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Updated November 2019
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Protein Info
Short Name:
SSH1
Full Name:
Protein phosphatase Slingshot homolog 1
Alias:
EC 3.1.3.16; EC 3.1.3.48; HSSH-1L; Slingshot-1L; SSH1L; SSH-1L
Type:
Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16
Mass (Da):
115511
Number AA:
1049
UniProt ID:
Q8WYL5
International Prot ID:
IPI00103742
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004725
GO:0008138
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0000902
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
L
V
T
L
Q
R
S
P
T
P
Site 2
S9
A
L
V
T
L
Q
R
S
P
T
P
S
A
A
S
Site 3
T11
V
T
L
Q
R
S
P
T
P
S
A
A
S
S
S
Site 4
S13
L
Q
R
S
P
T
P
S
A
A
S
S
S
A
S
Site 5
S16
S
P
T
P
S
A
A
S
S
S
A
S
N
S
E
Site 6
S17
P
T
P
S
A
A
S
S
S
A
S
N
S
E
L
Site 7
S18
T
P
S
A
A
S
S
S
A
S
N
S
E
L
E
Site 8
S20
S
A
A
S
S
S
A
S
N
S
E
L
E
A
G
Site 9
S22
A
S
S
S
A
S
N
S
E
L
E
A
G
S
E
Site 10
S37
E
D
R
K
L
N
L
S
L
S
E
S
F
F
M
Site 11
S39
R
K
L
N
L
S
L
S
E
S
F
F
M
V
K
Site 12
S57
L
F
L
Q
Q
G
S
S
P
Q
G
Q
R
S
L
Site 13
S63
S
S
P
Q
G
Q
R
S
L
Q
H
P
H
K
H
Site 14
S99
K
L
A
V
R
L
E
S
A
W
A
D
R
V
R
Site 15
S114
Y
M
V
V
V
Y
S
S
G
R
Q
D
T
E
E
Site 16
T119
Y
S
S
G
R
Q
D
T
E
E
N
I
L
L
G
Site 17
S130
I
L
L
G
V
D
F
S
S
K
E
S
K
S
C
Site 18
S131
L
L
G
V
D
F
S
S
K
E
S
K
S
C
T
Site 19
S134
V
D
F
S
S
K
E
S
K
S
C
T
I
G
M
Site 20
T138
S
K
E
S
K
S
C
T
I
G
M
V
L
R
L
Site 21
S147
G
M
V
L
R
L
W
S
D
T
K
I
H
L
D
Site 22
T149
V
L
R
L
W
S
D
T
K
I
H
L
D
G
D
Site 23
S160
L
D
G
D
G
G
F
S
V
S
T
A
G
R
M
Site 24
S162
G
D
G
G
F
S
V
S
T
A
G
R
M
H
I
Site 25
Y197
E
V
A
R
R
H
N
Y
F
P
G
G
V
A
L
Site 26
S232
N
A
M
Q
D
L
E
S
T
R
P
D
S
P
A
Site 27
T233
A
M
Q
D
L
E
S
T
R
P
D
S
P
A
L
Site 28
S237
L
E
S
T
R
P
D
S
P
A
L
F
V
D
K
Site 29
T251
K
P
T
E
G
E
R
T
E
R
L
I
K
A
K
Site 30
S265
K
L
R
S
I
M
M
S
Q
D
L
E
N
V
T
Site 31
S273
Q
D
L
E
N
V
T
S
K
E
I
R
N
E
L
Site 32
S310
L
G
Q
M
D
K
P
S
L
I
F
D
H
L
Y
Site 33
S325
L
G
S
E
W
N
A
S
N
L
E
E
L
Q
G
Site 34
S333
N
L
E
E
L
Q
G
S
G
V
D
Y
I
L
N
Site 35
Y337
L
Q
G
S
G
V
D
Y
I
L
N
V
T
R
E
Site 36
Y361
A
Y
H
N
I
R
V
Y
D
E
E
T
T
D
L
Site 37
S402
M
G
V
S
R
S
A
S
T
V
I
A
Y
A
M
Site 38
T403
G
V
S
R
S
A
S
T
V
I
A
Y
A
M
K
Site 39
Y407
S
A
S
T
V
I
A
Y
A
M
K
E
F
G
W
Site 40
Y420
G
W
P
L
E
K
A
Y
N
Y
V
K
Q
K
R
Site 41
Y422
P
L
E
K
A
Y
N
Y
V
K
Q
K
R
S
I
Site 42
S428
N
Y
V
K
Q
K
R
S
I
T
R
P
N
A
G
Site 43
T430
V
K
Q
K
R
S
I
T
R
P
N
A
G
F
M
Site 44
S441
A
G
F
M
R
Q
L
S
E
Y
E
G
I
L
D
Site 45
Y443
F
M
R
Q
L
S
E
Y
E
G
I
L
D
A
S
Site 46
S450
Y
E
G
I
L
D
A
S
K
Q
R
H
N
K
L
Site 47
T462
N
K
L
W
R
Q
Q
T
D
S
S
L
Q
Q
P
Site 48
S464
L
W
R
Q
Q
T
D
S
S
L
Q
Q
P
V
D
Site 49
S465
W
R
Q
Q
T
D
S
S
L
Q
Q
P
V
D
D
Site 50
T483
P
G
D
F
L
P
E
T
P
D
G
T
P
E
S
Site 51
T487
L
P
E
T
P
D
G
T
P
E
S
Q
L
P
F
Site 52
S490
T
P
D
G
T
P
E
S
Q
L
P
F
L
D
D
Site 53
S515
P
C
C
F
R
R
L
S
D
P
L
L
P
S
P
Site 54
S521
L
S
D
P
L
L
P
S
P
E
D
E
T
G
S
Site 55
S528
S
P
E
D
E
T
G
S
L
V
H
L
E
D
P
Site 56
S576
K
K
K
L
E
F
G
S
P
K
G
R
S
G
S
Site 57
S583
S
P
K
G
R
S
G
S
L
L
Q
V
E
E
T
Site 58
T590
S
L
L
Q
V
E
E
T
E
R
E
E
G
L
G
Site 59
S622
S
E
N
L
N
N
N
S
K
R
S
C
P
N
G
Site 60
S625
L
N
N
N
S
K
R
S
C
P
N
G
M
E
D
Site 61
S645
I
L
N
K
V
K
P
S
Y
K
S
C
A
D
C
Site 62
Y646
L
N
K
V
K
P
S
Y
K
S
C
A
D
C
M
Site 63
Y654
K
S
C
A
D
C
M
Y
P
T
A
S
G
A
P
Site 64
S658
D
C
M
Y
P
T
A
S
G
A
P
E
A
S
R
Site 65
S696
S
P
V
A
H
L
A
S
R
S
R
V
P
E
K
Site 66
S698
V
A
H
L
A
S
R
S
R
V
P
E
K
P
A
Site 67
S706
R
V
P
E
K
P
A
S
G
P
T
E
P
P
P
Site 68
S720
P
F
L
P
P
A
G
S
R
R
A
D
T
S
G
Site 69
T725
A
G
S
R
R
A
D
T
S
G
P
G
A
G
A
Site 70
S726
G
S
R
R
A
D
T
S
G
P
G
A
G
A
A
Site 71
S739
A
A
L
E
P
P
A
S
L
L
E
P
S
R
E
Site 72
T747
L
L
E
P
S
R
E
T
P
K
V
L
P
K
S
Site 73
S754
T
P
K
V
L
P
K
S
L
L
L
K
N
S
H
Site 74
S760
K
S
L
L
L
K
N
S
H
C
D
K
N
P
P
Site 75
S768
H
C
D
K
N
P
P
S
T
E
V
V
I
K
E
Site 76
S778
V
V
I
K
E
E
S
S
P
K
K
D
M
K
P
Site 77
S794
K
D
L
R
L
L
F
S
N
E
S
E
K
P
T
Site 78
S797
R
L
L
F
S
N
E
S
E
K
P
T
T
N
S
Site 79
T801
S
N
E
S
E
K
P
T
T
N
S
Y
L
M
Q
Site 80
T802
N
E
S
E
K
P
T
T
N
S
Y
L
M
Q
H
Site 81
Y805
E
K
P
T
T
N
S
Y
L
M
Q
H
Q
E
S
Site 82
T826
A
G
L
V
R
K
H
T
K
E
L
E
R
L
K
Site 83
S834
K
E
L
E
R
L
K
S
V
P
A
D
P
A
P
Site 84
S843
P
A
D
P
A
P
P
S
R
D
G
P
A
S
R
Site 85
S849
P
S
R
D
G
P
A
S
R
L
E
A
S
I
P
Site 86
S854
P
A
S
R
L
E
A
S
I
P
E
E
S
Q
D
Site 87
S859
E
A
S
I
P
E
E
S
Q
D
P
A
A
L
H
Site 88
S875
L
G
P
L
V
M
P
S
Q
A
G
S
D
E
K
Site 89
S879
V
M
P
S
Q
A
G
S
D
E
K
S
E
A
A
Site 90
S883
Q
A
G
S
D
E
K
S
E
A
A
P
A
S
L
Site 91
S889
K
S
E
A
A
P
A
S
L
E
G
G
S
L
K
Site 92
S894
P
A
S
L
E
G
G
S
L
K
S
P
P
P
F
Site 93
S897
L
E
G
G
S
L
K
S
P
P
P
F
F
Y
R
Site 94
Y903
K
S
P
P
P
F
F
Y
R
L
D
H
T
S
S
Site 95
T908
F
F
Y
R
L
D
H
T
S
S
F
S
K
D
F
Site 96
S909
F
Y
R
L
D
H
T
S
S
F
S
K
D
F
L
Site 97
S910
Y
R
L
D
H
T
S
S
F
S
K
D
F
L
K
Site 98
T918
F
S
K
D
F
L
K
T
I
C
Y
T
P
T
S
Site 99
Y921
D
F
L
K
T
I
C
Y
T
P
T
S
S
S
M
Site 100
T922
F
L
K
T
I
C
Y
T
P
T
S
S
S
M
S
Site 101
T924
K
T
I
C
Y
T
P
T
S
S
S
M
S
S
N
Site 102
S925
T
I
C
Y
T
P
T
S
S
S
M
S
S
N
L
Site 103
S926
I
C
Y
T
P
T
S
S
S
M
S
S
N
L
T
Site 104
S927
C
Y
T
P
T
S
S
S
M
S
S
N
L
T
R
Site 105
S929
T
P
T
S
S
S
M
S
S
N
L
T
R
S
S
Site 106
S930
P
T
S
S
S
M
S
S
N
L
T
R
S
S
S
Site 107
T933
S
S
M
S
S
N
L
T
R
S
S
S
S
D
S
Site 108
S935
M
S
S
N
L
T
R
S
S
S
S
D
S
I
H
Site 109
S936
S
S
N
L
T
R
S
S
S
S
D
S
I
H
S
Site 110
S937
S
N
L
T
R
S
S
S
S
D
S
I
H
S
V
Site 111
S938
N
L
T
R
S
S
S
S
D
S
I
H
S
V
R
Site 112
S940
T
R
S
S
S
S
D
S
I
H
S
V
R
G
K
Site 113
S943
S
S
S
D
S
I
H
S
V
R
G
K
P
G
L
Site 114
T955
P
G
L
V
K
Q
R
T
Q
E
I
E
T
R
L
Site 115
T968
R
L
R
L
A
G
L
T
V
S
S
P
L
K
R
Site 116
S970
R
L
A
G
L
T
V
S
S
P
L
K
R
S
H
Site 117
S971
L
A
G
L
T
V
S
S
P
L
K
R
S
H
S
Site 118
S976
V
S
S
P
L
K
R
S
H
S
L
A
K
L
G
Site 119
S978
S
P
L
K
R
S
H
S
L
A
K
L
G
S
L
Site 120
S984
H
S
L
A
K
L
G
S
L
T
F
S
T
E
D
Site 121
S988
K
L
G
S
L
T
F
S
T
E
D
L
S
S
E
Site 122
T989
L
G
S
L
T
F
S
T
E
D
L
S
S
E
A
Site 123
S993
T
F
S
T
E
D
L
S
S
E
A
D
P
S
T
Site 124
S994
F
S
T
E
D
L
S
S
E
A
D
P
S
T
V
Site 125
S999
L
S
S
E
A
D
P
S
T
V
A
D
S
Q
D
Site 126
T1000
S
S
E
A
D
P
S
T
V
A
D
S
Q
D
T
Site 127
S1004
D
P
S
T
V
A
D
S
Q
D
T
T
L
S
E
Site 128
T1008
V
A
D
S
Q
D
T
T
L
S
E
S
S
F
L
Site 129
S1010
D
S
Q
D
T
T
L
S
E
S
S
F
L
H
E
Site 130
S1013
D
T
T
L
S
E
S
S
F
L
H
E
P
Q
G
Site 131
T1021
F
L
H
E
P
Q
G
T
P
R
D
P
A
A
T
Site 132
T1028
T
P
R
D
P
A
A
T
S
K
P
S
G
K
P
Site 133
S1029
P
R
D
P
A
A
T
S
K
P
S
G
K
P
A
Site 134
S1032
P
A
A
T
S
K
P
S
G
K
P
A
P
E
N
Site 135
S1042
P
A
P
E
N
L
K
S
P
S
W
M
S
K
S
Site 136
S1044
P
E
N
L
K
S
P
S
W
M
S
K
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation