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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPTOR
Full Name:
Regulatory-associated protein of mTOR
Alias:
KIAA1303; KOG1; Mip1; P150 target of rapamycin (TOR)-scaffold protein; RAPTOR; Regulatory associated protein of mTOR; Regulatory associated protein of MTOR, complex 1; Regulatory-associated protein of mTOR: P150 target of rapamycin (TOR)-scaffold protein; RPOR
Type:
Adapter/scaffold protein
Mass (Da):
149038
Number AA:
1335
UniProt ID:
Q8N122
International Prot ID:
IPI00166044
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031931
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0032403
PhosphoSite+
KinaseNET
Biological Process:
GO:0031669
GO:0032008
GO:0008361
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
S
E
M
L
Q
S
P
L
L
G
L
G
E
Site 2
T22
E
E
D
E
A
D
L
T
D
W
N
L
P
L
A
Site 3
S44
E
K
I
E
G
S
K
S
L
A
Q
S
W
R
M
Site 4
S48
G
S
K
S
L
A
Q
S
W
R
M
K
D
R
M
Site 5
T79
P
P
D
V
V
K
T
T
P
C
A
R
L
E
C
Site 6
S92
E
C
W
I
D
P
L
S
M
G
P
Q
K
A
L
Site 7
Y119
N
W
Q
P
R
A
R
Y
K
Q
S
L
D
P
T
Site 8
S122
P
R
A
R
Y
K
Q
S
L
D
P
T
V
D
E
Site 9
T126
Y
K
Q
S
L
D
P
T
V
D
E
V
K
K
L
Site 10
S136
E
V
K
K
L
C
T
S
L
R
R
N
A
K
E
Site 11
Y150
E
E
R
V
L
F
H
Y
N
G
H
G
V
P
R
Site 12
T159
G
H
G
V
P
R
P
T
V
N
G
E
V
W
V
Site 13
Y171
V
W
V
F
N
K
N
Y
T
Q
Y
I
P
L
S
Site 14
Y174
F
N
K
N
Y
T
Q
Y
I
P
L
S
I
Y
D
Site 15
Y180
Q
Y
I
P
L
S
I
Y
D
L
Q
T
W
M
G
Site 16
S188
D
L
Q
T
W
M
G
S
P
S
I
F
V
Y
D
Site 17
S236
A
Q
M
P
L
P
P
S
M
K
N
C
I
Q
L
Site 18
T307
G
R
L
N
D
R
R
T
P
L
G
E
L
N
W
Site 19
S359
L
A
E
R
I
M
R
S
Y
N
C
T
P
V
S
Site 20
Y360
A
E
R
I
M
R
S
Y
N
C
T
P
V
S
S
Site 21
T363
I
M
R
S
Y
N
C
T
P
V
S
S
P
R
L
Site 22
S366
S
Y
N
C
T
P
V
S
S
P
R
L
P
P
T
Site 23
S367
Y
N
C
T
P
V
S
S
P
R
L
P
P
T
Y
Site 24
Y374
S
P
R
L
P
P
T
Y
M
H
A
M
W
Q
A
Site 25
T401
P
T
I
I
E
E
G
T
A
F
R
H
S
P
F
Site 26
S406
E
G
T
A
F
R
H
S
P
F
F
A
E
Q
L
Site 27
S482
Y
V
L
K
L
L
Q
S
S
A
R
E
L
R
P
Site 28
S483
V
L
K
L
L
Q
S
S
A
R
E
L
R
P
L
Site 29
Y517
V
K
D
N
G
H
K
Y
F
L
S
V
L
A
D
Site 30
Y526
L
S
V
L
A
D
P
Y
M
P
A
E
H
R
T
Site 31
S599
R
W
C
G
V
R
D
S
A
H
E
K
L
Y
S
Site 32
S606
S
A
H
E
K
L
Y
S
L
L
S
D
P
I
P
Site 33
S609
E
K
L
Y
S
L
L
S
D
P
I
P
E
V
R
Site 34
S630
L
G
T
F
V
G
N
S
A
E
R
T
D
H
S
Site 35
T634
V
G
N
S
A
E
R
T
D
H
S
T
T
I
D
Site 36
T638
A
E
R
T
D
H
S
T
T
I
D
H
N
V
A
Site 37
S656
A
Q
L
V
S
D
G
S
P
M
V
R
K
E
L
Site 38
Y692
F
I
E
E
E
K
N
Y
A
L
P
S
P
A
T
Site 39
S696
E
K
N
Y
A
L
P
S
P
A
T
T
E
G
G
Site 40
T699
Y
A
L
P
S
P
A
T
T
E
G
G
S
L
T
Site 41
T700
A
L
P
S
P
A
T
T
E
G
G
S
L
T
P
Site 42
S704
P
A
T
T
E
G
G
S
L
T
P
V
R
D
S
Site 43
T706
T
T
E
G
G
S
L
T
P
V
R
D
S
P
C
Site 44
S711
S
L
T
P
V
R
D
S
P
C
T
P
R
L
R
Site 45
T714
P
V
R
D
S
P
C
T
P
R
L
R
S
V
S
Site 46
S719
P
C
T
P
R
L
R
S
V
S
S
Y
G
N
I
Site 47
S721
T
P
R
L
R
S
V
S
S
Y
G
N
I
R
A
Site 48
S722
P
R
L
R
S
V
S
S
Y
G
N
I
R
A
V
Site 49
Y723
R
L
R
S
V
S
S
Y
G
N
I
R
A
V
A
Site 50
S734
R
A
V
A
T
A
R
S
L
N
K
S
L
Q
N
Site 51
S738
T
A
R
S
L
N
K
S
L
Q
N
L
S
L
T
Site 52
S743
N
K
S
L
Q
N
L
S
L
T
E
E
S
G
G
Site 53
T745
S
L
Q
N
L
S
L
T
E
E
S
G
G
A
V
Site 54
S760
A
F
S
P
G
N
L
S
T
S
S
S
A
S
S
Site 55
T761
F
S
P
G
N
L
S
T
S
S
S
A
S
S
T
Site 56
S762
S
P
G
N
L
S
T
S
S
S
A
S
S
T
L
Site 57
S763
P
G
N
L
S
T
S
S
S
A
S
S
T
L
G
Site 58
S764
G
N
L
S
T
S
S
S
A
S
S
T
L
G
S
Site 59
S766
L
S
T
S
S
S
A
S
S
T
L
G
S
P
E
Site 60
S767
S
T
S
S
S
A
S
S
T
L
G
S
P
E
N
Site 61
T768
T
S
S
S
A
S
S
T
L
G
S
P
E
N
E
Site 62
S771
S
A
S
S
T
L
G
S
P
E
N
E
E
H
I
Site 63
S780
E
N
E
E
H
I
L
S
F
E
T
I
D
K
M
Site 64
S791
I
D
K
M
R
R
A
S
S
Y
S
S
L
N
S
Site 65
S792
D
K
M
R
R
A
S
S
Y
S
S
L
N
S
L
Site 66
Y793
K
M
R
R
A
S
S
Y
S
S
L
N
S
L
I
Site 67
S794
M
R
R
A
S
S
Y
S
S
L
N
S
L
I
G
Site 68
S795
R
R
A
S
S
Y
S
S
L
N
S
L
I
G
V
Site 69
S836
V
A
M
K
V
L
N
S
I
A
Y
K
A
T
V
Site 70
T842
N
S
I
A
Y
K
A
T
V
N
A
R
P
Q
R
Site 71
T853
R
P
Q
R
V
L
D
T
S
S
L
T
Q
S
A
Site 72
S854
P
Q
R
V
L
D
T
S
S
L
T
Q
S
A
P
Site 73
S855
Q
R
V
L
D
T
S
S
L
T
Q
S
A
P
A
Site 74
T857
V
L
D
T
S
S
L
T
Q
S
A
P
A
S
P
Site 75
S859
D
T
S
S
L
T
Q
S
A
P
A
S
P
T
N
Site 76
S863
L
T
Q
S
A
P
A
S
P
T
N
K
G
V
H
Site 77
T865
Q
S
A
P
A
S
P
T
N
K
G
V
H
I
H
Site 78
S877
H
I
H
Q
A
G
G
S
P
P
A
S
S
T
S
Site 79
S881
A
G
G
S
P
P
A
S
S
T
S
S
S
S
L
Site 80
S882
G
G
S
P
P
A
S
S
T
S
S
S
S
L
T
Site 81
T883
G
S
P
P
A
S
S
T
S
S
S
S
L
T
N
Site 82
S884
S
P
P
A
S
S
T
S
S
S
S
L
T
N
D
Site 83
S885
P
P
A
S
S
T
S
S
S
S
L
T
N
D
V
Site 84
S886
P
A
S
S
T
S
S
S
S
L
T
N
D
V
A
Site 85
S887
A
S
S
T
S
S
S
S
L
T
N
D
V
A
K
Site 86
T889
S
T
S
S
S
S
L
T
N
D
V
A
K
Q
P
Site 87
S898
D
V
A
K
Q
P
V
S
R
D
L
P
S
G
R
Site 88
S903
P
V
S
R
D
L
P
S
G
R
P
G
T
T
G
Site 89
T908
L
P
S
G
R
P
G
T
T
G
P
A
G
A
Q
Site 90
Y916
T
G
P
A
G
A
Q
Y
T
P
H
S
H
Q
F
Site 91
T917
G
P
A
G
A
Q
Y
T
P
H
S
H
Q
F
P
Site 92
S920
G
A
Q
Y
T
P
H
S
H
Q
F
P
R
T
R
Site 93
S949
D
D
A
A
G
H
K
S
F
I
S
A
T
V
Q
Site 94
T954
H
K
S
F
I
S
A
T
V
Q
T
G
F
C
D
Site 95
S982
P
E
E
H
D
L
E
S
Q
I
R
K
E
R
E
Site 96
S996
E
W
R
F
L
R
N
S
R
V
R
R
Q
A
Q
Site 97
S1027
N
R
N
P
G
V
P
S
V
V
K
F
H
P
F
Site 98
Y1059
E
K
G
E
K
L
D
Y
F
H
N
G
N
P
R
Site 99
Y1067
F
H
N
G
N
P
R
Y
T
R
V
T
A
M
E
Site 100
T1071
N
P
R
Y
T
R
V
T
A
M
E
Y
L
N
G
Site 101
Y1075
T
R
V
T
A
M
E
Y
L
N
G
Q
D
C
S
Site 102
S1116
V
T
A
W
Q
G
L
S
D
M
L
P
T
T
R
Site 103
T1152
R
I
V
R
I
W
D
T
D
R
E
M
K
V
Q
Site 104
T1163
M
K
V
Q
D
I
P
T
G
A
D
S
C
V
T
Site 105
S1171
G
A
D
S
C
V
T
S
L
S
C
D
S
H
R
Site 106
S1173
D
S
C
V
T
S
L
S
C
D
S
H
R
S
L
Site 107
S1189
V
A
G
L
G
D
G
S
I
R
V
Y
D
R
R
Site 108
Y1193
G
D
G
S
I
R
V
Y
D
R
R
M
A
L
S
Site 109
T1211
V
M
T
Y
R
E
H
T
A
W
V
V
K
A
S
Site 110
S1218
T
A
W
V
V
K
A
S
L
Q
K
R
P
D
G
Site 111
S1229
R
P
D
G
H
I
V
S
V
S
V
N
G
D
V
Site 112
T1277
C
G
S
V
N
Q
F
T
A
I
Y
N
S
S
G
Site 113
Y1292
E
L
I
N
N
I
K
Y
Y
D
G
F
M
G
Q
Site 114
Y1293
L
I
N
N
I
K
Y
Y
D
G
F
M
G
Q
R
Site 115
Y1324
A
V
G
S
N
D
Y
Y
I
S
V
Y
S
V
E
Site 116
S1326
G
S
N
D
Y
Y
I
S
V
Y
S
V
E
K
R
Site 117
Y1328
N
D
Y
Y
I
S
V
Y
S
V
E
K
R
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation