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Updated November 2019
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Protein Info
Short Name:
ARAP3
Full Name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Alias:
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; CEND3; CENTD3; Drag1; FLJ21065
Type:
GTPase activating protein, ARF; GTPase activating protein, Rac/Rho
Mass (Da):
169844
Number AA:
1544
UniProt ID:
Q8WWN8
International Prot ID:
IPI00103380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005100
GO:0005547
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0035024
GO:0030336
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
A
T
V
H
L
E
Q
Y
A
D
T
F
R
R
H
Site 2
T24
H
L
E
Q
Y
A
D
T
F
R
R
H
G
L
A
Site 3
T32
F
R
R
H
G
L
A
T
A
G
A
A
R
G
L
Site 4
T52
K
Q
L
G
I
S
A
T
G
H
R
K
R
I
L
Site 5
T64
R
I
L
R
L
L
Q
T
G
T
E
E
G
S
L
Site 6
T66
L
R
L
L
Q
T
G
T
E
E
G
S
L
D
P
Site 7
S70
Q
T
G
T
E
E
G
S
L
D
P
K
S
D
S
Site 8
S75
E
G
S
L
D
P
K
S
D
S
A
M
E
P
S
Site 9
S77
S
L
D
P
K
S
D
S
A
M
E
P
S
P
S
Site 10
S82
S
D
S
A
M
E
P
S
P
S
P
A
P
Q
A
Site 11
S84
S
A
M
E
P
S
P
S
P
A
P
Q
A
Q
P
Site 12
T100
K
P
V
P
K
P
R
T
V
F
G
G
L
S
G
Site 13
S106
R
T
V
F
G
G
L
S
G
P
A
T
T
Q
R
Site 14
T110
G
G
L
S
G
P
A
T
T
Q
R
P
G
L
S
Site 15
T111
G
L
S
G
P
A
T
T
Q
R
P
G
L
S
P
Site 16
S117
T
T
Q
R
P
G
L
S
P
A
L
G
G
P
G
Site 17
S126
A
L
G
G
P
G
V
S
R
S
P
E
P
S
P
Site 18
S128
G
G
P
G
V
S
R
S
P
E
P
S
P
R
P
Site 19
S132
V
S
R
S
P
E
P
S
P
R
P
P
P
L
P
Site 20
T140
P
R
P
P
P
L
P
T
S
S
S
E
Q
S
S
Site 21
S141
R
P
P
P
L
P
T
S
S
S
E
Q
S
S
A
Site 22
S142
P
P
P
L
P
T
S
S
S
E
Q
S
S
A
L
Site 23
S143
P
P
L
P
T
S
S
S
E
Q
S
S
A
L
N
Site 24
S146
P
T
S
S
S
E
Q
S
S
A
L
N
T
V
E
Site 25
S147
T
S
S
S
E
Q
S
S
A
L
N
T
V
E
M
Site 26
T151
E
Q
S
S
A
L
N
T
V
E
M
M
P
N
S
Site 27
Y160
E
M
M
P
N
S
I
Y
F
G
L
D
S
R
G
Site 28
S165
S
I
Y
F
G
L
D
S
R
G
R
A
Q
A
A
Site 29
S179
A
Q
D
K
A
P
D
S
S
Q
I
S
A
P
T
Site 30
S180
Q
D
K
A
P
D
S
S
Q
I
S
A
P
T
P
Site 31
S183
A
P
D
S
S
Q
I
S
A
P
T
P
A
L
R
Site 32
T186
S
S
Q
I
S
A
P
T
P
A
L
R
P
T
T
Site 33
T192
P
T
P
A
L
R
P
T
T
G
T
V
H
I
M
Site 34
T193
T
P
A
L
R
P
T
T
G
T
V
H
I
M
D
Site 35
T195
A
L
R
P
T
T
G
T
V
H
I
M
D
P
G
Site 36
Y205
I
M
D
P
G
C
L
Y
Y
G
V
Q
P
V
G
Site 37
T213
Y
G
V
Q
P
V
G
T
P
G
A
P
D
R
R
Site 38
S222
G
A
P
D
R
R
E
S
R
G
V
C
Q
G
R
Site 39
S235
G
R
A
E
H
R
L
S
R
Q
D
L
E
A
R
Site 40
Y247
E
A
R
E
D
A
G
Y
A
S
L
E
L
P
G
Site 41
S249
R
E
D
A
G
Y
A
S
L
E
L
P
G
D
S
Site 42
T257
L
E
L
P
G
D
S
T
L
L
S
P
T
L
E
Site 43
S260
P
G
D
S
T
L
L
S
P
T
L
E
T
E
E
Site 44
T268
P
T
L
E
T
E
E
T
S
D
D
L
I
S
P
Site 45
S269
T
L
E
T
E
E
T
S
D
D
L
I
S
P
Y
Site 46
S274
E
T
S
D
D
L
I
S
P
Y
A
S
F
S
F
Site 47
Y276
S
D
D
L
I
S
P
Y
A
S
F
S
F
T
A
Site 48
S278
D
L
I
S
P
Y
A
S
F
S
F
T
A
D
R
Site 49
S280
I
S
P
Y
A
S
F
S
F
T
A
D
R
L
T
Site 50
T282
P
Y
A
S
F
S
F
T
A
D
R
L
T
P
L
Site 51
S291
D
R
L
T
P
L
L
S
G
W
L
D
K
L
S
Site 52
S298
S
G
W
L
D
K
L
S
P
Q
G
N
Y
V
F
Site 53
Y303
K
L
S
P
Q
G
N
Y
V
F
Q
R
R
F
V
Site 54
Y319
F
N
G
R
S
L
M
Y
F
G
S
D
K
D
P
Site 55
S322
R
S
L
M
Y
F
G
S
D
K
D
P
F
P
K
Site 56
S342
T
A
I
E
M
T
R
S
S
K
D
N
K
F
Q
Site 57
S343
A
I
E
M
T
R
S
S
K
D
N
K
F
Q
V
Site 58
Y422
S
P
G
E
L
A
L
Y
K
S
E
Q
A
F
S
Site 59
S424
G
E
L
A
L
Y
K
S
E
Q
A
F
S
L
G
Site 60
S443
F
I
E
L
Q
G
C
S
V
R
E
T
K
S
R
Site 61
T447
Q
G
C
S
V
R
E
T
K
S
R
S
F
D
L
Site 62
S449
C
S
V
R
E
T
K
S
R
S
F
D
L
L
T
Site 63
S451
V
R
E
T
K
S
R
S
F
D
L
L
T
P
H
Site 64
T456
S
R
S
F
D
L
L
T
P
H
R
C
F
S
F
Site 65
S462
L
T
P
H
R
C
F
S
F
T
A
E
S
G
G
Site 66
T464
P
H
R
C
F
S
F
T
A
E
S
G
G
A
R
Site 67
S473
E
S
G
G
A
R
Q
S
W
A
A
A
L
Q
E
Site 68
S487
E
A
V
T
E
T
L
S
D
Y
E
V
A
E
K
Site 69
Y489
V
T
E
T
L
S
D
Y
E
V
A
E
K
I
W
Site 70
S509
R
Q
C
A
D
C
G
S
S
R
P
D
W
A
A
Site 71
S536
G
Q
H
R
A
L
G
S
G
I
S
K
V
Q
S
Site 72
S539
R
A
L
G
S
G
I
S
K
V
Q
S
L
K
L
Site 73
S543
S
G
I
S
K
V
Q
S
L
K
L
D
T
S
V
Site 74
T548
V
Q
S
L
K
L
D
T
S
V
W
S
N
E
I
Site 75
S549
Q
S
L
K
L
D
T
S
V
W
S
N
E
I
V
Site 76
T574
A
N
R
F
W
A
G
T
L
P
P
G
E
G
L
Site 77
T586
E
G
L
H
P
D
A
T
P
G
P
R
G
E
F
Site 78
S595
G
P
R
G
E
F
I
S
R
K
Y
R
L
G
L
Site 79
Y598
G
E
F
I
S
R
K
Y
R
L
G
L
F
R
K
Site 80
Y610
F
R
K
P
H
P
Q
Y
P
D
H
S
Q
L
L
Site 81
S614
H
P
Q
Y
P
D
H
S
Q
L
L
Q
A
L
C
Site 82
S656
F
P
P
A
P
D
G
S
C
P
G
L
L
P
S
Site 83
S663
S
C
P
G
L
L
P
S
D
P
S
P
G
V
Y
Site 84
S666
G
L
L
P
S
D
P
S
P
G
V
Y
N
E
V
Site 85
Y670
S
D
P
S
P
G
V
Y
N
E
V
V
V
R
A
Site 86
Y679
E
V
V
V
R
A
T
Y
S
G
F
L
Y
C
S
Site 87
Y684
A
T
Y
S
G
F
L
Y
C
S
P
V
S
N
K
Site 88
S686
Y
S
G
F
L
Y
C
S
P
V
S
N
K
A
G
Site 89
S689
F
L
Y
C
S
P
V
S
N
K
A
G
P
S
P
Site 90
S695
V
S
N
K
A
G
P
S
P
P
R
R
G
R
D
Site 91
S720
A
A
L
E
M
F
A
S
E
N
S
P
E
P
L
Site 92
S723
E
M
F
A
S
E
N
S
P
E
P
L
S
L
I
Site 93
S728
E
N
S
P
E
P
L
S
L
I
Q
P
Q
D
I
Site 94
T745
L
G
V
S
P
P
P
T
D
P
G
D
R
F
P
Site 95
S774
F
G
T
D
G
A
D
S
L
E
A
W
T
S
A
Site 96
S780
D
S
L
E
A
W
T
S
A
V
G
K
W
F
S
Site 97
S790
G
K
W
F
S
P
L
S
C
H
Q
L
L
G
P
Site 98
S809
L
G
R
L
W
L
R
S
P
S
H
T
A
P
A
Site 99
S811
R
L
W
L
R
S
P
S
H
T
A
P
A
P
G
Site 100
T813
W
L
R
S
P
S
H
T
A
P
A
P
G
L
W
Site 101
S836
G
D
H
L
F
L
C
S
A
P
G
P
G
P
P
Site 102
S858
L
R
R
L
Q
E
I
S
V
V
S
A
A
D
T
Site 103
T865
S
V
V
S
A
A
D
T
P
D
K
K
E
H
L
Site 104
Y882
V
E
T
G
R
T
L
Y
L
Q
G
E
G
R
L
Site 105
T892
G
E
G
R
L
D
F
T
A
W
N
A
A
I
G
Site 106
Y941
G
L
R
L
E
G
V
Y
R
K
G
G
A
R
A
Site 107
S950
K
G
G
A
R
A
R
S
L
R
L
L
A
E
F
Site 108
S963
E
F
R
R
D
A
R
S
V
K
L
R
P
G
E
Site 109
T977
E
H
F
V
E
D
V
T
D
T
L
K
R
F
F
Site 110
T979
F
V
E
D
V
T
D
T
L
K
R
F
F
R
E
Site 111
T992
R
E
L
D
D
P
V
T
S
A
R
L
L
P
R
Site 112
S993
E
L
D
D
P
V
T
S
A
R
L
L
P
R
W
Site 113
Y1016
K
N
Q
R
L
E
K
Y
K
D
V
I
G
C
L
Site 114
T1030
L
P
R
V
N
R
R
T
L
A
T
L
I
G
H
Site 115
T1033
V
N
R
R
T
L
A
T
L
I
G
H
L
Y
R
Site 116
T1066
F
A
P
S
V
F
Q
T
D
G
R
G
E
H
E
Site 117
S1114
T
W
K
D
V
Q
L
S
Q
A
G
D
L
I
M
Site 118
Y1124
G
D
L
I
M
E
V
Y
I
E
Q
Q
L
P
D
Site 119
T1143
L
K
V
S
P
T
L
T
A
E
E
L
T
N
Q
Site 120
S1224
F
T
G
I
R
R
E
S
P
R
V
G
L
L
R
Site 121
S1242
E
P
P
R
L
L
G
S
R
F
Q
E
R
F
F
Site 122
S1264
L
L
L
K
E
K
K
S
S
K
P
E
R
E
W
Site 123
S1265
L
L
K
E
K
K
S
S
K
P
E
R
E
W
P
Site 124
T1290
R
K
K
L
K
P
P
T
P
W
G
F
T
L
I
Site 125
Y1304
I
L
E
K
M
H
L
Y
L
S
C
T
D
E
D
Site 126
S1306
E
K
M
H
L
Y
L
S
C
T
D
E
D
E
M
Site 127
S1337
P
V
V
L
R
R
H
S
S
S
D
L
A
R
Q
Site 128
S1338
V
V
L
R
R
H
S
S
S
D
L
A
R
Q
K
Site 129
S1339
V
L
R
R
H
S
S
S
D
L
A
R
Q
K
F
Site 130
T1348
L
A
R
Q
K
F
G
T
M
P
L
L
P
I
R
Site 131
S1365
D
S
G
A
T
L
L
S
A
N
Q
T
L
R
R
Site 132
T1369
T
L
L
S
A
N
Q
T
L
R
R
L
H
N
R
Site 133
T1378
R
R
L
H
N
R
R
T
L
S
M
F
F
P
M
Site 134
S1380
L
H
N
R
R
T
L
S
M
F
F
P
M
K
S
Site 135
S1387
S
M
F
F
P
M
K
S
S
Q
G
S
V
E
E
Site 136
S1388
M
F
F
P
M
K
S
S
Q
G
S
V
E
E
Q
Site 137
S1391
P
M
K
S
S
Q
G
S
V
E
E
Q
E
E
L
Site 138
Y1403
E
E
L
E
E
P
V
Y
E
E
P
V
Y
E
E
Site 139
Y1408
P
V
Y
E
E
P
V
Y
E
E
V
G
A
F
P
Site 140
S1422
P
E
L
I
Q
D
T
S
T
S
F
S
T
T
R
Site 141
S1424
L
I
Q
D
T
S
T
S
F
S
T
T
R
E
W
Site 142
S1426
Q
D
T
S
T
S
F
S
T
T
R
E
W
T
V
Site 143
T1428
T
S
T
S
F
S
T
T
R
E
W
T
V
K
P
Site 144
T1432
F
S
T
T
R
E
W
T
V
K
P
E
N
P
L
Site 145
T1440
V
K
P
E
N
P
L
T
S
Q
K
S
L
D
Q
Site 146
S1441
K
P
E
N
P
L
T
S
Q
K
S
L
D
Q
P
Site 147
S1444
N
P
L
T
S
Q
K
S
L
D
Q
P
F
L
S
Site 148
S1451
S
L
D
Q
P
F
L
S
K
S
S
T
L
G
Q
Site 149
S1453
D
Q
P
F
L
S
K
S
S
T
L
G
Q
E
E
Site 150
T1455
P
F
L
S
K
S
S
T
L
G
Q
E
E
R
P
Site 151
S1471
E
P
P
P
G
P
P
S
K
S
S
P
Q
A
R
Site 152
S1473
P
P
G
P
P
S
K
S
S
P
Q
A
R
G
S
Site 153
S1474
P
G
P
P
S
K
S
S
P
Q
A
R
G
S
L
Site 154
S1480
S
S
P
Q
A
R
G
S
L
E
E
Q
L
L
Q
Site 155
S1490
E
Q
L
L
Q
E
L
S
S
L
I
L
R
K
G
Site 156
S1491
Q
L
L
Q
E
L
S
S
L
I
L
R
K
G
E
Site 157
T1500
I
L
R
K
G
E
T
T
A
G
L
G
S
P
S
Site 158
S1505
E
T
T
A
G
L
G
S
P
S
Q
P
S
S
P
Site 159
S1507
T
A
G
L
G
S
P
S
Q
P
S
S
P
Q
S
Site 160
S1510
L
G
S
P
S
Q
P
S
S
P
Q
S
P
S
P
Site 161
S1511
G
S
P
S
Q
P
S
S
P
Q
S
P
S
P
T
Site 162
S1514
S
Q
P
S
S
P
Q
S
P
S
P
T
G
L
P
Site 163
S1516
P
S
S
P
Q
S
P
S
P
T
G
L
P
T
Q
Site 164
T1518
S
P
Q
S
P
S
P
T
G
L
P
T
Q
T
P
Site 165
T1522
P
S
P
T
G
L
P
T
Q
T
P
G
F
P
T
Site 166
T1524
P
T
G
L
P
T
Q
T
P
G
F
P
T
Q
P
Site 167
T1529
T
Q
T
P
G
F
P
T
Q
P
P
C
T
S
S
Site 168
T1534
F
P
T
Q
P
P
C
T
S
S
P
P
S
S
Q
Site 169
S1535
P
T
Q
P
P
C
T
S
S
P
P
S
S
Q
P
Site 170
S1536
T
Q
P
P
C
T
S
S
P
P
S
S
Q
P
L
Site 171
S1539
P
C
T
S
S
P
P
S
S
Q
P
L
T
_
_
Site 172
S1540
C
T
S
S
P
P
S
S
Q
P
L
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation