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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK8
Full Name:
Serine/threonine-protein kinase Nek8
Alias:
EC 2.7.11.1; NEK12A; NIMA-related kinase 12a
Type:
Protein-serine kinase, Other group, NEK family
Mass (Da):
74806
Number AA:
692
UniProt ID:
Q86SG6
International Prot ID:
IPI00328397
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y66
N
H
P
N
V
I
E
Y
Y
E
N
F
L
E
D
Site 2
Y67
H
P
N
V
I
E
Y
Y
E
N
F
L
E
D
K
Site 3
S98
F
I
Q
K
R
C
N
S
L
L
E
E
E
T
I
Site 4
T131
I
L
H
R
D
L
K
T
Q
N
I
L
L
D
K
Site 5
S151
K
I
G
D
F
G
I
S
K
I
L
S
S
K
S
Site 6
S155
F
G
I
S
K
I
L
S
S
K
S
K
A
Y
T
Site 7
S156
G
I
S
K
I
L
S
S
K
S
K
A
Y
T
V
Site 8
S158
S
K
I
L
S
S
K
S
K
A
Y
T
V
V
G
Site 9
Y161
L
S
S
K
S
K
A
Y
T
V
V
G
T
P
C
Site 10
T162
S
S
K
S
K
A
Y
T
V
V
G
T
P
C
Y
Site 11
S171
V
G
T
P
C
Y
I
S
P
E
L
C
E
G
K
Site 12
Y180
E
L
C
E
G
K
P
Y
N
Q
K
S
D
I
W
Site 13
S224
S
G
T
F
A
P
I
S
D
R
Y
S
P
E
L
Site 14
Y227
F
A
P
I
S
D
R
Y
S
P
E
L
R
Q
L
Site 15
S228
A
P
I
S
D
R
Y
S
P
E
L
R
Q
L
V
Site 16
S250
P
A
Q
R
P
P
L
S
H
I
M
A
Q
P
L
Site 17
S271
N
L
H
T
D
V
G
S
V
R
M
R
R
A
E
Site 18
S280
R
M
R
R
A
E
K
S
V
A
P
S
N
T
G
Site 19
S284
A
E
K
S
V
A
P
S
N
T
G
S
R
T
T
Site 20
T286
K
S
V
A
P
S
N
T
G
S
R
T
T
S
V
Site 21
S288
V
A
P
S
N
T
G
S
R
T
T
S
V
R
C
Site 22
T290
P
S
N
T
G
S
R
T
T
S
V
R
C
R
G
Site 23
T291
S
N
T
G
S
R
T
T
S
V
R
C
R
G
I
Site 24
S292
N
T
G
S
R
T
T
S
V
R
C
R
G
I
P
Site 25
S350
Q
K
A
G
V
T
R
S
G
R
L
I
L
W
E
Site 26
T414
T
D
R
G
I
I
M
T
F
G
S
G
S
N
G
Site 27
S427
N
G
C
L
G
H
G
S
L
T
D
I
S
Q
P
Site 28
S432
H
G
S
L
T
D
I
S
Q
P
T
I
V
E
A
Site 29
S472
F
A
W
G
R
G
D
S
G
R
L
G
L
G
T
Site 30
T479
S
G
R
L
G
L
G
T
R
E
S
H
S
C
P
Site 31
S482
L
G
L
G
T
R
E
S
H
S
C
P
Q
Q
V
Site 32
S484
L
G
T
R
E
S
H
S
C
P
Q
Q
V
P
M
Site 33
S521
G
Q
A
L
A
C
G
S
N
R
F
N
K
L
G
Site 34
S533
K
L
G
L
D
H
L
S
L
G
E
E
P
V
P
Site 35
S565
L
D
Q
E
P
L
L
S
I
D
L
G
T
A
H
Site 36
T577
T
A
H
S
A
A
V
T
A
S
G
D
C
Y
T
Site 37
Y583
V
T
A
S
G
D
C
Y
T
F
G
S
N
Q
H
Site 38
T584
T
A
S
G
D
C
Y
T
F
G
S
N
Q
H
G
Site 39
T597
H
G
Q
L
G
T
N
T
R
R
G
S
R
A
P
Site 40
S601
G
T
N
T
R
R
G
S
R
A
P
C
K
V
Q
Site 41
S632
T
V
A
I
G
A
E
S
E
V
Y
S
W
G
K
Site 42
Y635
I
G
A
E
S
E
V
Y
S
W
G
K
G
A
R
Site 43
S636
G
A
E
S
E
V
Y
S
W
G
K
G
A
R
G
Site 44
T663
R
P
V
Q
L
D
E
T
H
P
Y
T
V
T
S
Site 45
Y666
Q
L
D
E
T
H
P
Y
T
V
T
S
V
S
C
Site 46
T667
L
D
E
T
H
P
Y
T
V
T
S
V
S
C
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation