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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSC1
Full Name:
Hamartin
Alias:
KIAA0243; LAM; TSC; Tuberous sclerosis 1; Tuberous sclerosis 1 gene; Tuberous sclerosis 1 protein; Tuberous sclerosis 1 protein homolog
Type:
Tumour suppressor protein
Mass (Da):
129767
Number AA:
1164
UniProt ID:
Q92574
International Prot ID:
IPI00022043
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033596
GO:0005938
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0051087
GO:0047485
PhosphoSite+
KinaseNET
Biological Process:
GO:0032862
GO:0007160
GO:0032007
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
V
F
K
E
N
L
N
S
D
R
G
P
M
L
V
Site 2
Y48
L
V
N
T
L
V
D
Y
Y
L
E
T
S
S
Q
Site 3
Y49
V
N
T
L
V
D
Y
Y
L
E
T
S
S
Q
P
Site 4
S54
D
Y
Y
L
E
T
S
S
Q
P
A
L
H
I
L
Site 5
T62
Q
P
A
L
H
I
L
T
T
L
Q
E
P
H
D
Site 6
T63
P
A
L
H
I
L
T
T
L
Q
E
P
H
D
K
Site 7
Y79
L
L
D
R
I
N
E
Y
V
G
K
A
A
T
R
Site 8
S108
P
S
W
K
H
K
L
S
Q
A
P
L
L
P
S
Site 9
S115
S
Q
A
P
L
L
P
S
L
L
K
C
L
K
M
Site 10
T124
L
K
C
L
K
M
D
T
D
V
V
V
L
T
T
Site 11
T130
D
T
D
V
V
V
L
T
T
G
V
L
V
L
I
Site 12
T138
T
G
V
L
V
L
I
T
M
L
P
M
I
P
Q
Site 13
S146
M
L
P
M
I
P
Q
S
G
K
Q
H
L
L
D
Site 14
S162
F
D
I
F
G
R
L
S
S
W
C
L
K
K
P
Site 15
S163
D
I
F
G
R
L
S
S
W
C
L
K
K
P
G
Site 16
S205
N
F
V
S
F
L
R
S
H
Y
S
M
K
E
N
Site 17
Y207
V
S
F
L
R
S
H
Y
S
M
K
E
N
L
E
Site 18
S208
S
F
L
R
S
H
Y
S
M
K
E
N
L
E
T
Site 19
T215
S
M
K
E
N
L
E
T
F
E
E
V
V
K
P
Site 20
T252
R
R
W
K
R
L
E
T
H
D
V
V
I
E
C
Site 21
T267
A
K
I
S
L
D
P
T
E
A
S
Y
E
D
G
Site 22
S270
S
L
D
P
T
E
A
S
Y
E
D
G
Y
S
V
Site 23
Y275
E
A
S
Y
E
D
G
Y
S
V
S
H
Q
I
S
Site 24
S276
A
S
Y
E
D
G
Y
S
V
S
H
Q
I
S
A
Site 25
S278
Y
E
D
G
Y
S
V
S
H
Q
I
S
A
R
F
Site 26
S282
Y
S
V
S
H
Q
I
S
A
R
F
P
H
R
S
Site 27
S289
S
A
R
F
P
H
R
S
A
D
V
T
T
S
P
Site 28
T293
P
H
R
S
A
D
V
T
T
S
P
Y
A
D
T
Site 29
S295
R
S
A
D
V
T
T
S
P
Y
A
D
T
Q
N
Site 30
Y297
A
D
V
T
T
S
P
Y
A
D
T
Q
N
S
Y
Site 31
T300
T
T
S
P
Y
A
D
T
Q
N
S
Y
G
C
A
Site 32
S303
P
Y
A
D
T
Q
N
S
Y
G
C
A
T
S
T
Site 33
Y304
Y
A
D
T
Q
N
S
Y
G
C
A
T
S
T
P
Site 34
S309
N
S
Y
G
C
A
T
S
T
P
Y
S
T
S
R
Site 35
T310
S
Y
G
C
A
T
S
T
P
Y
S
T
S
R
L
Site 36
Y312
G
C
A
T
S
T
P
Y
S
T
S
R
L
M
L
Site 37
S315
T
S
T
P
Y
S
T
S
R
L
M
L
L
N
M
Site 38
T329
M
P
G
Q
L
P
Q
T
L
S
S
P
S
T
R
Site 39
S331
G
Q
L
P
Q
T
L
S
S
P
S
T
R
L
I
Site 40
S332
Q
L
P
Q
T
L
S
S
P
S
T
R
L
I
T
Site 41
S334
P
Q
T
L
S
S
P
S
T
R
L
I
T
E
P
Site 42
T335
Q
T
L
S
S
P
S
T
R
L
I
T
E
P
P
Site 43
T339
S
P
S
T
R
L
I
T
E
P
P
Q
A
T
L
Site 44
T345
I
T
E
P
P
Q
A
T
L
W
S
P
S
M
V
Site 45
T356
P
S
M
V
C
G
M
T
T
P
P
T
S
P
G
Site 46
T357
S
M
V
C
G
M
T
T
P
P
T
S
P
G
N
Site 47
T360
C
G
M
T
T
P
P
T
S
P
G
N
V
P
P
Site 48
S361
G
M
T
T
P
P
T
S
P
G
N
V
P
P
D
Site 49
S370
G
N
V
P
P
D
L
S
H
P
Y
S
K
V
F
Site 50
Y373
P
P
D
L
S
H
P
Y
S
K
V
F
G
T
T
Site 51
S374
P
D
L
S
H
P
Y
S
K
V
F
G
T
T
A
Site 52
T386
T
T
A
G
G
K
G
T
P
L
G
T
P
A
T
Site 53
T390
G
K
G
T
P
L
G
T
P
A
T
S
P
P
P
Site 54
T393
T
P
L
G
T
P
A
T
S
P
P
P
A
P
L
Site 55
S394
P
L
G
T
P
A
T
S
P
P
P
A
P
L
C
Site 56
S403
P
P
A
P
L
C
H
S
D
D
Y
V
H
I
S
Site 57
Y406
P
L
C
H
S
D
D
Y
V
H
I
S
L
P
Q
Site 58
S410
S
D
D
Y
V
H
I
S
L
P
Q
A
T
V
T
Site 59
T415
H
I
S
L
P
Q
A
T
V
T
P
P
R
K
E
Site 60
T417
S
L
P
Q
A
T
V
T
P
P
R
K
E
E
R
Site 61
S427
R
K
E
E
R
M
D
S
A
R
P
C
L
H
R
Site 62
S444
H
L
L
N
D
R
G
S
E
E
P
P
G
S
K
Site 63
S450
G
S
E
E
P
P
G
S
K
G
S
V
T
L
S
Site 64
S453
E
P
P
G
S
K
G
S
V
T
L
S
D
L
P
Site 65
T455
P
G
S
K
G
S
V
T
L
S
D
L
P
G
F
Site 66
S468
G
F
L
G
D
L
A
S
E
E
D
S
I
E
K
Site 67
S472
D
L
A
S
E
E
D
S
I
E
K
D
K
E
E
Site 68
S483
D
K
E
E
A
A
I
S
R
E
L
S
E
I
T
Site 69
S487
A
A
I
S
R
E
L
S
E
I
T
T
A
E
A
Site 70
T491
R
E
L
S
E
I
T
T
A
E
A
E
P
V
V
Site 71
S505
V
P
R
G
G
F
D
S
P
F
Y
R
D
S
L
Site 72
Y508
G
G
F
D
S
P
F
Y
R
D
S
L
P
G
S
Site 73
S511
D
S
P
F
Y
R
D
S
L
P
G
S
Q
R
K
Site 74
S515
Y
R
D
S
L
P
G
S
Q
R
K
T
H
S
A
Site 75
T519
L
P
G
S
Q
R
K
T
H
S
A
A
S
S
S
Site 76
S521
G
S
Q
R
K
T
H
S
A
A
S
S
S
Q
G
Site 77
S524
R
K
T
H
S
A
A
S
S
S
Q
G
A
S
V
Site 78
S525
K
T
H
S
A
A
S
S
S
Q
G
A
S
V
N
Site 79
S526
T
H
S
A
A
S
S
S
Q
G
A
S
V
N
P
Site 80
S530
A
S
S
S
Q
G
A
S
V
N
P
E
P
L
H
Site 81
S538
V
N
P
E
P
L
H
S
S
L
D
K
L
G
P
Site 82
S539
N
P
E
P
L
H
S
S
L
D
K
L
G
P
D
Site 83
T547
L
D
K
L
G
P
D
T
P
K
Q
A
F
T
P
Site 84
T553
D
T
P
K
Q
A
F
T
P
I
D
L
P
C
G
Site 85
S561
P
I
D
L
P
C
G
S
A
D
E
S
P
A
G
Site 86
S565
P
C
G
S
A
D
E
S
P
A
G
D
R
E
C
Site 87
T574
A
G
D
R
E
C
Q
T
S
L
E
T
S
I
F
Site 88
S575
G
D
R
E
C
Q
T
S
L
E
T
S
I
F
T
Site 89
S579
C
Q
T
S
L
E
T
S
I
F
T
P
S
P
C
Site 90
T582
S
L
E
T
S
I
F
T
P
S
P
C
K
I
P
Site 91
S584
E
T
S
I
F
T
P
S
P
C
K
I
P
P
P
Site 92
T592
P
C
K
I
P
P
P
T
R
V
G
F
G
S
G
Site 93
S598
P
T
R
V
G
F
G
S
G
Q
P
P
P
Y
D
Site 94
Y604
G
S
G
Q
P
P
P
Y
D
H
L
F
E
V
A
Site 95
T624
H
H
F
V
I
R
K
T
E
E
L
L
K
K
A
Site 96
S644
E
D
G
V
P
S
T
S
P
M
E
V
L
D
R
Site 97
S671
L
N
K
L
P
L
P
S
K
S
V
D
W
T
H
Site 98
S673
K
L
P
L
P
S
K
S
V
D
W
T
H
F
G
Site 99
T677
P
S
K
S
V
D
W
T
H
F
G
G
S
P
P
Site 100
S682
D
W
T
H
F
G
G
S
P
P
S
D
E
I
R
Site 101
S685
H
F
G
G
S
P
P
S
D
E
I
R
T
L
R
Site 102
T690
P
P
S
D
E
I
R
T
L
R
D
Q
L
L
L
Site 103
Y704
L
L
H
N
Q
L
L
Y
E
R
F
K
R
Q
Q
Site 104
Y761
L
Q
K
E
Q
A
R
Y
N
Q
L
Q
E
Q
R
Site 105
T770
Q
L
Q
E
Q
R
D
T
M
V
T
K
L
H
S
Site 106
T773
E
Q
R
D
T
M
V
T
K
L
H
S
Q
I
R
Site 107
S777
T
M
V
T
K
L
H
S
Q
I
R
Q
L
Q
H
Site 108
S793
R
E
E
F
Y
N
Q
S
Q
E
L
Q
T
K
L
Site 109
S829
C
H
T
E
L
L
L
S
Q
V
S
Q
K
L
S
Site 110
S832
E
L
L
L
S
Q
V
S
Q
K
L
S
N
S
E
Site 111
S836
S
Q
V
S
Q
K
L
S
N
S
E
S
V
Q
Q
Site 112
S838
V
S
Q
K
L
S
N
S
E
S
V
Q
Q
Q
M
Site 113
S840
Q
K
L
S
N
S
E
S
V
Q
Q
Q
M
E
F
Site 114
Y862
L
G
E
V
N
E
L
Y
L
E
Q
L
Q
N
K
Site 115
S871
E
Q
L
Q
N
K
H
S
D
T
T
K
E
V
E
Site 116
T873
L
Q
N
K
H
S
D
T
T
K
E
V
E
M
M
Site 117
T874
Q
N
K
H
S
D
T
T
K
E
V
E
M
M
K
Site 118
S893
K
E
L
E
K
N
R
S
H
V
L
Q
Q
T
Q
Site 119
T899
R
S
H
V
L
Q
Q
T
Q
R
L
D
T
S
Q
Site 120
T904
Q
Q
T
Q
R
L
D
T
S
Q
K
R
I
L
E
Site 121
S905
Q
T
Q
R
L
D
T
S
Q
K
R
I
L
E
L
Site 122
Y929
L
L
L
E
Q
K
K
Y
L
E
D
V
K
L
Q
Site 123
T955
Y
E
A
Q
K
R
I
T
Q
V
F
E
L
E
I
Site 124
Y966
E
L
E
I
L
D
L
Y
G
R
L
E
K
D
G
Site 125
T1018
A
S
G
H
N
G
E
T
K
T
P
R
P
S
S
Site 126
T1020
G
H
N
G
E
T
K
T
P
R
P
S
S
A
R
Site 127
S1024
E
T
K
T
P
R
P
S
S
A
R
G
S
S
G
Site 128
S1025
T
K
T
P
R
P
S
S
A
R
G
S
S
G
S
Site 129
S1029
R
P
S
S
A
R
G
S
S
G
S
R
G
G
G
Site 130
S1030
P
S
S
A
R
G
S
S
G
S
R
G
G
G
G
Site 131
S1032
S
A
R
G
S
S
G
S
R
G
G
G
G
S
S
Site 132
S1038
G
S
R
G
G
G
G
S
S
S
S
S
S
E
L
Site 133
S1039
S
R
G
G
G
G
S
S
S
S
S
S
E
L
S
Site 134
S1040
R
G
G
G
G
S
S
S
S
S
S
E
L
S
T
Site 135
S1041
G
G
G
G
S
S
S
S
S
S
E
L
S
T
P
Site 136
S1042
G
G
G
S
S
S
S
S
S
E
L
S
T
P
E
Site 137
S1043
G
G
S
S
S
S
S
S
E
L
S
T
P
E
K
Site 138
S1046
S
S
S
S
S
E
L
S
T
P
E
K
P
P
H
Site 139
T1047
S
S
S
S
E
L
S
T
P
E
K
P
P
H
Q
Site 140
S1060
H
Q
R
A
G
P
F
S
S
R
W
E
T
T
M
Site 141
S1061
Q
R
A
G
P
F
S
S
R
W
E
T
T
M
G
Site 142
T1065
P
F
S
S
R
W
E
T
T
M
G
E
A
S
A
Site 143
S1080
S
I
P
T
T
V
G
S
L
P
S
S
K
S
F
Site 144
S1084
T
V
G
S
L
P
S
S
K
S
F
L
G
M
K
Site 145
S1086
G
S
L
P
S
S
K
S
F
L
G
M
K
A
R
Site 146
S1100
R
E
L
F
R
N
K
S
E
S
Q
C
D
E
D
Site 147
S1102
L
F
R
N
K
S
E
S
Q
C
D
E
D
G
M
Site 148
T1110
Q
C
D
E
D
G
M
T
S
S
L
S
E
S
L
Site 149
S1112
D
E
D
G
M
T
S
S
L
S
E
S
L
K
T
Site 150
S1114
D
G
M
T
S
S
L
S
E
S
L
K
T
E
L
Site 151
S1116
M
T
S
S
L
S
E
S
L
K
T
E
L
G
K
Site 152
T1119
S
L
S
E
S
L
K
T
E
L
G
K
D
L
G
Site 153
S1141
N
L
D
G
P
H
P
S
P
P
T
P
D
S
V
Site 154
T1144
G
P
H
P
S
P
P
T
P
D
S
V
G
Q
L
Site 155
S1147
P
S
P
P
T
P
D
S
V
G
Q
L
H
I
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation