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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPH2
Full Name:
Tryptophan 5-hydroxylase 2
Alias:
FLJ37295; Neuronal tryptophan hydroxylase; NTPH; Tryptophan 5- monooxygenase 2; tryptophan hydroxylase 2
Type:
EC 1.14.16.4; Amino Acid Metabolism - tryptophan; Oxidoreductase
Mass (Da):
56057
Number AA:
490
UniProt ID:
Q8IWU9
International Prot ID:
IPI00217398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016597
GO:0005506
GO:0004510
PhosphoSite+
KinaseNET
Biological Process:
GO:0009072
GO:0055114
GO:0042427
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
M
M
M
F
S
S
K
Y
W
A
R
R
G
F
S
Site 2
S19
Y
W
A
R
R
G
F
S
L
D
S
A
V
P
E
Site 3
S22
R
R
G
F
S
L
D
S
A
V
P
E
E
H
Q
Site 4
T35
H
Q
L
L
G
S
S
T
L
N
K
P
N
S
G
Site 5
S41
S
T
L
N
K
P
N
S
G
K
N
D
D
K
G
Site 6
S53
D
K
G
N
K
G
S
S
K
R
E
A
A
T
E
Site 7
T59
S
S
K
R
E
A
A
T
E
S
G
K
T
A
V
Site 8
S99
V
H
I
E
S
R
K
S
R
R
R
S
S
E
V
Site 9
S103
S
R
K
S
R
R
R
S
S
E
V
E
I
F
V
Site 10
S104
R
K
S
R
R
R
S
S
E
V
E
I
F
V
D
Site 11
T134
K
F
Q
T
T
I
V
T
L
N
P
P
E
N
I
Site 12
T143
N
P
P
E
N
I
W
T
E
E
E
E
L
E
D
Site 13
S159
P
W
F
P
R
K
I
S
E
L
D
K
C
S
H
Site 14
Y187
P
G
F
K
D
N
V
Y
R
Q
R
R
K
Y
F
Site 15
Y193
V
Y
R
Q
R
R
K
Y
F
V
D
V
A
M
G
Site 16
Y203
D
V
A
M
G
Y
K
Y
G
Q
P
I
P
R
V
Site 17
Y212
Q
P
I
P
R
V
E
Y
T
E
E
E
T
K
T
Site 18
T219
Y
T
E
E
E
T
K
T
W
G
V
V
F
R
E
Site 19
S228
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Site 20
Y231
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Site 21
Y239
P
T
H
A
C
R
E
Y
L
K
N
F
P
L
L
Site 22
Y249
N
F
P
L
L
T
K
Y
C
G
Y
R
E
D
N
Site 23
S264
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Site 24
T274
L
K
E
R
S
G
F
T
V
R
P
V
A
G
Y
Site 25
S283
R
P
V
A
G
Y
L
S
P
R
D
F
L
A
G
Site 26
Y293
D
F
L
A
G
L
A
Y
R
V
F
H
C
T
Q
Site 27
Y301
R
V
F
H
C
T
Q
Y
I
R
H
G
S
D
P
Site 28
S306
T
Q
Y
I
R
H
G
S
D
P
L
Y
T
P
E
Site 29
Y310
R
H
G
S
D
P
L
Y
T
P
E
P
D
T
C
Site 30
T311
H
G
S
D
P
L
Y
T
P
E
P
D
T
C
H
Site 31
T316
L
Y
T
P
E
P
D
T
C
H
E
L
L
G
H
Site 32
S336
D
P
K
F
A
Q
F
S
Q
E
I
G
L
A
S
Site 33
S343
S
Q
E
I
G
L
A
S
L
G
A
S
D
E
D
Site 34
S347
G
L
A
S
L
G
A
S
D
E
D
V
Q
K
L
Site 35
Y376
Q
E
G
Q
L
R
A
Y
G
A
G
L
L
S
S
Site 36
S382
A
Y
G
A
G
L
L
S
S
I
G
E
L
K
H
Site 37
S392
G
E
L
K
H
A
L
S
D
K
A
C
V
K
A
Site 38
T404
V
K
A
F
D
P
K
T
T
C
L
Q
E
C
L
Site 39
Y419
I
T
T
F
Q
E
A
Y
F
V
S
E
S
F
E
Site 40
S424
E
A
Y
F
V
S
E
S
F
E
E
A
K
E
K
Site 41
S438
K
M
R
D
F
A
K
S
I
T
R
P
F
S
V
Site 42
T440
R
D
F
A
K
S
I
T
R
P
F
S
V
Y
F
Site 43
S444
K
S
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Site 44
Y446
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Q
S
Site 45
T451
S
V
Y
F
N
P
Y
T
Q
S
I
E
I
L
K
Site 46
T460
S
I
E
I
L
K
D
T
R
S
I
E
N
V
V
Site 47
S462
E
I
L
K
D
T
R
S
I
E
N
V
V
Q
D
Site 48
S472
N
V
V
Q
D
L
R
S
D
L
N
T
V
C
D
Site 49
T476
D
L
R
S
D
L
N
T
V
C
D
A
L
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation