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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
REPS2
Full Name:
RalBP1-associated Eps domain-containing protein 2
Alias:
Partner of Ral-binding protein 1; Partner of RalBP1; POB1; RALBP1 associated Eps domain containing 2; RalBP1-interacting protein 2
Type:
Adaptor/scaffold; G protein regulator, misc.
Mass (Da):
71534
Number AA:
660
UniProt ID:
Q8NFH8
International Prot ID:
IPI00332687
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007173
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
G
P
P
P
L
L
L
S
E
G
E
Q
Q
C
Y
Site 2
Y38
S
E
G
E
Q
Q
C
Y
S
E
L
F
A
R
C
Site 3
S55
A
A
G
G
G
P
G
S
G
P
P
E
A
A
R
Site 4
Y103
C
G
A
K
R
V
G
Y
F
G
P
T
Q
F
Y
Site 5
S121
K
L
I
A
A
A
Q
S
G
L
P
V
R
I
E
Site 6
T159
N
P
A
E
L
H
G
T
K
V
Q
I
P
Y
L
Site 7
S172
Y
L
T
T
E
K
N
S
F
K
R
M
D
D
E
Site 8
T185
D
E
D
K
Q
Q
E
T
Q
S
P
T
M
S
P
Site 9
S187
D
K
Q
Q
E
T
Q
S
P
T
M
S
P
L
A
Site 10
T189
Q
Q
E
T
Q
S
P
T
M
S
P
L
A
S
P
Site 11
S191
E
T
Q
S
P
T
M
S
P
L
A
S
P
P
S
Site 12
S195
P
T
M
S
P
L
A
S
P
P
S
S
P
P
H
Site 13
S198
S
P
L
A
S
P
P
S
S
P
P
H
Y
Q
R
Site 14
S199
P
L
A
S
P
P
S
S
P
P
H
Y
Q
R
V
Site 15
Y203
P
P
S
S
P
P
H
Y
Q
R
V
P
L
S
H
Site 16
S209
H
Y
Q
R
V
P
L
S
H
G
Y
S
K
L
R
Site 17
Y212
R
V
P
L
S
H
G
Y
S
K
L
R
S
S
A
Site 18
S213
V
P
L
S
H
G
Y
S
K
L
R
S
S
A
E
Site 19
S217
H
G
Y
S
K
L
R
S
S
A
E
Q
M
H
P
Site 20
S218
G
Y
S
K
L
R
S
S
A
E
Q
M
H
P
A
Site 21
Y227
E
Q
M
H
P
A
P
Y
E
A
R
Q
P
L
V
Site 22
S239
P
L
V
Q
P
E
G
S
S
S
G
G
P
G
T
Site 23
S241
V
Q
P
E
G
S
S
S
G
G
P
G
T
K
P
Site 24
T246
S
S
S
G
G
P
G
T
K
P
L
R
H
Q
A
Site 25
S254
K
P
L
R
H
Q
A
S
L
I
R
S
F
S
V
Site 26
S258
H
Q
A
S
L
I
R
S
F
S
V
E
R
E
L
Site 27
S260
A
S
L
I
R
S
F
S
V
E
R
E
L
Q
D
Site 28
S269
E
R
E
L
Q
D
N
S
S
Y
P
D
E
P
W
Site 29
S270
R
E
L
Q
D
N
S
S
Y
P
D
E
P
W
R
Site 30
Y271
E
L
Q
D
N
S
S
Y
P
D
E
P
W
R
I
Site 31
T279
P
D
E
P
W
R
I
T
E
E
Q
R
E
Y
Y
Site 32
Y285
I
T
E
E
Q
R
E
Y
Y
V
N
Q
F
R
S
Site 33
Y286
T
E
E
Q
R
E
Y
Y
V
N
Q
F
R
S
L
Site 34
S292
Y
Y
V
N
Q
F
R
S
L
Q
P
D
P
S
S
Site 35
S298
R
S
L
Q
P
D
P
S
S
F
I
S
G
S
V
Site 36
S299
S
L
Q
P
D
P
S
S
F
I
S
G
S
V
A
Site 37
S302
P
D
P
S
S
F
I
S
G
S
V
A
K
N
F
Site 38
T311
S
V
A
K
N
F
F
T
K
S
K
L
S
I
P
Site 39
S313
A
K
N
F
F
T
K
S
K
L
S
I
P
E
L
Site 40
S321
K
L
S
I
P
E
L
S
Y
I
W
E
L
S
D
Site 41
S327
L
S
Y
I
W
E
L
S
D
A
D
C
D
G
A
Site 42
Y354
I
V
A
R
K
N
G
Y
P
L
P
E
G
L
P
Site 43
T363
L
P
E
G
L
P
P
T
L
Q
P
E
Y
L
Q
Site 44
Y368
P
P
T
L
Q
P
E
Y
L
Q
A
A
F
P
K
Site 45
S385
W
D
C
Q
L
F
D
S
Y
S
E
S
L
P
A
Site 46
Y386
D
C
Q
L
F
D
S
Y
S
E
S
L
P
A
N
Site 47
S387
C
Q
L
F
D
S
Y
S
E
S
L
P
A
N
Q
Site 48
S389
L
F
D
S
Y
S
E
S
L
P
A
N
Q
Q
P
Site 49
S406
L
N
R
M
E
K
T
S
V
K
D
M
A
D
L
Site 50
T421
P
V
P
N
Q
D
V
T
S
D
D
K
Q
A
L
Site 51
S422
V
P
N
Q
D
V
T
S
D
D
K
Q
A
L
K
Site 52
S430
D
D
K
Q
A
L
K
S
T
I
N
E
A
L
P
Site 53
S441
E
A
L
P
K
D
V
S
E
D
P
A
T
P
K
Site 54
T446
D
V
S
E
D
P
A
T
P
K
D
S
N
S
L
Site 55
S450
D
P
A
T
P
K
D
S
N
S
L
K
A
R
P
Site 56
S452
A
T
P
K
D
S
N
S
L
K
A
R
P
R
S
Site 57
S459
S
L
K
A
R
P
R
S
R
S
Y
S
S
T
S
Site 58
S461
K
A
R
P
R
S
R
S
Y
S
S
T
S
I
E
Site 59
Y462
A
R
P
R
S
R
S
Y
S
S
T
S
I
E
E
Site 60
S463
R
P
R
S
R
S
Y
S
S
T
S
I
E
E
A
Site 61
T465
R
S
R
S
Y
S
S
T
S
I
E
E
A
M
K
Site 62
S466
S
R
S
Y
S
S
T
S
I
E
E
A
M
K
R
Site 63
T479
K
R
G
E
D
P
P
T
P
P
P
R
P
Q
K
Site 64
T487
P
P
P
R
P
Q
K
T
H
S
R
A
S
S
L
Site 65
S489
P
R
P
Q
K
T
H
S
R
A
S
S
L
D
L
Site 66
S492
Q
K
T
H
S
R
A
S
S
L
D
L
N
K
V
Site 67
S493
K
T
H
S
R
A
S
S
L
D
L
N
K
V
F
Site 68
S503
L
N
K
V
F
Q
P
S
V
P
A
T
K
S
G
Site 69
T507
F
Q
P
S
V
P
A
T
K
S
G
L
L
P
P
Site 70
S509
P
S
V
P
A
T
K
S
G
L
L
P
P
P
P
Site 71
S525
L
P
P
R
P
C
P
S
Q
S
E
Q
V
S
E
Site 72
S527
P
R
P
C
P
S
Q
S
E
Q
V
S
E
A
E
Site 73
S531
P
S
Q
S
E
Q
V
S
E
A
E
L
L
P
Q
Site 74
S540
A
E
L
L
P
Q
L
S
R
A
P
S
Q
A
A
Site 75
S544
P
Q
L
S
R
A
P
S
Q
A
A
E
S
S
P
Site 76
S549
A
P
S
Q
A
A
E
S
S
P
A
K
K
D
V
Site 77
S550
P
S
Q
A
A
E
S
S
P
A
K
K
D
V
L
Site 78
Y558
P
A
K
K
D
V
L
Y
S
Q
P
P
S
K
P
Site 79
S559
A
K
K
D
V
L
Y
S
Q
P
P
S
K
P
I
Site 80
S563
V
L
Y
S
Q
P
P
S
K
P
I
R
R
K
F
Site 81
T577
F
R
P
E
N
Q
A
T
E
N
Q
E
P
S
T
Site 82
S583
A
T
E
N
Q
E
P
S
T
A
A
S
G
P
A
Site 83
T584
T
E
N
Q
E
P
S
T
A
A
S
G
P
A
S
Site 84
S587
Q
E
P
S
T
A
A
S
G
P
A
S
A
A
T
Site 85
S591
T
A
A
S
G
P
A
S
A
A
T
M
K
P
H
Site 86
T594
S
G
P
A
S
A
A
T
M
K
P
H
P
T
V
Site 87
T600
A
T
M
K
P
H
P
T
V
Q
K
Q
S
S
K
Site 88
S631
A
V
L
A
R
L
N
S
E
L
Q
Q
Q
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation