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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTRF
Full Name:
Polymerase I and transcript release factor
Alias:
Cavin-1; Leucine-zipper protein FKSG13
Type:
Transcription protein, initiation complex
Mass (Da):
43476
Number AA:
390
UniProt ID:
Q6NZI2
International Prot ID:
IPI00176903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005901
GO:0005829
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0003716
GO:0005515
GO:0042134
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006361
GO:0006353
Phosida
TranscriptoNet
STRING
Kinexus Products
Polymerase I and transcript release factor Y308 phosphosite-specific antibody AB-PN533#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN533#Polymerase I and transcript release factor (H305-S311, human) pY308 phosphopeptide - Powder PE-04AEP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEP95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
E
D
P
T
L
Y
I
V
E
R
P
Site 2
Y7
_
M
E
D
P
T
L
Y
I
V
E
R
P
L
P
Site 3
Y16
V
E
R
P
L
P
G
Y
P
D
A
E
A
P
E
Site 4
S25
D
A
E
A
P
E
P
S
S
A
G
A
Q
A
A
Site 5
S26
A
E
A
P
E
P
S
S
A
G
A
Q
A
A
E
Site 6
S36
A
Q
A
A
E
E
P
S
G
A
G
S
E
E
L
Site 7
S40
E
E
P
S
G
A
G
S
E
E
L
I
K
S
D
Site 8
S46
G
S
E
E
L
I
K
S
D
Q
V
N
G
V
L
Site 9
S88
E
M
E
G
A
V
Q
S
I
Q
G
E
L
S
K
Site 10
S94
Q
S
I
Q
G
E
L
S
K
L
G
K
A
H
A
Site 11
T103
L
G
K
A
H
A
T
T
S
N
T
V
S
K
L
Site 12
S104
G
K
A
H
A
T
T
S
N
T
V
S
K
L
L
Site 13
T106
A
H
A
T
T
S
N
T
V
S
K
L
L
E
K
Site 14
S108
A
T
T
S
N
T
V
S
K
L
L
E
K
V
R
Site 15
S118
L
E
K
V
R
K
V
S
V
N
V
K
T
V
R
Site 16
T123
K
V
S
V
N
V
K
T
V
R
G
S
L
E
R
Site 17
S127
N
V
K
T
V
R
G
S
L
E
R
Q
A
G
Q
Site 18
Y156
R
N
F
K
V
M
I
Y
Q
D
E
V
K
L
P
Site 19
S167
V
K
L
P
A
K
L
S
I
S
K
S
L
K
E
Site 20
S169
L
P
A
K
L
S
I
S
K
S
L
K
E
S
E
Site 21
S171
A
K
L
S
I
S
K
S
L
K
E
S
E
A
L
Site 22
S175
I
S
K
S
L
K
E
S
E
A
L
P
E
K
E
Site 23
S202
D
A
A
A
L
E
L
S
S
D
E
A
V
E
V
Site 24
S203
A
A
A
L
E
L
S
S
D
E
A
V
E
V
E
Site 25
S216
V
E
E
V
I
E
E
S
R
A
E
R
I
K
R
Site 26
S224
R
A
E
R
I
K
R
S
G
L
R
R
V
D
D
Site 27
T244
S
K
E
K
M
E
K
T
K
V
R
T
R
E
N
Site 28
T259
L
E
K
T
R
L
K
T
K
E
N
L
E
K
T
Site 29
T269
N
L
E
K
T
R
H
T
L
E
K
R
M
N
K
Site 30
T292
E
R
R
E
K
L
K
T
S
R
D
K
L
R
K
Site 31
S300
S
R
D
K
L
R
K
S
F
T
P
D
H
V
V
Site 32
T302
D
K
L
R
K
S
F
T
P
D
H
V
V
Y
A
Site 33
Y308
F
T
P
D
H
V
V
Y
A
R
S
K
T
A
V
Polymerase I and transcript release factor Y308 phosphosite-specific antibody AB-PN533#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN533#Polymerase I and transcript release factor (H305-S311, human) pY308 phosphopeptide - Powder PE-04AEP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEP95
Site 34
T313
V
V
Y
A
R
S
K
T
A
V
Y
K
V
P
P
Site 35
Y316
A
R
S
K
T
A
V
Y
K
V
P
P
F
T
F
Site 36
T322
V
Y
K
V
P
P
F
T
F
H
V
K
K
I
R
Site 37
S365
A
G
D
L
R
R
G
S
S
P
D
V
H
A
L
Site 38
S366
G
D
L
R
R
G
S
S
P
D
V
H
A
L
L
Site 39
T376
V
H
A
L
L
E
I
T
E
E
S
D
A
V
L
Site 40
S379
L
L
E
I
T
E
E
S
D
A
V
L
V
D
K
Site 41
S387
D
A
V
L
V
D
K
S
D
S
D
_
_
_
_
Site 42
S389
V
L
V
D
K
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation