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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CES3
Full Name:
Carboxylesterase 3
Alias:
Liver carboxylesterase 31 homolog
Type:
Mass (Da):
62282
Number AA:
571
UniProt ID:
Q6UWW8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
R
A
V
R
V
E
S
G
V
L
V
G
V
V
Site 2
T25
L
L
L
A
C
P
A
T
A
T
G
P
E
V
A
Site 3
T38
V
A
Q
P
E
V
D
T
T
L
G
R
V
R
G
Site 4
T39
A
Q
P
E
V
D
T
T
L
G
R
V
R
G
R
Site 5
S76
P
L
G
P
D
R
F
S
A
P
H
P
A
Q
P
Site 6
S91
W
E
G
V
R
D
A
S
T
A
P
P
M
C
L
Site 7
T92
E
G
V
R
D
A
S
T
A
P
P
M
C
L
Q
Site 8
S103
M
C
L
Q
D
V
E
S
M
N
S
S
R
F
V
Site 9
S106
Q
D
V
E
S
M
N
S
S
R
F
V
L
N
G
Site 10
S107
D
V
E
S
M
N
S
S
R
F
V
L
N
G
K
Site 11
S119
N
G
K
Q
Q
I
F
S
V
S
E
D
C
L
V
Site 12
S163
A
A
T
S
Y
D
G
S
A
L
A
A
Y
G
D
Site 13
S255
F
H
R
A
I
T
Q
S
G
V
I
T
T
P
G
Site 14
T260
T
Q
S
G
V
I
T
T
P
G
I
I
D
S
H
Site 15
S266
T
T
P
G
I
I
D
S
H
P
W
P
L
A
Q
Site 16
S284
N
T
L
A
C
S
S
S
S
P
A
E
M
V
Q
Site 17
S304
E
G
E
E
L
V
L
S
K
K
L
K
N
T
I
Site 18
T310
L
S
K
K
L
K
N
T
I
Y
P
L
T
V
D
Site 19
Y312
K
K
L
K
N
T
I
Y
P
L
T
V
D
G
T
Site 20
T319
Y
P
L
T
V
D
G
T
V
F
P
K
S
P
K
Site 21
S324
D
G
T
V
F
P
K
S
P
K
E
L
L
K
E
Site 22
T361
R
G
W
G
L
L
D
T
M
E
Q
M
S
R
E
Site 23
Y395
M
P
T
V
I
D
E
Y
L
G
S
N
S
D
A
Site 24
S398
V
I
D
E
Y
L
G
S
N
S
D
A
Q
A
K
Site 25
S424
F
I
N
V
P
T
V
S
F
S
R
Y
L
R
D
Site 26
S426
N
V
P
T
V
S
F
S
R
Y
L
R
D
S
G
Site 27
Y428
P
T
V
S
F
S
R
Y
L
R
D
S
G
S
P
Site 28
S432
F
S
R
Y
L
R
D
S
G
S
P
V
F
F
Y
Site 29
S434
R
Y
L
R
D
S
G
S
P
V
F
F
Y
E
F
Site 30
Y439
S
G
S
P
V
F
F
Y
E
F
Q
H
R
P
S
Site 31
S446
Y
E
F
Q
H
R
P
S
S
F
A
K
I
K
P
Site 32
S447
E
F
Q
H
R
P
S
S
F
A
K
I
K
P
A
Site 33
S478
P
F
L
M
D
E
S
S
R
L
A
F
P
E
A
Site 34
S493
T
E
E
E
K
Q
L
S
L
T
M
M
A
Q
W
Site 35
T495
E
E
K
Q
L
S
L
T
M
M
A
Q
W
T
H
Site 36
S511
A
R
T
G
D
P
N
S
K
A
L
P
P
W
P
Site 37
Y526
Q
F
N
Q
A
E
Q
Y
L
E
I
N
P
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation