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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBCK
Full Name:
TBC domain-containing protein kinase-like protein
Alias:
Type:
Mass (Da):
100661
Number AA:
893
UniProt ID:
Q8TEA7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T47
G
R
F
Q
I
L
K
T
I
T
H
P
R
L
C
Site 2
T49
F
Q
I
L
K
T
I
T
H
P
R
L
C
Q
Y
Site 3
Y56
T
H
P
R
L
C
Q
Y
V
D
I
S
R
G
K
Site 4
S77
V
A
E
H
C
E
R
S
L
E
D
L
L
R
E
Site 5
Y106
E
V
L
Q
G
L
Q
Y
M
N
K
H
G
I
V
Site 6
S118
G
I
V
H
R
A
L
S
P
H
N
I
L
L
D
Site 7
Y138
K
L
A
K
F
G
L
Y
H
M
T
A
H
G
D
Site 8
Y153
D
V
D
F
P
I
G
Y
P
S
Y
L
A
P
E
Site 9
T169
I
A
Q
G
I
F
K
T
T
D
H
M
P
S
K
Site 10
S175
K
T
T
D
H
M
P
S
K
K
P
L
P
S
G
Site 11
S181
P
S
K
K
P
L
P
S
G
P
K
S
D
V
W
Site 12
S185
P
L
P
S
G
P
K
S
D
V
W
S
L
G
I
Site 13
S206
V
G
R
K
L
F
Q
S
L
D
I
S
E
R
L
Site 14
T255
D
L
L
N
K
C
L
T
F
H
P
S
K
R
P
Site 15
S259
K
C
L
T
F
H
P
S
K
R
P
T
P
D
Q
Site 16
T263
F
H
P
S
K
R
P
T
P
D
Q
L
M
K
D
Site 17
S277
D
K
V
F
S
E
V
S
P
L
Y
T
P
F
T
Site 18
Y280
F
S
E
V
S
P
L
Y
T
P
F
T
K
P
A
Site 19
T281
S
E
V
S
P
L
Y
T
P
F
T
K
P
A
S
Site 20
T284
S
P
L
Y
T
P
F
T
K
P
A
S
L
F
S
Site 21
S288
T
P
F
T
K
P
A
S
L
F
S
S
S
L
R
Site 22
S292
K
P
A
S
L
F
S
S
S
L
R
C
A
D
L
Site 23
T300
S
L
R
C
A
D
L
T
L
P
E
D
I
S
Q
Site 24
S306
L
T
L
P
E
D
I
S
Q
L
C
K
D
I
N
Site 25
Y316
C
K
D
I
N
N
D
Y
L
A
E
R
S
I
E
Site 26
S321
N
D
Y
L
A
E
R
S
I
E
E
V
Y
Y
L
Site 27
Y326
E
R
S
I
E
E
V
Y
Y
L
W
C
L
A
G
Site 28
S348
V
N
K
E
I
I
R
S
K
P
P
I
C
T
L
Site 29
T354
R
S
K
P
P
I
C
T
L
P
N
F
L
F
E
Site 30
S365
F
L
F
E
D
G
E
S
F
G
Q
G
R
D
R
Site 31
S373
F
G
Q
G
R
D
R
S
S
L
L
D
D
T
T
Site 32
S374
G
Q
G
R
D
R
S
S
L
L
D
D
T
T
V
Site 33
S384
D
D
T
T
V
T
L
S
L
C
Q
L
R
N
R
Site 34
Y401
D
V
G
G
E
A
F
Y
P
L
L
E
D
D
Q
Site 35
S409
P
L
L
E
D
D
Q
S
N
L
P
H
S
N
S
Site 36
S414
D
Q
S
N
L
P
H
S
N
S
N
N
E
L
S
Site 37
S416
S
N
L
P
H
S
N
S
N
N
E
L
S
A
A
Site 38
Y437
I
R
E
K
D
T
E
Y
Q
L
N
R
I
I
L
Site 39
Y452
F
D
R
L
L
K
A
Y
P
Y
K
K
N
Q
I
Site 40
Y454
R
L
L
K
A
Y
P
Y
K
K
N
Q
I
W
K
Site 41
Y490
E
G
A
I
H
A
K
Y
D
A
I
D
K
D
T
Site 42
T497
Y
D
A
I
D
K
D
T
P
I
P
T
D
R
Q
Site 43
T501
D
K
D
T
P
I
P
T
D
R
Q
I
E
V
D
Site 44
Y515
D
I
P
R
C
H
Q
Y
D
E
L
L
S
S
P
Site 45
S521
Q
Y
D
E
L
L
S
S
P
E
G
H
A
K
F
Site 46
Y544
V
S
H
P
D
L
V
Y
W
Q
G
L
D
S
L
Site 47
Y579
A
F
I
P
K
Y
L
Y
N
F
F
L
K
D
N
Site 48
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Site 49
T704
S
I
N
L
F
C
W
T
P
K
S
A
T
Y
R
Site 50
S720
H
A
Q
P
P
K
P
S
S
D
S
S
G
G
R
Site 51
S721
A
Q
P
P
K
P
S
S
D
S
S
G
G
R
S
Site 52
S723
P
P
K
P
S
S
D
S
S
G
G
R
S
S
A
Site 53
S724
P
K
P
S
S
D
S
S
G
G
R
S
S
A
P
Site 54
S728
S
D
S
S
G
G
R
S
S
A
P
Y
F
S
A
Site 55
S729
D
S
S
G
G
R
S
S
A
P
Y
F
S
A
E
Site 56
Y732
G
G
R
S
S
A
P
Y
F
S
A
E
C
P
D
Site 57
S734
R
S
S
A
P
Y
F
S
A
E
C
P
D
P
P
Site 58
T743
E
C
P
D
P
P
K
T
D
L
S
R
E
S
I
Site 59
S746
D
P
P
K
T
D
L
S
R
E
S
I
P
L
N
Site 60
S749
K
T
D
L
S
R
E
S
I
P
L
N
D
L
K
Site 61
S757
I
P
L
N
D
L
K
S
E
V
S
P
R
I
S
Site 62
S760
N
D
L
K
S
E
V
S
P
R
I
S
A
E
D
Site 63
S764
S
E
V
S
P
R
I
S
A
E
D
L
I
D
L
Site 64
T777
D
L
C
E
L
T
V
T
G
H
F
K
T
P
S
Site 65
T782
T
V
T
G
H
F
K
T
P
S
K
K
T
K
S
Site 66
S784
T
G
H
F
K
T
P
S
K
K
T
K
S
S
K
Site 67
T787
F
K
T
P
S
K
K
T
K
S
S
K
P
K
L
Site 68
S789
T
P
S
K
K
T
K
S
S
K
P
K
L
L
V
Site 69
S790
P
S
K
K
T
K
S
S
K
P
K
L
L
V
V
Site 70
S802
L
V
V
D
I
R
N
S
E
D
F
I
R
G
H
Site 71
T829
F
T
A
E
G
E
L
T
Q
G
P
Y
T
A
M
Site 72
Y833
G
E
L
T
Q
G
P
Y
T
A
M
L
Q
N
F
Site 73
S890
T
G
L
L
T
I
P
S
P
Q
I
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation