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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKN3
Full Name:
Serine/threonine-protein kinase N3
Alias:
EC 2.7.11.13; PKN-beta; Serine,threonine-protein kinase N3
Type:
Protein-serine kinase, AGC group, PKN family
Mass (Da):
99421
Number AA:
889
UniProt ID:
Q6P5Z2
International Prot ID:
IPI00413780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
P
R
Q
P
G
P
S
Q
W
P
P
E
D
E
Site 2
T45
E
N
L
R
R
V
A
T
D
R
R
H
L
G
H
Site 3
S59
H
V
Q
Q
L
L
R
S
S
N
R
R
L
E
Q
Site 4
S60
V
Q
Q
L
L
R
S
S
N
R
R
L
E
Q
L
Site 5
S93
G
P
A
E
P
V
A
S
G
P
R
P
W
A
E
Site 6
T135
T
H
T
C
A
S
G
T
P
K
E
R
K
L
L
Site 7
S165
L
L
R
M
K
I
S
S
L
E
A
S
G
S
P
Site 8
S169
K
I
S
S
L
E
A
S
G
S
P
E
P
G
P
Site 9
S171
S
S
L
E
A
S
G
S
P
E
P
G
P
E
L
Site 10
S205
K
N
V
V
K
L
L
S
S
R
R
T
Q
D
R
Site 11
S206
N
V
V
K
L
L
S
S
R
R
T
Q
D
R
K
Site 12
T209
K
L
L
S
S
R
R
T
Q
D
R
K
A
L
A
Site 13
T254
H
P
L
R
S
R
V
T
R
E
L
R
A
A
V
Site 14
Y264
L
R
A
A
V
P
G
Y
P
Q
P
S
G
T
P
Site 15
S268
V
P
G
Y
P
Q
P
S
G
T
P
V
K
P
T
Site 16
T270
G
Y
P
Q
P
S
G
T
P
V
K
P
T
A
L
Site 17
S299
L
T
A
V
P
G
R
S
P
A
A
A
L
A
S
Site 18
S306
S
P
A
A
A
L
A
S
S
P
S
E
G
W
L
Site 19
S307
P
A
A
A
L
A
S
S
P
S
E
G
W
L
R
Site 20
S309
A
A
L
A
S
S
P
S
E
G
W
L
R
T
K
Site 21
T357
A
E
Q
S
W
D
Q
T
F
V
I
P
L
E
R
Site 22
S400
D
N
A
C
H
Q
L
S
L
S
L
V
P
Q
G
Site 23
S434
Q
R
Q
E
R
I
F
S
K
R
R
G
Q
D
F
Site 24
S445
G
Q
D
F
L
R
A
S
Q
M
N
L
G
M
A
Site 25
S466
M
N
L
L
P
P
C
S
S
P
S
T
I
S
P
Site 26
S467
N
L
L
P
P
C
S
S
P
S
T
I
S
P
P
Site 27
S469
L
P
P
C
S
S
P
S
T
I
S
P
P
K
G
Site 28
T470
P
P
C
S
S
P
S
T
I
S
P
P
K
G
C
Site 29
S472
C
S
S
P
S
T
I
S
P
P
K
G
C
P
R
Site 30
T480
P
P
K
G
C
P
R
T
P
T
T
L
R
E
A
Site 31
T482
K
G
C
P
R
T
P
T
T
L
R
E
A
S
D
Site 32
T483
G
C
P
R
T
P
T
T
L
R
E
A
S
D
P
Site 33
S488
P
T
T
L
R
E
A
S
D
P
A
T
P
S
N
Site 34
T492
R
E
A
S
D
P
A
T
P
S
N
F
L
P
K
Site 35
S494
A
S
D
P
A
T
P
S
N
F
L
P
K
K
T
Site 36
T501
S
N
F
L
P
K
K
T
P
L
G
E
E
M
T
Site 37
T508
T
P
L
G
E
E
M
T
P
P
P
K
P
P
R
Site 38
Y517
P
P
K
P
P
R
L
Y
L
P
Q
E
P
T
S
Site 39
T523
L
Y
L
P
Q
E
P
T
S
E
E
T
P
R
T
Site 40
S524
Y
L
P
Q
E
P
T
S
E
E
T
P
R
T
K
Site 41
T527
Q
E
P
T
S
E
E
T
P
R
T
K
R
P
H
Site 42
T530
T
S
E
E
T
P
R
T
K
R
P
H
M
E
P
Site 43
T539
R
P
H
M
E
P
R
T
R
R
G
P
S
P
P
Site 44
S544
P
R
T
R
R
G
P
S
P
P
A
S
P
T
R
Site 45
S548
R
G
P
S
P
P
A
S
P
T
R
K
P
P
R
Site 46
T550
P
S
P
P
A
S
P
T
R
K
P
P
R
L
Q
Site 47
Y584
Q
F
K
G
T
G
K
Y
Y
A
I
K
A
L
K
Site 48
Y585
F
K
G
T
G
K
Y
Y
A
I
K
A
L
K
K
Site 49
S597
L
K
K
Q
E
V
L
S
R
D
E
I
E
S
L
Site 50
S603
L
S
R
D
E
I
E
S
L
Y
C
E
K
R
I
Site 51
Y605
R
D
E
I
E
S
L
Y
C
E
K
R
I
L
E
Site 52
T716
G
I
G
F
G
D
R
T
S
T
F
C
G
T
P
Site 53
S717
I
G
F
G
D
R
T
S
T
F
C
G
T
P
E
Site 54
T718
G
F
G
D
R
T
S
T
F
C
G
T
P
E
F
Site 55
T722
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
Site 56
Y736
E
V
L
T
Q
E
A
Y
T
R
A
V
D
W
W
Site 57
T763
E
C
P
F
P
G
D
T
E
E
E
V
F
D
C
Site 58
T820
K
V
Q
P
F
F
R
T
T
N
W
Q
A
L
L
Site 59
Y847
C
G
P
A
D
L
R
Y
F
E
G
E
F
T
G
Site 60
T853
R
Y
F
E
G
E
F
T
G
L
P
P
A
L
T
Site 61
T860
T
G
L
P
P
A
L
T
P
P
A
P
H
S
L
Site 62
S866
L
T
P
P
A
P
H
S
L
L
T
A
R
Q
Q
Site 63
T869
P
A
P
H
S
L
L
T
A
R
Q
Q
A
A
F
Site 64
S883
F
R
D
F
D
F
V
S
E
R
F
L
E
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation