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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GSG2
Full Name:
Serine/threonine-protein kinase haspin
Alias:
EC 2.7.11.1; Germ cell-specific gene 2 protein; Haploid germ cell-specific nuclear protein kinase; HASP
Type:
Protein-serine kinase, Other group, Haspin family
Mass (Da):
88460
Number AA:
798
UniProt ID:
Q8TF76
International Prot ID:
IPI00397836
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0016568
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
S
L
P
G
P
G
S
R
L
F
R
T
Y
G
Site 2
T15
P
G
S
R
L
F
R
T
Y
G
A
A
D
G
R
Site 3
Y16
G
S
R
L
F
R
T
Y
G
A
A
D
G
R
R
Site 4
S46
D
R
R
R
F
F
N
S
S
G
S
S
D
A
S
Site 5
S47
R
R
R
F
F
N
S
S
G
S
S
D
A
S
I
Site 6
S49
R
F
F
N
S
S
G
S
S
D
A
S
I
G
D
Site 7
S50
F
F
N
S
S
G
S
S
D
A
S
I
G
D
P
Site 8
S53
S
S
G
S
S
D
A
S
I
G
D
P
S
Q
S
Site 9
S58
D
A
S
I
G
D
P
S
Q
S
D
D
P
D
D
Site 10
S60
S
I
G
D
P
S
Q
S
D
D
P
D
D
P
D
Site 11
S74
D
D
P
D
F
P
G
S
P
V
R
R
R
R
R
Site 12
S93
R
V
P
K
D
R
P
S
L
T
V
T
P
K
R
Site 13
T95
P
K
D
R
P
S
L
T
V
T
P
K
R
W
K
Site 14
T97
D
R
P
S
L
T
V
T
P
K
R
W
K
L
R
Site 15
S108
W
K
L
R
A
R
P
S
L
T
V
T
P
R
R
Site 16
T110
L
R
A
R
P
S
L
T
V
T
P
R
R
L
G
Site 17
T112
A
R
P
S
L
T
V
T
P
R
R
L
G
L
R
Site 18
S127
A
R
P
P
Q
K
C
S
T
P
C
G
P
L
R
Site 19
T128
R
P
P
Q
K
C
S
T
P
C
G
P
L
R
L
Site 20
S140
L
R
L
P
P
F
P
S
R
D
S
G
R
L
S
Site 21
S143
P
P
F
P
S
R
D
S
G
R
L
S
P
D
L
Site 22
S147
S
R
D
S
G
R
L
S
P
D
L
S
V
C
G
Site 23
S151
G
R
L
S
P
D
L
S
V
C
G
Q
P
R
D
Site 24
S179
L
A
S
P
C
P
G
S
P
T
P
R
D
S
V
Site 25
T181
S
P
C
P
G
S
P
T
P
R
D
S
V
I
S
Site 26
S185
G
S
P
T
P
R
D
S
V
I
S
I
G
T
S
Site 27
S211
D
L
H
L
P
E
V
S
L
D
R
A
S
L
P
Site 28
S216
E
V
S
L
D
R
A
S
L
P
C
S
Q
E
E
Site 29
S220
D
R
A
S
L
P
C
S
Q
E
E
A
T
G
G
Site 30
T237
D
T
R
M
V
H
Q
T
R
A
S
L
R
S
V
Site 31
S251
V
L
F
G
L
M
N
S
G
T
P
E
D
S
E
Site 32
T253
F
G
L
M
N
S
G
T
P
E
D
S
E
F
R
Site 33
S257
N
S
G
T
P
E
D
S
E
F
R
A
D
G
K
Site 34
S287
G
P
E
G
P
G
L
S
S
T
G
K
R
R
A
Site 35
S288
P
E
G
P
G
L
S
S
T
G
K
R
R
A
T
Site 36
T289
E
G
P
G
L
S
S
T
G
K
R
R
A
T
G
Site 37
T295
S
T
G
K
R
R
A
T
G
Q
D
S
C
Q
E
Site 38
S317
R
R
E
H
Q
E
A
S
V
P
K
G
R
I
V
Site 39
T328
G
R
I
V
P
R
G
T
D
R
L
E
R
T
R
Site 40
S336
D
R
L
E
R
T
R
S
S
R
K
S
K
H
Q
Site 41
S337
R
L
E
R
T
R
S
S
R
K
S
K
H
Q
E
Site 42
S340
R
T
R
S
S
R
K
S
K
H
Q
E
A
T
E
Site 43
T346
K
S
K
H
Q
E
A
T
E
T
S
L
L
H
S
Site 44
T348
K
H
Q
E
A
T
E
T
S
L
L
H
S
H
R
Site 45
S349
H
Q
E
A
T
E
T
S
L
L
H
S
H
R
F
Site 46
S353
T
E
T
S
L
L
H
S
H
R
F
K
K
G
Q
Site 47
S366
G
Q
K
L
G
K
D
S
F
P
T
Q
D
L
T
Site 48
T373
S
F
P
T
Q
D
L
T
P
L
Q
N
A
C
F
Site 49
S387
F
W
T
K
T
R
A
S
F
S
F
H
K
K
K
Site 50
S389
T
K
T
R
A
S
F
S
F
H
K
K
K
I
V
Site 51
S415
T
A
T
S
L
S
G
S
L
L
S
E
C
S
N
Site 52
S418
S
L
S
G
S
L
L
S
E
C
S
N
R
P
V
Site 53
S421
G
S
L
L
S
E
C
S
N
R
P
V
M
N
R
Site 54
S430
R
P
V
M
N
R
T
S
G
A
P
S
S
W
H
Site 55
S434
N
R
T
S
G
A
P
S
S
W
H
S
S
S
M
Site 56
S435
R
T
S
G
A
P
S
S
W
H
S
S
S
M
Y
Site 57
S438
G
A
P
S
S
W
H
S
S
S
M
Y
L
L
S
Site 58
S439
A
P
S
S
W
H
S
S
S
M
Y
L
L
S
P
Site 59
S440
P
S
S
W
H
S
S
S
M
Y
L
L
S
P
L
Site 60
Y442
S
W
H
S
S
S
M
Y
L
L
S
P
L
N
T
Site 61
T449
Y
L
L
S
P
L
N
T
L
S
I
S
N
K
K
Site 62
S451
L
S
P
L
N
T
L
S
I
S
N
K
K
A
S
Site 63
S453
P
L
N
T
L
S
I
S
N
K
K
A
S
D
A
Site 64
S458
S
I
S
N
K
K
A
S
D
A
E
K
V
Y
G
Site 65
Y464
A
S
D
A
E
K
V
Y
G
E
C
S
Q
K
G
Site 66
S468
E
K
V
Y
G
E
C
S
Q
K
G
P
V
P
F
Site 67
S476
Q
K
G
P
V
P
F
S
H
C
L
P
T
E
K
Site 68
S524
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
Site 69
T528
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
Site 70
S546
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
Site 71
T553
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
Site 72
Y580
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
Site 73
S582
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
Site 74
S586
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
Site 75
T617
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
Site 76
S621
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
Site 77
T624
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
Site 78
S642
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
Site 79
T660
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
Site 80
S661
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
Site 81
Y667
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
Site 82
T668
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
Site 83
S673
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
Site 84
S674
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Site 85
Y688
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
Site 86
T689
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
Site 87
T712
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
Site 88
Y717
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
Site 89
Y722
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
Site 90
Y736
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
Site 91
Y747
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Site 92
T764
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
Site 93
T780
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation