KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HDAC7
Full Name:
Histone deacetylase 7
Alias:
DKFZP586J0917; EC 3.5.1.98; HD7a; HDA7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7a
Type:
Hydrolase; EC 3.5.1.98
Mass (Da):
102927
Number AA:
952
UniProt ID:
Q8WUI4
International Prot ID:
IPI00386808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000118
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0070491
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0032703
GO:0045668
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
A
G
L
Q
Q
Q
R
S
V
E
P
M
R
L
S
Site 2
S49
S
V
E
P
M
R
L
S
M
D
T
P
M
P
E
Site 3
T52
P
M
R
L
S
M
D
T
P
M
P
E
L
Q
V
Site 4
S75
Q
L
L
H
K
D
K
S
K
R
S
A
V
A
S
Site 5
S78
H
K
D
K
S
K
R
S
A
V
A
S
S
V
V
Site 6
S82
S
K
R
S
A
V
A
S
S
V
V
K
Q
K
L
Site 7
T104
Q
Q
A
A
L
E
R
T
V
H
P
N
S
P
G
Site 8
S109
E
R
T
V
H
P
N
S
P
G
I
P
Y
R
T
Site 9
Y114
P
N
S
P
G
I
P
Y
R
T
L
E
P
L
E
Site 10
T116
S
P
G
I
P
Y
R
T
L
E
P
L
E
T
E
Site 11
T122
R
T
L
E
P
L
E
T
E
G
A
T
R
S
M
Site 12
S128
E
T
E
G
A
T
R
S
M
L
S
S
F
L
P
Site 13
S139
S
F
L
P
P
V
P
S
L
P
S
D
P
P
E
Site 14
S142
P
P
V
P
S
L
P
S
D
P
P
E
H
F
P
Site 15
T153
E
H
F
P
L
R
K
T
V
S
E
P
N
L
K
Site 16
S155
F
P
L
R
K
T
V
S
E
P
N
L
K
L
R
Site 17
S168
L
R
Y
K
P
K
K
S
L
E
R
R
K
N
P
Site 18
S181
N
P
L
L
R
K
E
S
A
P
P
S
L
R
R
Site 19
S185
R
K
E
S
A
P
P
S
L
R
R
R
P
A
E
Site 20
T193
L
R
R
R
P
A
E
T
L
G
D
S
S
P
S
Site 21
S197
P
A
E
T
L
G
D
S
S
P
S
S
S
S
T
Site 22
S198
A
E
T
L
G
D
S
S
P
S
S
S
S
T
P
Site 23
S200
T
L
G
D
S
S
P
S
S
S
S
T
P
A
S
Site 24
S201
L
G
D
S
S
P
S
S
S
S
T
P
A
S
G
Site 25
S202
G
D
S
S
P
S
S
S
S
T
P
A
S
G
C
Site 26
S203
D
S
S
P
S
S
S
S
T
P
A
S
G
C
S
Site 27
T204
S
S
P
S
S
S
S
T
P
A
S
G
C
S
S
Site 28
S207
S
S
S
S
T
P
A
S
G
C
S
S
P
N
D
Site 29
S211
T
P
A
S
G
C
S
S
P
N
D
S
E
H
G
Site 30
S215
G
C
S
S
P
N
D
S
E
H
G
P
N
P
I
Site 31
S225
G
P
N
P
I
L
G
S
E
A
L
L
G
Q
R
Site 32
S239
R
L
R
L
Q
E
T
S
V
A
P
F
A
L
P
Site 33
T255
V
S
L
L
P
A
I
T
L
G
L
P
A
P
A
Site 34
S266
P
A
P
A
R
A
D
S
D
R
R
T
H
P
T
Site 35
T270
R
A
D
S
D
R
R
T
H
P
T
L
G
P
R
Site 36
T273
S
D
R
R
T
H
P
T
L
G
P
R
G
P
I
Site 37
S283
P
R
G
P
I
L
G
S
P
H
T
P
L
F
L
Site 38
T286
P
I
L
G
S
P
H
T
P
L
F
L
P
H
G
Site 39
T301
L
E
P
E
A
G
G
T
L
P
S
R
L
Q
P
Site 40
T341
F
A
Q
S
L
M
T
T
E
R
L
S
G
S
G
Site 41
S345
L
M
T
T
E
R
L
S
G
S
G
L
H
W
P
Site 42
S354
S
G
L
H
W
P
L
S
R
T
R
S
E
P
L
Site 43
T356
L
H
W
P
L
S
R
T
R
S
E
P
L
P
P
Site 44
S358
W
P
L
S
R
T
R
S
E
P
L
P
P
S
A
Site 45
S364
R
S
E
P
L
P
P
S
A
T
A
P
P
P
P
Site 46
T366
E
P
L
P
P
S
A
T
A
P
P
P
P
G
P
Site 47
T383
P
R
L
E
Q
L
K
T
H
V
Q
V
I
K
R
Site 48
S395
I
K
R
S
A
K
P
S
E
K
P
R
L
R
Q
Site 49
S405
P
R
L
R
Q
I
P
S
A
E
D
L
E
T
D
Site 50
T411
P
S
A
E
D
L
E
T
D
G
G
G
P
G
Q
Site 51
S464
A
G
R
L
P
R
G
S
T
G
D
T
V
L
L
Site 52
T465
G
R
L
P
R
G
S
T
G
D
T
V
L
L
P
Site 53
T468
P
R
G
S
T
G
D
T
V
L
L
P
L
A
Q
Site 54
S482
Q
G
G
H
R
P
L
S
R
A
Q
S
S
P
A
Site 55
S486
R
P
L
S
R
A
Q
S
S
P
A
A
P
A
S
Site 56
S487
P
L
S
R
A
Q
S
S
P
A
A
P
A
S
L
Site 57
S493
S
S
P
A
A
P
A
S
L
S
A
P
E
P
A
Site 58
S495
P
A
A
P
A
S
L
S
A
P
E
P
A
S
Q
Site 59
S501
L
S
A
P
E
P
A
S
Q
A
R
V
L
S
S
Site 60
S507
A
S
Q
A
R
V
L
S
S
S
E
T
P
A
R
Site 61
S508
S
Q
A
R
V
L
S
S
S
E
T
P
A
R
T
Site 62
S509
Q
A
R
V
L
S
S
S
E
T
P
A
R
T
L
Site 63
T511
R
V
L
S
S
S
E
T
P
A
R
T
L
P
F
Site 64
T515
S
S
E
T
P
A
R
T
L
P
F
T
T
G
L
Site 65
T519
P
A
R
T
L
P
F
T
T
G
L
I
Y
D
S
Site 66
Y524
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Site 67
S550
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
Site 68
S562
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
Site 69
S573
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
Site 70
S579
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
Site 71
S582
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
Site 72
Y589
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
R
Site 73
T591
R
H
V
L
L
Y
G
T
N
P
L
S
R
L
K
Site 74
S595
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
Site 75
T627
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
Site 76
T717
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
Site 77
Y719
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
Site 78
S723
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
Site 79
Y726
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
Site 80
S728
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
Site 81
S741
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
Site 82
Y822
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
Site 83
T846
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
Site 84
S868
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
Site 85
S903
G
C
M
Q
R
L
A
S
C
P
D
S
W
V
P
Site 86
S907
R
L
A
S
C
P
D
S
W
V
P
R
V
P
G
Site 87
S940
I
L
A
E
D
R
P
S
E
Q
L
V
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation