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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SirT2
Full Name:
NAD-dependent deacetylase sirtuin-2
Alias:
SIR2L; SIR2-like 2; SIR2-like protein 2; Sirtuin (silent mating type information regulation 2) 2
Type:
EC 3.5.1.-; Deacetylase
Mass (Da):
43182
Number AA:
389
UniProt ID:
Q8IXJ6
International Prot ID:
IPI00179109
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005677
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0070403
GO:0017136
GO:0035035
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0000183
GO:0006348
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
E
P
D
P
S
H
P
L
E
T
Q
A
Site 2
S23
K
V
Q
E
A
Q
D
S
D
S
D
S
E
G
G
Site 3
S25
Q
E
A
Q
D
S
D
S
D
S
E
G
G
A
A
Site 4
S27
A
Q
D
S
D
S
D
S
E
G
G
A
A
G
G
Site 5
S46
D
F
L
R
N
L
F
S
Q
T
L
S
L
G
S
Site 6
T48
L
R
N
L
F
S
Q
T
L
S
L
G
S
Q
K
Site 7
S50
N
L
F
S
Q
T
L
S
L
G
S
Q
K
E
R
Site 8
S53
S
Q
T
L
S
L
G
S
Q
K
E
R
L
L
D
Site 9
T63
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
Site 10
S98
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
Site 11
S100
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
Site 12
Y104
R
S
P
S
T
G
L
Y
D
N
L
E
K
Y
H
Site 13
Y110
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
Site 14
Y114
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
Site 15
Y123
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
Site 16
Y139
F
A
L
A
K
E
L
Y
P
G
Q
F
K
P
T
Site 17
Y150
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
Site 18
Y165
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
Site 19
S199
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
Site 20
Y204
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
Site 21
T218
E
K
I
F
S
E
V
T
P
K
C
E
D
C
Q
Site 22
S226
P
K
C
E
D
C
Q
S
L
V
K
P
D
I
V
Site 23
S271
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
L
Site 24
S274
Q
P
F
A
S
L
I
S
K
A
P
L
S
T
P
Site 25
T280
I
S
K
A
P
L
S
T
P
R
L
L
I
N
K
Site 26
S293
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
Site 27
S311
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
Site 28
Y315
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
Site 29
S351
L
V
R
R
E
H
A
S
I
D
A
Q
S
G
A
Site 30
S364
G
A
G
V
P
N
P
S
T
S
A
S
P
K
K
Site 31
T365
A
G
V
P
N
P
S
T
S
A
S
P
K
K
S
Site 32
S366
G
V
P
N
P
S
T
S
A
S
P
K
K
S
P
Site 33
S368
P
N
P
S
T
S
A
S
P
K
K
S
P
P
P
Site 34
S372
T
S
A
S
P
K
K
S
P
P
P
A
K
D
E
Site 35
T383
A
K
D
E
A
R
T
T
E
R
E
K
P
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation