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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNNI3K
Full Name:
Serine/threonine-protein kinase TNNI3K
Alias:
Cardiac ankyrin repeat kinase;TNNI3-interacting kinase
Type:
Mass (Da):
104179
Number AA:
936
UniProt ID:
Q59H18
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
R
D
P
P
E
V
S
L
R
E
A
T
Q
R
Site 2
T16
E
V
S
L
R
E
A
T
Q
R
K
L
R
R
F
Site 3
S24
Q
R
K
L
R
R
F
S
E
L
R
G
K
L
V
Site 4
Y100
L
Q
C
L
E
K
L
Y
G
D
K
W
N
S
F
Site 5
S114
F
T
I
L
L
I
H
S
D
E
W
K
K
K
V
Site 6
Y125
K
K
K
V
S
E
S
Y
V
I
T
I
E
R
L
Site 7
T128
V
S
E
S
Y
V
I
T
I
E
R
L
E
D
D
Site 8
T144
Q
I
K
E
K
E
L
T
E
L
R
N
I
F
G
Site 9
S152
E
L
R
N
I
F
G
S
D
E
A
F
S
K
V
Site 10
T187
G
K
K
S
H
I
R
T
L
M
L
K
G
L
R
Site 11
S196
M
L
K
G
L
R
P
S
R
L
T
R
N
G
F
Site 12
T199
G
L
R
P
S
R
L
T
R
N
G
F
T
A
L
Site 13
S220
D
N
A
E
L
I
T
S
L
L
H
S
G
A
D
Site 14
Y277
T
P
L
H
I
A
A
Y
Y
G
H
E
Q
V
T
Site 15
S297
F
G
A
D
V
N
V
S
G
E
V
G
D
R
P
Site 16
S309
D
R
P
L
H
L
A
S
A
K
G
F
L
N
I
Site 17
Y354
G
H
H
D
I
V
K
Y
L
L
Q
S
D
L
E
Site 18
Y370
Q
P
H
V
V
N
I
Y
G
D
T
P
L
H
L
Site 19
S394
A
K
E
I
I
Q
I
S
G
T
E
S
L
T
K
Site 20
S398
I
Q
I
S
G
T
E
S
L
T
K
E
N
I
F
Site 21
S406
L
T
K
E
N
I
F
S
E
T
A
F
H
S
A
Site 22
Y416
A
F
H
S
A
C
T
Y
G
K
S
I
D
L
V
Site 23
T443
H
Q
G
R
D
G
H
T
G
L
H
S
A
C
Y
Site 24
S475
N
L
V
A
C
D
P
S
R
S
S
G
E
K
D
Site 25
S478
A
C
D
P
S
R
S
S
G
E
K
D
E
Q
T
Site 26
T500
K
G
H
D
A
I
V
T
L
L
K
H
Y
K
R
Site 27
Y505
I
V
T
L
L
K
H
Y
K
R
P
Q
D
E
L
Site 28
Y517
D
E
L
P
C
N
E
Y
S
Q
P
G
G
D
G
Site 29
S518
E
L
P
C
N
E
Y
S
Q
P
G
G
D
G
S
Site 30
S525
S
Q
P
G
G
D
G
S
Y
V
S
V
P
S
P
Site 31
Y526
Q
P
G
G
D
G
S
Y
V
S
V
P
S
P
L
Site 32
S528
G
G
D
G
S
Y
V
S
V
P
S
P
L
G
K
Site 33
S531
G
S
Y
V
S
V
P
S
P
L
G
K
I
K
S
Site 34
S538
S
P
L
G
K
I
K
S
M
T
K
E
K
A
D
Site 35
S562
S
H
F
H
L
Q
L
S
E
I
E
F
H
E
I
Site 36
S572
E
F
H
E
I
I
G
S
G
S
F
G
K
V
Y
Site 37
S574
H
E
I
I
G
S
G
S
F
G
K
V
Y
K
G
Site 38
Y579
S
G
S
F
G
K
V
Y
K
G
R
C
R
N
K
Site 39
T597
I
K
R
Y
R
A
N
T
Y
C
S
K
S
D
V
Site 40
Y598
K
R
Y
R
A
N
T
Y
C
S
K
S
D
V
D
Site 41
S650
I
S
G
G
S
L
F
S
L
L
H
E
Q
K
R
Site 42
Y677
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
P
Site 43
Y698
N
S
H
N
I
L
L
Y
E
D
G
H
A
V
V
Site 44
S716
G
E
S
R
F
L
Q
S
L
D
E
D
N
M
T
Site 45
T723
S
L
D
E
D
N
M
T
K
Q
P
G
N
L
R
Site 46
Y789
H
I
R
P
P
I
G
Y
S
I
P
K
P
I
S
Site 47
S790
I
R
P
P
I
G
Y
S
I
P
K
P
I
S
S
Site 48
S797
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
Site 49
S814
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
Site 50
S831
L
C
N
I
E
L
M
S
P
A
S
S
N
S
S
Site 51
S834
I
E
L
M
S
P
A
S
S
N
S
S
G
S
L
Site 52
S835
E
L
M
S
P
A
S
S
N
S
S
G
S
L
S
Site 53
S837
M
S
P
A
S
S
N
S
S
G
S
L
S
P
S
Site 54
S838
S
P
A
S
S
N
S
S
G
S
L
S
P
S
S
Site 55
S840
A
S
S
N
S
S
G
S
L
S
P
S
S
S
S
Site 56
S842
S
N
S
S
G
S
L
S
P
S
S
S
S
D
C
Site 57
S844
S
S
G
S
L
S
P
S
S
S
S
D
C
L
V
Site 58
S845
S
G
S
L
S
P
S
S
S
S
D
C
L
V
N
Site 59
S846
G
S
L
S
P
S
S
S
S
D
C
L
V
N
R
Site 60
S847
S
L
S
P
S
S
S
S
D
C
L
V
N
R
G
Site 61
S859
N
R
G
G
P
G
R
S
H
V
A
A
L
R
S
Site 62
S866
S
H
V
A
A
L
R
S
R
F
E
L
E
Y
A
Site 63
Y872
R
S
R
F
E
L
E
Y
A
L
N
A
R
S
Y
Site 64
Y879
Y
A
L
N
A
R
S
Y
A
A
L
S
Q
S
A
Site 65
S883
A
R
S
Y
A
A
L
S
Q
S
A
G
Q
Y
S
Site 66
Y889
L
S
Q
S
A
G
Q
Y
S
S
Q
G
L
S
L
Site 67
S890
S
Q
S
A
G
Q
Y
S
S
Q
G
L
S
L
E
Site 68
S891
Q
S
A
G
Q
Y
S
S
Q
G
L
S
L
E
E
Site 69
S895
Q
Y
S
S
Q
G
L
S
L
E
E
M
K
R
S
Site 70
S902
S
L
E
E
M
K
R
S
L
Q
Y
T
P
I
D
Site 71
T906
M
K
R
S
L
Q
Y
T
P
I
D
K
Y
G
Y
Site 72
Y911
Q
Y
T
P
I
D
K
Y
G
Y
V
S
D
P
M
Site 73
Y913
T
P
I
D
K
Y
G
Y
V
S
D
P
M
S
S
Site 74
S925
M
S
S
M
H
F
H
S
C
R
N
S
S
S
F
Site 75
S929
H
F
H
S
C
R
N
S
S
S
F
E
D
S
S
Site 76
S930
F
H
S
C
R
N
S
S
S
F
E
D
S
S
_
Site 77
S931
H
S
C
R
N
S
S
S
F
E
D
S
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation