KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DAB2IP
Full Name:
Disabled homolog 2-interacting protein
Alias:
AF9Q34; AIP1; ASK1-interacting protein 1; ASK-interacting; ASK-interacting 1; ASK-interacting protein; DAB2 interacting; DAB2 interacting protein; DAB2 interaction; DAB2-disabled 2-interacting; DAB2P; DIP1/2; DOC-2/DAB2 interactive protein; KIAA1743; NGAP-like; NGAP-like protein
Type:
Intracellular, Membrane, Cytoplasm protein
Mass (Da):
131625
Number AA:
1189
UniProt ID:
Q5VWQ8
International Prot ID:
IPI00789361
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
G
G
S
A
R
K
Site 2
S6
_
_
M
S
A
G
G
S
A
R
K
S
T
G
R
Site 3
S10
A
G
G
S
A
R
K
S
T
G
R
S
S
Y
Y
Site 4
T11
G
G
S
A
R
K
S
T
G
R
S
S
Y
Y
Y
Site 5
S14
A
R
K
S
T
G
R
S
S
Y
Y
Y
R
L
L
Site 6
S15
R
K
S
T
G
R
S
S
Y
Y
Y
R
L
L
R
Site 7
Y16
K
S
T
G
R
S
S
Y
Y
Y
R
L
L
R
R
Site 8
Y17
S
T
G
R
S
S
Y
Y
Y
R
L
L
R
R
P
Site 9
Y18
T
G
R
S
S
Y
Y
Y
R
L
L
R
R
P
R
Site 10
S31
P
R
L
Q
R
Q
R
S
R
S
R
S
R
T
R
Site 11
S33
L
Q
R
Q
R
S
R
S
R
S
R
T
R
P
A
Site 12
S35
R
Q
R
S
R
S
R
S
R
T
R
P
A
R
E
Site 13
T37
R
S
R
S
R
S
R
T
R
P
A
R
E
S
P
Site 14
S43
R
T
R
P
A
R
E
S
P
Q
E
R
P
G
S
Site 15
S50
S
P
Q
E
R
P
G
S
R
R
S
L
P
G
S
Site 16
S53
E
R
P
G
S
R
R
S
L
P
G
S
L
S
E
Site 17
S57
S
R
R
S
L
P
G
S
L
S
E
K
S
P
S
Site 18
S59
R
S
L
P
G
S
L
S
E
K
S
P
S
M
E
Site 19
S62
P
G
S
L
S
E
K
S
P
S
M
E
P
S
A
Site 20
S64
S
L
S
E
K
S
P
S
M
E
P
S
A
A
T
Site 21
S68
K
S
P
S
M
E
P
S
A
A
T
P
F
R
V
Site 22
T71
S
M
E
P
S
A
A
T
P
F
R
V
T
G
F
Site 23
S80
F
R
V
T
G
F
L
S
R
R
L
K
G
S
I
Site 24
S86
L
S
R
R
L
K
G
S
I
K
R
T
K
S
Q
Site 25
T90
L
K
G
S
I
K
R
T
K
S
Q
P
K
L
D
Site 26
S92
G
S
I
K
R
T
K
S
Q
P
K
L
D
R
N
Site 27
S101
P
K
L
D
R
N
H
S
F
R
H
I
L
P
G
Site 28
S122
A
A
A
D
N
E
R
S
H
L
M
P
R
L
K
Site 29
S131
L
M
P
R
L
K
E
S
R
S
H
E
S
L
L
Site 30
S133
P
R
L
K
E
S
R
S
H
E
S
L
L
S
P
Site 31
S136
K
E
S
R
S
H
E
S
L
L
S
P
S
S
A
Site 32
S139
R
S
H
E
S
L
L
S
P
S
S
A
V
E
A
Site 33
Y169
S
S
I
L
G
Q
D
Y
C
F
E
V
T
T
S
Site 34
T174
Q
D
Y
C
F
E
V
T
T
S
S
G
S
K
C
Site 35
T175
D
Y
C
F
E
V
T
T
S
S
G
S
K
C
F
Site 36
S176
Y
C
F
E
V
T
T
S
S
G
S
K
C
F
S
Site 37
S179
E
V
T
T
S
S
G
S
K
C
F
S
C
R
S
Site 38
S183
S
S
G
S
K
C
F
S
C
R
S
A
A
E
R
Site 39
S186
S
K
C
F
S
C
R
S
A
A
E
R
D
K
W
Site 40
S208
V
H
P
N
K
D
N
S
R
R
V
E
H
I
L
Site 41
Y231
D
L
P
A
K
K
K
Y
L
C
E
L
C
L
D
Site 42
T246
D
V
L
Y
A
R
T
T
G
K
L
K
T
D
N
Site 43
T251
R
T
T
G
K
L
K
T
D
N
V
F
W
G
E
Site 44
T270
H
N
L
P
P
L
R
T
V
T
V
H
L
Y
R
Site 45
T272
L
P
P
L
R
T
V
T
V
H
L
Y
R
E
T
Site 46
Y276
R
T
V
T
V
H
L
Y
R
E
T
D
K
K
K
Site 47
T279
T
V
H
L
Y
R
E
T
D
K
K
K
K
K
E
Site 48
S289
K
K
K
K
E
R
N
S
Y
L
G
L
V
S
L
Site 49
Y290
K
K
K
E
R
N
S
Y
L
G
L
V
S
L
P
Site 50
Y311
R
Q
F
V
E
K
W
Y
P
V
V
T
P
N
P
Site 51
T315
E
K
W
Y
P
V
V
T
P
N
P
K
G
G
K
Site 52
T336
R
I
K
A
R
Y
Q
T
I
T
I
L
P
M
E
Site 53
T338
K
A
R
Y
Q
T
I
T
I
L
P
M
E
M
Y
Site 54
Y345
T
I
L
P
M
E
M
Y
K
E
F
A
E
H
I
Site 55
S368
A
A
L
E
P
I
L
S
A
K
T
K
E
E
M
Site 56
T416
H
L
I
F
R
E
N
T
L
A
T
K
A
I
E
Site 57
Y425
A
T
K
A
I
E
E
Y
L
K
L
V
G
Q
K
Site 58
Y433
L
K
L
V
G
Q
K
Y
L
Q
D
A
L
G
E
Site 59
Y446
G
E
F
I
K
A
L
Y
E
S
D
E
N
C
E
Site 60
S457
E
N
C
E
V
D
P
S
K
C
S
A
A
D
L
Site 61
S460
E
V
D
P
S
K
C
S
A
A
D
L
P
E
H
Site 62
S499
E
L
K
E
V
F
A
S
W
R
Q
E
C
S
S
Site 63
S505
A
S
W
R
Q
E
C
S
S
R
G
R
P
D
I
Site 64
S506
S
W
R
Q
E
C
S
S
R
G
R
P
D
I
S
Site 65
S513
S
R
G
R
P
D
I
S
E
R
L
I
S
A
S
Site 66
Y542
L
F
N
L
L
Q
E
Y
P
D
D
R
T
A
R
Site 67
T547
Q
E
Y
P
D
D
R
T
A
R
T
L
T
L
I
Site 68
T552
D
R
T
A
R
T
L
T
L
I
A
K
V
T
Q
Site 69
S569
A
N
F
A
K
F
G
S
K
E
E
Y
M
S
F
Site 70
Y573
K
F
G
S
K
E
E
Y
M
S
F
M
N
Q
F
Site 71
S575
G
S
K
E
E
Y
M
S
F
M
N
Q
F
L
E
Site 72
S596
Q
R
F
L
L
E
I
S
N
P
E
T
L
S
N
Site 73
T600
L
E
I
S
N
P
E
T
L
S
N
T
A
G
F
Site 74
S602
I
S
N
P
E
T
L
S
N
T
A
G
F
E
G
Site 75
Y610
N
T
A
G
F
E
G
Y
I
D
L
G
R
E
L
Site 76
S619
D
L
G
R
E
L
S
S
L
H
S
L
L
W
E
Site 77
S622
R
E
L
S
S
L
H
S
L
L
W
E
A
V
S
Site 78
T651
R
I
L
R
D
V
H
T
A
L
S
T
P
G
S
Site 79
S654
R
D
V
H
T
A
L
S
T
P
G
S
G
Q
L
Site 80
T655
D
V
H
T
A
L
S
T
P
G
S
G
Q
L
P
Site 81
S658
T
A
L
S
T
P
G
S
G
Q
L
P
G
T
N
Site 82
T664
G
S
G
Q
L
P
G
T
N
D
L
A
S
T
P
Site 83
S669
P
G
T
N
D
L
A
S
T
P
G
S
G
S
S
Site 84
T670
G
T
N
D
L
A
S
T
P
G
S
G
S
S
S
Site 85
S673
D
L
A
S
T
P
G
S
G
S
S
S
I
S
A
Site 86
S675
A
S
T
P
G
S
G
S
S
S
I
S
A
G
L
Site 87
S676
S
T
P
G
S
G
S
S
S
I
S
A
G
L
Q
Site 88
S677
T
P
G
S
G
S
S
S
I
S
A
G
L
Q
K
Site 89
S679
G
S
G
S
S
S
I
S
A
G
L
Q
K
M
V
Site 90
S702
I
D
F
T
R
L
P
S
P
T
P
E
N
K
D
Site 91
T704
F
T
R
L
P
S
P
T
P
E
N
K
D
L
F
Site 92
S716
D
L
F
F
V
T
R
S
S
G
V
Q
P
S
P
Site 93
S722
R
S
S
G
V
Q
P
S
P
A
R
S
S
S
Y
Site 94
S726
V
Q
P
S
P
A
R
S
S
S
Y
S
E
A
N
Site 95
S727
Q
P
S
P
A
R
S
S
S
Y
S
E
A
N
E
Site 96
S728
P
S
P
A
R
S
S
S
Y
S
E
A
N
E
P
Site 97
Y729
S
P
A
R
S
S
S
Y
S
E
A
N
E
P
D
Site 98
S730
P
A
R
S
S
S
Y
S
E
A
N
E
P
D
L
Site 99
S745
Q
M
A
N
G
G
K
S
L
S
M
V
D
L
Q
Site 100
S747
A
N
G
G
K
S
L
S
M
V
D
L
Q
D
A
Site 101
T756
V
D
L
Q
D
A
R
T
L
D
G
E
A
G
S
Site 102
S763
T
L
D
G
E
A
G
S
P
A
G
P
D
V
L
Site 103
T790
A
G
W
P
A
R
A
T
P
V
N
L
A
G
L
Site 104
T806
T
V
R
R
A
G
Q
T
P
T
T
P
G
T
S
Site 105
T808
R
R
A
G
Q
T
P
T
T
P
G
T
S
E
G
Site 106
T809
R
A
G
Q
T
P
T
T
P
G
T
S
E
G
A
Site 107
T812
Q
T
P
T
T
P
G
T
S
E
G
A
P
G
R
Site 108
S827
P
Q
L
L
A
P
L
S
F
Q
N
P
V
Y
Q
Site 109
Y833
L
S
F
Q
N
P
V
Y
Q
M
A
A
G
L
P
Site 110
S842
M
A
A
G
L
P
L
S
P
R
G
L
G
D
S
Site 111
S849
S
P
R
G
L
G
D
S
G
S
E
G
H
S
S
Site 112
S851
R
G
L
G
D
S
G
S
E
G
H
S
S
L
S
Site 113
S855
D
S
G
S
E
G
H
S
S
L
S
S
H
S
N
Site 114
S856
S
G
S
E
G
H
S
S
L
S
S
H
S
N
S
Site 115
S858
S
E
G
H
S
S
L
S
S
H
S
N
S
E
E
Site 116
S859
E
G
H
S
S
L
S
S
H
S
N
S
E
E
L
Site 117
S861
H
S
S
L
S
S
H
S
N
S
E
E
L
A
A
Site 118
S863
S
L
S
S
H
S
N
S
E
E
L
A
A
A
A
Site 119
S874
A
A
A
A
K
L
G
S
F
S
T
A
A
E
E
Site 120
S895
E
L
A
R
R
Q
M
S
L
T
E
K
G
G
Q
Site 121
T897
A
R
R
Q
M
S
L
T
E
K
G
G
Q
P
T
Site 122
T904
T
E
K
G
G
Q
P
T
V
P
R
Q
N
S
A
Site 123
S910
P
T
V
P
R
Q
N
S
A
G
P
Q
R
R
I
Site 124
T935
P
P
A
P
R
G
R
T
P
P
N
L
L
S
T
Site 125
S941
R
T
P
P
N
L
L
S
T
L
Q
Y
P
R
P
Site 126
T942
T
P
P
N
L
L
S
T
L
Q
Y
P
R
P
S
Site 127
Y945
N
L
L
S
T
L
Q
Y
P
R
P
S
S
G
T
Site 128
S949
T
L
Q
Y
P
R
P
S
S
G
T
L
A
S
A
Site 129
S950
L
Q
Y
P
R
P
S
S
G
T
L
A
S
A
S
Site 130
T952
Y
P
R
P
S
S
G
T
L
A
S
A
S
P
D
Site 131
S955
P
S
S
G
T
L
A
S
A
S
P
D
W
V
G
Site 132
S957
S
G
T
L
A
S
A
S
P
D
W
V
G
P
S
Site 133
S964
S
P
D
W
V
G
P
S
T
R
L
R
Q
Q
S
Site 134
T965
P
D
W
V
G
P
S
T
R
L
R
Q
Q
S
S
Site 135
S971
S
T
R
L
R
Q
Q
S
S
S
S
K
G
D
S
Site 136
S972
T
R
L
R
Q
Q
S
S
S
S
K
G
D
S
P
Site 137
S973
R
L
R
Q
Q
S
S
S
S
K
G
D
S
P
E
Site 138
S974
L
R
Q
Q
S
S
S
S
K
G
D
S
P
E
L
Site 139
S978
S
S
S
S
K
G
D
S
P
E
L
K
P
R
A
Site 140
S992
A
V
H
K
Q
G
P
S
P
V
S
P
N
A
L
Site 141
S995
K
Q
G
P
S
P
V
S
P
N
A
L
D
R
T
Site 142
S1031
P
H
R
D
R
L
R
S
K
D
E
L
S
Q
A
Site 143
S1036
L
R
S
K
D
E
L
S
Q
A
E
K
D
L
A
Site 144
S1052
L
Q
D
K
L
R
I
S
T
K
K
L
E
E
Y
Site 145
T1053
Q
D
K
L
R
I
S
T
K
K
L
E
E
Y
E
Site 146
Y1059
S
T
K
K
L
E
E
Y
E
T
L
F
K
C
Q
Site 147
T1061
K
K
L
E
E
Y
E
T
L
F
K
C
Q
E
E
Site 148
S1108
G
I
I
S
R
L
M
S
V
E
E
E
L
K
K
Site 149
S1126
E
M
Q
A
A
V
D
S
K
Q
K
I
I
D
A
Site 150
S1140
A
Q
E
K
R
I
A
S
L
D
A
A
N
A
R
Site 151
S1150
A
A
N
A
R
L
M
S
A
L
T
Q
L
K
E
Site 152
T1153
A
R
L
M
S
A
L
T
Q
L
K
E
R
Y
S
Site 153
S1160
T
Q
L
K
E
R
Y
S
M
Q
A
R
N
G
I
Site 154
S1168
M
Q
A
R
N
G
I
S
P
T
N
P
T
K
L
Site 155
T1173
G
I
S
P
T
N
P
T
K
L
Q
I
T
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation