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Updated November 2019
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Protein Info
Short Name:
RYR2
Full Name:
Ryanodine receptor 2
Alias:
ARVC2; ARVD2; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; Ryanodine receptor 2 (cardiac); RYR-2; VTSIP
Type:
Channel, ligand-gated
Mass (Da):
564742
Number AA:
4965
UniProt ID:
Q92736
International Prot ID:
IPI00023217
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034704
GO:0005886
GO:0001950
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005516
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0060048
GO:0005513
GO:0008627
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
A
R
A
K
T
R
S
S
S
C
E
L
Site 2
S9
G
A
R
A
K
T
R
S
S
S
C
E
L
M
M
Site 3
S10
A
R
A
K
T
R
S
S
S
C
E
L
M
M
K
Site 4
S11
R
A
K
T
R
S
S
S
C
E
L
M
M
K
W
Site 5
S26
F
C
S
A
P
Q
P
S
T
K
N
N
R
S
Y
Site 6
T27
C
S
A
P
Q
P
S
T
K
N
N
R
S
Y
A
Site 7
Y33
S
T
K
N
N
R
S
Y
A
W
Q
Q
K
D
L
Site 8
T59
I
P
R
M
C
P
Q
T
S
P
S
A
P
L
C
Site 9
S60
P
R
M
C
P
Q
T
S
P
S
A
P
L
C
W
Site 10
S62
M
C
P
Q
T
S
P
S
A
P
L
C
W
S
S
Site 11
S68
P
S
A
P
L
C
W
S
S
P
S
L
S
G
R
Site 12
S69
S
A
P
L
C
W
S
S
P
S
L
S
G
R
C
Site 13
S71
P
L
C
W
S
S
P
S
L
S
G
R
C
R
R
Site 14
Y127
R
H
S
Y
S
G
M
Y
L
C
C
L
S
T
S
Site 15
S132
G
M
Y
L
C
C
L
S
T
S
R
S
S
T
D
Site 16
T133
M
Y
L
C
C
L
S
T
S
R
S
S
T
D
K
Site 17
S134
Y
L
C
C
L
S
T
S
R
S
S
T
D
K
L
Site 18
S136
C
C
L
S
T
S
R
S
S
T
D
K
L
A
F
Site 19
S137
C
L
S
T
S
R
S
S
T
D
K
L
A
F
D
Site 20
T138
L
S
T
S
R
S
S
T
D
K
L
A
F
D
V
Site 21
S168
H
P
A
S
K
Q
R
S
E
G
E
K
V
R
V
Site 22
Y189
V
S
V
S
S
E
R
Y
L
H
L
S
Y
G
N
Site 23
S193
S
E
R
Y
L
H
L
S
Y
G
N
G
S
L
H
Site 24
Y194
E
R
Y
L
H
L
S
Y
G
N
G
S
L
H
V
Site 25
T244
G
H
M
D
E
C
L
T
V
P
S
G
E
H
G
Site 26
T257
H
G
E
E
Q
R
R
T
V
H
Y
E
G
G
A
Site 27
Y260
E
Q
R
R
T
V
H
Y
E
G
G
A
V
S
V
Site 28
S266
H
Y
E
G
G
A
V
S
V
H
A
R
S
L
W
Site 29
T277
R
S
L
W
R
L
E
T
L
R
V
A
W
S
G
Site 30
S283
E
T
L
R
V
A
W
S
G
S
H
I
R
W
G
Site 31
T299
P
F
R
L
R
H
V
T
T
G
K
Y
L
S
L
Site 32
Y303
R
H
V
T
T
G
K
Y
L
S
L
M
E
D
K
Site 33
S305
V
T
T
G
K
Y
L
S
L
M
E
D
K
N
L
Site 34
S324
K
E
K
A
D
V
K
S
T
A
F
T
F
R
S
Site 35
T328
D
V
K
S
T
A
F
T
F
R
S
S
K
E
K
Site 36
S332
T
A
F
T
F
R
S
S
K
E
K
L
D
V
G
Site 37
S350
E
V
D
G
M
G
T
S
E
I
K
Y
G
D
S
Site 38
Y354
M
G
T
S
E
I
K
Y
G
D
S
V
C
Y
I
Site 39
Y372
D
T
G
L
W
L
T
Y
Q
S
V
D
V
K
S
Site 40
S374
G
L
W
L
T
Y
Q
S
V
D
V
K
S
V
R
Site 41
S379
Y
Q
S
V
D
V
K
S
V
R
M
G
S
I
Q
Site 42
S384
V
K
S
V
R
M
G
S
I
Q
R
K
A
I
M
Site 43
S402
G
H
M
D
D
G
I
S
L
S
R
S
Q
H
E
Site 44
S404
M
D
D
G
I
S
L
S
R
S
Q
H
E
E
S
Site 45
S406
D
G
I
S
L
S
R
S
Q
H
E
E
S
R
T
Site 46
S411
S
R
S
Q
H
E
E
S
R
T
A
R
V
I
R
Site 47
T413
S
Q
H
E
E
S
R
T
A
R
V
I
R
S
T
Site 48
S419
R
T
A
R
V
I
R
S
T
V
F
L
F
N
R
Site 49
S435
I
R
G
L
D
A
L
S
K
K
A
K
A
S
T
Site 50
Y460
S
L
Q
D
L
I
G
Y
F
H
P
P
D
E
H
Site 51
S507
I
D
R
L
H
V
Y
S
S
A
A
H
F
A
D
Site 52
S508
D
R
L
H
V
Y
S
S
A
A
H
F
A
D
V
Site 53
S523
A
G
R
E
A
G
E
S
W
K
S
I
L
N
S
Site 54
S526
E
A
G
E
S
W
K
S
I
L
N
S
L
Y
E
Site 55
S552
N
C
A
Q
F
S
G
S
L
D
W
L
I
S
R
Site 56
S558
G
S
L
D
W
L
I
S
R
L
E
R
L
E
A
Site 57
S594
I
K
E
G
H
I
K
S
I
I
S
L
L
D
K
Site 58
S597
G
H
I
K
S
I
I
S
L
L
D
K
H
G
R
Site 59
S651
T
R
L
V
N
H
V
S
S
M
R
P
N
I
F
Site 60
S662
P
N
I
F
L
G
V
S
E
G
S
A
Q
Y
K
Site 61
Y673
A
Q
Y
K
K
W
Y
Y
E
L
M
V
D
H
T
Site 62
T680
Y
E
L
M
V
D
H
T
E
P
F
V
T
A
E
Site 63
T685
D
H
T
E
P
F
V
T
A
E
A
T
H
L
R
Site 64
S697
H
L
R
V
G
W
A
S
T
E
G
Y
S
P
Y
Site 65
T698
L
R
V
G
W
A
S
T
E
G
Y
S
P
Y
P
Site 66
Y701
G
W
A
S
T
E
G
Y
S
P
Y
P
G
G
G
Site 67
S702
W
A
S
T
E
G
Y
S
P
Y
P
G
G
G
E
Site 68
Y704
S
T
E
G
Y
S
P
Y
P
G
G
G
E
E
W
Site 69
S722
G
V
G
D
D
L
F
S
Y
G
F
D
G
L
H
Site 70
T738
W
S
G
C
I
A
R
T
V
S
S
P
N
Q
H
Site 71
S740
G
C
I
A
R
T
V
S
S
P
N
Q
H
L
L
Site 72
S741
C
I
A
R
T
V
S
S
P
N
Q
H
L
L
R
Site 73
T749
P
N
Q
H
L
L
R
T
D
D
V
I
S
C
C
Site 74
S765
D
L
S
A
P
S
I
S
F
R
I
N
G
Q
P
Site 75
Y817
K
F
L
P
P
P
G
Y
A
P
C
Y
E
A
V
Site 76
Y821
P
P
G
Y
A
P
C
Y
E
A
V
L
P
K
E
Site 77
S835
E
K
L
K
V
E
H
S
R
E
Y
K
Q
E
R
Site 78
Y838
K
V
E
H
S
R
E
Y
K
Q
E
R
T
Y
T
Site 79
Y844
E
Y
K
Q
E
R
T
Y
T
R
D
L
L
G
P
Site 80
T845
Y
K
Q
E
R
T
Y
T
R
D
L
L
G
P
T
Site 81
Y929
L
P
E
Q
E
R
N
Y
N
L
Q
M
S
L
E
Site 82
S951
L
G
C
H
V
G
I
S
D
E
H
A
E
D
K
Site 83
Y968
K
M
K
L
P
K
N
Y
Q
L
T
S
G
Y
K
Site 84
S982
K
P
A
P
M
D
L
S
F
I
K
L
T
P
S
Site 85
S989
S
F
I
K
L
T
P
S
Q
E
A
M
V
D
K
Site 86
Y1016
R
I
R
Q
G
W
T
Y
G
I
Q
Q
D
V
K
Site 87
T1034
N
P
R
L
V
P
Y
T
L
L
D
D
R
T
K
Site 88
T1040
Y
T
L
L
D
D
R
T
K
K
S
N
K
D
S
Site 89
S1043
L
D
D
R
T
K
K
S
N
K
D
S
L
R
E
Site 90
S1047
T
K
K
S
N
K
D
S
L
R
E
A
V
R
T
Site 91
T1054
S
L
R
E
A
V
R
T
L
L
G
Y
G
Y
N
Site 92
Y1060
R
T
L
L
G
Y
G
Y
N
L
E
A
P
D
Q
Site 93
S1077
A
A
R
A
E
V
C
S
G
T
G
E
R
F
R
Site 94
T1091
R
I
F
R
A
E
K
T
Y
A
V
K
A
G
R
Site 95
Y1092
I
F
R
A
E
K
T
Y
A
V
K
A
G
R
W
Site 96
Y1100
A
V
K
A
G
R
W
Y
F
E
F
E
T
V
T
Site 97
S1128
Q
P
D
Q
E
L
G
S
D
E
R
A
F
A
F
Site 98
Y1150
W
H
Q
G
N
E
H
Y
G
R
S
W
Q
A
G
Site 99
S1184
G
E
I
L
L
D
D
S
G
S
E
L
A
F
K
Site 100
T1246
V
N
T
N
R
D
I
T
M
W
L
S
K
R
L
Site 101
T1274
E
V
T
R
I
D
G
T
I
D
S
S
P
C
L
Site 102
S1277
R
I
D
G
T
I
D
S
S
P
C
L
K
V
T
Site 103
S1278
I
D
G
T
I
D
S
S
P
C
L
K
V
T
Q
Site 104
T1284
S
S
P
C
L
K
V
T
Q
K
S
F
G
S
Q
Site 105
S1287
C
L
K
V
T
Q
K
S
F
G
S
Q
N
S
N
Site 106
S1290
V
T
Q
K
S
F
G
S
Q
N
S
N
T
D
I
Site 107
S1293
K
S
F
G
S
Q
N
S
N
T
D
I
M
F
Y
Site 108
T1295
F
G
S
Q
N
S
N
T
D
I
M
F
Y
R
L
Site 109
Y1300
S
N
T
D
I
M
F
Y
R
L
S
M
P
I
E
Site 110
Y1335
P
K
N
D
L
E
D
Y
D
A
D
S
D
F
E
Site 111
S1339
L
E
D
Y
D
A
D
S
D
F
E
V
L
M
K
Site 112
Y1374
E
F
N
N
H
K
D
Y
A
Q
E
K
P
S
R
Site 113
T1391
Q
R
F
L
L
R
R
T
K
P
D
Y
S
T
S
Site 114
Y1395
L
R
R
T
K
P
D
Y
S
T
S
H
S
A
R
Site 115
S1396
R
R
T
K
P
D
Y
S
T
S
H
S
A
R
L
Site 116
S1398
T
K
P
D
Y
S
T
S
H
S
A
R
L
T
E
Site 117
S1400
P
D
Y
S
T
S
H
S
A
R
L
T
E
D
V
Site 118
T1404
T
S
H
S
A
R
L
T
E
D
V
L
A
D
D
Site 119
Y1415
L
A
D
D
R
D
D
Y
D
F
L
M
Q
T
S
Site 120
Y1425
L
M
Q
T
S
T
Y
Y
Y
S
V
R
I
F
P
Site 121
Y1426
M
Q
T
S
T
Y
Y
Y
S
V
R
I
F
P
G
Site 122
Y1451
I
T
S
D
F
H
Q
Y
D
T
G
F
D
L
D
Site 123
T1453
S
D
F
H
Q
Y
D
T
G
F
D
L
D
R
V
Site 124
T1464
L
D
R
V
R
T
V
T
V
T
L
G
D
E
K
Site 125
T1466
R
V
R
T
V
T
V
T
L
G
D
E
K
G
K
Site 126
S1477
E
K
G
K
V
H
E
S
I
K
R
S
N
C
Y
Site 127
Y1484
S
I
K
R
S
N
C
Y
M
V
C
A
G
E
S
Site 128
S1491
Y
M
V
C
A
G
E
S
M
S
P
G
Q
G
R
Site 129
S1493
V
C
A
G
E
S
M
S
P
G
Q
G
R
N
N
Site 130
S1526
I
A
N
G
K
E
L
S
T
Y
Y
Q
V
E
P
Site 131
Y1528
N
G
K
E
L
S
T
Y
Y
Q
V
E
P
S
T
Site 132
Y1529
G
K
E
L
S
T
Y
Y
Q
V
E
P
S
T
K
Site 133
S1571
L
S
A
G
L
F
K
S
E
H
K
N
P
V
P
Site 134
S1607
Q
F
L
K
V
D
V
S
R
I
S
E
R
Q
G
Site 135
S1610
K
V
D
V
S
R
I
S
E
R
Q
G
W
L
V
Site 136
S1627
L
D
P
L
Q
F
M
S
L
H
I
P
E
E
N
Site 137
S1636
H
I
P
E
E
N
R
S
V
D
I
L
E
L
T
Site 138
T1643
S
V
D
I
L
E
L
T
E
Q
E
E
L
L
K
Site 139
Y1653
E
E
L
L
K
F
H
Y
H
T
L
R
L
Y
S
Site 140
T1714
I
H
L
S
S
Y
A
T
A
R
L
M
M
N
N
Site 141
Y1723
R
L
M
M
N
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Site 293
T4025
F
L
K
L
K
D
L
T
S
S
D
T
F
K
E
Site 294
S4026
L
K
L
K
D
L
T
S
S
D
T
F
K
E
Y
Site 295
S4027
K
L
K
D
L
T
S
S
D
T
F
K
E
Y
D
Site 296
T4029
K
D
L
T
S
S
D
T
F
K
E
Y
D
P
D
Site 297
Y4033
S
S
D
T
F
K
E
Y
D
P
D
G
K
G
V
Site 298
S4042
P
D
G
K
G
V
I
S
K
R
D
F
H
K
A
Site 299
Y4056
A
M
E
S
H
K
H
Y
T
Q
S
E
T
E
F
Site 300
S4059
S
H
K
H
Y
T
Q
S
E
T
E
F
L
L
S
Site 301
S4066
S
E
T
E
F
L
L
S
C
A
E
T
D
E
N
Site 302
T4070
F
L
L
S
C
A
E
T
D
E
N
E
T
L
D
Site 303
Y4078
D
E
N
E
T
L
D
Y
E
E
F
V
K
R
F
Site 304
S4104
A
V
L
L
T
N
L
S
E
H
M
P
N
D
T
Site 305
T4115
P
N
D
T
R
L
Q
T
F
L
E
L
A
E
S
Site 306
S4139
G
R
I
E
I
M
G
S
A
K
R
I
E
R
V
Site 307
Y4147
A
K
R
I
E
R
V
Y
F
E
I
S
E
S
S
Site 308
S4151
E
R
V
Y
F
E
I
S
E
S
S
R
T
Q
W
Site 309
S4153
V
Y
F
E
I
S
E
S
S
R
T
Q
W
E
K
Site 310
T4156
E
I
S
E
S
S
R
T
Q
W
E
K
P
Q
V
Site 311
S4166
E
K
P
Q
V
K
E
S
K
R
Q
F
I
F
D
Site 312
S4205
M
Q
L
A
A
Q
I
S
E
S
D
L
N
E
R
Site 313
S4207
L
A
A
Q
I
S
E
S
D
L
N
E
R
S
A
Site 314
S4213
E
S
D
L
N
E
R
S
A
N
K
E
E
S
E
Site 315
S4219
R
S
A
N
K
E
E
S
E
K
E
R
P
E
E
Site 316
S4258
L
T
L
M
R
M
L
S
L
K
S
L
K
K
Q
Site 317
S4261
M
R
M
L
S
L
K
S
L
K
K
Q
M
K
K
Site 318
T4336
L
A
N
M
P
D
P
T
Q
D
E
V
R
G
D
Site 319
T4362
A
L
P
S
E
D
L
T
D
L
K
E
L
T
E
Site 320
T4368
L
T
D
L
K
E
L
T
E
E
S
D
L
L
S
Site 321
S4371
L
K
E
L
T
E
E
S
D
L
L
S
D
I
F
Site 322
Y4389
L
K
R
E
G
G
Q
Y
K
L
I
P
H
N
P
Site 323
S4401
H
N
P
N
A
G
L
S
D
L
M
S
N
P
V
Site 324
S4405
A
G
L
S
D
L
M
S
N
P
V
P
M
P
E
Site 325
T4433
E
K
E
E
K
E
E
T
K
S
E
P
E
K
A
Site 326
S4435
E
E
K
E
E
T
K
S
E
P
E
K
A
E
G
Site 327
T4465
Q
K
L
R
Q
L
H
T
H
R
Y
G
E
P
E
Site 328
Y4468
R
Q
L
H
T
H
R
Y
G
E
P
E
V
P
E
Site 329
S4476
G
E
P
E
V
P
E
S
A
F
W
K
K
I
I
Site 330
Y4485
F
W
K
K
I
I
A
Y
Q
Q
K
L
L
N
Y
Site 331
Y4492
Y
Q
Q
K
L
L
N
Y
F
A
R
N
F
Y
N
Site 332
Y4498
N
Y
F
A
R
N
F
Y
N
M
R
M
L
A
L
Site 333
S4523
L
F
Y
K
V
S
T
S
S
V
V
E
G
K
E
Site 334
S4535
G
K
E
L
P
T
R
S
S
S
E
N
A
K
V
Site 335
S4536
K
E
L
P
T
R
S
S
S
E
N
A
K
V
T
Site 336
S4537
E
L
P
T
R
S
S
S
E
N
A
K
V
T
S
Site 337
T4543
S
S
E
N
A
K
V
T
S
L
D
S
S
S
H
Site 338
S4544
S
E
N
A
K
V
T
S
L
D
S
S
S
H
R
Site 339
S4547
A
K
V
T
S
L
D
S
S
S
H
R
I
I
A
Site 340
Y4557
H
R
I
I
A
V
H
Y
V
L
E
E
S
S
G
Site 341
Y4565
V
L
E
E
S
S
G
Y
M
E
P
T
L
R
I
Site 342
Y4614
K
L
E
F
D
G
L
Y
I
T
E
Q
P
S
E
Site 343
T4616
E
F
D
G
L
Y
I
T
E
Q
P
S
E
D
D
Site 344
Y4642
T
Q
S
F
P
N
N
Y
W
D
K
F
V
K
R
Site 345
Y4655
K
R
K
V
M
D
K
Y
G
E
F
Y
G
R
D
Site 346
Y4659
M
D
K
Y
G
E
F
Y
G
R
D
R
I
S
E
Site 347
S4665
F
Y
G
R
D
R
I
S
E
L
L
G
M
D
K
Site 348
S4678
D
K
A
A
L
D
F
S
D
A
R
E
K
K
K
Site 349
S4691
K
K
P
K
K
D
S
S
L
S
A
V
L
N
S
Site 350
S4693
P
K
K
D
S
S
L
S
A
V
L
N
S
I
D
Site 351
Y4703
L
N
S
I
D
V
K
Y
Q
M
W
K
L
G
V
Site 352
S4756
K
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Site 353
S4757
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Q
Site 354
Y4779
L
A
V
V
V
Y
L
Y
T
V
V
A
F
N
F
Site 355
Y4791
F
N
F
F
R
K
F
Y
N
K
S
E
D
G
D
Site 356
S4794
F
R
K
F
Y
N
K
S
E
D
G
D
T
P
D
Site 357
T4799
N
K
S
E
D
G
D
T
P
D
M
K
C
D
D
Site 358
Y4837
E
D
P
A
G
D
E
Y
E
I
Y
R
I
I
F
Site 359
Y4840
A
G
D
E
Y
E
I
Y
R
I
I
F
D
I
T
Site 360
Y4895
I
C
G
I
G
N
D
Y
F
D
T
V
P
H
G
Site 361
T4898
I
G
N
D
Y
F
D
T
V
P
H
G
F
E
T
Site 362
T4929
Y
L
I
N
K
D
E
T
E
H
T
G
Q
E
S
Site 363
T4932
N
K
D
E
T
E
H
T
G
Q
E
S
Y
V
W
Site 364
Y4937
E
H
T
G
Q
E
S
Y
V
W
K
M
Y
Q
E
Site 365
Y4960
G
D
C
F
R
K
Q
Y
E
D
Q
L
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation