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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KHS2
Full Name:
Mitogen-activated protein kinase kinase kinase kinase 3
Alias:
EC 2.7.11.1; Germinal center kinase related protein kinase; GLK; Kinase KHS2; M4K3; MAP4K3; MAPK,ERK kinase kinase kinase 3; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; RAB8IPL1
Type:
EC 2.7.1.37; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; KHS subfamily
Mass (Da):
101316
Number AA:
894
UniProt ID:
Q8IVH8
International Prot ID:
IPI00217024
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0006468
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
P
G
F
D
L
S
R
R
N
P
Q
E
D
Site 2
S24
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
Site 3
T26
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
Site 4
Y27
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
Site 5
Y31
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
Site 6
Y76
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
Site 7
S79
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
Site 8
Y80
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
Site 9
Y102
G
G
S
L
Q
D
I
Y
H
V
T
G
P
L
S
Site 10
Y115
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
Site 11
Y125
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
Site 12
Y126
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
Site 13
T145
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
Site 14
S170
A
T
I
A
K
R
K
S
F
I
G
T
P
Y
W
Site 15
T174
K
R
K
S
F
I
G
T
P
Y
W
M
A
P
E
Site 16
S229
A
L
F
L
M
T
K
S
N
F
Q
P
P
K
L
Site 17
T255
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
Site 18
T263
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
Site 19
S317
A
V
P
H
R
I
H
S
T
S
R
N
V
R
E
Site 20
T318
V
P
H
R
I
H
S
T
S
R
N
V
R
E
E
Site 21
S319
P
H
R
I
H
S
T
S
R
N
V
R
E
E
K
Site 22
T327
R
N
V
R
E
E
K
T
R
S
E
I
T
F
G
Site 23
S329
V
R
E
E
K
T
R
S
E
I
T
F
G
Q
V
Site 24
T332
E
K
T
R
S
E
I
T
F
G
Q
V
K
F
D
Site 25
T346
D
P
P
L
R
K
E
T
E
P
H
H
E
L
P
Site 26
S355
P
H
H
E
L
P
D
S
D
G
F
L
D
S
S
Site 27
S361
D
S
D
G
F
L
D
S
S
E
E
I
Y
Y
T
Site 28
S362
S
D
G
F
L
D
S
S
E
E
I
Y
Y
T
A
Site 29
Y366
L
D
S
S
E
E
I
Y
Y
T
A
R
S
N
L
Site 30
Y367
D
S
S
E
E
I
Y
Y
T
A
R
S
N
L
D
Site 31
T368
S
S
E
E
I
Y
Y
T
A
R
S
N
L
D
L
Site 32
Y379
N
L
D
L
Q
L
E
Y
G
Q
G
H
Q
G
G
Site 33
Y387
G
Q
G
H
Q
G
G
Y
F
L
G
A
N
K
S
Site 34
S394
Y
F
L
G
A
N
K
S
L
L
K
S
V
E
E
Site 35
S398
A
N
K
S
L
L
K
S
V
E
E
E
L
H
Q
Site 36
S422
D
E
G
D
D
D
E
S
K
H
S
T
L
K
A
Site 37
T426
D
D
E
S
K
H
S
T
L
K
A
K
I
P
P
Site 38
S441
P
L
P
P
K
P
K
S
I
F
I
P
Q
E
M
Site 39
T451
I
P
Q
E
M
H
S
T
E
D
E
N
Q
G
T
Site 40
T458
T
E
D
E
N
Q
G
T
I
K
R
C
P
M
S
Site 41
S465
T
I
K
R
C
P
M
S
G
S
P
A
K
P
S
Site 42
S467
K
R
C
P
M
S
G
S
P
A
K
P
S
Q
V
Site 43
S472
S
G
S
P
A
K
P
S
Q
V
P
P
R
P
P
Site 44
S497
A
L
G
N
G
M
S
S
F
Q
L
N
G
E
R
Site 45
S507
L
N
G
E
R
D
G
S
L
C
Q
Q
Q
N
E
Site 46
T518
Q
Q
N
E
H
R
G
T
N
L
S
R
K
E
K
Site 47
S521
E
H
R
G
T
N
L
S
R
K
E
K
K
D
V
Site 48
S533
K
D
V
P
K
P
I
S
N
G
L
P
P
T
P
Site 49
T539
I
S
N
G
L
P
P
T
P
K
V
H
M
G
A
Site 50
Y574
N
P
D
T
R
D
Q
Y
L
I
F
G
A
E
E
Site 51
Y584
F
G
A
E
E
G
I
Y
T
L
N
L
N
E
L
Site 52
T585
G
A
E
E
G
I
Y
T
L
N
L
N
E
L
H
Site 53
T594
N
L
N
E
L
H
E
T
S
M
E
Q
L
F
P
Site 54
S616
V
M
N
N
C
L
L
S
I
S
G
K
A
S
Q
Site 55
S618
N
N
C
L
L
S
I
S
G
K
A
S
Q
L
Y
Site 56
S622
L
S
I
S
G
K
A
S
Q
L
Y
S
H
N
L
Site 57
Y625
S
G
K
A
S
Q
L
Y
S
H
N
L
P
G
L
Site 58
S626
G
K
A
S
Q
L
Y
S
H
N
L
P
G
L
F
Site 59
Y635
N
L
P
G
L
F
D
Y
A
R
Q
M
Q
K
L
Site 60
S661
R
I
L
P
R
K
F
S
V
S
A
K
I
P
E
Site 61
S663
L
P
R
K
F
S
V
S
A
K
I
P
E
T
K
Site 62
Y687
N
P
Y
T
G
H
K
Y
L
C
G
A
L
Q
T
Site 63
T756
N
Q
V
V
R
F
E
T
V
N
P
N
S
T
S
Site 64
S761
F
E
T
V
N
P
N
S
T
S
S
W
F
T
E
Site 65
S763
T
V
N
P
N
S
T
S
S
W
F
T
E
S
D
Site 66
S764
V
N
P
N
S
T
S
S
W
F
T
E
S
D
T
Site 67
T767
N
S
T
S
S
W
F
T
E
S
D
T
P
Q
T
Site 68
S769
T
S
S
W
F
T
E
S
D
T
P
Q
T
N
V
Site 69
T771
S
W
F
T
E
S
D
T
P
Q
T
N
V
T
H
Site 70
S806
N
L
Q
G
R
L
K
S
S
R
K
L
S
S
E
Site 71
S807
L
Q
G
R
L
K
S
S
R
K
L
S
S
E
L
Site 72
S811
L
K
S
S
R
K
L
S
S
E
L
T
F
D
F
Site 73
S812
K
S
S
R
K
L
S
S
E
L
T
F
D
F
Q
Site 74
T815
R
K
L
S
S
E
L
T
F
D
F
Q
I
E
S
Site 75
S842
K
H
G
M
Q
G
R
S
F
R
S
N
E
V
T
Site 76
T849
S
F
R
S
N
E
V
T
Q
E
I
S
D
S
T
Site 77
S853
N
E
V
T
Q
E
I
S
D
S
T
R
I
F
R
Site 78
S855
V
T
Q
E
I
S
D
S
T
R
I
F
R
L
L
Site 79
T875
V
V
L
E
S
R
P
T
D
N
P
T
A
N
S
Site 80
T879
S
R
P
T
D
N
P
T
A
N
S
N
L
Y
I
Site 81
Y885
P
T
A
N
S
N
L
Y
I
L
A
G
H
E
N
Site 82
S893
I
L
A
G
H
E
N
S
Y
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation