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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAF1L
Full Name:
Transcription initiation factor TFIID subunit 1-like
Alias:
Transcription initiation factor TFIID 210 kDa subunit
Type:
Protein-serine kinase, Atypical group, TAF1 family
Mass (Da):
207302
Number AA:
1826
UniProt ID:
Q8IZX4
International Prot ID:
IPI00100867
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005669
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0017025
GO:0004402
PhosphoSite+
KinaseNET
Biological Process:
GO:0007140
GO:0006357
GO:0006352
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
T
V
T
A
A
I
M
S
D
S
D
S
E
E
D
Site 2
S23
T
A
A
I
M
S
D
S
D
S
E
E
D
S
S
Site 3
S25
A
I
M
S
D
S
D
S
E
E
D
S
S
G
G
Site 4
S29
D
S
D
S
E
E
D
S
S
G
G
G
P
F
T
Site 5
S30
S
D
S
E
E
D
S
S
G
G
G
P
F
T
L
Site 6
T81
G
S
L
I
T
E
L
T
A
N
E
E
L
T
G
Site 7
T89
A
N
E
E
L
T
G
T
G
G
A
L
V
N
D
Site 8
S102
N
D
E
G
W
I
R
S
T
E
D
A
V
D
Y
Site 9
T103
D
E
G
W
I
R
S
T
E
D
A
V
D
Y
S
Site 10
Y109
S
T
E
D
A
V
D
Y
S
D
I
N
E
V
A
Site 11
S110
T
E
D
A
V
D
Y
S
D
I
N
E
V
A
E
Site 12
S120
N
E
V
A
E
D
E
S
Q
R
H
Q
Q
T
M
Site 13
S129
R
H
Q
Q
T
M
G
S
L
Q
P
L
Y
H
S
Site 14
Y134
M
G
S
L
Q
P
L
Y
H
S
D
Y
D
E
D
Site 15
S136
S
L
Q
P
L
Y
H
S
D
Y
D
E
D
D
Y
Site 16
Y138
Q
P
L
Y
H
S
D
Y
D
E
D
D
Y
D
A
Site 17
Y143
S
D
Y
D
E
D
D
Y
D
A
D
C
E
D
I
Site 18
T175
D
K
D
Q
D
A
I
T
C
V
S
E
S
G
E
Site 19
S203
A
S
E
K
V
D
F
S
S
Y
S
D
S
E
S
Site 20
S204
S
E
K
V
D
F
S
S
Y
S
D
S
E
S
E
Site 21
Y205
E
K
V
D
F
S
S
Y
S
D
S
E
S
E
M
Site 22
S206
K
V
D
F
S
S
Y
S
D
S
E
S
E
M
G
Site 23
S208
D
F
S
S
Y
S
D
S
E
S
E
M
G
P
Q
Site 24
S210
S
S
Y
S
D
S
E
S
E
M
G
P
Q
E
A
Site 25
T228
E
S
E
D
G
K
L
T
L
P
L
A
G
I
M
Site 26
S245
D
A
T
K
L
L
P
S
V
T
E
L
F
P
E
Site 27
S273
G
P
G
K
N
V
P
S
V
W
R
S
A
R
R
Site 28
S277
N
V
P
S
V
W
R
S
A
R
R
K
R
K
K
Site 29
S300
Q
I
Q
E
V
E
C
S
V
E
S
E
V
S
Q
Site 30
S303
E
V
E
C
S
V
E
S
E
V
S
Q
K
S
L
Site 31
S306
C
S
V
E
S
E
V
S
Q
K
S
L
W
N
Y
Site 32
S309
E
S
E
V
S
Q
K
S
L
W
N
Y
D
Y
A
Site 33
Y313
S
Q
K
S
L
W
N
Y
D
Y
A
P
P
P
P
Site 34
Y315
K
S
L
W
N
Y
D
Y
A
P
P
P
P
P
E
Site 35
S338
T
M
M
V
P
V
E
S
K
F
S
Q
S
T
G
Site 36
S341
V
P
V
E
S
K
F
S
Q
S
T
G
D
V
D
Site 37
T351
T
G
D
V
D
K
V
T
D
T
K
P
R
V
A
Site 38
T353
D
V
D
K
V
T
D
T
K
P
R
V
A
E
W
Site 39
Y362
P
R
V
A
E
W
R
Y
G
P
A
R
L
W
Y
Site 40
Y369
Y
G
P
A
R
L
W
Y
D
M
L
G
V
S
E
Site 41
S375
W
Y
D
M
L
G
V
S
E
D
G
S
G
F
D
Site 42
S379
L
G
V
S
E
D
G
S
G
F
D
Y
G
F
K
Site 43
Y383
E
D
G
S
G
F
D
Y
G
F
K
L
R
K
T
Site 44
T390
Y
G
F
K
L
R
K
T
Q
H
E
P
V
I
K
Site 45
S410
E
F
R
K
L
E
E
S
N
G
T
D
L
L
A
Site 46
S451
G
T
K
P
Q
G
A
S
L
A
G
W
L
P
S
Site 47
Y467
K
T
R
N
V
M
A
Y
N
V
Q
Q
G
F
A
Site 48
Y484
L
D
D
D
K
P
W
Y
S
I
F
P
I
D
N
Site 49
Y496
I
D
N
E
D
L
V
Y
G
R
W
E
D
N
I
Site 50
T540
P
D
E
K
E
E
A
T
S
N
S
P
S
K
E
Site 51
S541
D
E
K
E
E
A
T
S
N
S
P
S
K
E
S
Site 52
S543
K
E
E
A
T
S
N
S
P
S
K
E
S
K
K
Site 53
S545
E
A
T
S
N
S
P
S
K
E
S
K
K
E
S
Site 54
S548
S
N
S
P
S
K
E
S
K
K
E
S
S
L
K
Site 55
S552
S
K
E
S
K
K
E
S
S
L
K
K
S
R
I
Site 56
S553
K
E
S
K
K
E
S
S
L
K
K
S
R
I
L
Site 57
S557
K
E
S
S
L
K
K
S
R
I
L
L
G
K
T
Site 58
S576
E
E
P
Q
Q
N
M
S
Q
P
E
V
K
D
P
Site 59
Y591
W
N
L
S
N
D
E
Y
Y
F
P
K
Q
Q
G
Site 60
Y592
N
L
S
N
D
E
Y
Y
F
P
K
Q
Q
G
L
Site 61
T602
K
Q
Q
G
L
R
G
T
F
G
G
N
I
I
Q
Site 62
Y642
H
R
P
P
L
K
K
Y
S
F
G
A
L
S
Q
Site 63
S643
R
P
P
L
K
K
Y
S
F
G
A
L
S
Q
P
Site 64
S648
K
Y
S
F
G
A
L
S
Q
P
G
P
H
S
V
Site 65
S654
L
S
Q
P
G
P
H
S
V
Q
P
L
L
K
H
Site 66
S676
R
E
Q
E
R
Q
A
S
G
G
G
E
L
F
F
Site 67
T686
G
E
L
F
F
M
R
T
P
Q
D
L
T
G
K
Site 68
T691
M
R
T
P
Q
D
L
T
G
K
D
G
D
L
I
Site 69
Y702
G
D
L
I
L
A
E
Y
S
E
E
N
G
P
L
Site 70
S703
D
L
I
L
A
E
Y
S
E
E
N
G
P
L
M
Site 71
Y722
M
A
T
K
I
K
N
Y
Y
K
R
K
P
G
K
Site 72
Y723
A
T
K
I
K
N
Y
Y
K
R
K
P
G
K
D
Site 73
Y738
P
G
A
P
D
C
K
Y
G
E
T
V
Y
C
H
Site 74
Y743
C
K
Y
G
E
T
V
Y
C
H
T
S
P
F
L
Site 75
S747
E
T
V
Y
C
H
T
S
P
F
L
G
S
L
H
Site 76
S752
H
T
S
P
F
L
G
S
L
H
P
G
Q
L
L
Site 77
Y772
N
L
F
R
A
P
V
Y
L
H
K
M
P
E
T
Site 78
Y790
I
I
R
T
R
Q
G
Y
Y
I
R
E
L
V
D
Site 79
S815
F
E
V
P
G
P
N
S
R
R
A
N
M
H
I
Site 80
S855
D
I
K
K
A
F
P
S
H
S
E
S
S
I
R
Site 81
S857
K
K
A
F
P
S
H
S
E
S
S
I
R
K
R
Site 82
S859
A
F
P
S
H
S
E
S
S
I
R
K
R
L
K
Site 83
S860
F
P
S
H
S
E
S
S
I
R
K
R
L
K
L
Site 84
S885
S
N
W
W
V
L
K
S
D
F
R
L
P
T
E
Site 85
T891
K
S
D
F
R
L
P
T
E
E
E
I
R
A
K
Site 86
S900
E
E
I
R
A
K
V
S
P
E
Q
C
C
A
Y
Site 87
Y907
S
P
E
Q
C
C
A
Y
Y
S
M
I
A
A
K
Site 88
Y922
Q
R
L
K
D
A
G
Y
G
E
K
S
F
F
A
Site 89
S926
D
A
G
Y
G
E
K
S
F
F
A
P
E
E
E
Site 90
S983
T
G
C
G
E
G
F
S
Y
V
K
I
P
N
K
Site 91
Y984
G
C
G
E
G
F
S
Y
V
K
I
P
N
K
P
Site 92
T1006
E
P
Q
A
V
K
K
T
V
T
G
T
D
A
D
Site 93
S1018
D
A
D
L
R
R
L
S
L
K
N
A
K
Q
L
Site 94
S1052
I
D
V
V
R
T
M
S
T
E
Q
A
H
S
G
Site 95
S1058
M
S
T
E
Q
A
H
S
G
E
G
P
M
S
K
Site 96
S1064
H
S
G
E
G
P
M
S
K
F
A
R
G
S
R
Site 97
S1070
M
S
K
F
A
R
G
S
R
F
S
V
A
E
H
Site 98
S1073
F
A
R
G
S
R
F
S
V
A
E
H
Q
E
R
Site 99
S1098
L
Q
N
K
V
L
S
S
T
E
V
L
S
T
D
Site 100
S1103
L
S
S
T
E
V
L
S
T
D
T
D
S
I
S
Site 101
T1104
S
S
T
E
V
L
S
T
D
T
D
S
I
S
A
Site 102
T1106
T
E
V
L
S
T
D
T
D
S
I
S
A
E
D
Site 103
S1108
V
L
S
T
D
T
D
S
I
S
A
E
D
S
D
Site 104
S1110
S
T
D
T
D
S
I
S
A
E
D
S
D
F
E
Site 105
S1114
D
S
I
S
A
E
D
S
D
F
E
E
M
G
K
Site 106
T1132
N
M
L
Q
N
K
K
T
S
S
Q
L
S
R
E
Site 107
S1134
L
Q
N
K
K
T
S
S
Q
L
S
R
E
W
E
Site 108
S1137
K
K
T
S
S
Q
L
S
R
E
W
E
E
Q
E
Site 109
S1157
R
M
L
L
V
A
G
S
A
A
S
G
N
N
H
Site 110
T1169
N
N
H
R
D
D
V
T
A
S
M
T
S
L
K
Site 111
S1171
H
R
D
D
V
T
A
S
M
T
S
L
K
S
S
Site 112
T1173
D
D
V
T
A
S
M
T
S
L
K
S
S
A
T
Site 113
S1174
D
V
T
A
S
M
T
S
L
K
S
S
A
T
G
Site 114
S1177
A
S
M
T
S
L
K
S
S
A
T
G
H
C
L
Site 115
S1178
S
M
T
S
L
K
S
S
A
T
G
H
C
L
K
Site 116
Y1187
T
G
H
C
L
K
I
Y
R
T
F
R
D
E
E
Site 117
T1189
H
C
L
K
I
Y
R
T
F
R
D
E
E
G
K
Site 118
Y1198
R
D
E
E
G
K
E
Y
V
R
C
E
T
V
R
Site 119
T1203
K
E
Y
V
R
C
E
T
V
R
K
P
A
V
I
Site 120
Y1213
K
P
A
V
I
D
A
Y
V
R
I
R
T
T
K
Site 121
T1218
D
A
Y
V
R
I
R
T
T
K
D
E
K
F
I
Site 122
T1219
A
Y
V
R
I
R
T
T
K
D
E
K
F
I
Q
Site 123
Y1301
T
N
K
F
C
P
L
Y
Y
Q
T
N
V
P
P
Site 124
Y1302
N
K
F
C
P
L
Y
Y
Q
T
N
V
P
P
S
Site 125
T1304
F
C
P
L
Y
Y
Q
T
N
V
P
P
S
K
P
Site 126
S1309
Y
Q
T
N
V
P
P
S
K
P
V
A
M
T
E
Site 127
T1325
Q
E
E
E
L
E
K
T
V
I
H
N
D
N
E
Site 128
S1359
V
H
E
V
R
R
K
S
L
V
L
K
F
P
K
Site 129
T1379
K
K
K
R
R
V
G
T
T
V
H
C
D
Y
L
Site 130
T1380
K
K
R
R
V
G
T
T
V
H
C
D
Y
L
N
Site 131
Y1385
G
T
T
V
H
C
D
Y
L
N
I
P
H
K
S
Site 132
T1398
K
S
I
H
R
R
R
T
D
P
M
V
T
L
S
Site 133
T1403
R
R
T
D
P
M
V
T
L
S
S
I
L
E
S
Site 134
S1410
T
L
S
S
I
L
E
S
I
I
N
D
M
R
D
Site 135
T1421
D
M
R
D
L
P
N
T
H
P
F
H
T
P
V
Site 136
T1426
P
N
T
H
P
F
H
T
P
V
N
A
K
V
V
Site 137
Y1436
N
A
K
V
V
K
D
Y
Y
K
I
I
T
R
P
Site 138
Y1437
A
K
V
V
K
D
Y
Y
K
I
I
T
R
P
M
Site 139
T1448
T
R
P
M
D
L
Q
T
L
R
E
N
V
R
K
Site 140
Y1458
E
N
V
R
K
C
L
Y
P
S
R
E
E
F
R
Site 141
S1460
V
R
K
C
L
Y
P
S
R
E
E
F
R
E
H
Site 142
S1475
L
E
L
I
V
K
N
S
A
T
Y
N
G
P
K
Site 143
T1477
L
I
V
K
N
S
A
T
Y
N
G
P
K
H
S
Site 144
Y1478
I
V
K
N
S
A
T
Y
N
G
P
K
H
S
L
Site 145
S1484
T
Y
N
G
P
K
H
S
L
T
Q
I
S
Q
S
Site 146
T1486
N
G
P
K
H
S
L
T
Q
I
S
Q
S
M
L
Site 147
S1489
K
H
S
L
T
Q
I
S
Q
S
M
L
D
L
C
Site 148
S1491
S
L
T
Q
I
S
Q
S
M
L
D
L
C
D
E
Site 149
Y1559
N
K
K
F
V
P
D
Y
Y
K
M
I
V
N
P
Site 150
Y1560
K
K
F
V
P
D
Y
Y
K
M
I
V
N
P
V
Site 151
T1571
V
N
P
V
D
L
E
T
I
R
K
N
I
S
K
Site 152
Y1581
K
N
I
S
K
H
K
Y
Q
S
R
E
S
F
L
Site 153
S1583
I
S
K
H
K
Y
Q
S
R
E
S
F
L
D
D
Site 154
S1586
H
K
Y
Q
S
R
E
S
F
L
D
D
V
N
L
Site 155
S1598
V
N
L
I
L
A
N
S
V
K
Y
N
G
P
E
Site 156
Y1601
I
L
A
N
S
V
K
Y
N
G
P
E
S
Q
Y
Site 157
S1606
V
K
Y
N
G
P
E
S
Q
Y
T
K
T
A
Q
Site 158
T1609
N
G
P
E
S
Q
Y
T
K
T
A
Q
E
I
V
Site 159
Y1620
Q
E
I
V
N
I
C
Y
Q
T
I
T
E
Y
D
Site 160
Y1626
C
Y
Q
T
I
T
E
Y
D
E
H
L
T
Q
L
Site 161
S1652
L
E
E
A
E
L
E
S
L
D
P
M
T
P
G
Site 162
T1657
L
E
S
L
D
P
M
T
P
G
P
Y
T
S
Q
Site 163
Y1661
D
P
M
T
P
G
P
Y
T
S
Q
P
P
D
M
Site 164
T1662
P
M
T
P
G
P
Y
T
S
Q
P
P
D
M
Y
Site 165
S1663
M
T
P
G
P
Y
T
S
Q
P
P
D
M
Y
D
Site 166
Y1669
T
S
Q
P
P
D
M
Y
D
T
N
T
S
L
S
Site 167
T1671
Q
P
P
D
M
Y
D
T
N
T
S
L
S
T
S
Site 168
T1673
P
D
M
Y
D
T
N
T
S
L
S
T
S
R
D
Site 169
S1674
D
M
Y
D
T
N
T
S
L
S
T
S
R
D
A
Site 170
S1676
Y
D
T
N
T
S
L
S
T
S
R
D
A
S
V
Site 171
S1678
T
N
T
S
L
S
T
S
R
D
A
S
V
F
Q
Site 172
S1682
L
S
T
S
R
D
A
S
V
F
Q
D
E
S
N
Site 173
S1691
F
Q
D
E
S
N
L
S
V
L
D
I
S
T
A
Site 174
T1697
L
S
V
L
D
I
S
T
A
T
P
E
K
Q
M
Site 175
T1699
V
L
D
I
S
T
A
T
P
E
K
Q
M
C
Q
Site 176
S1716
G
R
L
G
E
E
D
S
D
V
D
V
E
G
Y
Site 177
T1751
L
A
D
E
E
E
G
T
V
Q
Q
P
E
A
S
Site 178
S1778
D
D
E
E
D
A
G
S
D
E
E
G
D
N
P
Site 179
S1787
E
E
G
D
N
P
F
S
A
I
Q
L
S
E
S
Site 180
S1792
P
F
S
A
I
Q
L
S
E
S
G
S
D
S
D
Site 181
S1794
S
A
I
Q
L
S
E
S
G
S
D
S
D
V
G
Site 182
S1796
I
Q
L
S
E
S
G
S
D
S
D
V
G
Y
G
Site 183
S1798
L
S
E
S
G
S
D
S
D
V
G
Y
G
G
I
Site 184
Y1802
G
S
D
S
D
V
G
Y
G
G
I
R
P
K
Q
Site 185
S1817
P
F
M
L
Q
H
A
S
G
E
H
K
D
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation