KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MAGI2
Full Name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Alias:
ACVRIP1; ARIP1; Atrophin-1 interacting protein 1; Atrophin-1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; KIAA0705; MAGI-2; Membrane associated guanylate kinase inverted-2; Membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2
Type:
Adapter/scaffold protein
Mass (Da):
158754
Number AA:
1455
UniProt ID:
Q86UL8
International Prot ID:
IPI00413880
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
K
S
L
K
K
K
S
H
W
T
S
K
V
H
Site 2
S13
K
K
K
S
H
W
T
S
K
V
H
E
S
V
I
Site 3
Y54
V
K
P
G
K
V
A
Y
E
S
G
S
K
L
V
Site 4
S56
P
G
K
V
A
Y
E
S
G
S
K
L
V
S
E
Site 5
S58
K
V
A
Y
E
S
G
S
K
L
V
S
E
E
L
Site 6
S62
E
S
G
S
K
L
V
S
E
E
L
L
L
E
V
Site 7
Y111
V
D
K
D
L
R
H
Y
L
N
L
R
F
Q
K
Site 8
S120
N
L
R
F
Q
K
G
S
V
D
H
E
L
Q
Q
Site 9
Y134
Q
I
I
R
D
N
L
Y
L
R
T
V
P
C
T
Site 10
T137
R
D
N
L
Y
L
R
T
V
P
C
T
T
R
P
Site 11
T141
Y
L
R
T
V
P
C
T
T
R
P
H
K
E
G
Site 12
S169
D
F
M
E
L
E
K
S
G
A
L
L
E
S
G
Site 13
S175
K
S
G
A
L
L
E
S
G
T
Y
E
D
N
Y
Site 14
T177
G
A
L
L
E
S
G
T
Y
E
D
N
Y
Y
G
Site 15
Y178
A
L
L
E
S
G
T
Y
E
D
N
Y
Y
G
T
Site 16
Y182
S
G
T
Y
E
D
N
Y
Y
G
T
P
K
P
P
Site 17
Y183
G
T
Y
E
D
N
Y
Y
G
T
P
K
P
P
A
Site 18
T185
Y
E
D
N
Y
Y
G
T
P
K
P
P
A
E
P
Site 19
T208
D
Q
I
L
P
G
A
T
P
S
A
E
G
K
R
Site 20
S210
I
L
P
G
A
T
P
S
A
E
G
K
R
K
R
Site 21
S220
G
K
R
K
R
N
K
S
V
S
N
M
E
K
A
Site 22
S222
R
K
R
N
K
S
V
S
N
M
E
K
A
S
I
Site 23
S228
V
S
N
M
E
K
A
S
I
E
P
P
E
E
E
Site 24
T250
N
G
N
G
V
V
V
T
P
E
S
S
E
H
E
Site 25
S260
S
S
E
H
E
D
K
S
A
G
A
S
G
E
M
Site 26
S264
E
D
K
S
A
G
A
S
G
E
M
P
S
Q
P
Site 27
S269
G
A
S
G
E
M
P
S
Q
P
Y
P
A
P
V
Site 28
Y272
G
E
M
P
S
Q
P
Y
P
A
P
V
Y
S
Q
Site 29
Y277
Q
P
Y
P
A
P
V
Y
S
Q
P
E
E
L
K
Site 30
S278
P
Y
P
A
P
V
Y
S
Q
P
E
E
L
K
E
Site 31
T290
L
K
E
Q
M
D
D
T
K
P
T
K
P
E
D
Site 32
Y312
P
D
N
W
E
M
A
Y
T
E
K
G
E
V
Y
Site 33
Y319
Y
T
E
K
G
E
V
Y
F
I
D
H
N
T
K
Site 34
T327
F
I
D
H
N
T
K
T
T
S
W
L
D
P
R
Site 35
Y362
E
K
I
D
D
P
I
Y
G
T
Y
Y
V
D
H
Site 36
Y365
D
D
P
I
Y
G
T
Y
Y
V
D
H
I
N
R
Site 37
Y366
D
P
I
Y
G
T
Y
Y
V
D
H
I
N
R
R
Site 38
T374
V
D
H
I
N
R
R
T
Q
F
E
N
P
V
L
Site 39
S418
P
L
F
T
R
D
A
S
Q
L
K
G
T
F
L
Site 40
T423
D
A
S
Q
L
K
G
T
F
L
S
T
T
L
K
Site 41
S426
Q
L
K
G
T
F
L
S
T
T
L
K
K
S
N
Site 42
T427
L
K
G
T
F
L
S
T
T
L
K
K
S
N
M
Site 43
T428
K
G
T
F
L
S
T
T
L
K
K
S
N
M
G
Site 44
S432
L
S
T
T
L
K
K
S
N
M
G
F
G
F
T
Site 45
S454
D
E
F
L
Q
V
K
S
V
I
P
D
G
P
A
Site 46
Y510
N
L
V
L
C
R
G
Y
P
L
P
F
D
P
E
Site 47
S522
D
P
E
D
P
A
N
S
M
V
P
P
L
A
I
Site 48
Y544
M
V
N
G
R
H
N
Y
E
T
Y
L
E
Y
I
Site 49
T546
N
G
R
H
N
Y
E
T
Y
L
E
Y
I
S
R
Site 50
Y547
G
R
H
N
Y
E
T
Y
L
E
Y
I
S
R
T
Site 51
Y550
N
Y
E
T
Y
L
E
Y
I
S
R
T
S
Q
S
Site 52
S555
L
E
Y
I
S
R
T
S
Q
S
V
P
D
I
T
Site 53
S557
Y
I
S
R
T
S
Q
S
V
P
D
I
T
D
R
Site 54
T562
S
Q
S
V
P
D
I
T
D
R
P
P
H
S
L
Site 55
S568
I
T
D
R
P
P
H
S
L
H
S
M
P
T
D
Site 56
S571
R
P
P
H
S
L
H
S
M
P
T
D
G
Q
L
Site 57
T581
T
D
G
Q
L
D
G
T
Y
P
P
P
V
H
D
Site 58
Y582
D
G
Q
L
D
G
T
Y
P
P
P
V
H
D
D
Site 59
S592
P
V
H
D
D
N
V
S
M
A
S
S
G
A
T
Site 60
S596
D
N
V
S
M
A
S
S
G
A
T
Q
A
E
L
Site 61
T618
G
A
Q
G
F
G
F
T
I
A
D
S
P
T
G
Site 62
S622
F
G
F
T
I
A
D
S
P
T
G
Q
R
V
K
Site 63
T675
D
C
P
I
G
S
E
T
S
L
I
I
H
R
G
Site 64
S676
C
P
I
G
S
E
T
S
L
I
I
H
R
G
G
Site 65
S686
I
H
R
G
G
F
F
S
P
W
K
T
P
K
P
Site 66
T690
G
F
F
S
P
W
K
T
P
K
P
I
M
D
R
Site 67
S703
D
R
W
E
N
Q
G
S
P
Q
T
S
L
S
A
Site 68
S707
N
Q
G
S
P
Q
T
S
L
S
A
P
A
I
P
Site 69
S709
G
S
P
Q
T
S
L
S
A
P
A
I
P
Q
N
Site 70
S726
F
P
P
A
L
H
R
S
S
F
P
D
S
T
E
Site 71
S727
P
P
A
L
H
R
S
S
F
P
D
S
T
E
A
Site 72
S731
H
R
S
S
F
P
D
S
T
E
A
F
D
P
R
Site 73
T732
R
S
S
F
P
D
S
T
E
A
F
D
P
R
K
Site 74
Y743
D
P
R
K
P
D
P
Y
E
L
Y
E
K
S
R
Site 75
Y746
K
P
D
P
Y
E
L
Y
E
K
S
R
A
I
Y
Site 76
S749
P
Y
E
L
Y
E
K
S
R
A
I
Y
E
S
R
Site 77
Y753
Y
E
K
S
R
A
I
Y
E
S
R
Q
Q
V
P
Site 78
S755
K
S
R
A
I
Y
E
S
R
Q
Q
V
P
P
R
Site 79
T763
R
Q
Q
V
P
P
R
T
S
F
R
M
D
S
S
Site 80
S764
Q
Q
V
P
P
R
T
S
F
R
M
D
S
S
G
Site 81
S769
R
T
S
F
R
M
D
S
S
G
P
D
Y
K
E
Site 82
S770
T
S
F
R
M
D
S
S
G
P
D
Y
K
E
L
Site 83
Y774
M
D
S
S
G
P
D
Y
K
E
L
D
V
H
L
Site 84
Y827
H
P
G
D
E
L
V
Y
V
D
G
I
P
V
A
Site 85
Y840
V
A
G
K
T
H
R
Y
V
I
D
L
M
H
H
Site 86
T857
R
N
G
Q
V
N
L
T
V
R
R
K
V
L
C
Site 87
S875
P
C
P
E
N
G
R
S
P
G
S
V
S
T
H
Site 88
S878
E
N
G
R
S
P
G
S
V
S
T
H
H
S
S
Site 89
S880
G
R
S
P
G
S
V
S
T
H
H
S
S
P
R
Site 90
T881
R
S
P
G
S
V
S
T
H
H
S
S
P
R
S
Site 91
S884
G
S
V
S
T
H
H
S
S
P
R
S
D
Y
A
Site 92
S885
S
V
S
T
H
H
S
S
P
R
S
D
Y
A
T
Site 93
S888
T
H
H
S
S
P
R
S
D
Y
A
T
Y
T
N
Site 94
Y890
H
S
S
P
R
S
D
Y
A
T
Y
T
N
S
N
Site 95
T892
S
P
R
S
D
Y
A
T
Y
T
N
S
N
H
A
Site 96
T894
R
S
D
Y
A
T
Y
T
N
S
N
H
A
A
P
Site 97
S896
D
Y
A
T
Y
T
N
S
N
H
A
A
P
S
S
Site 98
S902
N
S
N
H
A
A
P
S
S
N
A
S
P
P
E
Site 99
S903
S
N
H
A
A
P
S
S
N
A
S
P
P
E
G
Site 100
S906
A
A
P
S
S
N
A
S
P
P
E
G
F
A
S
Site 101
S913
S
P
P
E
G
F
A
S
H
S
L
Q
T
S
D
Site 102
S915
P
E
G
F
A
S
H
S
L
Q
T
S
D
V
V
Site 103
S919
A
S
H
S
L
Q
T
S
D
V
V
I
H
R
K
Site 104
S944
S
S
L
N
R
P
E
S
G
S
T
I
T
V
P
Site 105
S946
L
N
R
P
E
S
G
S
T
I
T
V
P
H
K
Site 106
T947
N
R
P
E
S
G
S
T
I
T
V
P
H
K
I
Site 107
T949
P
E
S
G
S
T
I
T
V
P
H
K
I
G
R
Site 108
S961
I
G
R
I
I
D
G
S
P
A
D
R
C
A
K
Site 109
S1001
L
I
K
D
A
G
L
S
V
T
L
R
I
I
P
Site 110
T1003
K
D
A
G
L
S
V
T
L
R
I
I
P
Q
E
Site 111
S1014
I
P
Q
E
E
L
N
S
P
T
S
A
P
S
S
Site 112
T1016
Q
E
E
L
N
S
P
T
S
A
P
S
S
E
K
Site 113
S1017
E
E
L
N
S
P
T
S
A
P
S
S
E
K
Q
Site 114
S1020
N
S
P
T
S
A
P
S
S
E
K
Q
S
P
M
Site 115
S1021
S
P
T
S
A
P
S
S
E
K
Q
S
P
M
A
Site 116
S1025
A
P
S
S
E
K
Q
S
P
M
A
Q
Q
S
P
Site 117
S1031
Q
S
P
M
A
Q
Q
S
P
L
A
Q
Q
S
P
Site 118
S1037
Q
S
P
L
A
Q
Q
S
P
L
A
Q
P
S
P
Site 119
S1043
Q
S
P
L
A
Q
P
S
P
A
T
P
N
S
P
Site 120
T1046
L
A
Q
P
S
P
A
T
P
N
S
P
I
A
Q
Site 121
S1049
P
S
P
A
T
P
N
S
P
I
A
Q
P
A
P
Site 122
S1068
Q
L
Q
G
H
E
N
S
Y
R
S
E
V
K
A
Site 123
T1089
D
I
R
Q
P
P
F
T
D
Y
R
Q
P
P
L
Site 124
Y1091
R
Q
P
P
F
T
D
Y
R
Q
P
P
L
D
Y
Site 125
Y1098
Y
R
Q
P
P
L
D
Y
R
Q
P
P
G
G
D
Site 126
Y1106
R
Q
P
P
G
G
D
Y
Q
Q
P
P
P
L
D
Site 127
Y1114
Q
Q
P
P
P
L
D
Y
R
Q
P
P
L
L
D
Site 128
Y1122
R
Q
P
P
L
L
D
Y
R
Q
H
S
P
D
T
Site 129
S1126
L
L
D
Y
R
Q
H
S
P
D
T
R
Q
Y
P
Site 130
T1129
Y
R
Q
H
S
P
D
T
R
Q
Y
P
L
S
D
Site 131
Y1132
H
S
P
D
T
R
Q
Y
P
L
S
D
Y
R
Q
Site 132
S1135
D
T
R
Q
Y
P
L
S
D
Y
R
Q
P
Q
D
Site 133
Y1137
R
Q
Y
P
L
S
D
Y
R
Q
P
Q
D
F
D
Site 134
Y1145
R
Q
P
Q
D
F
D
Y
F
T
V
D
M
E
K
Site 135
T1147
P
Q
D
F
D
Y
F
T
V
D
M
E
K
G
A
Site 136
S1160
G
A
K
G
F
G
F
S
I
R
G
G
R
E
Y
Site 137
Y1167
S
I
R
G
G
R
E
Y
K
M
D
L
Y
V
L
Site 138
Y1172
R
E
Y
K
M
D
L
Y
V
L
R
L
A
E
D
Site 139
T1206
G
E
S
T
R
D
M
T
H
A
R
A
I
E
L
Site 140
S1216
R
A
I
E
L
I
K
S
G
G
R
R
V
R
L
Site 141
T1229
R
L
L
L
K
R
G
T
G
Q
V
P
E
Y
D
Site 142
Y1235
G
T
G
Q
V
P
E
Y
D
E
P
A
P
W
S
Site 143
S1243
D
E
P
A
P
W
S
S
P
A
A
A
A
P
G
Site 144
S1266
D
D
G
L
A
P
F
S
P
S
H
P
A
P
P
Site 145
S1268
G
L
A
P
F
S
P
S
H
P
A
P
P
S
D
Site 146
S1274
P
S
H
P
A
P
P
S
D
P
S
H
Q
I
S
Site 147
S1277
P
A
P
P
S
D
P
S
H
Q
I
S
P
G
P
Site 148
S1281
S
D
P
S
H
Q
I
S
P
G
P
T
W
D
I
Site 149
T1285
H
Q
I
S
P
G
P
T
W
D
I
K
R
E
H
Site 150
S1301
V
R
K
P
K
E
L
S
A
C
G
Q
K
K
Q
Site 151
S1317
L
G
E
Q
R
E
R
S
A
S
P
Q
R
A
A
Site 152
S1319
E
Q
R
E
R
S
A
S
P
Q
R
A
A
R
P
Site 153
S1345
P
E
A
G
R
P
A
S
E
A
R
A
P
G
L
Site 154
S1375
A
P
R
A
A
A
G
S
E
L
C
R
R
E
G
Site 155
S1397
A
G
P
G
G
G
G
S
G
A
L
E
A
E
G
Site 156
S1439
G
P
W
K
V
P
G
S
D
K
L
P
S
V
L
Site 157
S1444
P
G
S
D
K
L
P
S
V
L
K
P
G
A
S
Site 158
S1451
S
V
L
K
P
G
A
S
A
A
S
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation