KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Net1
Full Name:
Neuroepithelial cell-transforming gene 1 protein
Alias:
ARHG8; ARHGEF8; NET1A; neuroepithelial cell transforming 1; Neuroepithelial cell transforming gene 1 protein; p65 Net1 proto- oncogene; Rho guanine nucleotide exchange factor 8
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
67740
Number AA:
596
UniProt ID:
Q7Z628
International Prot ID:
IPI00385312
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
P
R
P
R
R
R
S
R
R
A
S
G
L
S
Site 2
S21
R
R
R
S
R
R
A
S
G
L
S
T
E
G
A
Site 3
S24
S
R
R
A
S
G
L
S
T
E
G
A
T
G
P
Site 4
T25
R
R
A
S
G
L
S
T
E
G
A
T
G
P
S
Site 5
T29
G
L
S
T
E
G
A
T
G
P
S
A
D
T
S
Site 6
S32
T
E
G
A
T
G
P
S
A
D
T
S
G
S
E
Site 7
T35
A
T
G
P
S
A
D
T
S
G
S
E
L
D
G
Site 8
S36
T
G
P
S
A
D
T
S
G
S
E
L
D
G
R
Site 9
S38
P
S
A
D
T
S
G
S
E
L
D
G
R
C
S
Site 10
S45
S
E
L
D
G
R
C
S
L
R
R
G
S
S
F
Site 11
S50
R
C
S
L
R
R
G
S
S
F
T
F
L
T
P
Site 12
S51
C
S
L
R
R
G
S
S
F
T
F
L
T
P
G
Site 13
T53
L
R
R
G
S
S
F
T
F
L
T
P
G
P
N
Site 14
T56
G
S
S
F
T
F
L
T
P
G
P
N
W
D
F
Site 15
T64
P
G
P
N
W
D
F
T
L
K
R
K
R
R
E
Site 16
S78
E
K
D
D
D
V
V
S
L
S
S
L
D
L
K
Site 17
S80
D
D
D
V
V
S
L
S
S
L
D
L
K
E
P
Site 18
S81
D
D
V
V
S
L
S
S
L
D
L
K
E
P
S
Site 19
S100
R
P
L
A
R
V
T
S
L
A
N
L
I
S
P
Site 20
S106
T
S
L
A
N
L
I
S
P
V
R
N
G
A
V
Site 21
T119
A
V
R
R
F
G
Q
T
I
Q
S
F
T
L
R
Site 22
S122
R
F
G
Q
T
I
Q
S
F
T
L
R
G
D
H
Site 23
T124
G
Q
T
I
Q
S
F
T
L
R
G
D
H
R
S
Site 24
S131
T
L
R
G
D
H
R
S
P
A
S
A
Q
K
F
Site 25
S134
G
D
H
R
S
P
A
S
A
Q
K
F
S
S
R
Site 26
S139
P
A
S
A
Q
K
F
S
S
R
S
T
V
P
T
Site 27
S140
A
S
A
Q
K
F
S
S
R
S
T
V
P
T
P
Site 28
S142
A
Q
K
F
S
S
R
S
T
V
P
T
P
A
K
Site 29
T143
Q
K
F
S
S
R
S
T
V
P
T
P
A
K
R
Site 30
T146
S
S
R
S
T
V
P
T
P
A
K
R
R
S
S
Site 31
S152
P
T
P
A
K
R
R
S
S
A
L
W
S
E
M
Site 32
S153
T
P
A
K
R
R
S
S
A
L
W
S
E
M
L
Site 33
S157
R
R
S
S
A
L
W
S
E
M
L
D
I
T
M
Site 34
T163
W
S
E
M
L
D
I
T
M
K
E
S
L
T
T
Site 35
S167
L
D
I
T
M
K
E
S
L
T
T
R
E
I
R
Site 36
T169
I
T
M
K
E
S
L
T
T
R
E
I
R
R
Q
Site 37
Y180
I
R
R
Q
E
A
I
Y
E
M
S
R
G
E
Q
Site 38
Y200
L
K
L
A
R
K
A
Y
H
D
P
M
L
K
L
Site 39
S208
H
D
P
M
L
K
L
S
I
M
S
E
E
E
L
Site 40
T216
I
M
S
E
E
E
L
T
H
I
F
G
D
L
D
Site 41
S224
H
I
F
G
D
L
D
S
Y
I
P
L
H
E
D
Site 42
T234
P
L
H
E
D
L
L
T
R
I
G
E
A
T
K
Site 43
T240
L
T
R
I
G
E
A
T
K
P
D
G
T
V
E
Site 44
T245
E
A
T
K
P
D
G
T
V
E
Q
I
G
H
I
Site 45
Y266
R
L
N
A
Y
R
G
Y
C
S
N
Q
L
A
A
Site 46
S296
F
L
Q
R
C
L
E
S
P
F
S
R
K
L
D
Site 47
S299
R
C
L
E
S
P
F
S
R
K
L
D
L
W
S
Site 48
S306
S
R
K
L
D
L
W
S
F
L
D
I
P
R
S
Site 49
S313
S
F
L
D
I
P
R
S
R
L
V
K
Y
P
L
Site 50
Y318
P
R
S
R
L
V
K
Y
P
L
L
L
K
E
I
Site 51
T329
L
K
E
I
L
K
H
T
P
K
E
H
P
D
V
Site 52
Y364
K
G
E
S
E
C
Q
Y
Y
I
D
K
L
E
Y
Site 53
Y365
G
E
S
E
C
Q
Y
Y
I
D
K
L
E
Y
L
Site 54
S384
R
D
P
R
I
E
A
S
K
V
L
L
C
H
G
Site 55
S395
L
C
H
G
E
L
R
S
K
S
G
H
K
L
Y
Site 56
S397
H
G
E
L
R
S
K
S
G
H
K
L
Y
I
F
Site 57
Y402
S
K
S
G
H
K
L
Y
I
F
L
F
Q
D
I
Site 58
T417
L
V
L
T
R
P
V
T
R
N
E
R
H
S
Y
Site 59
S423
V
T
R
N
E
R
H
S
Y
Q
V
Y
R
Q
P
Site 60
Y424
T
R
N
E
R
H
S
Y
Q
V
Y
R
Q
P
I
Site 61
Y427
E
R
H
S
Y
Q
V
Y
R
Q
P
I
P
V
Q
Site 62
S451
G
D
V
R
M
G
G
S
F
R
G
A
F
S
N
Site 63
S457
G
S
F
R
G
A
F
S
N
S
E
K
A
K
N
Site 64
S459
F
R
G
A
F
S
N
S
E
K
A
K
N
I
F
Site 65
S474
R
I
R
F
H
D
P
S
P
A
Q
S
H
T
L
Site 66
S478
H
D
P
S
P
A
Q
S
H
T
L
Q
A
N
D
Site 67
S508
A
P
F
Q
S
A
G
S
P
P
E
L
Q
G
L
Site 68
S528
E
C
E
G
N
H
P
S
A
R
K
L
T
A
Q
Site 69
T533
H
P
S
A
R
K
L
T
A
Q
R
R
A
S
T
Site 70
S539
L
T
A
Q
R
R
A
S
T
V
S
S
V
T
Q
Site 71
T540
T
A
Q
R
R
A
S
T
V
S
S
V
T
Q
V
Site 72
S542
Q
R
R
A
S
T
V
S
S
V
T
Q
V
E
V
Site 73
S543
R
R
A
S
T
V
S
S
V
T
Q
V
E
V
D
Site 74
Y554
V
E
V
D
E
N
A
Y
R
C
G
S
G
M
Q
Site 75
S558
E
N
A
Y
R
C
G
S
G
M
Q
M
A
E
D
Site 76
S566
G
M
Q
M
A
E
D
S
K
S
L
K
T
H
Q
Site 77
S568
Q
M
A
E
D
S
K
S
L
K
T
H
Q
T
Q
Site 78
T571
E
D
S
K
S
L
K
T
H
Q
T
Q
P
G
I
Site 79
T574
K
S
L
K
T
H
Q
T
Q
P
G
I
R
R
A
Site 80
S587
R
A
R
D
K
A
L
S
G
G
K
R
K
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation