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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFWD2
Full Name:
E3 ubiquitin-protein ligase RFWD2
Alias:
Constitutive photomorphogenesis protein 1 homolog; COP1; FLJ10416; HCOP1; Ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200; RNF200; Ubiquitin- protein ligase COP1
Type:
Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Mass (Da):
80474
Number AA:
731
UniProt ID:
Q8NHY2
International Prot ID:
IPI00171771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
G
S
R
Q
A
G
S
G
S
A
G
T
S
P
Site 2
S11
S
R
Q
A
G
S
G
S
A
G
T
S
P
G
S
Site 3
T14
A
G
S
G
S
A
G
T
S
P
G
S
S
A
A
Site 4
S15
G
S
G
S
A
G
T
S
P
G
S
S
A
A
S
Site 5
S18
S
A
G
T
S
P
G
S
S
A
A
S
S
V
T
Site 6
S19
A
G
T
S
P
G
S
S
A
A
S
S
V
T
S
Site 7
S22
S
P
G
S
S
A
A
S
S
V
T
S
A
S
S
Site 8
S23
P
G
S
S
A
A
S
S
V
T
S
A
S
S
S
Site 9
T25
S
S
A
A
S
S
V
T
S
A
S
S
S
L
S
Site 10
S26
S
A
A
S
S
V
T
S
A
S
S
S
L
S
S
Site 11
S28
A
S
S
V
T
S
A
S
S
S
L
S
S
S
P
Site 12
S29
S
S
V
T
S
A
S
S
S
L
S
S
S
P
S
Site 13
S30
S
V
T
S
A
S
S
S
L
S
S
S
P
S
P
Site 14
S32
T
S
A
S
S
S
L
S
S
S
P
S
P
P
S
Site 15
S33
S
A
S
S
S
L
S
S
S
P
S
P
P
S
V
Site 16
S34
A
S
S
S
L
S
S
S
P
S
P
P
S
V
A
Site 17
S36
S
S
L
S
S
S
P
S
P
P
S
V
A
V
S
Site 18
S83
G
S
G
G
G
A
V
S
T
G
L
S
R
H
S
Site 19
T84
S
G
G
G
A
V
S
T
G
L
S
R
H
S
C
Site 20
S87
G
A
V
S
T
G
L
S
R
H
S
C
A
A
R
Site 21
S90
S
T
G
L
S
R
H
S
C
A
A
R
P
S
A
Site 22
S96
H
S
C
A
A
R
P
S
A
G
V
G
G
S
S
Site 23
S102
P
S
A
G
V
G
G
S
S
S
S
L
G
S
G
Site 24
S103
S
A
G
V
G
G
S
S
S
S
L
G
S
G
S
Site 25
S104
A
G
V
G
G
S
S
S
S
L
G
S
G
S
R
Site 26
S105
G
V
G
G
S
S
S
S
L
G
S
G
S
R
K
Site 27
S108
G
S
S
S
S
L
G
S
G
S
R
K
R
P
L
Site 28
S110
S
S
S
L
G
S
G
S
R
K
R
P
L
L
A
Site 29
S126
L
C
N
G
L
I
N
S
Y
E
D
K
S
N
D
Site 30
Y127
C
N
G
L
I
N
S
Y
E
D
K
S
N
D
F
Site 31
Y147
F
D
M
I
E
E
A
Y
M
T
K
C
G
H
S
Site 32
Y184
V
D
N
I
D
H
L
Y
P
N
F
L
V
N
E
Site 33
S210
K
R
F
K
L
D
H
S
V
S
S
T
N
G
H
Site 34
S212
F
K
L
D
H
S
V
S
S
T
N
G
H
R
W
Site 35
T214
L
D
H
S
V
S
S
T
N
G
H
R
W
Q
I
Site 36
S287
E
Q
I
Q
K
E
L
S
V
L
E
E
D
I
K
Site 37
S300
I
K
R
V
E
E
M
S
G
L
Y
S
P
V
S
Site 38
Y303
V
E
E
M
S
G
L
Y
S
P
V
S
E
D
S
Site 39
S304
E
E
M
S
G
L
Y
S
P
V
S
E
D
S
T
Site 40
S307
S
G
L
Y
S
P
V
S
E
D
S
T
V
P
Q
Site 41
S310
Y
S
P
V
S
E
D
S
T
V
P
Q
F
E
A
Site 42
T311
S
P
V
S
E
D
S
T
V
P
Q
F
E
A
P
Site 43
S319
V
P
Q
F
E
A
P
S
P
S
H
S
S
I
I
Site 44
S321
Q
F
E
A
P
S
P
S
H
S
S
I
I
D
S
Site 45
S323
E
A
P
S
P
S
H
S
S
I
I
D
S
T
E
Site 46
S324
A
P
S
P
S
H
S
S
I
I
D
S
T
E
Y
Site 47
S328
S
H
S
S
I
I
D
S
T
E
Y
S
Q
P
P
Site 48
T329
H
S
S
I
I
D
S
T
E
Y
S
Q
P
P
G
Site 49
Y331
S
I
I
D
S
T
E
Y
S
Q
P
P
G
F
S
Site 50
S332
I
I
D
S
T
E
Y
S
Q
P
P
G
F
S
G
Site 51
S338
Y
S
Q
P
P
G
F
S
G
S
S
Q
T
K
K
Site 52
S341
P
P
G
F
S
G
S
S
Q
T
K
K
Q
P
W
Site 53
Y349
Q
T
K
K
Q
P
W
Y
N
S
T
L
A
S
R
Site 54
S351
K
K
Q
P
W
Y
N
S
T
L
A
S
R
R
K
Site 55
T352
K
Q
P
W
Y
N
S
T
L
A
S
R
R
K
R
Site 56
S355
W
Y
N
S
T
L
A
S
R
R
K
R
L
T
A
Site 57
T361
A
S
R
R
K
R
L
T
A
H
F
E
D
L
E
Site 58
Y371
F
E
D
L
E
Q
C
Y
F
S
T
R
M
S
R
Site 59
S373
D
L
E
Q
C
Y
F
S
T
R
M
S
R
I
S
Site 60
S377
C
Y
F
S
T
R
M
S
R
I
S
D
D
S
R
Site 61
S380
S
T
R
M
S
R
I
S
D
D
S
R
T
A
S
Site 62
S383
M
S
R
I
S
D
D
S
R
T
A
S
Q
L
D
Site 63
T385
R
I
S
D
D
S
R
T
A
S
Q
L
D
E
F
Site 64
S387
S
D
D
S
R
T
A
S
Q
L
D
E
F
Q
E
Site 65
Y402
C
L
S
K
F
T
R
Y
N
S
V
R
P
L
A
Site 66
S404
S
K
F
T
R
Y
N
S
V
R
P
L
A
T
L
Site 67
T410
N
S
V
R
P
L
A
T
L
S
Y
A
S
D
L
Site 68
S412
V
R
P
L
A
T
L
S
Y
A
S
D
L
Y
N
Site 69
Y413
R
P
L
A
T
L
S
Y
A
S
D
L
Y
N
G
Site 70
Y418
L
S
Y
A
S
D
L
Y
N
G
S
S
I
V
S
Site 71
S421
A
S
D
L
Y
N
G
S
S
I
V
S
S
I
E
Site 72
S422
S
D
L
Y
N
G
S
S
I
V
S
S
I
E
F
Site 73
S425
Y
N
G
S
S
I
V
S
S
I
E
F
D
R
D
Site 74
S426
N
G
S
S
I
V
S
S
I
E
F
D
R
D
C
Site 75
Y435
E
F
D
R
D
C
D
Y
F
A
I
A
G
V
T
Site 76
Y450
K
K
I
K
V
Y
E
Y
D
T
V
I
Q
D
A
Site 77
T452
I
K
V
Y
E
Y
D
T
V
I
Q
D
A
V
D
Site 78
Y462
Q
D
A
V
D
I
H
Y
P
E
N
E
M
T
C
Site 79
Y481
S
C
I
S
W
S
S
Y
H
K
N
L
L
A
S
Site 80
S489
H
K
N
L
L
A
S
S
D
Y
E
G
T
V
I
Site 81
T502
V
I
L
W
D
G
F
T
G
Q
R
S
K
V
Y
Site 82
Y509
T
G
Q
R
S
K
V
Y
Q
E
H
E
K
R
C
Site 83
S531
M
D
P
K
L
L
A
S
G
S
D
D
A
K
V
Site 84
S533
P
K
L
L
A
S
G
S
D
D
A
K
V
K
L
Site 85
S548
W
S
T
N
L
D
N
S
V
A
S
I
E
A
K
Site 86
S564
N
V
C
C
V
K
F
S
P
S
S
R
Y
H
L
Site 87
S567
C
V
K
F
S
P
S
S
R
Y
H
L
A
F
G
Site 88
Y569
K
F
S
P
S
S
R
Y
H
L
A
F
G
C
A
Site 89
Y582
C
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Site 90
Y583
A
D
H
C
V
H
Y
Y
D
L
R
N
T
K
Q
Site 91
S603
K
G
H
R
K
A
V
S
Y
A
K
F
V
S
G
Site 92
Y604
G
H
R
K
A
V
S
Y
A
K
F
V
S
G
E
Site 93
S615
V
S
G
E
E
I
V
S
A
S
T
D
S
Q
L
Site 94
S617
G
E
E
I
V
S
A
S
T
D
S
Q
L
K
L
Site 95
Y631
L
W
N
V
G
K
P
Y
C
L
R
S
F
K
G
Site 96
S635
G
K
P
Y
C
L
R
S
F
K
G
H
I
N
E
Site 97
Y654
G
L
A
S
N
G
D
Y
I
A
C
G
S
E
N
Site 98
S659
G
D
Y
I
A
C
G
S
E
N
N
S
L
Y
L
Site 99
S663
A
C
G
S
E
N
N
S
L
Y
L
Y
Y
K
G
Site 100
Y665
G
S
E
N
N
S
L
Y
L
Y
Y
K
G
L
S
Site 101
Y667
E
N
N
S
L
Y
L
Y
Y
K
G
L
S
K
T
Site 102
T674
Y
Y
K
G
L
S
K
T
L
L
T
F
K
F
D
Site 103
S685
F
K
F
D
T
V
K
S
V
L
D
K
D
R
K
Site 104
T696
K
D
R
K
E
D
D
T
N
E
F
V
S
A
V
Site 105
S713
R
A
L
P
D
G
E
S
N
V
L
I
A
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation