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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARD3
Full Name:
Partitioning defective 3 homolog
Alias:
ASIP; Atypical PKC isotype-specific interacting protein; Atypical PKC isotype-specific-interacting protein; Baz; Bazooka; CTCL tumor antigen se2- 5; CTCL tumor antigen se2-5; PAR3; PAR-3; Par-3 partitioning defective 3; PAR3-alpha; PARD-3; PARD3A; Partitioning-defective 3 homolog
Type:
Adapter/scaffold protein
Mass (Da):
151423
Number AA:
1356
UniProt ID:
Q8TEW0
International Prot ID:
IPI00154915
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005938
GO:0012505
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0008356
GO:0007409
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
D
G
H
M
K
V
F
S
L
I
Q
Q
A
V
T
Site 2
T32
S
L
I
Q
Q
A
V
T
R
Y
R
K
A
I
A
Site 3
Y44
A
I
A
K
D
P
N
Y
W
I
Q
V
H
R
L
Site 4
T91
P
H
H
G
G
D
G
T
S
A
S
S
T
G
T
Site 5
S92
H
H
G
G
D
G
T
S
A
S
S
T
G
T
Q
Site 6
S94
G
G
D
G
T
S
A
S
S
T
G
T
Q
S
P
Site 7
T96
D
G
T
S
A
S
S
T
G
T
Q
S
P
E
I
Site 8
T98
T
S
A
S
S
T
G
T
Q
S
P
E
I
F
G
Site 9
S100
A
S
S
T
G
T
Q
S
P
E
I
F
G
S
E
Site 10
S106
Q
S
P
E
I
F
G
S
E
L
G
T
N
N
V
Site 11
Y119
N
V
S
A
F
Q
P
Y
Q
A
T
S
E
I
E
Site 12
T128
A
T
S
E
I
E
V
T
P
S
V
L
R
A
N
Site 13
S130
S
E
I
E
V
T
P
S
V
L
R
A
N
M
P
Site 14
S143
M
P
L
H
V
R
R
S
S
D
P
A
L
I
G
Site 15
S144
P
L
H
V
R
R
S
S
D
P
A
L
I
G
L
Site 16
S152
D
P
A
L
I
G
L
S
T
S
V
S
D
S
N
Site 17
S154
A
L
I
G
L
S
T
S
V
S
D
S
N
F
S
Site 18
S156
I
G
L
S
T
S
V
S
D
S
N
F
S
S
E
Site 19
S158
L
S
T
S
V
S
D
S
N
F
S
S
E
E
P
Site 20
S162
V
S
D
S
N
F
S
S
E
E
P
S
R
K
N
Site 21
S166
N
F
S
S
E
E
P
S
R
K
N
P
T
R
W
Site 22
S174
R
K
N
P
T
R
W
S
T
T
A
G
F
L
K
Site 23
T175
K
N
P
T
R
W
S
T
T
A
G
F
L
K
Q
Site 24
S187
L
K
Q
N
T
A
G
S
P
K
T
C
D
R
K
Site 25
T190
N
T
A
G
S
P
K
T
C
D
R
K
K
D
E
Site 26
Y199
D
R
K
K
D
E
N
Y
R
S
L
P
R
D
T
Site 27
S201
K
K
D
E
N
Y
R
S
L
P
R
D
T
S
N
Site 28
T206
Y
R
S
L
P
R
D
T
S
N
W
S
N
Q
F
Site 29
S207
R
S
L
P
R
D
T
S
N
W
S
N
Q
F
Q
Site 30
S220
F
Q
R
D
N
A
R
S
S
L
S
A
S
H
P
Site 31
S221
Q
R
D
N
A
R
S
S
L
S
A
S
H
P
M
Site 32
S223
D
N
A
R
S
S
L
S
A
S
H
P
M
V
G
Site 33
S225
A
R
S
S
L
S
A
S
H
P
M
V
G
K
W
Site 34
T243
Q
E
Q
D
E
D
G
T
E
E
D
N
S
R
V
Site 35
S248
D
G
T
E
E
D
N
S
R
V
E
P
V
G
H
Site 36
S267
L
E
H
I
P
N
F
S
L
D
D
M
V
K
L
Site 37
Y366
P
A
A
N
K
E
Q
Y
E
Q
L
S
Q
S
E
Site 38
S370
K
E
Q
Y
E
Q
L
S
Q
S
E
K
N
N
Y
Site 39
S372
Q
Y
E
Q
L
S
Q
S
E
K
N
N
Y
Y
S
Site 40
Y377
S
Q
S
E
K
N
N
Y
Y
S
S
R
F
S
P
Site 41
Y378
Q
S
E
K
N
N
Y
Y
S
S
R
F
S
P
D
Site 42
S379
S
E
K
N
N
Y
Y
S
S
R
F
S
P
D
S
Site 43
S380
E
K
N
N
Y
Y
S
S
R
F
S
P
D
S
Q
Site 44
S383
N
Y
Y
S
S
R
F
S
P
D
S
Q
Y
I
D
Site 45
S386
S
S
R
F
S
P
D
S
Q
Y
I
D
N
R
S
Site 46
Y388
R
F
S
P
D
S
Q
Y
I
D
N
R
S
V
N
Site 47
S393
S
Q
Y
I
D
N
R
S
V
N
S
A
G
L
H
Site 48
T401
V
N
S
A
G
L
H
T
V
Q
R
A
P
R
L
Site 49
S417
H
P
P
E
Q
I
D
S
H
S
R
L
P
H
S
Site 50
S419
P
E
Q
I
D
S
H
S
R
L
P
H
S
A
H
Site 51
S424
S
H
S
R
L
P
H
S
A
H
P
S
G
K
P
Site 52
S428
L
P
H
S
A
H
P
S
G
K
P
P
S
A
P
Site 53
S433
H
P
S
G
K
P
P
S
A
P
A
S
A
P
Q
Site 54
S437
K
P
P
S
A
P
A
S
A
P
Q
N
V
F
S
Site 55
S444
S
A
P
Q
N
V
F
S
T
T
V
S
S
G
Y
Site 56
T445
A
P
Q
N
V
F
S
T
T
V
S
S
G
Y
N
Site 57
T446
P
Q
N
V
F
S
T
T
V
S
S
G
Y
N
T
Site 58
S448
N
V
F
S
T
T
V
S
S
G
Y
N
T
K
K
Site 59
T453
T
V
S
S
G
Y
N
T
K
K
I
G
K
R
L
Site 60
S474
G
T
E
G
L
G
F
S
I
T
S
R
D
V
T
Site 61
T481
S
I
T
S
R
D
V
T
I
G
G
S
A
P
I
Site 62
S485
R
D
V
T
I
G
G
S
A
P
I
Y
V
K
N
Site 63
Y489
I
G
G
S
A
P
I
Y
V
K
N
I
L
P
R
Site 64
S523
G
V
D
L
V
G
K
S
Q
E
E
V
V
S
L
Site 65
S529
K
S
Q
E
E
V
V
S
L
L
R
S
T
K
M
Site 66
S533
E
V
V
S
L
L
R
S
T
K
M
E
G
T
V
Site 67
T534
V
V
S
L
L
R
S
T
K
M
E
G
T
V
S
Site 68
T539
R
S
T
K
M
E
G
T
V
S
L
L
V
F
R
Site 69
S541
T
K
M
E
G
T
V
S
L
L
V
F
R
Q
E
Site 70
S561
R
E
L
N
A
E
P
S
Q
M
Q
I
P
K
E
Site 71
T579
E
D
E
D
I
V
L
T
P
D
G
T
R
E
F
Site 72
T588
D
G
T
R
E
F
L
T
F
E
V
P
L
N
D
Site 73
S604
G
S
A
G
L
G
V
S
V
K
G
N
R
S
K
Site 74
S631
I
I
N
G
G
A
A
S
K
D
G
R
L
R
V
Site 75
T661
T
N
Q
D
A
M
E
T
L
R
R
S
M
S
T
Site 76
S665
A
M
E
T
L
R
R
S
M
S
T
E
G
N
K
Site 77
S667
E
T
L
R
R
S
M
S
T
E
G
N
K
R
G
Site 78
T668
T
L
R
R
S
M
S
T
E
G
N
K
R
G
M
Site 79
S685
L
I
V
A
R
R
I
S
K
C
N
E
L
K
S
Site 80
S692
S
K
C
N
E
L
K
S
P
G
S
P
P
G
P
Site 81
S695
N
E
L
K
S
P
G
S
P
P
G
P
E
L
P
Site 82
S715
D
D
R
E
R
R
I
S
H
S
L
Y
S
G
I
Site 83
S717
R
E
R
R
I
S
H
S
L
Y
S
G
I
E
G
Site 84
Y719
R
R
I
S
H
S
L
Y
S
G
I
E
G
L
D
Site 85
S720
R
I
S
H
S
L
Y
S
G
I
E
G
L
D
E
Site 86
S728
G
I
E
G
L
D
E
S
P
S
R
N
A
A
L
Site 87
S730
E
G
L
D
E
S
P
S
R
N
A
A
L
S
R
Site 88
S736
P
S
R
N
A
A
L
S
R
I
M
G
E
S
G
Site 89
S742
L
S
R
I
M
G
E
S
G
K
Y
Q
L
S
P
Site 90
Y745
I
M
G
E
S
G
K
Y
Q
L
S
P
T
V
N
Site 91
S748
E
S
G
K
Y
Q
L
S
P
T
V
N
M
P
Q
Site 92
T750
G
K
Y
Q
L
S
P
T
V
N
M
P
Q
D
D
Site 93
T758
V
N
M
P
Q
D
D
T
V
I
I
E
D
D
R
Site 94
S774
P
V
L
P
P
H
L
S
D
Q
S
S
S
S
S
Site 95
S777
P
P
H
L
S
D
Q
S
S
S
S
S
H
D
D
Site 96
S778
P
H
L
S
D
Q
S
S
S
S
S
H
D
D
V
Site 97
S780
L
S
D
Q
S
S
S
S
S
H
D
D
V
G
F
Site 98
S781
S
D
Q
S
S
S
S
S
H
D
D
V
G
F
V
Site 99
S803
A
K
A
A
I
S
D
S
A
D
C
S
L
S
P
Site 100
S807
I
S
D
S
A
D
C
S
L
S
P
D
V
D
P
Site 101
S809
D
S
A
D
C
S
L
S
P
D
V
D
P
V
L
Site 102
S827
R
E
G
F
G
R
Q
S
M
S
E
K
R
T
K
Site 103
S829
G
F
G
R
Q
S
M
S
E
K
R
T
K
Q
F
Site 104
T833
Q
S
M
S
E
K
R
T
K
Q
F
S
D
A
S
Site 105
S837
E
K
R
T
K
Q
F
S
D
A
S
Q
L
D
F
Site 106
S840
T
K
Q
F
S
D
A
S
Q
L
D
F
V
K
T
Site 107
T847
S
Q
L
D
F
V
K
T
R
K
S
K
S
M
D
Site 108
S850
D
F
V
K
T
R
K
S
K
S
M
D
L
G
I
Site 109
S852
V
K
T
R
K
S
K
S
M
D
L
G
I
A
D
Site 110
T865
A
D
E
T
K
L
N
T
V
D
D
Q
K
A
G
Site 111
S873
V
D
D
Q
K
A
G
S
P
S
R
D
V
G
P
Site 112
S875
D
Q
K
A
G
S
P
S
R
D
V
G
P
S
L
Site 113
S881
P
S
R
D
V
G
P
S
L
G
L
K
K
S
S
Site 114
S887
P
S
L
G
L
K
K
S
S
S
L
E
S
L
Q
Site 115
S888
S
L
G
L
K
K
S
S
S
L
E
S
L
Q
T
Site 116
S889
L
G
L
K
K
S
S
S
L
E
S
L
Q
T
A
Site 117
S892
K
K
S
S
S
L
E
S
L
Q
T
A
V
A
E
Site 118
T895
S
S
L
E
S
L
Q
T
A
V
A
E
V
T
L
Site 119
S924
R
G
R
G
C
N
E
S
F
R
A
A
I
D
K
Site 120
S932
F
R
A
A
I
D
K
S
Y
D
K
P
A
V
D
Site 121
Y933
R
A
A
I
D
K
S
Y
D
K
P
A
V
D
D
Site 122
T947
D
D
D
E
G
M
E
T
L
E
E
D
T
E
E
Site 123
T952
M
E
T
L
E
E
D
T
E
E
S
S
R
S
G
Site 124
S955
L
E
E
D
T
E
E
S
S
R
S
G
R
E
S
Site 125
S956
E
E
D
T
E
E
S
S
R
S
G
R
E
S
V
Site 126
S958
D
T
E
E
S
S
R
S
G
R
E
S
V
S
T
Site 127
S962
S
S
R
S
G
R
E
S
V
S
T
A
S
D
Q
Site 128
S964
R
S
G
R
E
S
V
S
T
A
S
D
Q
P
S
Site 129
T965
S
G
R
E
S
V
S
T
A
S
D
Q
P
S
H
Site 130
S967
R
E
S
V
S
T
A
S
D
Q
P
S
H
S
L
Site 131
S971
S
T
A
S
D
Q
P
S
H
S
L
E
R
Q
M
Site 132
S973
A
S
D
Q
P
S
H
S
L
E
R
Q
M
N
G
Site 133
T988
N
Q
E
K
G
D
K
T
D
R
K
K
D
K
T
Site 134
T995
T
D
R
K
K
D
K
T
G
K
E
K
K
K
D
Site 135
S1046
G
K
I
K
I
Q
E
S
F
T
S
E
E
E
R
Site 136
S1049
K
I
Q
E
S
F
T
S
E
E
E
R
I
R
M
Site 137
T1067
Q
E
R
I
Q
A
K
T
R
E
F
R
E
R
Q
Site 138
Y1080
R
Q
A
R
E
R
D
Y
A
E
I
Q
D
F
H
Site 139
Y1098
G
C
D
D
E
L
M
Y
G
G
V
S
S
Y
E
Site 140
Y1104
M
Y
G
G
V
S
S
Y
E
G
S
M
A
L
N
Site 141
S1107
G
V
S
S
Y
E
G
S
M
A
L
N
A
R
P
Site 142
S1116
A
L
N
A
R
P
Q
S
P
R
E
G
H
M
M
Site 143
Y1127
G
H
M
M
D
A
L
Y
A
Q
V
K
K
P
R
Site 144
S1136
Q
V
K
K
P
R
N
S
K
P
S
P
V
D
S
Site 145
S1139
K
P
R
N
S
K
P
S
P
V
D
S
N
R
S
Site 146
S1143
S
K
P
S
P
V
D
S
N
R
S
T
P
S
N
Site 147
S1146
S
P
V
D
S
N
R
S
T
P
S
N
H
D
R
Site 148
T1147
P
V
D
S
N
R
S
T
P
S
N
H
D
R
I
Site 149
T1176
D
V
E
D
R
R
R
T
Y
S
F
E
Q
P
W
Site 150
Y1177
V
E
D
R
R
R
T
Y
S
F
E
Q
P
W
P
Site 151
S1178
E
D
R
R
R
T
Y
S
F
E
Q
P
W
P
N
Site 152
T1190
W
P
N
A
R
P
A
T
Q
S
G
R
H
S
V
Site 153
S1192
N
A
R
P
A
T
Q
S
G
R
H
S
V
S
V
Site 154
S1196
A
T
Q
S
G
R
H
S
V
S
V
E
V
Q
M
Site 155
S1198
Q
S
G
R
H
S
V
S
V
E
V
Q
M
Q
R
Site 156
S1213
Q
R
Q
E
E
R
E
S
S
Q
Q
A
Q
R
Q
Site 157
S1214
R
Q
E
E
R
E
S
S
Q
Q
A
Q
R
Q
Y
Site 158
Y1221
S
Q
Q
A
Q
R
Q
Y
S
S
L
P
R
Q
S
Site 159
S1222
Q
Q
A
Q
R
Q
Y
S
S
L
P
R
Q
S
R
Site 160
S1223
Q
A
Q
R
Q
Y
S
S
L
P
R
Q
S
R
K
Site 161
S1228
Y
S
S
L
P
R
Q
S
R
K
N
A
S
S
V
Site 162
S1233
R
Q
S
R
K
N
A
S
S
V
S
Q
D
S
W
Site 163
S1234
Q
S
R
K
N
A
S
S
V
S
Q
D
S
W
E
Site 164
S1236
R
K
N
A
S
S
V
S
Q
D
S
W
E
Q
N
Site 165
S1239
A
S
S
V
S
Q
D
S
W
E
Q
N
Y
S
P
Site 166
Y1244
Q
D
S
W
E
Q
N
Y
S
P
G
E
G
F
Q
Site 167
S1245
D
S
W
E
Q
N
Y
S
P
G
E
G
F
Q
S
Site 168
S1252
S
P
G
E
G
F
Q
S
A
K
E
N
P
R
Y
Site 169
Y1259
S
A
K
E
N
P
R
Y
S
S
Y
Q
G
S
R
Site 170
S1260
A
K
E
N
P
R
Y
S
S
Y
Q
G
S
R
N
Site 171
S1261
K
E
N
P
R
Y
S
S
Y
Q
G
S
R
N
G
Site 172
Y1262
E
N
P
R
Y
S
S
Y
Q
G
S
R
N
G
Y
Site 173
S1265
R
Y
S
S
Y
Q
G
S
R
N
G
Y
L
G
G
Site 174
Y1269
Y
Q
G
S
R
N
G
Y
L
G
G
H
G
F
N
Site 175
S1304
Q
M
K
K
Q
P
P
S
E
G
P
S
N
Y
D
Site 176
S1308
Q
P
P
S
E
G
P
S
N
Y
D
S
Y
K
K
Site 177
Y1310
P
S
E
G
P
S
N
Y
D
S
Y
K
K
V
Q
Site 178
S1312
E
G
P
S
N
Y
D
S
Y
K
K
V
Q
D
P
Site 179
Y1313
G
P
S
N
Y
D
S
Y
K
K
V
Q
D
P
S
Site 180
S1320
Y
K
K
V
Q
D
P
S
Y
A
P
P
K
G
P
Site 181
Y1321
K
K
V
Q
D
P
S
Y
A
P
P
K
G
P
F
Site 182
S1335
F
R
Q
D
V
P
P
S
P
S
Q
V
A
R
L
Site 183
S1337
Q
D
V
P
P
S
P
S
Q
V
A
R
L
N
R
Site 184
T1347
A
R
L
N
R
L
Q
T
P
E
K
G
R
P
F
Site 185
Y3326
I
K
D
K
N
K
F
Y
F
P
S
L
Q
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation