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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAO1
Full Name:
Serine/threonine-protein kinase TAO1
Alias:
EC 2.7.11.1; FLJ14314; HKFC-B; KIAA1361; MAP3K16; MARKK; PSK2; Serine,threonine kinase TAO1; Serine/threonine kinase TAO1; STE20-like kinase PSK2; TAO kinase 1; TAOK1
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; TAO subfamily
Mass (Da):
116070
Number AA:
1001
UniProt ID:
Q7L7X3
International Prot ID:
IPI00002232
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0043231
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase TAO1 S181 phosphosite-specific antibody AB-PK826#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK826#Serine/threonine-protein kinase TAO1 Y309 phosphosite-specific antibody AB-PK827#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK827#Serine/threonine-protein kinase TAO1 (P178-G184, human) pS181 phosphopeptide - Powder PE-04ALF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALF99#Serine/threonine-protein kinase TAO1 (N306-M312, human) pY309 phosphopeptide - Powder PE-04APX95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APX95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
S
T
N
R
A
G
S
L
K
D
P
E
I
A
Site 2
T29
E
D
P
E
K
L
F
T
D
L
R
E
I
G
H
Site 3
Y43
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
T
Site 4
S60
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
T
Site 5
Y61
V
A
I
K
K
M
S
Y
S
G
K
Q
S
T
E
Site 6
S62
A
I
K
K
M
S
Y
S
G
K
Q
S
T
E
K
Site 7
S66
M
S
Y
S
G
K
Q
S
T
E
K
W
Q
D
I
Site 8
Y95
S
I
E
Y
K
G
C
Y
L
R
E
H
T
A
W
Site 9
Y107
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
Site 10
S113
E
Y
C
L
G
S
A
S
D
L
L
E
V
H
K
Site 11
S174
L
A
D
F
G
S
A
S
M
A
S
P
A
N
S
Site 12
S177
F
G
S
A
S
M
A
S
P
A
N
S
F
V
G
Site 13
S181
S
M
A
S
P
A
N
S
F
V
G
T
P
Y
W
Serine/threonine-protein kinase TAO1 S181 phosphosite-specific antibody AB-PK826#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK826#Serine/threonine-protein kinase TAO1 (P178-G184, human) pS181 phosphopeptide - Powder PE-04ALF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALF99
Site 14
T185
P
A
N
S
F
V
G
T
P
Y
W
M
A
P
E
Site 15
S242
Y
H
I
A
Q
N
E
S
P
T
L
Q
S
N
E
Site 16
S247
N
E
S
P
T
L
Q
S
N
E
W
S
D
Y
F
Site 17
Y253
Q
S
N
E
W
S
D
Y
F
R
N
F
V
D
S
Site 18
T271
K
I
P
Q
D
R
P
T
S
E
E
L
L
K
H
Site 19
S272
I
P
Q
D
R
P
T
S
E
E
L
L
K
H
I
Site 20
Y309
R
E
L
D
N
L
Q
Y
R
K
M
K
K
L
L
Serine/threonine-protein kinase TAO1 Y309 phosphosite-specific antibody AB-PK827#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK827#Serine/threonine-protein kinase TAO1 (N306-M312, human) pY309 phosphopeptide - Powder PE-04APX95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APX95
Site 21
T344
H
G
V
G
R
T
G
T
V
N
S
V
G
S
N
Site 22
S347
G
R
T
G
T
V
N
S
V
G
S
N
Q
S
I
Site 23
S350
G
T
V
N
S
V
G
S
N
Q
S
I
P
S
M
Site 24
S353
N
S
V
G
S
N
Q
S
I
P
S
M
S
I
S
Site 25
S356
G
S
N
Q
S
I
P
S
M
S
I
S
A
S
S
Site 26
S358
N
Q
S
I
P
S
M
S
I
S
A
S
S
Q
S
Site 27
S360
S
I
P
S
M
S
I
S
A
S
S
Q
S
S
S
Site 28
S362
P
S
M
S
I
S
A
S
S
Q
S
S
S
V
N
Site 29
S363
S
M
S
I
S
A
S
S
Q
S
S
S
V
N
S
Site 30
S365
S
I
S
A
S
S
Q
S
S
S
V
N
S
L
P
Site 31
S366
I
S
A
S
S
Q
S
S
S
V
N
S
L
P
D
Site 32
S367
S
A
S
S
Q
S
S
S
V
N
S
L
P
D
V
Site 33
S370
S
Q
S
S
S
V
N
S
L
P
D
V
S
D
D
Site 34
S375
V
N
S
L
P
D
V
S
D
D
K
S
E
L
D
Site 35
S379
P
D
V
S
D
D
K
S
E
L
D
M
M
E
G
Site 36
T389
D
M
M
E
G
D
H
T
V
M
S
N
S
S
V
Site 37
S392
E
G
D
H
T
V
M
S
N
S
S
V
I
H
L
Site 38
S394
D
H
T
V
M
S
N
S
S
V
I
H
L
K
P
Site 39
Y406
L
K
P
E
E
E
N
Y
R
E
E
G
D
P
R
Site 40
T414
R
E
E
G
D
P
R
T
R
A
S
D
P
Q
S
Site 41
S417
G
D
P
R
T
R
A
S
D
P
Q
S
P
P
Q
Site 42
S421
T
R
A
S
D
P
Q
S
P
P
Q
V
S
R
H
Site 43
S426
P
Q
S
P
P
Q
V
S
R
H
K
S
H
Y
R
Site 44
S430
P
Q
V
S
R
H
K
S
H
Y
R
N
R
E
H
Site 45
Y432
V
S
R
H
K
S
H
Y
R
N
R
E
H
F
A
Site 46
T440
R
N
R
E
H
F
A
T
I
R
T
A
S
L
V
Site 47
T443
E
H
F
A
T
I
R
T
A
S
L
V
T
R
Q
Site 48
S445
F
A
T
I
R
T
A
S
L
V
T
R
Q
M
Q
Site 49
S458
M
Q
E
H
E
Q
D
S
E
L
R
E
Q
M
S
Site 50
S465
S
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Site 51
Y467
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Site 52
T480
Q
H
Q
K
Q
L
M
T
L
E
N
K
L
K
A
Site 53
T502
R
L
D
K
D
L
E
T
Q
R
N
N
F
A
A
Site 54
S530
E
K
E
A
K
V
M
S
N
E
E
K
K
F
Q
Site 55
S550
Q
Q
K
K
E
L
N
S
F
L
E
S
Q
K
R
Site 56
S554
E
L
N
S
F
L
E
S
Q
K
R
E
Y
K
L
Site 57
Y559
L
E
S
Q
K
R
E
Y
K
L
R
K
E
Q
L
Site 58
S575
E
E
L
N
E
N
Q
S
T
P
K
K
E
K
Q
Site 59
T576
E
L
N
E
N
Q
S
T
P
K
K
E
K
Q
E
Site 60
Y610
L
L
R
R
Q
R
Q
Y
L
E
L
E
C
R
R
Site 61
T643
E
E
L
N
K
R
Q
T
Q
K
D
L
E
H
A
Site 62
S658
M
L
L
R
Q
H
E
S
M
Q
E
L
E
F
R
Site 63
T669
L
E
F
R
H
L
N
T
I
Q
K
M
R
C
E
Site 64
T684
L
I
R
L
Q
H
Q
T
E
L
T
N
Q
L
E
Site 65
S714
E
V
R
Q
Q
P
K
S
L
K
S
K
E
L
Q
Site 66
T734
Q
D
T
C
K
I
Q
T
R
Q
Y
K
A
L
R
Site 67
Y737
C
K
I
Q
T
R
Q
Y
K
A
L
R
N
H
L
Site 68
T747
L
R
N
H
L
L
E
T
T
P
K
S
E
H
K
Site 69
T748
R
N
H
L
L
E
T
T
P
K
S
E
H
K
A
Site 70
S751
L
L
E
T
T
P
K
S
E
H
K
A
V
L
K
Site 71
S778
L
A
E
Q
Y
D
H
S
I
N
E
M
L
S
T
Site 72
S784
H
S
I
N
E
M
L
S
T
Q
A
L
R
L
D
Site 73
T785
S
I
N
E
M
L
S
T
Q
A
L
R
L
D
E
Site 74
Y815
E
L
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
Site 75
S817
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
A
E
Site 76
S839
R
E
L
E
Q
R
V
S
L
R
R
A
L
L
E
Site 77
T861
L
A
L
Q
N
E
R
T
E
R
I
R
S
L
L
Site 78
S866
E
R
T
E
R
I
R
S
L
L
E
R
Q
A
R
Site 79
S880
R
E
I
E
A
F
D
S
E
S
M
R
L
G
F
Site 80
S882
I
E
A
F
D
S
E
S
M
R
L
G
F
S
N
Site 81
S896
N
M
V
L
S
N
L
S
P
E
A
F
S
H
S
Site 82
S901
N
L
S
P
E
A
F
S
H
S
Y
P
G
A
S
Site 83
S903
S
P
E
A
F
S
H
S
Y
P
G
A
S
G
W
Site 84
Y904
P
E
A
F
S
H
S
Y
P
G
A
S
G
W
S
Site 85
S908
S
H
S
Y
P
G
A
S
G
W
S
H
N
P
T
Site 86
S911
Y
P
G
A
S
G
W
S
H
N
P
T
G
G
P
Site 87
T915
S
G
W
S
H
N
P
T
G
G
P
G
P
H
W
Site 88
S948
P
Q
P
W
G
H
P
S
G
P
M
Q
G
V
P
Site 89
S958
M
Q
G
V
P
R
G
S
S
M
G
V
R
N
S
Site 90
S959
Q
G
V
P
R
G
S
S
M
G
V
R
N
S
P
Site 91
S965
S
S
M
G
V
R
N
S
P
Q
A
L
R
R
T
Site 92
T972
S
P
Q
A
L
R
R
T
A
S
G
G
R
T
E
Site 93
S974
Q
A
L
R
R
T
A
S
G
G
R
T
E
Q
G
Site 94
T978
R
T
A
S
G
G
R
T
E
Q
G
M
S
R
S
Site 95
S983
G
R
T
E
Q
G
M
S
R
S
T
S
V
T
S
Site 96
S985
T
E
Q
G
M
S
R
S
T
S
V
T
S
Q
I
Site 97
T986
E
Q
G
M
S
R
S
T
S
V
T
S
Q
I
S
Site 98
S987
Q
G
M
S
R
S
T
S
V
T
S
Q
I
S
N
Site 99
T989
M
S
R
S
T
S
V
T
S
Q
I
S
N
G
S
Site 100
S990
S
R
S
T
S
V
T
S
Q
I
S
N
G
S
H
Site 101
S993
T
S
V
T
S
Q
I
S
N
G
S
H
M
S
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation