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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC42BPA
Full Name:
Serine/threonine-protein kinase MRCK alpha
Alias:
CDC42-binding protein kinase alpha; DMPK-like alpha; EC 2.7.11.1; MRCK alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; PK428
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
AGC
group; DMPK family; GEK subfamily
Mass (Da):
197307
Number AA:
1732
UniProt ID:
Q5VT25
International Prot ID:
IPI00640468
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031252
GO:0005911
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Myotonic dystrophy kinase-related CDC42-binding kinasealpha pan-specific antibody AB-NK282-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK282-1#Myotonic dystrophy kinase-related CDC42-binding kinasealpha (C408-L427, human) peptide - Powder PE-01BED70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BED70
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
E
V
R
L
R
Q
Site 2
S45
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
Site 3
Y56
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
Site 4
T119
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
Site 5
Y151
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
Site 6
S167
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
Site 7
Y197
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
Site 8
S222
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
Site 9
S234
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
Site 10
S235
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Site 11
T240
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
Site 12
T280
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
Site 13
Y283
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Site 14
S286
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
Site 15
T290
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
Site 16
S324
L
I
R
R
L
I
C
S
R
E
H
R
L
G
Q
Site 17
S363
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
Site 18
S364
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
Site 19
T366
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
Site 20
T368
E
V
S
S
P
T
D
T
S
N
F
D
V
D
D
Site 21
S369
V
S
S
P
T
D
T
S
N
F
D
V
D
D
D
Site 22
T383
D
C
L
K
N
S
E
T
M
P
P
P
T
H
T
Site 23
T388
S
E
T
M
P
P
P
T
H
T
A
F
S
G
H
Site 24
T390
T
M
P
P
P
T
H
T
A
F
S
G
H
H
L
Site 25
T403
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
Site 26
S407
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
Site 27
S411
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
V
Site 28
T419
D
R
S
C
L
R
V
T
A
G
P
T
S
L
D
Site 29
Y444
N
N
L
A
T
E
A
Y
E
R
R
I
K
R
L
Site 30
S465
L
S
R
K
L
Q
E
S
T
Q
T
V
Q
A
L
Site 31
T468
K
L
Q
E
S
T
Q
T
V
Q
A
L
Q
Y
S
Site 32
Y474
Q
T
V
Q
A
L
Q
Y
S
T
V
D
G
P
L
Site 33
S475
T
V
Q
A
L
Q
Y
S
T
V
D
G
P
L
T
Site 34
T482
S
T
V
D
G
P
L
T
A
S
K
D
L
E
I
Site 35
T504
E
K
L
R
K
Q
V
T
E
S
S
H
L
E
Q
Site 36
Y533
A
F
R
Q
I
K
A
Y
E
K
Q
I
K
T
L
Site 37
T539
A
Y
E
K
Q
I
K
T
L
Q
Q
E
R
E
D
Site 38
S555
N
K
E
L
V
Q
A
S
E
R
L
K
N
Q
S
Site 39
S562
S
E
R
L
K
N
Q
S
K
E
L
K
D
A
H
Site 40
T587
M
E
I
N
E
R
L
T
E
L
H
T
Q
K
Q
Site 41
T591
E
R
L
T
E
L
H
T
Q
K
Q
K
L
A
R
Site 42
S616
L
V
M
Q
K
V
E
S
L
R
Q
E
L
R
R
Site 43
T624
L
R
Q
E
L
R
R
T
E
R
A
K
K
E
L
Site 44
S643
E
A
L
A
A
E
A
S
K
D
R
K
L
R
E
Site 45
S652
D
R
K
L
R
E
Q
S
E
H
Y
S
K
Q
L
Site 46
S656
R
E
Q
S
E
H
Y
S
K
Q
L
E
N
E
L
Site 47
S672
G
L
K
Q
K
Q
I
S
Y
S
P
G
V
C
S
Site 48
S674
K
Q
K
Q
I
S
Y
S
P
G
V
C
S
I
E
Site 49
S697
K
T
D
L
E
K
K
S
I
F
Y
E
E
E
L
Site 50
S705
I
F
Y
E
E
E
L
S
K
R
E
G
I
H
A
Site 51
S725
L
K
K
E
L
H
D
S
E
G
Q
Q
L
A
L
Site 52
T746
L
K
D
K
L
E
K
T
R
R
E
S
Q
S
E
Site 53
S750
L
E
K
T
R
R
E
S
Q
S
E
R
E
E
F
Site 54
S752
K
T
R
R
E
S
Q
S
E
R
E
E
F
E
S
Site 55
S759
S
E
R
E
E
F
E
S
E
F
K
Q
Q
Y
E
Site 56
Y765
E
S
E
F
K
Q
Q
Y
E
R
E
K
V
L
L
Site 57
T788
S
E
L
D
K
L
T
T
L
Y
E
N
L
S
I
Site 58
Y790
L
D
K
L
T
T
L
Y
E
N
L
S
I
H
N
Site 59
S794
T
T
L
Y
E
N
L
S
I
H
N
Q
Q
L
E
Site 60
S813
D
L
A
D
K
K
E
S
V
A
H
W
E
A
Q
Site 61
S829
T
E
I
I
Q
W
V
S
D
E
K
D
A
R
G
Site 62
Y837
D
E
K
D
A
R
G
Y
L
Q
A
L
A
S
K
Site 63
S843
G
Y
L
Q
A
L
A
S
K
M
T
E
E
L
E
Site 64
T846
Q
A
L
A
S
K
M
T
E
E
L
E
A
L
R
Site 65
S855
E
L
E
A
L
R
N
S
S
L
G
T
R
A
T
Site 66
S856
L
E
A
L
R
N
S
S
L
G
T
R
A
T
D
Site 67
T862
S
S
L
G
T
R
A
T
D
M
P
W
K
M
R
Site 68
S877
R
F
A
K
L
D
M
S
A
R
L
E
L
Q
S
Site 69
S884
S
A
R
L
E
L
Q
S
A
L
D
A
E
I
R
Site 70
T910
V
K
A
S
N
I
I
T
E
C
K
L
K
D
S
Site 71
S917
T
E
C
K
L
K
D
S
E
K
K
N
L
E
L
Site 72
S940
K
D
T
E
E
L
R
S
E
K
G
I
E
H
Q
Site 73
S949
K
G
I
E
H
Q
D
S
Q
H
S
F
L
A
F
Site 74
S952
E
H
Q
D
S
Q
H
S
F
L
A
F
L
N
T
Site 75
S970
A
L
D
Q
F
E
R
S
P
S
C
T
P
A
S
Site 76
S972
D
Q
F
E
R
S
P
S
C
T
P
A
S
K
G
Site 77
T974
F
E
R
S
P
S
C
T
P
A
S
K
G
R
R
Site 78
S977
S
P
S
C
T
P
A
S
K
G
R
R
T
V
D
Site 79
T982
P
A
S
K
G
R
R
T
V
D
S
T
P
L
S
Site 80
S985
K
G
R
R
T
V
D
S
T
P
L
S
V
H
T
Site 81
T986
G
R
R
T
V
D
S
T
P
L
S
V
H
T
P
Site 82
S989
T
V
D
S
T
P
L
S
V
H
T
P
T
L
R
Site 83
T992
S
T
P
L
S
V
H
T
P
T
L
R
K
K
G
Site 84
T994
P
L
S
V
H
T
P
T
L
R
K
K
G
C
P
Site 85
S1003
R
K
K
G
C
P
G
S
T
G
F
P
P
K
R
Site 86
T1012
G
F
P
P
K
R
K
T
H
Q
F
F
V
K
S
Site 87
T1022
F
F
V
K
S
F
T
T
P
T
K
C
H
Q
C
Site 88
T1060
T
C
V
N
K
A
P
T
T
C
P
V
P
P
E
Site 89
T1061
C
V
N
K
A
P
T
T
C
P
V
P
P
E
Q
Site 90
Y1085
Q
K
G
I
G
T
A
Y
E
G
H
V
R
I
P
Site 91
S1124
D
I
A
E
G
K
A
S
Q
P
S
V
V
I
S
Site 92
S1127
E
G
K
A
S
Q
P
S
V
V
I
S
Q
V
I
Site 93
S1131
S
Q
P
S
V
V
I
S
Q
V
I
D
M
R
D
Site 94
S1142
D
M
R
D
E
E
F
S
V
S
S
V
L
A
S
Site 95
S1144
R
D
E
E
F
S
V
S
S
V
L
A
S
D
V
Site 96
S1155
A
S
D
V
I
H
A
S
R
K
D
I
P
C
I
Site 97
S1168
C
I
F
R
V
T
A
S
Q
L
S
A
S
N
N
Site 98
S1171
R
V
T
A
S
Q
L
S
A
S
N
N
K
C
S
Site 99
S1173
T
A
S
Q
L
S
A
S
N
N
K
C
S
I
L
Site 100
T1185
S
I
L
M
L
A
D
T
E
N
E
K
N
K
W
Site 101
S1197
N
K
W
V
G
V
L
S
E
L
H
K
I
L
K
Site 102
S1212
K
N
K
F
R
D
R
S
V
Y
V
P
K
E
A
Site 103
Y1214
K
F
R
D
R
S
V
Y
V
P
K
E
A
Y
D
Site 104
S1222
V
P
K
E
A
Y
D
S
T
L
P
L
I
K
T
Site 105
T1223
P
K
E
A
Y
D
S
T
L
P
L
I
K
T
T
Site 106
S1284
D
Q
L
V
A
V
I
S
G
R
N
R
H
V
R
Site 107
S1296
H
V
R
L
F
P
M
S
A
L
D
G
R
E
T
Site 108
T1303
S
A
L
D
G
R
E
T
D
F
Y
K
L
S
E
Site 109
Y1306
D
G
R
E
T
D
F
Y
K
L
S
E
T
K
G
Site 110
T1316
S
E
T
K
G
C
Q
T
V
T
S
G
K
V
R
Site 111
S1319
K
G
C
Q
T
V
T
S
G
K
V
R
H
G
A
Site 112
Y1341
M
K
R
Q
V
L
C
Y
E
L
F
Q
S
K
T
Site 113
T1348
Y
E
L
F
Q
S
K
T
R
H
R
K
F
K
E
Site 114
S1378
Q
L
C
V
G
F
Q
S
G
F
L
R
Y
P
L
Site 115
Y1383
F
Q
S
G
F
L
R
Y
P
L
N
G
E
G
N
Site 116
Y1392
L
N
G
E
G
N
P
Y
S
M
L
H
S
N
D
Site 117
S1393
N
G
E
G
N
P
Y
S
M
L
H
S
N
D
H
Site 118
S1397
N
P
Y
S
M
L
H
S
N
D
H
T
L
S
F
Site 119
T1401
M
L
H
S
N
D
H
T
L
S
F
I
A
H
Q
Site 120
Y1433
C
F
N
S
I
G
I
Y
T
D
C
Q
G
R
R
Site 121
Y1457
A
N
P
S
S
C
C
Y
N
A
P
Y
L
S
V
Site 122
Y1461
S
C
C
Y
N
A
P
Y
L
S
V
Y
S
E
N
Site 123
T1483
N
S
M
E
W
I
Q
T
L
P
L
K
K
V
R
Site 124
S1497
R
P
L
N
N
E
G
S
L
N
L
L
G
L
E
Site 125
T1505
L
N
L
L
G
L
E
T
I
R
L
I
Y
F
K
Site 126
Y1510
L
E
T
I
R
L
I
Y
F
K
N
K
M
A
E
Site 127
T1526
D
E
L
V
V
P
E
T
S
D
N
S
R
K
Q
Site 128
S1527
E
L
V
V
P
E
T
S
D
N
S
R
K
Q
M
Site 129
Y1544
N
I
N
N
K
R
R
Y
S
F
R
V
P
E
E
Site 130
S1545
I
N
N
K
R
R
Y
S
F
R
V
P
E
E
E
Site 131
S1604
M
N
P
R
P
Q
E
S
R
T
V
F
S
G
S
Site 132
T1606
P
R
P
Q
E
S
R
T
V
F
S
G
S
V
S
Site 133
S1609
Q
E
S
R
T
V
F
S
G
S
V
S
I
P
S
Site 134
S1611
S
R
T
V
F
S
G
S
V
S
I
P
S
I
T
Site 135
S1613
T
V
F
S
G
S
V
S
I
P
S
I
T
K
S
Site 136
S1616
S
G
S
V
S
I
P
S
I
T
K
S
R
P
E
Site 137
T1618
S
V
S
I
P
S
I
T
K
S
R
P
E
P
G
Site 138
S1620
S
I
P
S
I
T
K
S
R
P
E
P
G
R
S
Site 139
S1627
S
R
P
E
P
G
R
S
M
S
A
S
S
G
L
Site 140
S1629
P
E
P
G
R
S
M
S
A
S
S
G
L
S
A
Site 141
S1631
P
G
R
S
M
S
A
S
S
G
L
S
A
R
S
Site 142
S1632
G
R
S
M
S
A
S
S
G
L
S
A
R
S
S
Site 143
S1635
M
S
A
S
S
G
L
S
A
R
S
S
A
Q
N
Site 144
S1638
S
S
G
L
S
A
R
S
S
A
Q
N
G
S
A
Site 145
S1639
S
G
L
S
A
R
S
S
A
Q
N
G
S
A
L
Site 146
S1644
R
S
S
A
Q
N
G
S
A
L
K
R
E
F
S
Site 147
S1651
S
A
L
K
R
E
F
S
G
G
S
Y
S
A
K
Site 148
S1654
K
R
E
F
S
G
G
S
Y
S
A
K
R
Q
P
Site 149
Y1655
R
E
F
S
G
G
S
Y
S
A
K
R
Q
P
M
Site 150
S1656
E
F
S
G
G
S
Y
S
A
K
R
Q
P
M
P
Site 151
S1664
A
K
R
Q
P
M
P
S
P
S
E
G
S
L
S
Site 152
S1666
R
Q
P
M
P
S
P
S
E
G
S
L
S
S
G
Site 153
S1669
M
P
S
P
S
E
G
S
L
S
S
G
G
M
D
Site 154
S1671
S
P
S
E
G
S
L
S
S
G
G
M
D
Q
G
Site 155
S1672
P
S
E
G
S
L
S
S
G
G
M
D
Q
G
S
Site 156
S1679
S
G
G
M
D
Q
G
S
D
A
P
A
R
D
F
Site 157
S1691
R
D
F
D
G
E
D
S
D
S
P
R
H
S
T
Site 158
S1693
F
D
G
E
D
S
D
S
P
R
H
S
T
A
S
Site 159
S1697
D
S
D
S
P
R
H
S
T
A
S
N
S
S
N
Site 160
T1698
S
D
S
P
R
H
S
T
A
S
N
S
S
N
L
Site 161
S1700
S
P
R
H
S
T
A
S
N
S
S
N
L
S
S
Site 162
S1702
R
H
S
T
A
S
N
S
S
N
L
S
S
P
P
Site 163
S1703
H
S
T
A
S
N
S
S
N
L
S
S
P
P
S
Site 164
S1706
A
S
N
S
S
N
L
S
S
P
P
S
P
A
S
Site 165
S1707
S
N
S
S
N
L
S
S
P
P
S
P
A
S
P
Site 166
S1710
S
N
L
S
S
P
P
S
P
A
S
P
R
K
T
Site 167
S1713
S
S
P
P
S
P
A
S
P
R
K
T
K
S
L
Site 168
T1717
S
P
A
S
P
R
K
T
K
S
L
S
L
E
S
Site 169
S1719
A
S
P
R
K
T
K
S
L
S
L
E
S
T
D
Site 170
S1721
P
R
K
T
K
S
L
S
L
E
S
T
D
R
G
Site 171
S1724
T
K
S
L
S
L
E
S
T
D
R
G
S
W
D
Site 172
T1725
K
S
L
S
L
E
S
T
D
R
G
S
W
D
P
Site 173
S1729
L
E
S
T
D
R
G
S
W
D
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation