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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK7
Full Name:
Serine/threonine-protein kinase Nek7
Alias:
EC 2.7.11.1; Kinase Nek7; NIMA (never in mitosis gene a)-related kinase 7; NIMA-related serine/threonine kinase NEK7
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Other group; NEK family
Mass (Da):
34551
Number AA:
302
UniProt ID:
Q8TDX7
International Prot ID:
IPI00152658
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
NIMA (never-in-mitosis)-related protein-serine kinase 7 T191+S195 phosphosite-specific antibody AB-PK735#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK735#NIMA (never-in-mitosis)-related protein-serine kinase 7 (T191-G198, human) pT191+pS195 phosphopeptide - Powder PE-04AHR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHR99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
E
Q
S
Q
G
M
Q
G
P
P
Site 2
Y28
A
L
R
P
D
M
G
Y
N
T
L
A
N
F
R
Site 3
T30
R
P
D
M
G
Y
N
T
L
A
N
F
R
I
E
Site 4
Y49
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
Site 5
Y97
N
H
P
N
V
I
K
Y
Y
A
S
F
I
E
D
Site 6
Y98
H
P
N
V
I
K
Y
Y
A
S
F
I
E
D
N
Site 7
S100
N
V
I
K
Y
Y
A
S
F
I
E
D
N
E
L
Site 8
S120
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
Site 9
Y141
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
Site 10
S147
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
Site 11
S154
S
A
L
E
H
M
H
S
R
R
V
M
H
R
D
Site 12
S187
L
G
L
G
R
F
F
S
S
K
T
T
A
A
H
Site 13
S188
G
L
G
R
F
F
S
S
K
T
T
A
A
H
S
Site 14
T190
G
R
F
F
S
S
K
T
T
A
A
H
S
L
V
Site 15
T191
R
F
F
S
S
K
T
T
A
A
H
S
L
V
G
NIMA (never-in-mitosis)-related protein-serine kinase 7 T191+S195 phosphosite-specific antibody AB-PK735#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK735#NIMA (never-in-mitosis)-related protein-serine kinase 7 (T191-G198, human) pT191+pS195 phosphopeptide - Powder PE-04AHR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHR99
Site 16
S195
S
K
T
T
A
A
H
S
L
V
G
T
P
Y
Y
NIMA (never-in-mitosis)-related protein-serine kinase 7 T191+S195 phosphosite-specific antibody AB-PK735#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK735#NIMA (never-in-mitosis)-related protein-serine kinase 7 (T191-G198, human) pT191+pS195 phosphopeptide - Powder PE-04AHR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHR99
Site 17
T199
A
A
H
S
L
V
G
T
P
Y
Y
M
S
P
E
Site 18
Y201
H
S
L
V
G
T
P
Y
Y
M
S
P
E
R
I
Site 19
Y202
S
L
V
G
T
P
Y
Y
M
S
P
E
R
I
H
Site 20
S204
V
G
T
P
Y
Y
M
S
P
E
R
I
H
E
N
Site 21
Y213
E
R
I
H
E
N
G
Y
N
F
K
S
D
I
W
Site 22
S234
Y
E
M
A
A
L
Q
S
P
F
Y
G
D
K
M
Site 23
Y237
A
A
L
Q
S
P
F
Y
G
D
K
M
N
L
Y
Site 24
Y244
Y
G
D
K
M
N
L
Y
S
L
C
K
K
I
E
Site 25
S245
G
D
K
M
N
L
Y
S
L
C
K
K
I
E
Q
Site 26
Y255
K
K
I
E
Q
C
D
Y
P
P
L
P
S
D
H
Site 27
S260
C
D
Y
P
P
L
P
S
D
H
Y
S
E
E
L
Site 28
Y263
P
P
L
P
S
D
H
Y
S
E
E
L
R
Q
L
Site 29
S264
P
L
P
S
D
H
Y
S
E
E
L
R
Q
L
V
Site 30
T286
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
Site 31
Y287
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
Site 32
Y289
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation