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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYLK3
Full Name:
Putative myosin light chain kinase 3
Alias:
Cardiac-MyBP-C-associated Ca/CaM kinase
Type:
Mass (Da):
88393
Number AA:
819
UniProt ID:
Q32MK0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
G
T
S
K
E
S
L
G
H
G
G
L
P
Site 2
T24
L
G
K
T
C
L
T
T
M
D
T
K
L
N
M
Site 3
T47
L
H
F
Q
E
D
V
T
E
K
L
Q
S
M
C
Site 4
S70
G
L
H
R
L
E
A
S
R
A
P
G
P
G
G
Site 5
T86
D
G
V
P
H
I
D
T
Q
A
G
W
P
E
V
Site 6
S152
R
V
P
W
R
R
G
S
P
G
D
S
P
E
E
Site 7
S156
R
R
G
S
P
G
D
S
P
E
E
N
K
E
R
Site 8
S176
G
K
P
K
H
V
L
S
T
S
G
V
Q
S
D
Site 9
S178
P
K
H
V
L
S
T
S
G
V
Q
S
D
A
R
Site 10
S182
L
S
T
S
G
V
Q
S
D
A
R
E
P
G
E
Site 11
S210
R
L
P
P
I
R
A
S
G
L
G
A
D
P
A
Site 12
S222
D
P
A
Q
A
V
V
S
P
G
Q
G
D
G
V
Site 13
T253
V
E
A
K
A
P
E
T
P
S
E
N
L
R
T
Site 14
S289
P
G
A
G
Q
G
A
S
S
S
R
P
D
P
E
Site 15
S290
G
A
G
Q
G
A
S
S
S
R
P
D
P
E
P
Site 16
S291
A
G
Q
G
A
S
S
S
R
P
D
P
E
P
L
Site 17
T305
L
E
E
G
T
R
L
T
P
G
P
G
P
Q
C
Site 18
T325
L
P
A
Q
A
R
A
T
H
S
G
G
E
T
P
Site 19
S327
A
Q
A
R
A
T
H
S
G
G
E
T
P
P
R
Site 20
T331
A
T
H
S
G
G
E
T
P
P
R
I
S
I
H
Site 21
S336
G
E
T
P
P
R
I
S
I
H
I
Q
E
M
D
Site 22
T344
I
H
I
Q
E
M
D
T
P
G
E
M
L
M
T
Site 23
T351
T
P
G
E
M
L
M
T
G
R
G
S
L
G
P
Site 24
T359
G
R
G
S
L
G
P
T
L
T
T
E
A
P
A
Site 25
T362
S
L
G
P
T
L
T
T
E
A
P
A
A
A
Q
Site 26
T378
G
K
Q
G
P
P
G
T
G
R
C
L
Q
A
P
Site 27
T387
R
C
L
Q
A
P
G
T
E
P
G
E
Q
T
P
Site 28
T393
G
T
E
P
G
E
Q
T
P
E
G
A
R
E
L
Site 29
S401
P
E
G
A
R
E
L
S
P
L
Q
E
S
S
S
Site 30
S406
E
L
S
P
L
Q
E
S
S
S
P
G
G
V
K
Site 31
S407
L
S
P
L
Q
E
S
S
S
P
G
G
V
K
A
Site 32
S408
S
P
L
Q
E
S
S
S
P
G
G
V
K
A
E
Site 33
S429
A
E
P
G
T
R
P
S
L
A
R
S
D
D
N
Site 34
S433
T
R
P
S
L
A
R
S
D
D
N
D
H
E
V
Site 35
S450
L
G
L
Q
Q
G
K
S
P
G
A
G
N
P
E
Site 36
S503
P
F
E
H
R
V
V
S
V
K
E
T
S
I
S
Site 37
T507
R
V
V
S
V
K
E
T
S
I
S
A
G
Y
E
Site 38
S510
S
V
K
E
T
S
I
S
A
G
Y
E
V
C
Q
Site 39
T533
F
G
Q
V
H
R
C
T
E
K
S
T
G
L
P
Site 40
S536
V
H
R
C
T
E
K
S
T
G
L
P
L
A
A
Site 41
S550
A
K
I
I
K
V
K
S
A
K
D
R
E
D
V
Site 42
Y576
H
V
N
L
I
Q
L
Y
D
A
F
E
S
K
H
Site 43
T602
G
E
L
F
D
R
I
T
D
E
K
Y
H
L
T
Site 44
Y606
D
R
I
T
D
E
K
Y
H
L
T
E
L
D
V
Site 45
Y626
Q
I
C
E
G
V
H
Y
L
H
Q
H
Y
I
L
Site 46
Y663
D
F
G
L
A
R
R
Y
K
P
R
E
K
L
K
Site 47
T675
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
Site 48
T735
S
W
D
F
D
A
D
T
F
E
G
L
S
E
E
Site 49
S740
A
D
T
F
E
G
L
S
E
E
A
K
D
F
V
Site 50
S756
R
L
L
V
K
E
K
S
C
R
M
S
A
T
Q
Site 51
S760
K
E
K
S
C
R
M
S
A
T
Q
C
L
K
H
Site 52
S778
N
N
L
P
A
K
A
S
R
S
K
T
R
L
K
Site 53
S780
L
P
A
K
A
S
R
S
K
T
R
L
K
S
Q
Site 54
T782
A
K
A
S
R
S
K
T
R
L
K
S
Q
L
L
Site 55
S786
R
S
K
T
R
L
K
S
Q
L
L
L
Q
K
Y
Site 56
Y793
S
Q
L
L
L
Q
K
Y
I
A
Q
R
K
W
K
Site 57
Y804
R
K
W
K
K
H
F
Y
V
V
T
A
A
N
R
Site 58
T807
K
K
H
F
Y
V
V
T
A
A
N
R
L
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation