Q
K
A
T
S
Site 112
Y855
S
S
W
V
I
T
E
Y
Q
K
A
T
S
K
L
Site 113
T874
G
M
L
P
T
D
K
T
V
F
S
E
N
R
D
Site 114
S877
P
T
D
K
T
V
F
S
E
N
R
D
H
R
Q
Site 115
S894
E
L
S
K
K
T
D
S
D
A
I
V
H
S
A
Site 116
S900
D
S
D
A
I
V
H
S
A
F
N
S
D
T
N
Site 117
S904
I
V
H
S
A
F
N
S
D
T
N
R
A
P
Q
Site 118
T906
H
S
A
F
N
S
D
T
N
R
A
P
Q
N
S
Site 119
S913
T
N
R
A
P
Q
N
S
S
P
F
S
K
H
H
Site 120
S914
N
R
A
P
Q
N
S
S
P
F
S
K
H
H
T
Site 121
S917
P
Q
N
S
S
P
F
S
K
H
H
T
E
I
S
Site 122
T921
S
P
F
S
K
H
H
T
E
I
S
V
S
T
N
Site 123
S924
S
K
H
H
T
E
I
S
V
S
T
N
E
Q
A
Site 124
S926
H
H
T
E
I
S
V
S
T
N
E
Q
A
I
A
Site 125
S943
N
A
V
T
T
M
A
S
Q
P
I
S
T
K
S
Site 126
S947
T
M
A
S
Q
P
I
S
T
K
S
E
N
I
C
Site 127
S950
S
Q
P
I
S
T
K
S
E
N
I
C
N
S
T
Site 128
S956
K
S
E
N
I
C
N
S
T
R
E
I
Q
G
I
Site 129
Y968
Q
G
I
E
K
H
P
Y
P
E
S
K
P
E
E
Site 130
S971
E
K
H
P
Y
P
E
S
K
P
E
E
V
S
R
Site 131
S977
E
S
K
P
E
E
V
S
R
S
S
G
I
V
T
Site 132
S979
K
P
E
E
V
S
R
S
S
G
I
V
T
S
G
Site 133
S980
P
E
E
V
S
R
S
S
G
I
V
T
S
G
S
Site 134
T984
S
R
S
S
G
I
V
T
S
G
S
R
K
E
R
Site 135
S985
R
S
S
G
I
V
T
S
G
S
R
K
E
R
C
Site 136
S987
S
G
I
V
T
S
G
S
R
K
E
R
C
I
G
Site 137
T999
C
I
G
Q
I
F
Q
T
E
E
Y
S
V
E
K
Site 138
S1003
I
F
Q
T
E
E
Y
S
V
E
K
S
L
G
P
Site 139
S1033
H
E
N
E
G
L
V
S
S
G
Q
S
L
Y
T
Site 140
S1034
E
N
E
G
L
V
S
S
G
Q
S
L
Y
T
S
Site 141
S1037
G
L
V
S
S
G
Q
S
L
Y
T
S
G
E
K
Site 142
Y1039
V
S
S
G
Q
S
L
Y
T
S
G
E
K
E
S
Site 143
S1041
S
G
Q
S
L
Y
T
S
G
E
K
E
S
D
S
Site 144
S1046
Y
T
S
G
E
K
E
S
D
S
S
A
S
T
S
Site 145
S1048
S
G
E
K
E
S
D
S
S
A
S
T
S
L
P
Site 146
S1049
G
E
K
E
S
D
S
S
A
S
T
S
L
P
V
Site 147
T1052
E
S
D
S
S
A
S
T
S
L
P
V
E
E
S
Site 148
S1053
S
D
S
S
A
S
T
S
L
P
V
E
E
S
Q
Site 149
S1059
T
S
L
P
V
E
E
S
Q
A
Q
G
N
E
S
Site 150
S1066
S
Q
A
Q
G
N
E
S
L
F
S
K
Y
T
N
Site 151
S1069
Q
G
N
E
S
L
F
S
K
Y
T
N
S
K
I
Site 152
Y1071
N
E
S
L
F
S
K
Y
T
N
S
K
I
P
Y
Site 153
T1072
E
S
L
F
S
K
Y
T
N
S
K
I
P
Y
F
Site 154
S1109
V
L
S
L
S
W
L
S
W
E
E
G
R
Q
K
Site 155
S1118
E
E
G
R
Q
K
E
S
V
K
K
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation