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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VRK2
Full Name:
Serine/threonine-protein kinase VRK2
Alias:
EC 2.7.11.1; Serine/threonine protein kinase VRK2; Vaccinia related kinase 2; Vaccinia-related kinase 2
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CK1
group; TTBK family
Mass (Da):
58141
Number AA:
508
UniProt ID:
Q86Y07
International Prot ID:
IPI00329275
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
P
P
K
R
N
E
K
Y
K
L
P
I
P
F
P
Site 2
Y44
S
G
G
F
G
L
I
Y
L
A
F
P
T
N
K
Site 3
Y64
R
H
V
V
K
V
E
Y
Q
E
N
G
P
L
F
Site 4
S72
Q
E
N
G
P
L
F
S
E
L
K
F
Y
Q
R
Site 5
Y77
L
F
S
E
L
K
F
Y
Q
R
V
A
K
K
D
Site 6
Y97
I
E
R
K
Q
L
D
Y
L
G
I
P
L
F
Y
Site 7
Y116
T
E
F
K
G
R
S
Y
R
F
M
V
M
E
R
Site 8
T137
K
I
S
G
Q
N
G
T
F
K
K
S
T
V
L
Site 9
S141
Q
N
G
T
F
K
K
S
T
V
L
Q
L
G
I
Site 10
T142
N
G
T
F
K
K
S
T
V
L
Q
L
G
I
R
Site 11
Y156
R
M
L
D
V
L
E
Y
I
H
E
N
E
Y
V
Site 12
Y162
E
Y
I
H
E
N
E
Y
V
H
G
D
I
K
A
Site 13
Y176
A
A
N
L
L
L
G
Y
K
N
P
D
Q
V
Y
Site 14
Y183
Y
K
N
P
D
Q
V
Y
L
A
D
Y
G
L
S
Site 15
Y187
D
Q
V
Y
L
A
D
Y
G
L
S
Y
R
Y
C
Site 16
Y193
D
Y
G
L
S
Y
R
Y
C
P
N
G
N
H
K
Site 17
Y202
P
N
G
N
H
K
Q
Y
Q
E
N
P
R
K
G
Site 18
T213
P
R
K
G
H
N
G
T
I
E
F
T
S
L
D
Site 19
S218
N
G
T
I
E
F
T
S
L
D
A
H
K
G
V
Site 20
S228
A
H
K
G
V
A
L
S
R
R
S
D
V
E
I
Site 21
S274
L
L
D
E
L
P
Q
S
V
L
K
W
A
P
S
Site 22
S283
L
K
W
A
P
S
G
S
S
C
C
E
I
A
Q
Site 23
S297
Q
F
L
V
C
A
H
S
L
A
Y
D
E
K
P
Site 24
Y306
A
Y
D
E
K
P
N
Y
Q
A
L
K
K
I
L
Site 25
S326
P
L
G
P
L
D
F
S
T
K
G
Q
S
I
N
Site 26
T327
L
G
P
L
D
F
S
T
K
G
Q
S
I
N
V
Site 27
S331
D
F
S
T
K
G
Q
S
I
N
V
H
T
P
N
Site 28
T336
G
Q
S
I
N
V
H
T
P
N
S
Q
K
V
D
Site 29
S339
I
N
V
H
T
P
N
S
Q
K
V
D
S
Q
K
Site 30
S344
P
N
S
Q
K
V
D
S
Q
K
A
A
T
K
Q
Site 31
S366
L
I
E
K
K
V
H
S
E
R
S
A
E
S
C
Site 32
T375
R
S
A
E
S
C
A
T
W
K
V
Q
K
E
E
Site 33
S396
N
N
E
A
A
Q
E
S
T
R
R
R
Q
K
Y
Site 34
Y403
S
T
R
R
R
Q
K
Y
Q
E
S
Q
E
P
L
Site 35
S406
R
R
Q
K
Y
Q
E
S
Q
E
P
L
N
E
V
Site 36
S415
E
P
L
N
E
V
N
S
F
P
Q
K
I
S
Y
Site 37
S421
N
S
F
P
Q
K
I
S
Y
T
Q
F
P
N
S
Site 38
Y422
S
F
P
Q
K
I
S
Y
T
Q
F
P
N
S
F
Site 39
T423
F
P
Q
K
I
S
Y
T
Q
F
P
N
S
F
Y
Site 40
S428
S
Y
T
Q
F
P
N
S
F
Y
E
P
H
Q
D
Site 41
Y430
T
Q
F
P
N
S
F
Y
E
P
H
Q
D
F
T
Site 42
T437
Y
E
P
H
Q
D
F
T
S
P
D
I
F
K
K
Site 43
S438
E
P
H
Q
D
F
T
S
P
D
I
F
K
K
S
Site 44
S445
S
P
D
I
F
K
K
S
R
S
P
S
W
Y
K
Site 45
S447
D
I
F
K
K
S
R
S
P
S
W
Y
K
Y
T
Site 46
S449
F
K
K
S
R
S
P
S
W
Y
K
Y
T
S
T
Site 47
Y451
K
S
R
S
P
S
W
Y
K
Y
T
S
T
V
S
Site 48
Y453
R
S
P
S
W
Y
K
Y
T
S
T
V
S
T
G
Site 49
T454
S
P
S
W
Y
K
Y
T
S
T
V
S
T
G
I
Site 50
S455
P
S
W
Y
K
Y
T
S
T
V
S
T
G
I
T
Site 51
T456
S
W
Y
K
Y
T
S
T
V
S
T
G
I
T
D
Site 52
T459
K
Y
T
S
T
V
S
T
G
I
T
D
L
E
S
Site 53
T462
S
T
V
S
T
G
I
T
D
L
E
S
S
T
G
Site 54
S466
T
G
I
T
D
L
E
S
S
T
G
L
W
P
T
Site 55
T473
S
S
T
G
L
W
P
T
I
S
Q
F
T
L
S
Site 56
S475
T
G
L
W
P
T
I
S
Q
F
T
L
S
E
E
Site 57
S480
T
I
S
Q
F
T
L
S
E
E
T
N
A
D
V
Site 58
Y488
E
E
T
N
A
D
V
Y
Y
Y
R
I
I
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation