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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Tip60
Full Name:
Histone acetyltransferase KAT5
Alias:
60 kDa Tat interactive protein; cPLA(2)-interacting protein; cPLA2; ESA1; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; HTATIP; HTATIP1; K (lysine) acetyltransferase 5; K-acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; Tat-interactive 60 kDa protein alpha isoform; Tat-interactive protein-60; TI60; TIP60
Type:
Acetyltransferase; EC 2.3.1.-; EC 2.3.1.48; Nuclear receptor co-regulator
Mass (Da):
58582
Number AA:
513
UniProt ID:
Q92993
International Prot ID:
IPI00290020
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035267
GO:0032777
GO:0000785
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0003682
GO:0004402
PhosphoSite+
KinaseNET
Biological Process:
GO:0006978
GO:0030521
GO:0006333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y44
I
S
G
R
K
L
F
Y
V
H
Y
I
D
F
N
Site 2
Y47
R
K
L
F
Y
V
H
Y
I
D
F
N
K
R
L
Site 3
T59
K
R
L
D
E
W
V
T
H
E
R
L
D
L
K
Site 4
T77
F
P
K
K
E
A
K
T
P
T
K
N
G
L
P
Site 5
S86
T
K
N
G
L
P
G
S
R
P
G
S
P
E
R
Site 6
S90
L
P
G
S
R
P
G
S
P
E
R
E
V
P
A
Site 7
S98
P
E
R
E
V
P
A
S
A
Q
A
S
G
K
T
Site 8
S135
G
E
P
D
Q
P
L
S
S
S
S
C
L
Q
P
Site 9
S136
E
P
D
Q
P
L
S
S
S
S
C
L
Q
P
N
Site 10
S137
P
D
Q
P
L
S
S
S
S
C
L
Q
P
N
H
Site 11
T147
L
Q
P
N
H
R
S
T
K
R
K
V
E
V
V
Site 12
S155
K
R
K
V
E
V
V
S
P
A
T
P
V
P
S
Site 13
T158
V
E
V
V
S
P
A
T
P
V
P
S
E
T
A
Site 14
S162
S
P
A
T
P
V
P
S
E
T
A
P
A
S
V
Site 15
S168
P
S
E
T
A
P
A
S
V
F
P
Q
N
G
A
Site 16
S190
Q
P
G
R
K
R
K
S
N
C
L
G
T
D
E
Site 17
T195
R
K
S
N
C
L
G
T
D
E
D
S
Q
D
S
Site 18
S199
C
L
G
T
D
E
D
S
Q
D
S
S
D
G
I
Site 19
S202
T
D
E
D
S
Q
D
S
S
D
G
I
P
S
A
Site 20
S203
D
E
D
S
Q
D
S
S
D
G
I
P
S
A
P
Site 21
S208
D
S
S
D
G
I
P
S
A
P
R
M
T
G
S
Site 22
T213
I
P
S
A
P
R
M
T
G
S
L
V
S
D
R
Site 23
S215
S
A
P
R
M
T
G
S
L
V
S
D
R
S
H
Site 24
S218
R
M
T
G
S
L
V
S
D
R
S
H
D
D
I
Site 25
S221
G
S
L
V
S
D
R
S
H
D
D
I
V
T
R
Site 26
T227
R
S
H
D
D
I
V
T
R
M
K
N
I
E
C
Site 27
Y246
R
H
R
L
K
P
W
Y
F
S
P
Y
P
Q
E
Site 28
S248
R
L
K
P
W
Y
F
S
P
Y
P
Q
E
L
T
Site 29
Y250
K
P
W
Y
F
S
P
Y
P
Q
E
L
T
T
L
Site 30
T281
K
C
L
Q
R
H
L
T
K
C
D
L
R
H
P
Site 31
T298
N
E
I
Y
R
K
G
T
I
S
F
F
E
I
D
Site 32
S300
I
Y
R
K
G
T
I
S
F
F
E
I
D
G
R
Site 33
S311
I
D
G
R
K
N
K
S
Y
S
Q
N
L
C
L
Site 34
Y312
D
G
R
K
N
K
S
Y
S
Q
N
L
C
L
L
Site 35
S313
G
R
K
N
K
S
Y
S
Q
N
L
C
L
L
A
Site 36
Y330
F
L
D
H
K
T
L
Y
Y
D
T
D
P
F
L
Site 37
Y331
L
D
H
K
T
L
Y
Y
D
T
D
P
F
L
F
Site 38
Y339
D
T
D
P
F
L
F
Y
V
M
T
E
Y
D
C
Site 39
Y354
K
G
F
H
I
V
G
Y
F
S
K
E
K
E
S
Site 40
S356
F
H
I
V
G
Y
F
S
K
E
K
E
S
T
E
Site 41
T362
F
S
K
E
K
E
S
T
E
D
Y
N
V
A
C
Site 42
Y365
E
K
E
S
T
E
D
Y
N
V
A
C
I
L
T
Site 43
T372
Y
N
V
A
C
I
L
T
L
P
P
Y
Q
R
R
Site 44
Y376
C
I
L
T
L
P
P
Y
Q
R
R
G
Y
G
K
Site 45
Y381
P
P
Y
Q
R
R
G
Y
G
K
L
L
I
E
F
Site 46
S389
G
K
L
L
I
E
F
S
Y
E
L
S
K
V
E
Site 47
Y390
K
L
L
I
E
F
S
Y
E
L
S
K
V
E
G
Site 48
S393
I
E
F
S
Y
E
L
S
K
V
E
G
K
T
G
Site 49
T399
L
S
K
V
E
G
K
T
G
T
P
E
K
P
L
Site 50
T401
K
V
E
G
K
T
G
T
P
E
K
P
L
S
D
Site 51
S407
G
T
P
E
K
P
L
S
D
L
G
L
L
S
Y
Site 52
S413
L
S
D
L
G
L
L
S
Y
R
S
Y
W
S
Q
Site 53
Y414
S
D
L
G
L
L
S
Y
R
S
Y
W
S
Q
T
Site 54
Y417
G
L
L
S
Y
R
S
Y
W
S
Q
T
I
L
E
Site 55
S419
L
S
Y
R
S
Y
W
S
Q
T
I
L
E
I
L
Site 56
S431
E
I
L
M
G
L
K
S
E
S
G
E
R
P
Q
Site 57
T440
S
G
E
R
P
Q
I
T
I
N
E
I
S
E
I
Site 58
S449
N
E
I
S
E
I
T
S
I
K
K
E
D
V
I
Site 59
S457
I
K
K
E
D
V
I
S
T
L
Q
Y
L
N
L
Site 60
Y467
Q
Y
L
N
L
I
N
Y
Y
K
G
Q
Y
I
L
Site 61
Y472
I
N
Y
Y
K
G
Q
Y
I
L
T
L
S
E
D
Site 62
T475
Y
K
G
Q
Y
I
L
T
L
S
E
D
I
V
D
Site 63
S477
G
Q
Y
I
L
T
L
S
E
D
I
V
D
G
H
Site 64
S497
K
R
L
L
R
I
D
S
K
C
L
H
F
T
P
Site 65
T503
D
S
K
C
L
H
F
T
P
K
D
W
S
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation